CN103720902A - Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof - Google Patents
Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine used for anorectal surgery wound healing and a preparation method thereof. The medicine is made from fourteen traditional Chinese medicinal materials such as herba schizonepetae, rheum officinale, cortex phellodendri, dandelion, radix sophorae flavescentis, Chinese parsnip roots, garden burnet, mint, cortex lycii radicis, mugwort leaves, compound of glauber-salt and liquorice, garden balsam stems, flos sophorae and fructus forsythia, and edible salt. The invention further discloses a preparation method of the medicine. According to the invention, the method of hip bath is adopted, so that the liquid medicine can directly act on the wound surface. Results of clinical researches show that the medicine has efficacy of clearing away heat and toxic materials, removing rots, eliminating pus, promoting blood circulation to remove blood stasis and generating tissue and healing wound and the medicine is applicable to anorectal diseases such as downward flow of damp-heat hemorrhoids, anal fissure, anal fistula, anal carbuncle, perianal abscess and the like. The curative effect is superior to that of metronidazole in a control group.
Description
Technical field
The present invention relates to a kind of Chinese medicine, relate to specifically a kind of Chinese medicine for the healing of anorectal postoperative wound, the invention still further relates to the preparation method of this Chinese medicine.
Background technology
Anorectal disease refers to a series of diseases relevant with anal orifice and rectal intestine, common are hemorrhoid, anal fissure, anal cryptitis, anal abscess (anal orifice and rectal intestine peripheral abscess), perianal hemorroids (anal fistula), proctoptosis (anorectal region prolapsus), rectal polyp (rectal polyp) and anorectal carcinoma (anorectal region cancer) etc., is common clinical and frequently-occurring disease.Its Therapeutic Method mainly be take operation as main, but because reaction and the complication such as proctalgia, hemorrhage, edema, falling inflation easily appear in postoperative patient, affect the healing of anorectal disease postoperative wound surface, bring great misery to patient's body and mind, directly have influence on the quality of life after operation in patients and resume work the time.Therefore how simple, convenient, effectively remove proctalgia after operation in patients, hemorrhage, edema, falling inflation etc., wound healing, becomes the key factor that affects hemorrhoid postoperative curative effect.In recent years, Chinese medicine, promoting to have had significant progress aspect healing postoperative wound surface of anorectal diseases, had been obtained larger development.
The postoperative sufferings that often occur of anorectal disease, edema, falling inflation, hemorrhage, the complication such as infection, affect wound repair, wherein pain is overworked the most common, < < abstracts of classic of internal medicine > > says: " general rule is not bitterly, pain is obstructed ", and < < disease guide case > > says: " through all sufferings skin ulcers of cloud, all belong to the heart ... so-called logical its QI and blood, not bitterly yet, if the real person of disease, qi stagnation hemagglutination, loose its blood of logical its gas is healed." so < < Yizong Jinjian > > says: " ... cause stagnation of QI blood addiction and have a pain ... all should be with the pleasant agent of the I that invigorates blood circulation." postoperative sufferings main diseases machine is stasis blocking, controls when removing blood stasis circulation of qi promoting, removing obstruction in the collateral to relieve pain is main, and tired blood is gone, and QI and blood is smooth, and general rule is not bitterly.In addition < < Linzheng Zhinan Yi > > says: " it is just sick at warp; pathogen usually intruding into collateral in protracted disease; through main gas, the main blood of network ..., gas is resistance for a long time both; blood also should be sick; follow the venation of row from numbness ", " long-pending wound into network, QI and blood is the stasis of blood all, popular mistake department, so-called pain is also obstructed." qi as the commander of blood, the capable blood of gas, the stagnation of QI is stasis, depressed blood stasis.QI and blood is held concurrently and is adjusted, and makes passages through which vital energy circulates unobstructed, and blood stasis dissipates, and the generation that alleviates algogenic substance, reaches " general rule is not bitterly ".The postoperative etiology and pathogenesis of anorectal disease is mainly qi depression to blood stasis due to damage, blockage of meridian, visceral dysfunction in a word.
