CN106727832A - A kind of pharmaceutical composition for controlling treatment trauma and postoperative edema - Google Patents
A kind of pharmaceutical composition for controlling treatment trauma and postoperative edema Download PDFInfo
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- 206010030113 Oedema Diseases 0.000 title claims abstract description 43
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 25
- 230000002980 postoperative effect Effects 0.000 title claims abstract description 19
- 208000014674 injury Diseases 0.000 title claims abstract description 16
- 230000008733 trauma Effects 0.000 title claims abstract description 16
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 29
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 14
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 13
- 239000013078 crystal Substances 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000001914 filtration Methods 0.000 claims abstract description 12
- 239000012535 impurity Substances 0.000 claims abstract description 12
- 239000010446 mirabilite Substances 0.000 claims abstract description 12
- 241000245665 Taraxacum Species 0.000 claims abstract description 11
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 238000007654 immersion Methods 0.000 claims abstract description 8
- 235000020097 white wine Nutrition 0.000 claims abstract description 8
- 239000000463 material Substances 0.000 claims abstract description 7
- 150000004688 heptahydrates Chemical class 0.000 claims abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 6
- 238000001816 cooling Methods 0.000 claims abstract description 5
- 239000000706 filtrate Substances 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 235000019640 taste Nutrition 0.000 claims abstract description 4
- 235000019628 coolness Nutrition 0.000 claims description 3
- 238000005538 encapsulation Methods 0.000 claims description 3
- 238000010792 warming Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 14
- 230000008961 swelling Effects 0.000 abstract description 5
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 20
- 208000010392 Bone Fractures Diseases 0.000 description 12
- 206010017076 Fracture Diseases 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 7
- 210000003414 extremity Anatomy 0.000 description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 229930195725 Mannitol Natural products 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 235000010355 mannitol Nutrition 0.000 description 5
- 239000000594 mannitol Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000007832 Na2SO4 Substances 0.000 description 4
- 210000002758 humerus Anatomy 0.000 description 4
- 238000001802 infusion Methods 0.000 description 4
- 238000001990 intravenous administration Methods 0.000 description 4
- 210000002414 leg Anatomy 0.000 description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 description 4
- AXNVHPCVMSNXNP-OXPBSUTMSA-N Aescin Chemical compound O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(C[C@H]14)(C)C)OC(=O)C(\C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O AXNVHPCVMSNXNP-OXPBSUTMSA-N 0.000 description 3
- AXNVHPCVMSNXNP-GKTCLTPXSA-N Aescin Natural products O=C(O[C@H]1[C@@H](OC(=O)C)[C@]2(CO)[C@@H](O)C[C@@]3(C)[C@@]4(C)[C@@H]([C@]5(C)[C@H]([C@](CO)(C)[C@@H](O[C@@H]6[C@@H](O[C@H]7[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O7)[C@@H](C(=O)O)O6)CC5)CC4)CC=C3[C@@H]2CC1(C)C)/C(=C/C)/C AXNVHPCVMSNXNP-GKTCLTPXSA-N 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 210000000689 upper leg Anatomy 0.000 description 3
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 2
- 244000192528 Chrysanthemum parthenium Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 241000132536 Cirsium Species 0.000 description 2
- 206010014418 Electrolyte imbalance Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 235000008384 feverfew Nutrition 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 210000001364 upper extremity Anatomy 0.000 description 2
- 241000729173 Cirsium japonicum Species 0.000 description 1
- 208000003044 Closed Fractures Diseases 0.000 description 1
- 208000024779 Comminuted Fractures Diseases 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010053652 Limb deformity Diseases 0.000 description 1
- 206010025282 Lymphoedema Diseases 0.000 description 1
- 206010030124 Oedema peripheral Diseases 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 206010049771 Shock haemorrhagic Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000292546 Taraxacum mongolicum Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 206010010121 compartment syndrome Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000002502 lymphedema Diseases 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 208000004141 microcephaly Diseases 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 235000019643 salty taste Nutrition 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
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Abstract
A kind of pharmaceutical composition for controlling treatment trauma and postoperative edema, is formulated by 4 taste medicinal materials, and quality proportioning is:Dislike hen 15~30, pseudo-ginseng 6~10, dandelion 30~50, glauber salt 250.Preparation method：(1) chopped up hen is disliked, together added with pseudo-ginseng in white wine, closing is placed in constant water bath box immersion, filtering and impurity removing；(2) clear water is placed in marmite, dandelion is dried according to formula addition, heat up immersion, natural cooling, filtering and impurity removing；(3) add glauber salt and immersion to dislike the white wine of hen in filtrate, stir and evenly mix, filtering and impurity removing, natural cooling；(4) after fully heptahydrate saltcake crystal is separated out, air-dry and break into fine grained, gained crystal grain is pharmaceutical composition of the invention.The present invention is carried as carrier with heptahydrate saltcake crystal and dislikes hen, Pu Gongcao and pseudo-ginseng, with strong water suction detumescence effect, shortens swelling time, is had no toxic side effect.Suitable for limb trauma and Post operation oedema.
