CN106421008A - Wound-healing traditional Chinese medicine composition for anal fistula as well as preparation method and application of traditional Chinese medicine - Google Patents
Wound-healing traditional Chinese medicine composition for anal fistula as well as preparation method and application of traditional Chinese medicine Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a wound-healing traditional Chinese medicine composition for anal fistula as well as a preparation method and application of the traditional Chinese medicine. The traditional Chinese medicine comprises the following components in parts by weight: 50-100 parts of salvia miltiorrhiza, 50-100 parts of climbing groundsel herb, 40-60 parts of radix astragali and 40-60 parts of radix sanguisorbae. The traditional Chinese medicine composition has the functions of promoting circulation, removing stasis, clearing away heat and toxic materials, restraining wetness and dryness, diminishing inflammation, relieving pain, astringing exudation and promoting granulation and has remarkable effects in the preparation of medicines for treating pressure sores of the anal fistula.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, relate to a kind of anal fistula more wound Chinese medicine composition and its preparation method and application,
Said composition is mainly used in the cleaning of the Crohn disease anal fistula surface of a wound, accelerates wound granulation hyperblastosis, wound healing.
Background technology
Crohn disease (Crohn ' s disease, CD) is the chronic inflamatory that a kind of cause of disease is still not clear, and anal fistula is
Common complication, incidence is up to 50%, and easy recurrent exerbation.Operation is essential therapeutic arsenals, special due to position
Property, repair with that repeatedly pollute and deposit, cause wound healing slow.Clinical shortage local cleaning fluid, can only be entered by physiological saline
Row cleans, and patient is painful, and doctor has a headache.It is clinical refractory disease.
Content of the invention
It is an object of the invention to overcome above-mentioned weak point to provide a kind of anal fistula more to create Chinese medicine composition.
It is a further object of the present invention to provide this anal fistula and more create the preparation method of Chinese medicine composition.
It is an object of the invention to be accomplished by：
A kind of anal fistula more creates Chinese medicine composition, and this Chinese medicine composition is made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight
Part.
Above-mentioned anal fistula more wound Chinese medicine composition is preferably made up of the component of following weight portion：
The red sage root 70～80 weight portion, climbing groundsel 70～80 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight
Part.
The preparation method of above-mentioned anal fistula more wound Chinese medicine composition comprises the following steps：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, decocting 2～3 times, 1～2 hour every time, collecting decoction
Being concentrated into liquid weight ratio is 1：When 1～2, cooling adds ethanol 2～3 times amount that mass concentration is more than 95%, precipitates 24 hours
Above, filter, reclaim ethanol to without alcohol taste.
Above-mentioned anal fistula debridement Chinese medicine composition can also add borax.
A kind of anal fistula more wound Chinese medicine composition can be made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight
Part, borax 15～25 weight portion.
Above-mentioned anal fistula more wound Chinese medicine composition is further preferably made up of the component of following weight portion：
The red sage root 70～80 weight portion, climbing groundsel 70～80 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight
Part, borax 15～25 weight portion.
The preparation method of above-mentioned borated anal fistula more wound Chinese medicine composition comprises the following steps：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, decocting 2～3 times, 1～2 hour every time, collecting decoction
Being concentrated into liquid weight ratio is 1：When 1～2, cooling adds ethanol 2～3 times amount that mass concentration is more than 95%, precipitates 24 hours
Above, filtering, recovery ethanol is extremely without alcohol taste, then adds borax mixing.
External preparation made by above-mentioned Chinese medicine composition and pharmaceutically acceptable auxiliary material, and described external preparation is preferably washed
Liquid.
Anal fistula of the present invention more wound washing lotion is specifically made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight
Part, glycerine 30～60 weight portion, then (crude drug comprises the red sage root, a thousand li to 180g-320g crude drug/500-1000ml to add pure water
Light, the Radix Astragali and garden burnet 4 taste medicinal material).
