CN106421824A - 超声治疗仪的生物耦合片及其制备方法 - Google Patents
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Abstract
本发明涉及超声治疗仪的生物耦合片及其制备方法,所述超声治疗仪的生物耦合片,由明胶制备液和植物提取液混合后,静置成固态凝胶片再切片而成;所述植物提取液由以下重量份的原料水提而成:芦荟:10份、菊花:3份、生蒲黄:5份、薄荷:5份、当归:5份、没药:5份、艾绒:5份、蛇床子:5份、首乌:7份、丹参:5份、独活:5份、益母草:10份、丹皮:10份、红花:10份、山楂:5份、川穹:5份。本发明由天然材料制作而成,易降解,卫生环保。
Description
技术领域
本发明涉及一种与超声治疗仪配合使用的、用于将超声导入到治疗区域皮肤的藕合贴片,还涉及一种上述藕合贴片的制备方法。
背景技术
现有的超声耦合制品主要有三类,一种是凝胶状的耦合剂,主要用于超声检测,一种是无纺布加药酒,还有一种是耦合贴片,后面两种一般用于超声治疗。
超声耦合剂使用时,像牙膏一样挤出涂抹在人体皮肤上,挤多挤少凭经验,使用时,容易弄脏衣物,检测完毕后,需用纸擦除皮肤上的残留物,不太方便,而且,超声耦合剂一般由化学材料制成,产生医疗垃圾,不环保,而且存在致敏情况。另外,在同等输出功率的情况下有效辐射面积较小,影响治疗效果。
无纺布加药酒在使用时,需配合一个超声固定套,超声固定套为一凹形铝箔套,浸染有药酒的无纺布容纳在凹形铝箔套的凹腔中,凹形铝箔套通过粘胶粘贴在超声治疗头上。和超声耦合剂一样,无纺布加药酒耦合制品也存在容易弄脏衣物,使用不方便,同等输出功率的情况下有效辐射面积小等缺点,另外,其使用时,产生另外的消耗品超声固定套,加重了环境负担。
超声耦合贴片,因自带粘性,可直接贴于治疗头超声辐射面的凹腔中(如图1所示,治疗头1上具有一凹腔11,超声辐射面为该凹腔11的底面),不产生另外的消耗品,又由于其为固态,所以不易弄脏衣物,使用后,在人体皮肤上无残留,所以使用方便。但现有技术中的耦合贴片通常由凝胶剂、溶剂(如纯化水)、防腐剂、保湿剂、粘结剂制成,包含较多的化学物质,而耦合贴片作为一种一次性用品,消耗量较大,现有的耦合贴片的组成,导致其不易降解,会对环境造成污染,而且存在致敏情况。
发明内容
本发明的第一发明目的是提供一种由天然材料制作而成,易降解,卫生环保的耦合贴片。
本发明的第二发明目的是提供一种上述耦合贴片的制备方法。
本发明通过如下技术方案实现其发明目的,一种超声治疗仪的生物耦合片,其特征在于,由明胶制备液和植物提取液混合后,静置成固态凝胶片再切片而成;
所述植物提取液由以下重量份的原料水提而成:
芦荟:10份、菊花:3份、生蒲黄:5份、薄荷:5份、当归:5份、没药:5份、艾绒:5份、蛇床子:5份、首乌:7份、丹参:5份、独活:5份、益母草:10份、丹皮:10份、红花:10份、山楂:5份、川穹:5份。
本发明依据我国制定的《医用超声藕合剂》的医药行业标准《yy0299‐1998》为依据研发制造,产品的性能更加完美。
本发明的第二发明目的通过如下技术方案实现:一种所述生物耦合片的制备方法,其特征在于,包括以下步骤:
1)采用重量比为2:1的纯化水热溶食用明胶,得到明胶制备液;