China's traditional medicine, to how promoting wound repair to have unique understanding and abundant clinical experience, is especially being given full play to the advantage of Chinese medicine in the external treatment of wound surface.Many doctors use promoting flow of QI and blood, push away Chen Zhixin, dampness is received pus, pus goes flesh life, sour and astringent closing in, promoting tissue regeneration and wound healing etc. to treat rule, in conjunction with self clinical experience, sum up many medicine for external use for clinical treatment.
Summary of the invention
The object of the invention is to give full play to the advantage of motherland's medical science aspect promotion healing postoperative wound surface of anorectal diseases, according to differential diagnosis in tcm opinion, control principle, provide a kind of evident in efficacy, Chinese medicine for the healing of anorectal postoperative wound easy to use and preparation method thereof.
For a Chinese medicine for anorectal postoperative wound healing, by the raw material of following weight parts, made: Herba Schizonepetae 120-200 part, Radix Et Rhizoma Rhei 10-50 part, Cortex Phellodendri 80-120 part, Herba Taraxaci 50-100 part, Radix Sophorae Flavescentis 80-120 part, Radix Saposhnikoviae 30-70 part, Radix Sanguisorbae 80-120 part, Herba Menthae 80-120 part, Cortex Lycii 50-100 part, Folium Artemisiae Argyi 80-120 part, Matrii Sulfas Exsiccatus 120-200 part, Herba speranskiae tuberculatae 50-100 part, Flos Sophorae 50-100 part, Fructus Forsythiae 80-120 part, Sal 120-200 part.
Preferably, the weight portion of described raw material is: Herba Schizonepetae 140-180 part, Radix Et Rhizoma Rhei 20-40 part, Cortex Phellodendri 90-110 part, Herba Taraxaci 60-80 part, Radix Sophorae Flavescentis 90-110 part, Radix Saposhnikoviae 40-60 part, Radix Sanguisorbae 90-110 part, Herba Menthae 90-110 part, Cortex Lycii 60-80 part, Folium Artemisiae Argyi 90-110 part, Matrii Sulfas Exsiccatus 140-180 part, Herba speranskiae tuberculatae 60-80 part, Flos Sophorae 60-80 part, Fructus Forsythiae 90-110 part, Sal 140-180 part.
Further preferably, the weight portion of described raw material is: 150 parts of Herba Schizonepetae, 30 parts of Radix Et Rhizoma Rhei, 100 parts of Cortex Phellodendris, 75 parts of Herba Taraxacis, 100 parts of Radix Sophorae Flavescentiss, 50 parts of Radix Saposhnikoviaes, 100 parts of Radix Sanguisorbaes, 100 parts of Herba Menthaes, 75 parts of Cortex Lycii, 100 parts of Folium Artemisiae Argyis, 150 parts of Matrii Sulfas Exsiccatus, 75 parts of Herba speranskiae tuberculataes, 75 parts, Flos Sophorae, 100 parts of Fructus Forsythiaes, 150 parts of Sal.
A kind of method of preparing described Chinese medicine provided by the invention is: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, add by weight 4-10 times of water, within merceration 30-60 minute, post-heating decocts 30-60 minute, then add Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, decoct again 10-40 minute, extracting juice; To adding by weight 1.5-4 times of decocting in medicinal residues, boil 10-40 minute, extracting juice again; Merge decocting liquid twice, filter, in filtrate, add Matrii Sulfas Exsiccatus and Sal and be concentrated into 1500-2500ml.
Preferred method is: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, add by weight 6 times of water, 40 minutes post-heating of merceration decoct 40 minutes, then add Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, decoct again extracting juice 30 minutes; To adding by weight 2 times of decoctings in medicinal residues, boil 30 minutes again extracting juice; Merge decocting liquid twice, filter, in filtrate, add Matrii Sulfas Exsiccatus and Sal and be concentrated into 2100ml.
The method of the described Chinese medicine of another kind of preparation provided by the invention is: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, add 30-60% ethanol, first infiltrate 2-5 hour, then use the speed seepage 5-15 hour of 4-8ml/min, collect effusion and add Matrii Sulfas Exsiccatus and Sal, reclaim ethanol and be concentrated into 1500-2500ml.The Effective Component of Chinese Medicine content that adopts the method to make is higher, better efficacy.
Preferred method is: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, add 40% ethanol, first infiltrate 3 hours, then use the speed seepage 12 hours of 6ml/min, collect effusion and add Matrii Sulfas Exsiccatus and Sal, reclaim ethanol and be concentrated into 2100ml.