The preparation method of above-mentioned anal fistula more wound washing lotion comprises the following steps：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, soak by water 2～3 times, 1～2 hour every time, merge and decoct
Liquid, filters, obtains extract, and extract being concentrated into medicinal material with extract weight ratio is 1：When 1～2, cooling, add extract 2
The mass concentration of～3 times amount is the ethanol of more than 95%, precipitates more than 24 hours, filters, and recovery ethanol is extremely without alcohol taste, then adds sweet
Oil and pure water mix to full dose.
The borated anal fistula of the present invention more wound washing lotion is made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight
Part, borax 15～25 weight portion, glycerine 30～60 weight portion, then add pure water 180g-320g crude drug/500-1000ml.
The preparation method of above-mentioned anal fistula more wound washing lotion comprises the following steps：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, soak by water 2～3 times, 1～2 hour every time, merge and decoct
Liquid, filters, obtains extract, and extract being concentrated into medicinal material with extract weight ratio is 1：When 1～2, cooling, add extract 2
The mass concentration of～3 times amount is the ethanol of more than 95%, precipitates more than 24 hours, filters, and recovery ethanol is extremely without alcohol taste, then adds boron
Sand, glycerine and pure water mix to full dose.
The using method of above-mentioned washing lotion：External application, in right amount, local apply put on the skin, soak or the surface of a wound clean and (can use warm water if desired
1 times of dilution), 2 times a day or follow the doctor's advice.
Anal fistula of the present invention more wound Chinese medicine composition prescription is mainly made up of the red sage root, climbing groundsel, the Radix Astragali, garden burnet,
Have promoting blood circulation and removing blood stasis, clearing heat and detoxicating, the function of convergence myogenic.Application in the medicine of preparation treatment anal fistula pressure sore has significantly
Effect.The washing lotion that this prescription is made is mainly used in the epacmastic surface of a wound of anal fistula pressure sore granulation and cleans.
Through extracorporeal bacteria inhibitor test prove to staphylococcus aureus, EHEC, pseudomonas aeruginosa, enterococcus faecalis,
The bacteriostasis rate of Candida albicans reaches more than 90%.
Animal experiment proves that the surface of a wound to the trauma surface infestation that bacterium infects for the anal fistula debridement washing lotion has control to infect and promotes wound
The effect of mouth healing.Clinical principium is applied, satisfactory effect.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further described：
Embodiment 1
Red sage root 80g, climbing groundsel 70g, Radix Astragali 60g, garden burnet 40g, borax 15g and glycerine 40g.
Preparation method：Taking the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet medicinal material 4 taste, decocting 2 times, water consumption is the 8 of medicinal material
Times, decocting 1.5 hours every time, it is 1 that collecting decoction is concentrated into liquid ratio：When 1, cooling adds the ethanol that mass concentration is 95% 3 times
Amount, precipitates more than 24 hours, filters, and recovery ethanol is extremely without alcohol taste, then it is complete to 1000ml to add borax, glycerine and pure water mixing
Amount.
Embodiment 2 red sage root 70g, climbing groundsel 80g, Radix Astragali 50g, garden burnet 50, borax 25g and glycerine 40g.
Preparation method：Taking the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet medicinal material 4 taste, decocting 3 times, water consumption is the 10 of medicinal material
Times, decocting 2 hours every time, it is 1 that collecting decoction is concentrated into liquid ratio：When 2, cooling adds ethanol 2 times amount that mass concentration is 95%,
Precipitating more than 24 hours, filtering, recovery ethanol is extremely without alcohol taste, then adds borax, glycerine and pure water mixing to 1000ml full dose.
Embodiment 3 red sage root 75g, climbing groundsel 75g, Radix Astragali 40g, garden burnet 60g, borax 18g and glycerine 50g.
Preparation method：Taking the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet medicinal material 4 taste, decocting 2 times, water consumption is the 6 of medicinal material
Times, decocting 1 hour every time, it is 1 that collecting decoction is concentrated into liquid ratio：When 2, cooling adds ethanol 2 times amount that mass concentration is 95%,
Precipitating more than 24 hours, filtering, recovery ethanol is extremely without alcohol taste, then adds borax, glycerine and pure water mixing to 1000ml full dose.