2)按以下重量份配置植物材料:芦荟:10份、菊花:3份、生蒲黄:5份、薄荷:5份、当归:5份、没药:5份、艾绒:5份、蛇床子:5份、首乌:7份、丹参:5份、独活:5份、益母草:10份、丹皮:10份、红花:10份、山楂:5份、川穹:5份;
然后,按重量份1份的植物材料加3倍的纯化水对所述植物材料进行水提,具体先加热至沸腾,然后用温火加热一小时后停止加热,温火加热期间每5分钟搅拌一次,最后,用120目纱布过滤得到植物提取液;
3)将所述明胶制备液与所述植物提取液按重量比1:1混合,然后加热搅拌使两者混合均匀,再静置一段时间使混合液冷却,将冷却的混合液倒入预先准备好的容器槽中,静置4~6小时,待混合液凝固成固态的凝胶片后,按要求切片即可得到所述生物耦合片。
依本发明方法获取的生物耦合片,粘性好,如图1所示,使用时可直接放入治疗头1的凹腔11,不需要借助耦合剂外套,在与治疗头1一起贴在病痛部位后(生物耦合片2需微微凸出于治疗头凹腔的腔口,以便与病疼部位皮肤良好接触),即可将治疗头发出的超声波有效的导入人体,使用非常方便。
相比于现有技术,本发明具有如下有益效果:
1)本发明相比于超声耦合剂和无纺布加药酒的耦合制品,具有使用方便,无会污染衣物,同等输出功率的情况下有效辐射面积大,材料易降解,环境负担小等优点;
2)本发明生物耦合片符合《医用超声藕合剂》的医药行业标准《yy0299‐1998》,按要求切成需要的尺寸,经紫外线杀菌再真空包装后,保质期可达两年。本发明生物耦合片相比于现有耦合贴片完全采用天然的材料制作而成,环保易降解,更加卫生环保,而且基本无致敏。
附图说明
图1为本发明生物耦合片的使用状态参考图。
具体实施方式
实施例一
选用纯化水倒入不锈钢器皿中加热至温度达60℃时加入食用明胶搅拌,纯化水与食用明胶的重量配比为2:1,待食用明胶完全溶解后,向得到的明胶制备液中加入配置好的植物提取液。植物提取液与明胶制备液按重量比1:1混合后,加热搅拌10分钟,然后静置30分钟,再倒入预先准备好的容器槽中(本实施例中容器槽为平底浅口槽,槽高3mm,长、宽各600mm左右)静置4-6小时,待混合液凝固成固态的凝胶片后,切成Φ4.0cm的小片,紫外线杀菌后,每片单独密封包装。
上述植物提取液可以自制也可以发外加工,如自制可以用1份植物材料,加3倍的水(质量比),加热至沸腾后用温火加热一小时,停止加热,温火加热期间每5分钟搅拌一次,用120目纱布过滤后,即可得到植物提取液。
植物材料包含以下质量比的原料:芦荟:10份、菊花:3份、生蒲黄:5份、薄荷:5份、当归:5份、没药:5份、艾绒:5份、蛇床子:5份、首乌:7份、丹参:5份、独活:5份、益母草:10份、丹皮:10份、红花:10份、山楂:5份、川穹:5份。
实施例二
实施例二与实施例一的差别在于,明胶制备液与植物提取液按质量比1:2进行混合。成品成半凝胶状,具有一定流动性。
实施例三
实施例三与实施例一的差别在于,明胶制备液与植物提取液按质量比2:1进行混合。成品为固态的凝胶片,且相比于实施例一较干燥。
实验一
上面三个实施例的配方(实施例一对应配方1,实施例二对应配方2,实施例三对应配方3)对应的部分指标实验数据如下:
表1
配方3粘度不符合《yy0299--1998》标准,配方2的综合指标,尤其是输出功率和有效辐射面积不如配方1,综上可见配方1为本发明最科学的配方。
实验二
实施例一与市场上现有藕合片的对比实验
表2