Description
Technical field
The present invention is relevant with medicinal preparation, in particular to the medicine for the treatment of oedema.
Background technology
Oedema is the common clinical symptoms of limb fracture.No matter operative treatment or manipulative reduction also occur in various degree
Oedema.Be unfavorable for if oedema can not be eliminated in time promoting extremities blood circulation, the supply of nutriment and wound and operation more
Close.Severe patient occurs wound infection, osteomyelitis and compartment syndrome, in addition amputation serious consequence.Therefore, disappear in early days
Swollen treatment is of great significance for the rehabilitation of fracture patient and clinical prognosis.The medicine of Chinese traditional treatment fracture and postoperative edema
Compositions report is more, but can be actually rare effective for the medicine of clinical treatment.At present, it is clinical generally to use ' β-seven leaves
The intravenous infusion of saponin(e sodium joint mannitol ' treatment is fractured and postoperative edema, but its curative effect differs greatly with clinical demand.Tibiofibula reefing
Continuous intravenous infusion 3 days afterwards, only 28.5% patient's oedema can substantially disappear, continuous intravenous infusion 7 days, and substantially regression person also only has oedema
81.1%.And long-term use ' intravenous infusion of beta-aescin sodium joint mannitol ' side effect is more, such as mannitol can cause renal function
And Electrolyte imbalance, beta-aescin sodium can cause phlebitis etc..It is quiet particularly with damaging with haemorrhagic shock fracture patient
Drop mannitol combined beta-aescin sodium eliminates oedema, will necessarily aggravate shock and the electrolyte disturbance for having existed.Thus may be used
See, the existing medicine swelling time for controlling treatment trauma and postoperative edema is long, cure rate is low, side effect is big, and curative effect can not meet clinic
Need, often the delay operative treatment best opportunity, influence fracture patient postoperative rehabilitation.
In Chinese patent database, it is related to the patent application for treating edema drugs a lot, but use mirabilite for treating oedema
Only：No. ZL2012100489131《Treat Chinese medicine composition of pig malignant edema of castrated and preparation method thereof》、
No. 2014106289956《Treat Chinese medicine composition of hydropsy for baby pigs and preparation method thereof》With No. 2016106724487《It is a kind of
Treat the External-applicationtraditional traditional Chinese medicinal of lower limb lymphedema》, these patent applications disclose some using Chinese medicine prepare
The medicine for treating oedema, but its curative effect is unclear.People also need to the types of drugs of better efficacy.
The content of the invention
The present invention is intended to provide a kind of pharmaceutical composition for controlling treatment trauma and postoperative edema, to increase the medicine for the treatment of oedema
Kind, quick effectively regression wound and Post operation edema of limbs and trunks, makes it not be delayed operative treatment, reduces complication and occurs, and promotes
Patient's early recovery.