Concentration of alcohol related in the present invention is weight concentration, as 40% ethanol refers in 100g ethanol water containing ethanol 40g.
In side, Herba Schizonepetae, Radix Saposhnikoviae have the effect of the removing toxic substances of dispeling the wind, removing dampness to relieve pain; It is principal agent altogether that Matrii Sulfas Exsiccatus, Radix Et Rhizoma Rhei have the effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating convergence pain relieving.Cortex Phellodendri, Fructus Forsythiae, Herba Taraxaci, Radix Sangusorbae have the accessory drugs that act as of heat-clearing and toxic substances removing, convergence promoting tissue regeneration and wound healing.Herba speranskiae tuberculatae, Flos Sophorae, Cortex Lycii promoting blood circulation and hemostasis, mass dissipating and swelling eliminating; Folium Artemisiae Argyi, Herba Menthae fragrance are walked to alter, and have loose ailment said due to cold or exposure promoting blood circulation and pain relieving; Radix Sophorae Flavescentis nature and flavor bitter cold, has heat clearing and damp drying, the effect of parasite killing diuresis.
Modern pharmacological research shows, Chinese medicine of the present invention has the capillary permeability of reduction and improves fragility, reduces the effect that body fluid exosmoses; Can make inflammation local vascular shrink, reduce contrafluxion or edema, have obvious anastalsis; Can promote epithelial physiological function, there is the effect that promotes ulcer healing.
The present invention adopts the method for demibain, makes medicinal liquid directly act on wound surface, and clinical research result shows, the present invention has heat-clearing and toxic substances removing, putrefaction removing except the effect of pus, blood circulation promoting and blood stasis dispelling, promoting tissue regeneration and wound healing.For anal and intestinal diseases such as damp heat downward flowing type hemorrhoid, anal fissure, anal fistula, anal abscess, perianal abscesses, curative effect is better than matched group metronidazole.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
Embodiment 1
For a Chinese medicine for anorectal postoperative wound healing, by following raw material, made:
Herba Schizonepetae 150g, Radix Et Rhizoma Rhei 30g, Cortex Phellodendri 100g, Herba Taraxaci 75g, Radix Sophorae Flavescentis 100g, Radix Saposhnikoviae 50g, Radix Sanguisorbae 100g, Herba Menthae 100g, Cortex Lycii 75g, Folium Artemisiae Argyi 100g, Matrii Sulfas Exsiccatus 150g, Herba speranskiae tuberculatae 75g, Flos Sophorae 75g, Fructus Forsythiae 100g, Sal 150g.
Preparation method is: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, add by weight 6 times of water, 40 minutes post-heating of merceration decoct 40 minutes, then add Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, decoct again extracting juice 30 minutes; To adding by weight 2 times of decoctings in medicinal residues, boil 30 minutes again extracting juice; Merge decocting liquid twice, filter, in filtrate, add Matrii Sulfas Exsiccatus and Sal and be concentrated into 2100ml.
Quality testing result: matrine content is 1.3 μ g/ml.
Embodiment 2
For a Chinese medicine for anorectal postoperative wound healing, by following raw material, made:
Herba Schizonepetae 150g, Radix Et Rhizoma Rhei 30g, Cortex Phellodendri 100g, Herba Taraxaci 75g, Radix Sophorae Flavescentis 100g, Radix Saposhnikoviae 50g, Radix Sanguisorbae 100g, Herba Menthae 100g, Cortex Lycii 75g, Folium Artemisiae Argyi 100g, Matrii Sulfas Exsiccatus 150g, Herba speranskiae tuberculatae 75g, Flos Sophorae 75g, Fructus Forsythiae 100g, Sal 150g.
Preparation method is: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, add 40% ethanol, first infiltrate 3 hours, then use the speed seepage 12 hours of 6ml/min, collect effusion and add Matrii Sulfas Exsiccatus and Sal, reclaim ethanol and be concentrated into 2100ml.
Quality testing result: matrine content is 1.7 μ g/ml.
Embodiment 3 pharmacodynamics tests
1. material
1.1 medicine embodiment 1,2 medicines, are concentrated into every ml containing medical material 1.2g); Herba Tubocapsici Anomali ointment, by Wuhan, Ma Yinglong Pharmaceutical limited company provides.