Embodiment 4 red sage root 70g, climbing groundsel 80g, Radix Astragali 50g, garden burnet 50 and glycerine 40g.
Preparation method：Taking the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet medicinal material 4 taste, decocting 3 times, water consumption is the 10 of medicinal material
Times, decocting 2 hours every time, it is 1 that collecting decoction is concentrated into liquid ratio：When 2, cooling adds ethanol 2 times amount that mass concentration is 95%,
Precipitating more than 24 hours, filtering, recovery ethanol is extremely without alcohol taste, then glycerol adding and pure water mix to 1000ml full dose.
With embodiment 4 more wound washing lotion, the clinical preliminary observation of drug combination is carried out to Crohn disease anal fistula patient, treatment
Each 15 cases of group, control group.2% borax soln is as comparison, and by clinical observation, conventional therapy merges Chinese medicine more wound washing lotion treatment gram
The sick anal fistula of sieve grace, cure rate significantly improves, and treatment time is greatly shortened, and recurrence rate is low, and patient compliance is good, and clinical practice is excellent
Gesture is obvious, the results are shown in Table 1.
Table 1 impact that more Crohn disease anal fistula is healed by wound washing lotion
Note：With compare,#p<0.05,##p<0.01
Test example 2：With the embodiment 2 more wound impact on bacterial infection wound healing for the washing lotion
1. experiment material
1.1 animal：Cleaning grade ICR mouse, body weight 20g～25g, male and female half and half, carried by Yangzhou University's comparative medicine center
Confession, animal used as test production licence：SCXK (Soviet Union) 2012-0004.
1.2 test medicine：More wound washing lotion (preparing according to embodiment 2 method)；More wound washing lotion stoste is (according to embodiment
4 methods prepare, and remaining does not only contain borax with embodiment 2)；Positive control (2% borax soln).
1.3 medicine preparations, dosage, packet and administering mode：
Medicine directly uses, it is not necessary to through dilution process.The method using liquid directly to rinse wounds in mice is administered, punching
Standard of washing is for rinsing the fester of wounds in mice, slough etc. well.
Test mice underwent operative infects staphylococcus aureus or Escherichia coli, prepares bacterial infection wound model.
After modeling success, animal is randomly divided into model group, negative control group, positive controls, more wound washing lotion, more wound washing lotion stoste
Group.Wherein, any type for the treatment of is not carried out after model group modeling success；Use raw after the animal model success of negative control group
Reason normal saline washing wounds in mice, morning and afternoon is respectively once；Positive controls uses 2% borax soln to rinse wounds in mice, morning and afternoon
Respectively once；Chinese medicinal lotion therapeutic component does not use corresponding Chinese medicinal lotion to rinse wounds in mice according to group, and morning and afternoon is respectively once.
2. test method
2.1.1 the impact experiment that more infection of staphylococcus aureus wounds in mice is repaired by wound washing lotion
Trauma surface infestation modeling experiment starts the previous day, inoculates staphylococcus aureus, 37 degree of lower trainings in superclean bench
Support overnight.The bacterium solution of incubated overnight was inoculated in fresh LB fluid nutrient medium according to 1: 100 in second day, trains under the conditions of 37 degree
Support to OD600=0.6～0.8.The bacterium solution that collection is cultivated is in 50ml centrifuge tube, and 3000rpm centrifuges 10 minutes, abandoning supernatant,
With fresh LB fluid nutrient medium, bacterium mud is suspended subsequently, and bacterial concentration is diluted to 5 × 1011Individual/ml, bacterium solution is placed in refrigerator
Standby.
