CN106420507B - The anti-ageing composition of whitening and cosmetics - Google Patents
The anti-ageing composition of whitening and cosmetics Download PDFInfo
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- CN106420507B CN106420507B CN201611103878.3A CN201611103878A CN106420507B CN 106420507 B CN106420507 B CN 106420507B CN 201611103878 A CN201611103878 A CN 201611103878A CN 106420507 B CN106420507 B CN 106420507B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention relates to cosmetic technical fields, the in particular to anti-ageing composition of whitening and cosmetics.The anti-ageing composition of the whitening is made of saskatoon procyanidine, Shitake Mushroom P.E and honeysuckle flower extract.The anti-ageing composition of whitening of the present invention is with saskatoon procyanidine for main functional active components, add Shitake Mushroom P.E and honeysuckle flower extract, Shitake Mushroom P.E, honeysuckle flower extract and saskatoon procyanidine are used in compounding, synergistic effect is played, makes product of the invention that there is apparent whitening anti-aging effect.The effect of Essence of the present invention ingredient is plant extracts, natural safety, non-stimulated, with apparent anti-ageing effect, skin can be helped to lock moisture, sufficiently improve skin vigor, it solves the problems, such as that skin is obscure, prevents skin lines from generating, make skin smooth rich in gloss, elasticity.
Description
Technical field
The present invention relates to cosmetic technical fields, the in particular to anti-ageing composition of whitening and cosmetics.
Background technique
The main factor of skin corrugation aging first is that skin is caused light aging by ultraviolet radioactive for a long time, and skin
Light aging is since free radical increases in skin, and damage biological film promotes elastomer to crosslink and polymerize, and accelerates skin old
Change.Free radical is effectively antagonized and removed to avoid the damaging action of free radical, is realized often through antioxidant.
The anti-aging cosmetics occurred currently on the market are many kinds of, mostly addition vitamins antioxidant such as vitamin
E, vitamin C, but this kind of antioxidant stability is poor, and application is restricted.Scholar, which studies, in recent years finds some plants
Or contain antioxidant content in Chinese herbal medicine, have to free radical resisting, promote skin metabolism, delay the effect of body aging.
For example, the patent of invention of Publication No. CN103385837A provides a kind of myrica rubra leaf proanthocyanidin toner, with myrica rubra leaf original
Anthocyanidin is main composition, has anti-oxidant, anti-aging, skin whitening, moisturizing and other effects.
Phenolic compound is by directly eliminating free radical, anti-lipid peroxidation reaction and in conjunction with biological film phospholipid etc.
Oxidative damage of a variety of mode of action antagonistic activity oxygen to cell membrane and protein.Polyphenols chemical combination containing phenolic hydroxyl group in recent years
Object has been to be concerned by more and more people, and is primarily due to its efficient inoxidizability and existing generality.Procyanidine is one
The polyphenol compound that kind is widely present in plant, many studies have shown that, procyanidine has extremely strong antioxidant activity, is
A kind of good oxygen-cent red radical scavenger and lipid peroxidation inhibitor, antioxidant effect are about 50 times of VE, and 20 times of VC,
It is the most effective natural of removing people's interior free yl generally acknowledged in the world at present, is that other antioxidants are incomparable
's.The good reputation of " skin vitamin ", " oral cosmetic product " is enjoyed in the national procyanidine such as America and Europe.Procyanidine has crease-resistant work
With because it can safeguard collagen synthesis, inhibit elastoser, assist body protective glue original albumen, improve skin elasticity,
The healthy cycle for improving skin, so that the generation of wrinkle be reduced or avoided.Procyanidine also can inhibit the activity of tyrosinase；It will
The catechol construction recovery of melanin makes pigment fade at phenolic structure；It can inhibit because of protein amino and nucleic acid amino hair
Raw Maillard reaction, to inhibit the formation of lipofuscin, senile plaque；Synergistic effect can be played between vitamin V C or VE, because
And there is sun-proof whitening function.Therefore, the skin care item for researching and developing a kind of novel whitening anti-aging containing procyanidine have weight
The realistic meaning wanted.