1.2 animal SD rats, body weight 250 ± 20g, male and female half and half, are provided by Hubei Province Disease Control and Prevention Center.
1.3 strain golden color staphylococcus bacterium liquid, every ml, containing 300,000,000, antibacterial, is provided by Hubei Province microbial room of university of TCM.
2. method
2.1 impacts on guinea pig skin ecchymosis
Guinea pig back is lost hair or feathers, use subsequently pliers bark pocket skin, exert oneself gradually, take and cause Cavia porcellus subcutaneous hemorrhage as degree, after 1 hour, there is ecchymosis, measure ecchymosis area, with medicine, be applied in ecchymosis place subsequently, twice of every day, coating is observed one week continuously, and with vernier caliper measurement ecchymosis diameter, calculate the ecchymosis area that disappears, the results are shown in Table 1.
The impact of table 1 the present invention on Cavia porcellus local skin Traumatic ecchymosis
With the comparison of ecchymosis model group, * P<0.05.
As seen from Table 1, the present invention has obvious regressive effect to guinea pig skin Traumatic ecchymosis, shows that the present invention has certain blood circulation promoting and blood stasis dispelling function.
2.2 impacts on skin infection animal model
By the depilation of 40 Cavia porcelluss the district's skin degerming that will lose hair or feathers, cuts a wound that diameter is 1cm, deeply reach subcutaneously, in each wound, inject staphylococcus aureus bacterium liquid 1ml, one day 1 time, till wound circumference appearance redness and purulent secretion.Cavia porcellus is divided into 4 groups: 1 group of embodiment, 2 groups of embodiment, Herba Tubocapsici Anomali ointment group, Sore model group, each organizes 10.1,2 groups of embodiment and Herba Tubocapsici Anomali ointment group are smeared medicine (being equivalent to medical material 1.2g) every day at wound infection place, Sore model group is smeared distilled water at wound infection place every day.After administration, wound wrapped up with gauze and separate raising.Record from from medication to wound without purulent secretion, the time of wound healing.
1) variation of pus: 3-4 days, 1,2 groups of wound red swelling of the skins of embodiment disappear and without purulent secretion, 5-6 days, Herba Tubocapsici Anomali ointment group wound red swelling of the skin disappears and without purulent secretion, and the 10th day, Sore model group is red and swollen protuberance and have purulent secretion still.
2) 1,2 groups of wound healing situation: embodiment and Herba Tubocapsici Anomali ointment group wound heal completely, corium and scar tissue collagenzation under mirror, and blood capillary reduces, and without obvious inflammatory cell infiltration, epithelium form has approached normal.Sore model group subcutaneous tissue suppurate as seen focus and ulcer, corium and subcutaneous visible granulation tissue hyperplasia under mirror, companion's inflammatory cell infiltration, granulation tissue surface is covered by epithelium.
The impact of table 2 the present invention on Cavia porcellus wound surface skin infection
| ? | n | Wound healing time (d) |
| Sore model group | 10 | 11.26±1.56 |
| Herba Tubocapsici Anomali ointment group | 10 | 7.17±1.27 |
| 1 group of embodiment | 10 | 5.87±1.38 |
| 2 groups of embodiment | 10 | 4.16±1.29 |
With the comparison of ecchymosis model group, * P<0.05.
As seen from Table 2, the present invention has obvious promotion Healing to Cavia porcellus wound surface.
Above evidence Chinese medicine of the present invention not only has the effect of anti-inflammation pain relieving (heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling), also there is the effect of removing the necrotic tissue and promoting granulation (putrefaction removing is except pus, promoting tissue regeneration and wound healing), can not only alleviate the postoperative wound pain of anorectal, can also blood circulation promoting and blood stasis dispelling, obviously promote wound healing.Its reason may can increase blood capillary quantity and permeability with the present invention, improves microcirculation, affects the generation of Fn Fiberonectin relevant with the synthetic grade of collagen.
Embodiment 4 clinical researches
1. patient's physical data
Patient's clinical data is in Table 3.
Table 3 variety classes anus anorectal disease patient's clinical data
2. contrast medicine adopts 0.5% metronidazole solution 200ml demibain to contrast.