Choose SPF level mouse 50, male and female half and half, body weight 20-25g, anaesthetized by yellow Jackets.Mouse prone position is solid
Fixed, strike off mouse back hair with double-edged razor blade, use 75% alcohol disinfecting subsequently.It in back nearly mouse hind leg position with backbone is
The full thickness skin of center line excision diameter about 1cm, and the surface of a wound after full thickness skin will be excised with syringe needle and draw by " well " font
Wound, the surface of a wound exposes after antiseptic gauze hemostasis.The petty cash staphylococcus aureus bacterium solution of 20 μ l is inoculated at the surface of a wound, every to ensure
The trauma surface infestation 1 × 10 of mouse10Individual staphylococcus aureus.Infect every day 2 times, for three days on end, until causing local infection,
Redness around wound, the surface of a wound has fester or oozes out.Random is 5 groups by mouse, i.e. model group, negative control group (physiological saline),
Positive controls (2% BAS), more wound washing lotion, more wound washing lotion stoste group.Each group rinses the surface of a wound 2 with corresponding washing lotion every day
Secondary, morning and afternoon respectively once, continuous 12 days.Within 1st, 3,5,7,9,11 day, measure back surface of a wound face in drug treatment by membrane process respectively
Long-pending.I.e. use the transparent plastic mulching surface of a wound, draw film along edge of wound, cut film, calculate surface of a wound area, and shrinkage from mold dimensions (referring to formula 1).In
Last puts to death mouse after being administered, and cuts surface of a wound skin, does histotomy, observe surface of a wound epithelium after HE dyeing after formalin is fixing
Rate, evaluates wound healing situation.
2.1.2 the impact experiment that more coli-infection wounds in mice is repaired by wound washing lotion
Experimental program is with infection of staphylococcus aureus wounds in mice reparative experiment.The bacterium infecting modeling changes large intestine bar into
Bacterium, the packet of animal used as test, therapeutic scheme and inspection target are tested with 2.1.1.
2.1.3 the histology experiment on the impact that bacterial infection wounds in mice is repaired for the washing lotion is more created
Take in 2.1.1 and 2.1.2 experiment and gather and be stored in the skin histology in 10% formalin solution, routine paraffin wax
Embedding, slice thick 4～5 μm, HE dyes, and observation by light microscope is simultaneously marked.Inspection project and score by rules are as follows：
(1) epidermal cell has or not degeneration necrosis, forms rotten to the corn, ulcer, crust：It is chosen as 0 point～4 points.0 point of nothing is downright bad, by
Gently to being heavily 1 point～4 points；(eyepiece 4 ×, the object lens 10 ×) measurement under 40 times of light microscopics with " the micro-chi in microscope side " of downright bad length
The length (cm/40 times) of ulcer.
(2) below slough, corium and hypodermis blood vessel have or not expansion, hyperemia, oedema, cell infiltration：It is chosen as 0
Divide～4 points.0 point without obvious pathology, 1 point～4 points lesion degrees are respectively slight, moderate, severe, pole severe；
(3) granulation tissue hyperplasia or fibrillatable：Divide 0 point～3 points, 0 point：Ripe granulation tissue, complete fibrillatable；3 points of nothings
Granulation tissue, without fibroblast proliferation；1 point：Granulation tissue is in the inmature stage in early days, and fibrillatable is inconspicuous；2 points：Slightly
Maturation, vasculitis Leukopenia in granulation tissue, fibroblast proliferation.
(4) damage epithelial tissue around has or not hyperplasia：It is divided into 0 point～3 points.Damage both sides are regenerated as 3 points without epithelium, 1 side
Having epithelium regeneration to be 2 points, it is 1 point that bilateral has epithelium regeneration, and it is 0 that bilateral has epithelium regeneration to combine at central portion or closely combine
Point.
3. result
3.1 impacts that more infection of staphylococcus aureus wounds in mice is repaired by wound washing lotion
As it can be seen from table 1 negative control group is slow with the wound healing of model group, saline therapy is for golden yellow
The healing of staphy lococcus infection wounds in mice does not has facilitation.The borax soln of 2% then can be obviously promoted mouse wound
Face heal, the 3rd after treatment day starts, and the surface of a wound of positive controls mouse is obviously reduced, shrinkage factor apparently higher than model group with
Negative control group.The therapeutic action of this wound healing to the 5th day seems more notable (p<0.01).In tested liquid,
More wound washing lotion stoste has preferable therapeutic action, within the 3rd day, can significantly reduce the surface of a wound (p after treatment<0.05), treat
Latter 7th day, the effect of this wound healing was remarkably reinforced (p<0.01).More wound washing lotion is to infection of staphylococcus aureus
The facilitation of wound healing emerges from after treatment on the 7th day.