Of the invention to control treatment trauma and the pharmaceutical composition of postoperative edema is formulated by 4 taste medicinal materials, its quality proportioning is:
Dislike hen 15~30, pseudo-ginseng 6~10, dandelion 30~50, glauber salt 250.
In above-mentioned medicinal material：
Dislike hen, i.e. setose thistle, be feverfew setose thistle (Cirsium japonicum) herb or root, it is sweet, it is cool in nature, can be cool
Blood, hemostasis, dissolving stasis, subduing inflammation（See that the new medical college in Zhejiang compiles《Dictionary of medicinal plant》Page 115）；Pseudo-ginseng, is Araliaceae ginseng
Pseudo-ginseng（Panax pseudo-ginseng）Root, its is warm in nature, sweet and slightly bitter taste, can stop blooding, scattered silt, detumescence, analgesic therapy（See《Chinese medicine
Voluminous dictionary》Page 54）；Dandelion, be feverfew dandelion (Taraxacum mongolicum) whole herb with root, bitter, property
It is cold, there are heat-clearing toxin-expelling functions（See《Dictionary of medicinal plant》Page 2459）；Glauber salt is pure anhydrous sodium sulfate（Na2SO4）, it is used for
Prepare seven water saltcake（Na2SO4•7H2O）, saltcake（Mirabilite）Acrid,bitter and salty taste, it is cold in nature, can purge heat, moisturize, softening hard masses（See《In
Medicine voluminous dictionary》Page 836）.
Above-mentioned medicinal material should meet《Chinese Pharmacopoeia》Regulation in version one in 2010 under each medicinal material.
The preparation method of the pharmaceutical composition for controlling treatment trauma and postoperative edema that inventor provides is comprised the following steps：
(1) it is first according to formula to chop up dry evil hen, joint pseudo-ginseng is together added in white wine, and closing is placed in 50 DEG C of perseverances
Warm water bath cabinet soaks 12h, and the removal of impurity is gone in filtering；
(2) 500mL water is placed in marmite again, dandelion is dried according to formula addition, be warming up to 100 DEG C of 5 min of immersion, nature
60 DEG C are cooled to, the removal of impurity is gone in filtering；
(3) glauber salt and immersion in advance is added to dislike the white wine of hen root according to formula in the filtrate of previous step, stirring and dissolving is mixed
It is even, the removal of impurity is refiltered, mixture is placed in 18 DEG C of environment temperature natural coolings；
(4) after fully heptahydrate saltcake crystal is separated out in previous step mixture, air-dry and break into fine grained, gumming is gone in filtering
End, the crystal grain of the fine uniform of gained is pharmaceutical composition of the invention, preserves stand-by with gauze package encapsulation.
Inventor points out：The saltcake crystal-chemical formula separated out in the pharmaceutical composition is Na2SO4 •7H2O, with enough
Coordinate bond attract hydrone ability, different from medical saltcake crystal（Na2SO4•10H2O）, heptahydrate saltcake contains 3 knots
Heshui molecular coordination bonds, water suction detumescence effect is much stronger than mirabilite hydrate crystal；With the knot in the saltcake crystal of the pharmaceutical composition
The active constituents of medicine such as evil hen, dandelion and pseudo-ginseng that brilliant hydrone is carried can efficiently enter and play profit promoting blood circulation and removing blood stasis in vivo
Water is acted on.
The treatment trauma and the pharmaceutical composition application method of postoperative edema controlled of the invention is external application, when using, uses the medicine
Composition is applied at oedema.
The present invention is carried as carrier with heptahydrate saltcake crystal and dislikes the pharmaceutical activity group of molecules such as hen, Pu Gongcao and pseudo-ginseng
Compound has strong water suction detumescence effect.Compared with mannitol combined Sodium Aescinate oedema effect, the pharmaceutical composition can
Substantially to shorten the edema extinction time, substantially regression person is 65% to medication 24h oedema, 4 days oedema of medication substantially regression person 90%
More than, and it is without any side effects.It is mainly used in limb trauma and Post operation oedema.