用合正多功能数码治疗仪HZ-CS30型对实施例一和现有的耦合贴片试用情况如下,如表2所示:在同等输出功率的情况下,传统的耦合贴片有效辐射面积为4.9cm2,本发明实施例一的生物耦合片有效辐射面积为6cm2。
实验三
本发明实施例一与现有耦合剂对比实验
表3
实验四
本发明实施例一与无纺布加药酒的耦合制品的对比实验
表4
本发明配方科学,配方如下:
芦荟:10份、菊花:3份、生蒲黄:5份、薄荷:5份、当归:5份、没药:5份、艾绒:5份、蛇床子:5份、首乌:7份、丹参:5份、独活:5份、益母草:10份、丹皮:10份、红花:10份、山楂:5份、川穹:5份。
各材料性能匹配,各材料性能如下:
芦荟
主要成份:芦荟宁、芦荟大黄素、芦荟苦素、芦荟多糖、芦荟皂甙,同时也有多种氨基酸、有机酸、纤维素、活性物质、酵素物质、微量元素等。
主要功效:增强体质、杀菌、抗炎、湿润美容、健胃下泄、强心活血、解毒、抗肿瘤、抗衰老、镇痛、镇静、防臭、防虫、防腐、防晒等。
菊花
主要成份:菊甙、维生素A样物质、维生素B1;含挥发油,油中主要为菊花酮、龙脑、龙脑乙酸酯等。
主要功效:清热除火,生津止渴,解毒,安神除烦,明目,消炎止痛等。
生蒲黄
主要成份:固甾醇、异鼠李亭。
主要功效:降血脂,抗动脉粥样硬化,治疗妇女经闭、痛经、脘腹刺痛,治疗跌打肿痛、血淋湿痛。
薄荷
主要成份:薄荷油(主要成分薄荷醇、薄荷酮)、薄荷霜、樟脑萜、柠檬萜、蛋白质、脂肪、碳水化合物、矿物质、维生素。
主要功效:祛脂降压,壮阳壮腰,提高免疫力,明目,壮骨,发汗解表,消炎止痛等。
当归
主要成份:多种氨基酸、挥发油、亚油酸、水溶性生物碱、蔗糖、维生素E、脂肪、β-谷固醇、烟酸、棕榈酸、硬脂酸、维生素B12等成分。
主要功效:补五脏、生肌肉、益中气、补血养血、调经止痛、润燥滑肠、抗衰老、抗贫血、解痉、增强免疫功能、扩张冠状动脉、增加血流、营养心肌、扩张周围血管、降低动脉血压等。
没药
主要成份:树脂、挥发油、树胶等。
主要功效:活血散瘀镇痛;外用有收敛和消炎作用;对多种皮肤癣菌有不同程度的抑制作用;在1:3000~1:300浓度下能抑制结核菌。
艾绒
主要成份:挥发油,为多成分混合物,经分离鉴定的有:萜品烯醇‐4、β‐石竹烯、蒿醇、芳樟醇、樟脑、龙脑、桉油素以及水芹烯)、毕澄茄烯、侧柏醇等。
主要功效:益气活血,温经通络,去寒止疼,升阳举陷,补虚固脱。
蛇床子
主要成份:香豆精类成分蛇床子素、挥发油,油中主要成分为左旋蒎烯,左旋莰烯及异戊酸龙脑脂等。
主要功效:温肾壮阳;燥湿杀虫;祛风止痒。主治男子阳痿;阴囊湿痒;女子宫寒不孕;寒湿带下;阴痒肿痛;风湿痹痛;湿疮疥癣。
首乌
主要成份:均二苯烯苷类化合物、羟基蒽醌类、聚合原花青素等有效成分。
主要功效:主治血虚之萎黄、面色不华、头晕、失眠;肝肾不足之腰膝酸软、头发早白、肠燥便秘、瘰疬、疮痈。
丹参
主要成份:脂溶性的二萜醌类化合物和水溶性的酚酸类成分。
主要功效:活血祛瘀,安神宁心,排脓,止痛。治心绞痛,月经不调,痛经,经闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒
独活
主要成份:根含柑内酯,独活内酯,独活属醇),异茴芹香豆精,花椒毒素,软木花椒素,欧前胡内酯,8-牛狼醇基补骨脂素,白芷素,硬脂酸,β-谷甾醇。
主要功效:散风止咳;除湿止痛。治疗主感冒;咳嗽;头痛;牙痛;风湿痹痛;麻风;风湿疹。
益母草