3.2 impacts that more coli-infection wounds in mice is repaired by wound washing lotion
From table 2 it can be seen that negative control group is slow with the wound healing of model group, saline therapy is for large intestine bar
The healing of the infectious wounds in mice of bacterium does not has facilitation.The borax soln of 2% then can be obviously promoted wounds in mice healing,
The 3rd day after treatment starts, and the surface of a wound of positive controls mouse has the effect of reducing, and shrinkage factor is apparently higher than model group (p<
0.05), the therapeutic action of this wound healing is continued for terminating to experiment.In tested liquid, more wound washing lotion stoste has
Preferable therapeutic action, can significantly improve the shrinkage factor (p of the surface of a wound after treatment on the 3rd day<0.01), and test whole
Its effect that significantly promote wound healing all can be observed in cycle.More the wound surface of a wound to coli-infection mouse for the washing lotion
Healing also has a facilitation, this act on treatment after within the 3rd day, emerge from, equally last till that whole experiment terminates.
3.3 pathological analysis that more bacterial infection wounds in mice reparation is affected by wound washing lotion
3.3.1 wound infection S. aureus L-forms pathological examination
8 mouse of model group all have ulcer different in size, skin surface show solid, organized and oozed by inflammatory necrosis
Going out the crust of composition, bottom shows a large amount of inflammatory cell, and granulation tissue is inmature, and part ulcer edge 1 side or 2 sides have epithelial tissue again
Raw.8 mouse local skins are shown in ulcer different in size, average length 1.67cm/40 times.See have thick-layer to add scab at 8 ulcer
Skin, wherein 6 is severe, 1 pole severe, 1 moderate.Having moderate cell infiltration bottom 1 ulcer, 7 is severe or pole
Severe, inflammatory cell type is mainly neutrophil leucocyte.Having no obvious granulation tissue bottom 4 ulcer, 2 is inmature granulation group
Knit (granulation tissue is made up of, and inside has cell infiltration) newborn capillary and fibroblast.Blood in another 2 granulation tissues
Pipe quantity reduces, and collagenous fibres increase, slightly ripe.Without epithelium regeneration around 4 ulcer, a small amount of epithelium regeneration is seen in 21 sides,
There is epithelium regeneration another 22 sides, extend to ulcer center.
8 mouse of negative control group all have ulcer different in size, skin surface show solid, organized by inflammatory necrosis
With the crust oozing out composition, bottom shows a large amount of inflammatory cell and inmature granulation tissue, and most ulcer edges are without epithelial tissue again
Raw.8 mouse local skins are shown in ulcer different in size, average length 1.54cm/40 times.See have thick-layer to add scab at 8 ulcer
Skin, wherein 5 is severe, 2 moderates, and 1 slight.Bottom ulcer, 1 only has pole severe cell infiltration, 7 severes.Inflammatory cell
The same model group of type.Having no obvious granulation tissue bottom 3 ulcer, 5 is inmature granulation tissue.Around 5 ulcer supreme
Skin regenerates, and the epithelium of a small amount of regeneration is seen in 31 sides.
8 murine lesion of positive group are little compared with model group, negative control group, and skin surface crust reduces, granulation bottom ulcer
It is ripe that two compositions are also relatively gone up in hyperblastosis, and epithelium regeneration increases.8 mouse local skins are shown in ulcer different in size, average length
1.38cm/40 again.Seeing there is crust at 8 ulcer, wherein 2 moderates, 5 slight, and 1 inconspicuous.6 severe inflammation bottom ulcer
Cellular infiltration, 2 moderates.The same model group of inflammatory cell type.Having no obvious granulation tissue bottom 1 ulcer, 5 is inmature meat
Bud tissue, in 2 granulation tissues, fibroblast is increased, blood vessel reduces, more ripe.Without epithelium regeneration around 2 ulcer, 61
The epithelium of a small amount of regeneration is seen in side.