3. Therapeutic Method Operation method is identical.After treatment group second day after operation begins to give embodiment 1 medicine 500ml warm water demibain 20～30min after defecation every day, routine is changed dressings, and the matched group second day after operation routine after warm water demibain that begins after defecation every day is changed dressings.Two groups of dressing change methods are identical, change dressings the time until wound surface heal completely.Observe two groups of differences of the aspect such as pain, hemorrhage, anastomotic stoma edema, anal stenosis after surgery.
4. inspection content is chosen clinical symptoms, electronic colonoscopy result, pathological examination results, haemanalysis, hepatic and renal function, electrolyte, a blood fat complete set, fasting glucose, six, tumor, electrocardiogram, courage type-B ultrasonic, rabat, urine stool examination etc. as observation index.
5. method for estimating curative effect and experimental result
1) performance assessment criteria
(1) degree that the cardinal symptom sign such as pain after overview wound healing time, wound surface area reducing rate and medication, edema, hemorrhage, falling inflation alleviates.
(2) when safety indexes treatment finishes, all check the projects such as blood, routine urinalysis and liver, renal function.
(3) health giving quality is observed the cardinal symptom signs such as itemized record pain, edema, hemorrhage, falling inflation and is treated forward and backward variation, and by the evaluation criteria record respectively of scoring, the integration sum that symptom total mark is above several symptoms.
2) curative effect judging standard
2.1 clinical symptoms, sign standards of grading
Table 4 curative effect standards of grading
2.2 Comprehensive Clinical efficacy assessment standards
With reference to the disease Standardization of diagnosis and curative effect > > of Chinese medicine industry standard traditional Chinese medical science anorectal section of the < < People's Republic of China (PRC), according to the symptom integral before and after treatment, calculate therapeutic index, according to therapeutic index, curative effect is divided into recovery from illness, effective, effective, invalid 4 standards.
2.2.1 therapeutic index: represent by n value.
N value computing formula:
2.2.2 efficacy assessment standard:
(1) clinical recovery: after treatment, clinical symptoms all disappears, n=l;
(2) effective: after treatment, the front symptom integral for the treatment of reduces, 75%<n value <1;
(3) effective: after treatment, the front symptom integral for the treatment of reduces, 50%<n value <75%;
(4) invalid: after treatment, the front symptom integral for the treatment of reduces, n value <50%.
3.1.3 statistical method
All average ± standard deviations for measurement data
represent, between two groups, relatively adopt t check; Enumeration data adopts x
2check; Ranked data adopt Ridit to analyze.
Two groups of curative effect comparisons (number of cases, %)
From the result of clinical trial, can find out, the present invention all has good curative effect to anal and intestinal diseases such as hemorrhoid, anal fissure, anal fistula, anal abscess, perianal abscesses, and total effective rate is all more than 85%.
Embodiment 5
For a Chinese medicine for anorectal postoperative wound healing, by following raw material, made:
Herba Schizonepetae 120g, Radix Et Rhizoma Rhei 50g, Cortex Phellodendri 80g, Herba Taraxaci 100g, Radix Sophorae Flavescentis 80g, Radix Saposhnikoviae 70g, Radix Sanguisorbae 80g, Herba Menthae 80g, Cortex Lycii 50g, Folium Artemisiae Argyi 80g, Matrii Sulfas Exsiccatus 120g, Herba speranskiae tuberculatae 100g, Flos Sophorae 100g, Fructus Forsythiae 80g, Sal 200g.
Get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, add by weight 4 times of water, 60 minutes post-heating of merceration decoct 60 minutes, then add Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, then decoct extracting juice 40 minutes; To adding by weight 1.5 times of decoctings in medicinal residues, boil 40 minutes again extracting juice; Merge decocting liquid twice, filter, in filtrate, add Matrii Sulfas Exsiccatus and Sal and be concentrated into 1500ml.
Embodiment 6
For a Chinese medicine for anorectal postoperative wound healing, by following raw material, made:
Herba Schizonepetae 200g, Radix Et Rhizoma Rhei 10g, Cortex Phellodendri 120g, Herba Taraxaci 50g, Radix Sophorae Flavescentis 120g, Radix Saposhnikoviae 30g, Radix Sanguisorbae 120g, Herba Menthae 120g, Cortex Lycii 100g, Folium Artemisiae Argyi 120g, Matrii Sulfas Exsiccatus 200g, Herba speranskiae tuberculatae 50g, Flos Sophorae 50g, Fructus Forsythiae 120g, Sal 120g.