Originally the pharmaceutical composition for the treatment of trauma and postoperative edema is controlled in clinical practice, has controlled treatment trauma and postoperative edema 100
Remaining example, cure rate is more than 90%.Model case has：
Case one：Lee, female, teacher, 62 years old, August 15 was gone to a doctor within 2014.Two months ago because of left side fracture of lateral epicondyle of humerus,
Row operative treatment, postoperative plaster fixing leaves ancon oedema after gypsum removal.Once oral blood-activating stasis-removing kind Chinese medicine one week, coordinated
Washout side's medicine, prescription is unknown.Night upper limb lifting, oedema does not disappear.It is postoperative to need rehabilitation, because oedema upper limbs can not bend
Song, CPM machines（Continuous Passive Movement device）Can not use and change the place of examination.At present symptom：Left upper extremity suspender belt suspends in midair, duration August, weather
Sweltering heat, air-conditioner temperature is not resistant to locally in therapeutic room, afraid of the wind cold.Local edema, pain, color of the leather obfuscation, there is purple patch
It is attached to around it, limbs of the diameter substantially than surrounding are big.Use pharmaceutical composition external application of the invention, 3 times/24h, 24h
Oedema substantially disappears afterwards, disappears completely after 3 days, fold locally occurs, and pain relief is no longer afraid of the wind cold, can the forging of row CPM machines
Refining, limb rehabilitation training.
Case two：Chen, man, car detailing teacher, 28 years old, in March, 2015 No. 11 went to a doctor.2h driving motorcycles are not before being admitted to hospital
Careful to fall down, left upper arm is directly clashed into hard thing, and left upper arm pain is felt at once, in continuation severe pain, left upper arm deformity, activity barrier
Hinder.Body is looked into：The notable swelling of hypomere, deformity in left upper arm, without open wound, local tenderness, can lay one's hand on and left humerus in hypomere fracture
Abrasive feel.Left upper arm movement of false joint.Hypomere transverse fracture in x-ray left humerus.Hypomere closed fracture in diagnosis left humerus.I.e.
Using pharmaceutical composition external application of the invention, 3 times/24h, oedema substantially disappears after external application 16h, disappears completely after 3 days.And in outer
4th day row operative treatment after applying.
Case three：Yuan, man, mill hand, 33 years old.The machine in quick rotation was stepped on because of biped before 5 hours one days by mistake
On belt, tripped in ground.Feel that left leg has an intense pain at once, it is impossible to stand and walk.The swelling of left leg stage casing is obvious, skin
Skin is shinny, and without breakage, ecchymoma is in livid purple color.Left leg stage casing is touched a tender spot substantially, there is annular tenderness and longitudinal crushing pain, there is different
Often activity, osteoacusis sound is interrupted.Also there is obvious tenderness at the 3cm of Fib L microcephaly lower section.X-ray checks that left tibia stage casing has one outside upper
Spiral fracture line under walking inwardly, fracture site separates 0.5cm, for no reason upper to move 2.5cm, about 15 ° of inside angulation, angled forward
About 5 °.Diagnosis：Left tibia stage casing closed spiral fracture.Immediately using pharmaceutical composition external application of the invention, 3 times/24h,
Oedema substantially disappears after external application 8h, disappears completely after 4 days.And in the 5th day row operative treatment after external application.
Case four：Zhang, man, 25 years old, builder.8 hours one days of cause construction careless fall ground, the water of landing
Adobe block pushes down both legs.Feel that bilateral thigh has an intense pain at once, it is impossible to stand and walk.Body is looked into：Bilateral thigh almost all
Swelling, ecchymoma is in livid purple color, and double lower limb tenderness is obvious.X ray examinations, it is comminuted at both thighs positive side bifilar lower about 1/3
Fracture.Diagnosis：Bifilar bone closed comminuted fracture.Pharmaceutical composition external application of the invention, 3 times/24h, external application 8h are used immediately
Oedema substantially disappears afterwards, disappears completely after 5 days.And in the 6th day row operative treatment after external application.