More wound 8 mouse lesion degrees of washing lotion group slightly mitigate compared with model group and negative control group.7 mouse local skins are shown in
Ulcer different in size, average length 1.77cm/40 times.7 only see crust at ulcer, wherein 5 moderates, slight or severe is each
1.Having severe cell infiltration bottom 7 ulcer, 1 has moderate inflammatory cell without subcutaneous at ulcer.The same mould of inflammatory cell type
Type group.Seeing the granulation tissue of naivety bottom 6 ulcer, in 1 granulation tissue, fibroblast is increased, blood vessel reduces, more ripe.
Without epithelium regeneration around 5 ulcer, the epithelium of a small amount of regeneration is seen in 21 sides.
More wound 8 mouse lesion degrees of washing lotion stoste group substantially mitigate compared with model group and negative control group.7 mouse local
Skin is shown in ulcer different in size, average length 1.07cm/40 times.5 only have degree of taking a favourable turn crust at ulcer, and 3 without obvious crust.
Having severe cell infiltration bottom 4 ulcer, 3 slight, and 1 without obvious cell infiltration.The same model group of inflammatory cell type.1
Without granulation tissue hyperplasia bottom ulcer, seeing the granulation tissue of naivety bottom 4 ulcer, 1 granulation tissue is more ripe.Burst for 1
Without epithelium regeneration around ulcer, the epithelium of a small amount of regeneration is seen in 21 sides, and epithelium regeneration is seen in 42 sides.
Each group pathological score statistic analysis result refers to table 3；Under each group 200 times of mirrors of pathological section, for details, see the appendix for photo.
3.3.2 wound infection Escherichia coli pathology diagosis result
8 mouse of model group all have ulcer different in size, skin surface show solid, organized and oozed by inflammatory necrosis
Going out the crust of composition, bottom shows a large amount of inflammatory cell, and most slight degree of mouse granulation tissue have with ulcer edge 1 side or 2 sides
Epithelial tissue regenerates.8 mouse local skins are shown in ulcer different in size, average length 1.16cm/40 times.See at 8 ulcer
Having crust, wherein 1 is severe, 3 moderates, and 4 slight.Have moderate cell infiltration bottom 1 ulcer, 7 be severe or
Pole severe, inflammatory cell type is mainly neutrophil leucocyte.(granulation tissue is by new life to see inmature granulation tissue bottom 1 ulcer
Capillary and fibroblast composition, inside have cell infiltration).In another 7 granulation tissues, blood vessel number reduces, and collagen is fine
Dimension increases, slightly ripe.Without epithelium regeneration around 2 ulcer, a small amount of epithelium regeneration is seen in 31 sides, and another 32 sides have epithelium again
Raw.
8 mouse of negative control group all have ulcer different in size, skin surface show solid, organized by inflammatory necrosis
With the crust oozing out composition, bottom shows a large amount of inflammatory cell and inmature granulation tissue, and part ulcer edge is shown in epithelial tissue again
Raw.8 mouse local skins are shown in ulcer different in size, average length 1.09cm/40 times.See there is crust, wherein at 8 ulcer
4 moderates, 3 slight, and 1 inconspicuous.Bottom ulcer, 1 only has pole severe cell infiltration, 7 severes.Inflammatory cell type is same
Model group.Having no obvious granulation tissue bottom 6 ulcer, 2 is inmature granulation tissue.Without epithelium regeneration around 2 ulcer,
The epithelium of a small amount of regeneration is seen in 21 sides, and there is epithelium regeneration 42 sides.
Positive 8 mouse skin degree of injury of group substantially mitigate compared with model group and negative control group.7 mouse local skins
See ulcer different in size, average length 1.09cm/40 times.See there is crust at 7 ulcer, wherein 2 moderates, 5 slight or
Slightly, 1 epithelial surface degree of taking a favourable turn crust.6 severe cell infiltration bottom ulcer, 2 moderates.The same model of inflammatory cell type
Group.3 is inmature granulation tissue, and 5 granulation tissues are more ripe.Around 2 ulcer, the epithelium of a small amount of regeneration is seen in 1 side, 52
There is epithelium regeneration side, and 1 skin surface is that epithelium covers, but is not fully connected.