Get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, add 30% ethanol, first infiltrate 5 hours, then use the speed seepage 5 hours of 8ml/min, collect effusion and add Matrii Sulfas Exsiccatus and Sal, reclaim ethanol and be concentrated into 1500ml.
Embodiment 7
For a Chinese medicine for anorectal postoperative wound healing, by following raw material, made:
Herba Schizonepetae 140g, Radix Et Rhizoma Rhei 40g, Cortex Phellodendri 110g, Herba Taraxaci 60g, Radix Sophorae Flavescentis 90g, Radix Saposhnikoviae 40g, Radix Sanguisorbae 110g, Herba Menthae 110g, Cortex Lycii 80g, Folium Artemisiae Argyi 110g, Matrii Sulfas Exsiccatus 140g, Herba speranskiae tuberculatae 80g, Flos Sophorae 80g, Fructus Forsythiae 110g, Sal 180g.
Get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, add by weight 10 times of water, 30 minutes post-heating of merceration decoct 30 minutes, then add Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, then decoct extracting juice 10 minutes; To adding by weight 4 times of decoctings in medicinal residues, boil 10 minutes again extracting juice; Merge decocting liquid twice, filter, in filtrate, add Matrii Sulfas Exsiccatus and Sal and be concentrated into 2500ml.
Embodiment 8
For a Chinese medicine for anorectal postoperative wound healing, by following raw material, made:
Herba Schizonepetae 180g, Radix Et Rhizoma Rhei 20g, Cortex Phellodendri 90g, Herba Taraxaci 80g, Radix Sophorae Flavescentis 110g, Radix Saposhnikoviae 60g, Radix Sanguisorbae 90g, Herba Menthae 90g, Cortex Lycii 60g, Folium Artemisiae Argyi 90g, Matrii Sulfas Exsiccatus 180g, Herba speranskiae tuberculatae 60g, Flos Sophorae 60g, Fructus Forsythiae 90g, Sal 140g.
Get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, add 60% ethanol, first infiltrate 2 hours, then use the speed seepage 15 hours of 4ml/min, collect effusion and add Matrii Sulfas Exsiccatus and Sal, reclaim ethanol and be concentrated into 2500ml.
Claims (7)
1. for a Chinese medicine for anorectal postoperative wound healing, it is characterized in that being made by the raw material of following weight parts: Herba Schizonepetae 120-200 part, Radix Et Rhizoma Rhei 10-50 part, Cortex Phellodendri 80-120 part, Herba Taraxaci 50-100 part, Radix Sophorae Flavescentis 80-120 part, Radix Saposhnikoviae 30-70 part, Radix Sanguisorbae 80-120 part, Herba Menthae 80-120 part, Cortex Lycii 50-100 part, Folium Artemisiae Argyi 80-120 part, Matrii Sulfas Exsiccatus 120-200 part, Herba speranskiae tuberculatae 50-100 part, Flos Sophorae 50-100 part, Fructus Forsythiae 80-120 part, Sal 120-200 part.
2. the Chinese medicine for the healing of anorectal postoperative wound according to claim 1, is characterized in that the weight portion of described raw material is: Herba Schizonepetae 140-180 part, Radix Et Rhizoma Rhei 20-40 part, Cortex Phellodendri 90-110 part, Herba Taraxaci 60-80 part, Radix Sophorae Flavescentis 90-110 part, Radix Saposhnikoviae 40-60 part, Radix Sanguisorbae 90-110 part, Herba Menthae 90-110 part, Cortex Lycii 60-80 part, Folium Artemisiae Argyi 90-110 part, Matrii Sulfas Exsiccatus 140-180 part, Herba speranskiae tuberculatae 60-80 part, Flos Sophorae 60-80 part, Fructus Forsythiae 90-110 part, Sal 140-180 part.