主要成份:益母草碱、水苏碱、益母草定、益母草宁、亚麻酸、β‐亚麻酸、月桂酸、油酸、苯甲酸、芸香甙、延胡索酸、甾醇、维生素A等.此外亦含精氨酸、4‐胍基‐1‐丁醇(4‐Guanidino‐1‐butanol)、4‐胍基‐丁酸、水苏糖。
主要功效:活血、祛淤、调经、消水。治疗妇女月经不调,胎漏难产,胞衣不下,产后血晕,瘀血腹痛,崩中漏下,尿血、泻血,痈肿疮疡。
丹皮
主要成份:牡丹酚、牡丹酚甙、牡丹酚原甙(牡丹酚甙十阿拉伯糖)、芍药甙。尚含挥发油0.15~0.4%及植物甾醇等。
主要功效:清热;活血散瘀。主温热病热入血分;发斑;吐衄;热泪盈眶病菌后期热伏阴分发热;阴虚骨蒸潮热;血滞经闭;痛经;痈肿疮毒;跌扑伤痛;风湿热痹。用于温毒发斑,吐血衄血,夜热早凉,无汗骨蒸,经闭痛经,痈肿疮毒,跌扑伤痛。
红花
主要成份:红花苷、新红花苷、前红花苷、红花醌苷、二十九烷、β‐谷甾醇及二棕榈酸、甘油酯、油酸、亚油酸、绿原酸等13种成分。
主要功效:活血通经、散瘀止痛。属活血化瘀药下属分类的活血调经药。山楂
主要成份:多种维生素、酒石酸、柠檬酸、山楂酸、苹果酸等,还含有黄铜类、内酯、糖类、蛋白质、脂肪和钙、磷、铁等矿物质。
主要功效:祛脂降压,消食;能防治心血管疾病;活血化淤;帮助子宫收缩等。
川穹
主要成份:生物碱含挥发油含内酯类化合物含有机酸含有香草醛、β‐谷甾醇、匙叶桉油烯醇、维生素A、蔗糖、脂肪油等。
主要功效:行气开郁,祛风燥湿,活血止痛。治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。用于月经不调,经闭痛经,瘕腹痛,胸胁刺痛,跌扑肿痛,头痛,风湿痹痛。
本发明配方中芦荟、薄荷、艾绒这些植物本身具有天然的防腐和杀菌作用,所以本发明无需特别添加防腐剂。本发明配方具有活血化瘀作用,可以透皮吸收,而且在超声的作用下,吸收效果得到加强,对人体好处多。
Claims (2)
1.一种超声治疗仪的生物耦合片,其特征在于,由明胶制备液和植物提取液混合后,静置成固态凝胶片再切片而成;
所述植物提取液由以下重量份的原料水提而成:
芦荟:10份、菊花:3份、生蒲黄:5份、薄荷:5份、当归:5份、没药:5份、艾绒:5份、蛇床子:5份、首乌:7份、丹参:5份、独活:5份、益母草:10份、丹皮:10份、红花:10份、山楂:5份、川穹:5份。
2.一种权利要求1所述生物耦合片的制备方法,其特征在于,包括以下步骤:
1)采用重量比为2:1的纯化水热溶食用明胶,得到明胶制备液;
2)按以下重量份配置植物材料:芦荟:10份、菊花:3份、生蒲黄:5份、薄荷:5份、当归:5份、没药:5份、艾绒:5份、蛇床子:5份、首乌:7份、丹参:5份、独活:5份、益母草:10份、丹皮:10份、红花:10份、山楂:5份、川穹:5份;
然后,按重量份1份的植物材料加3倍的纯化水对所述植物材料进行水提,具体先加热至沸腾,然后用温火加热一小时后停止加热,温火加热期间每5分钟搅拌一次,最后,用120目纱布过滤得到植物提取液;
3)将所述明胶制备液与所述植物提取液按重量比1:1混合,然后加热搅拌使两者混合均匀,再静置一段时间使混合液冷却,将冷却的混合液倒入预先准备好的容器槽中,静置4~6小时,待混合液凝固成固态的凝胶片后,按要求切片即可得到所述生物耦合片。
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