Specific embodiment
Embodiment prepares the pharmaceutical composition for controlling treatment trauma and postoperative edema
Chopped up hen root 25g is disliked first, joint pseudo-ginseng 10g is together added in white wine 80ml, closing is placed in 50 DEG C of waters bath with thermostatic control
Case soaks 12h, and the removal of impurity is gone in filtering, and reserved filtrate is standby；500mL water is placed in marmite, plus dandelion 50g again, 100 DEG C are warming up to
5min is decocted, 60 DEG C are naturally cooled to, the removal of impurity is gone in filtering, add glauber salt 250g and immersion in advance to dislike hen root in filtrate
White wine 80mL, stirring and dissolving is mixed, and refilters the removal of impurity, is placed in 18 DEG C of environment temperature natural coolings, treats that saltcake crystal is abundant
After precipitation, air-dry and break into fine grained, filtering removal powder, the crystal grain of the fine uniform of gained is medicine group of the invention
Compound, preserves stand-by with gauze package encapsulation.
Claims (3)
1. a kind of pharmaceutical composition for controlling treatment trauma and postoperative edema, it is characterised in that the pharmaceutical composition is prepared by 4 taste medicinal materials
Form, its quality proportioning is:
Dislike hen 15~30, pseudo-ginseng 6~10, dandelion 30~50, glauber salt 250.
2. the pharmaceutical composition for the treatment of trauma and postoperative edema is controlled as claimed in claim 1, it is characterised in that the pharmaceutical composition is by 4
Taste medicinal material is formulated, and its quality proportioning is:
Dislike hen 25, pseudo-ginseng 10, dandelion 50, glauber salt 250.
3. the pharmaceutical composition for the treatment of trauma and postoperative edema is controlled as claimed in claim 1, it is characterised in that the pharmaceutical composition
Preparation method comprise the following steps：
(1) it is first according to formula to chop up dry evil hen, joint pseudo-ginseng is together added in white wine, and closing is placed in 50 DEG C of perseverances
Warm water bath cabinet soaks 12h, and the removal of impurity is gone in filtering；
(2) 500mL water is placed in marmite again, dandelion is dried according to formula addition, be warming up to 100 DEG C of 5 min of immersion, nature
60 DEG C are cooled to, the removal of impurity is gone in filtering；
(3) glauber salt and immersion in advance is added to dislike the white wine of hen root according to formula in the filtrate of previous step, stirring and dissolving is mixed
It is even, the removal of impurity is refiltered, mixture is placed in 18 DEG C of natural coolings；
(4) after fully heptahydrate saltcake crystal is separated out in previous step mixture, air-dry and break into fine grained, gumming is gone in filtering
End, the crystal grain of the fine uniform of gained is pharmaceutical composition of the invention, preserves stand-by with gauze package encapsulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710043322.8A CN106727832A (en) | 2017-01-21 | 2017-01-21 | A kind of pharmaceutical composition for controlling treatment trauma and postoperative edema |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710043322.8A CN106727832A (en) | 2017-01-21 | 2017-01-21 | A kind of pharmaceutical composition for controlling treatment trauma and postoperative edema |
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| Publication Number | Publication Date |
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| CN106727832A true CN106727832A (en) | 2017-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710043322.8A Pending CN106727832A (en) | 2017-01-21 | 2017-01-21 | A kind of pharmaceutical composition for controlling treatment trauma and postoperative edema |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720902A (en) * | 2013-12-13 | 2014-04-16 | 武汉市第八医院 | Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof |
-
2017
- 2017-01-21 CN CN201710043322.8A patent/CN106727832A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103720902A (en) * | 2013-12-13 | 2014-04-16 | 武汉市第八医院 | Traditional Chinese medicine used for anorectal surgery wound healing and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 黄玉娥: "玄明粉坐浴在常见肛肠病中的临床应用", 《湖南中医学院学报》 * |
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