More wound 8 mouse lesion degrees of washing lotion mitigate compared with model group and negative control group.8 mouse local skins are good at short
The ulcer differing, average length 1.38cm/40 times.4 only see moderate crust, 4 slight crusts at ulcer.Bottom 7 ulcer
Have severe cell infiltration, 1 moderate, the same model group of inflammatory cell type.Without granulation tissue hyperplasia bottom 2 ulcer, 5 ulcer
The granulation tissue of naivety is seen in bottom, and 1 granulation tissue is more ripe.The epithelium of regeneration is seen in 31 sides, and the epithelium of regeneration is seen in 62 sides.
More wound 8 mouse lesion degrees of washing lotion stoste group substantially mitigate compared with model group and negative control group.8 mouse local
Skin is shown in ulcer different in size, average length 1.51cm/40 times.Seeing there is crust at 8 ulcer, wherein 6 is moderate, 2
Slightly.Bottom ulcer, 8 only have severe cell infiltration, the same model group of inflammatory cell type.Obvious granulation group is had no bottom 2 ulcer
Knitting, 2 is inmature granulation tissue.Without epithelium regeneration around 2 ulcer, the epithelium of regeneration is seen in 21 sides, and regeneration is seen in 42 sides
Epithelium.
Each group pathological score statistic analysis result refers to table 3.
Table 3 mouse skin pathology light and heavy degree appraisal result
| Group | Number of cases | Infect S. aureus L-forms group | Ehec infection group |
| Model group | 8 | 10.06±3.28 | 8.50±2.84 |
| Negative control group | 8 | 10.63±1.41 | 9.0±1.51 |
| Positive group | 8 | 8.00±2.59** | 6.13±2.09** |
| More wound washing lotion stoste group | 8 | 8.13±2.70* | 7.75±1.49* |
| More wound washing lotion | 8 | 10.38±3.37 | 8.25±2.68 |
Note：Each group with negative control group ratio：* P ＜ 0.05, * * P ＜ 0.01
4. conclusion
Mouse bacteria infection damage pathology shows as：There is ulcer in skin histology, and skin surface shows solid, by inflammation
Property slough and exudate composition crust, bottom shows a large amount of inflammatory cell, looks into and see granulation tissue hyperplasia bottom part ulcer,
Ulcer edge shows that epithelial tissue regenerates.Comparing with normal group has statistical significant difference, and skin trauma model copy is described
Success.
The present invention more wound washing lotion all can effectively reduce staphylococcus aureus or coli-infection mouse within the treatment phase
The area of the surface of a wound, significantly improves the shrinkage factor of the surface of a wound, and the healing to the surface of a wound has facilitation.Analyze from experimental data, to gold
The healing of the infectious wounds in mice of staphylococcus aureus has significant facilitation, heals coli-infection wounds in mice
Facilitation the most obvious.
Claims (13)
1. an anal fistula more creates Chinese medicine composition, it is characterised in that this Chinese medicine composition is made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight portion.
2. anal fistula according to claim 1 more creates Chinese medicine composition, it is characterised in that this Chinese medicine composition is by following weight
The component of part is made：
The red sage root 70～80 weight portion, climbing groundsel 70～80 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight portion.
3. an anal fistula more creates Chinese medicine composition, it is characterised in that this Chinese medicine composition is made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight portion,
Borax 15～25 weight portion.
4. anal fistula according to claim 3 more creates Chinese medicine composition, it is characterised in that this Chinese medicine composition is by following weight
The component of part is made：
The red sage root 70～80 weight portion, climbing groundsel 70～80 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight portion, boron
Sand 15～25 weight portion.
5. the Chinese medicine composition according to claim 1-4 any one claim, it is characterised in that said composition and medicine
Learn acceptable auxiliary material and make external preparation.
6. Chinese medicine composition according to claim 5, it is characterised in that described external preparation is washing lotion.