3. the Chinese medicine for the healing of anorectal postoperative wound according to claim 1, is characterized in that the weight portion of described raw material is: 150 parts of Herba Schizonepetae, 30 parts of Radix Et Rhizoma Rhei, 100 parts of Cortex Phellodendris, 75 parts of Herba Taraxacis, 100 parts of Radix Sophorae Flavescentiss, 50 parts of Radix Saposhnikoviaes, 100 parts of Radix Sanguisorbaes, 100 parts of Herba Menthaes, 75 parts of Cortex Lycii, 100 parts of Folium Artemisiae Argyis, 150 parts of Matrii Sulfas Exsiccatus, 75 parts of Herba speranskiae tuberculataes, 75 parts, Flos Sophorae, 100 parts of Fructus Forsythiaes, 150 parts of Sal.
4. a method of preparing claim 1-3 Chinese medicine described in any one, it is characterized in that: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, add by weight 4-10 times of water, within merceration 30-60 minute, post-heating decocts 30-60 minute, then add Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, decoct again 10-40 minute, extracting juice; To adding by weight 1.5-4 times of decocting in medicinal residues, boil 10-40 minute, extracting juice again; Merge decocting liquid twice, filter, in filtrate, add Matrii Sulfas Exsiccatus and Sal and be concentrated into 1500-2500ml.
5. preparation method according to claim 4, it is characterized in that: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, add by weight 6 times of water, 40 minutes post-heating of merceration decoct 40 minutes, then add Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, decoct again extracting juice 30 minutes; To adding by weight 2 times of decoctings in medicinal residues, boil 30 minutes again extracting juice; Merge decocting liquid twice, filter, in filtrate, add Matrii Sulfas Exsiccatus and Sal and be concentrated into 2100ml.
6. a method of preparing claim 1-3 Chinese medicine described in any one, it is characterized in that: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, add 30-60% ethanol, first infiltrate 2-5 hour, then use the speed seepage 5-15 hour of 4-8ml/min, collect effusion and add Matrii Sulfas Exsiccatus and Sal, reclaim ethanol and be concentrated into 1500-2500ml.
7. preparation method according to claim 6, it is characterized in that: get Cortex Phellodendri, Herba Taraxaci, Radix Sophorae Flavescentis, Radix Saposhnikoviae, Radix Sanguisorbae, Cortex Lycii, Herba speranskiae tuberculatae, Fructus Forsythiae, Herba Schizonepetae, Radix Et Rhizoma Rhei, Herba Menthae, Folium Artemisiae Argyi, Flos Sophorae, add 40% ethanol, first infiltrate 3 hours, then use the speed seepage 12 hours of 6ml/min, collect effusion and add Matrii Sulfas Exsiccatus and Sal, reclaim ethanol and be concentrated into 2100ml.
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| CN107397947A (en) * | 2016-05-18 | 2017-11-28 | 孙晋客 | Promote the traditional Chinese medicine lotion and its application method of fracture surgery wound healing |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491334A (en) * | 2014-12-25 | 2015-04-08 | 祝宝莲 | Traditional Chinese medicine fumigation lotion for treating pain after hemorrhoids operation and nursing method thereof |
| CN105079332A (en) * | 2015-10-08 | 2015-11-25 | 张晓倩 | Traditional Chinese medicine composition for treating perianal abscess caused by fire toxin accumulation |
| CN107397947A (en) * | 2016-05-18 | 2017-11-28 | 孙晋客 | Promote the traditional Chinese medicine lotion and its application method of fracture surgery wound healing |
| CN106421160A (en) * | 2016-05-25 | 2017-02-22 | 中国人民解放军南京军区南京总医院 | Wound-cleaning traditional Chinese medicine composition for anal fistula as well as preparation method and application of traditional Chinese medicine |
| CN106421008A (en) * | 2016-05-25 | 2017-02-22 | 中国人民解放军南京军区南京总医院 | Wound-healing traditional Chinese medicine composition for anal fistula as well as preparation method and application of traditional Chinese medicine |
| CN106389899A (en) * | 2016-05-31 | 2017-02-15 | 李春燕 | Pharmaceutical composition for anorectal postoperative filling |
| CN106310144A (en) * | 2016-11-15 | 2017-01-11 | 河南中医药大学 | Fuming and washing traditional Chinese medicine composition for treating piles |
| CN106727832A (en) * | 2017-01-21 | 2017-05-31 | 贵州省骨科医院 | A kind of pharmaceutical composition for controlling treatment trauma and postoperative edema |
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