7. the anal fistula described in a claim 1 or 2 more creates the preparation method of Chinese medicine composition, it is characterised in that the method includes
Following steps：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, decocting 2～3 times, 1～2 hour every time, collecting decoction concentrated
It is 1 to liquid weight ratio：When 1～2, cooling adds ethanol 2～3 times amount that mass concentration is more than 95%, precipitates more than 24 hours,
Filter, reclaim ethanol to without alcohol taste.
8. the anal fistula described in a claim 3 or 4 more creates the preparation method of Chinese medicine composition, it is characterised in that the method includes
Following steps：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, decocting 2～3 times, 1～2 hour every time, collecting decoction concentrated
It is 1 to liquid weight ratio：When 1～2, cooling adds ethanol 2～3 times amount that mass concentration is more than 95%, precipitates more than 24 hours,
Filtering, recovery ethanol is extremely without alcohol taste, then adds borax mixing.
9. an anal fistula more creates washing lotion, it is characterised in that this washing lotion is made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight portion,
Glycerine 30～60 weight portion, then add pure water to 180g-320g crude drug/500-1000ml.
10. the anal fistula described in a claim 9 more creates the preparation method of washing lotion, it is characterised in that the method includes following step
Suddenly：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, soak by water 2～3 times, 1～2 hour every time, collecting decoction, mistake
Filter, obtains extract, and extract being concentrated into medicinal material with extract weight ratio is 1：When 1～2, cooling, add extract 2～3 times
The mass concentration of amount is the ethanol of more than 95%, precipitate more than 24 hours, filters, and reclaims ethanol extremely without alcohol taste, then glycerol adding and
Pure water mixes to full dose.
11. 1 kinds of anal fistula more create washing lotion, it is characterised in that this washing lotion is made up of the component of following weight portion：
The red sage root 50～100 weight portion, climbing groundsel 50～100 weight portion, the Radix Astragali 40～60 weight portion, garden burnet 40～60 weight portion,
Borax 15～25 weight portion, glycerine 30～60 weight portion, then add pure water to 180g-320g crude drug/500-1000ml.
Anal fistula described in 12. 1 kinds of claims 11 heals and creates the preparation method of washing lotion, it is characterised in that the method includes following step
Suddenly：
By the red sage root, climbing groundsel, the Radix Astragali and the mixing of garden burnet 4 taste medicinal material, soak by water 2～3 times, 1～2 hour every time, collecting decoction, mistake
Filter, obtains extract, and extract being concentrated into medicinal material with extract weight ratio is 1：When 1～2, cooling, add extract 2～3 times
The mass concentration of amount is the ethanol of more than 95%, precipitate more than 24 hours, filters, and reclaims ethanol extremely without alcohol taste, then adds borax, sweet
Oil and pure water mix to full dose.
Anal fistula described in 13. claim 1-4 any one claims heals wound Chinese medicine composition in preparation treatment anal fistula pressure sore
Medicine in application.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115957258A (en) * | 2022-12-06 | 2023-04-14 | 中国人民解放军东部战区总医院 | Wound healing lotion and preparation process and application thereof |
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|---|---|---|---|---|
| CN1207298A (en) * | 1997-08-04 | 1999-02-10 | 段道文 | Fistula recovery ointment and preparing process thereof |
| CN103520447A (en) * | 2013-11-08 | 2014-01-22 | 金福树 | Externally used ointment suitable for anal fistula after operation |
| CN103720902A (en) * | 2013-12-13 | 2014-04-16 | 武汉市第八医院 | Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof |
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2016
- 2016-05-25 CN CN201610352439.XA patent/CN106421008A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1207298A (en) * | 1997-08-04 | 1999-02-10 | 段道文 | Fistula recovery ointment and preparing process thereof |
| CN103520447A (en) * | 2013-11-08 | 2014-01-22 | 金福树 | Externally used ointment suitable for anal fistula after operation |
| CN103720902A (en) * | 2013-12-13 | 2014-04-16 | 武汉市第八医院 | Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115957258A (en) * | 2022-12-06 | 2023-04-14 | 中国人民解放军东部战区总医院 | Wound healing lotion and preparation process and application thereof |
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