Summary of the invention
In view of this, the present invention provides the anti-ageing composition of whitening and cosmetics.The anti-ageing composition of whitening of the present invention and change
Cosmetic has apparent whitening anti-aging effect.
In order to achieve the above-mentioned object of the invention, the present invention the following technical schemes are provided:
The present invention provides a kind of anti-ageing compositions of whitening, by saskatoon procyanidine, Shitake Mushroom P.E and honeysuckle flowers
Extract composition.
Saskatoon, Classification system Amelanchier alnifolia Nutt. also known as Saskatoon berry belong to rose
Common vetch section Amelanchier machaka or dungarunga originate in North America from U.S. Alaska State to the big portion for crossing Canada West
Region-by-region and Middle West and Middle-north Area, be otherwise known as " the dove certain kind of berries " in history.It is big that saskatoon has become North America
The Important Economic woods tree species in land, receive significant attention and are planted by large area, and fruit is edible berry shape the operatic circle, initially
Green fades to brown, rufous, and the time is mature in early summer for coastal area, and hinterland then will be in late summer maturation, purple when mature
Black, glossy, oil, pulp outside bronzing, internal milky, juice bronzing, sour-sweet no astringent taste, and nutrition is rich
Still there are certain similarities with blueberry at being grouped as richness, either appearance, taste, contain the daily institute of a large amount of human body
In addition the total dietary fiber needed, the minerals such as each biostearin and necessary potassium, iron, magnesium, manganese are also rich in 18 kinds of amino acid,
It is noted that the composition of saskatoon Polyphenols antioxidant is also very much like with blueberry, the total phenol content in every 100g
Resist in saskatoon for 452mg (average value of two kinds of Smoky and Northline) according to the research of North America scientist
The contents level of oxidation component is higher, and the antioxidants such as Polyphenols therein, procyanidine, anthocyanidin, chlorogenic acid are reducing cancer
The disease incidence and auxiliary of a variety of diseases such as disease, heart disease, diabetes carry out showing preferable effect in terms of clinical treatment.Alder
Procyanidine rich in leaf Chinese bush cherry: the 3% of berry dry weight, the 10-14% of stem and leaf dry weight are accounted for.Hosseinan et al.
The fruit of strawberry, saskatoon, raspberry, wild blueberry, wild cherry and sea-buckthorn, fruit juice and pulp procyanidins are determined respectively
Content has simultaneously carried out comparative analysis, as a result, it has been found that the concentration of saskatoon fruit juice procyanidins is up to 1363mg/100mL,
Minimum 622mg/100mL in strawberry.The product of saskatoon is up to tens kinds at present, including makes wine, eats fruit, health care doctor raw
Medicine, advanced drink etc., but it is not directed to cosmetic field.
The present invention with saskatoon procyanidine be main functional active components, procyanidine have it is anti-oxidant, crease-resistant, change
Kind skin elasticity improves skin health circulation, the effect for inhibiting the activity of tyrosinase, lipofuscin and senile plaque being inhibited to be formed.
The present invention also adds Shitake Mushroom P.E and honeysuckle flower extract；Shitake Mushroom P.E lentinan rich in, in addition to this also
The natural resistance for having essential amino acid, microelement and vitamin there are many containing, can be improved skin activates immune live
Property cell；Honeysuckle flower extract can work to the immune system of body containing a large amount of polyphenol and chlorogenic acid, improve immune
The ratio of cell reduces the inflammation of skin.Both plant extracts and saskatoon procyanidine are used in compounding, and play collaboration
The effect of synergy makes product of the invention have apparent whitening anti-aging effect.
Preferably, in parts by weight, the anti-ageing composition of whitening includes: 1~6 parts by weight of saskatoon procyanidine, it is fragrant
0.7~1.8 parts by weight of mushroom extract, 0.5~2 parts by weight of honeysuckle flower extract.
In some embodiments provided by the invention, in parts by weight, the anti-ageing composition of whitening includes: saskatoon original flower
1 parts by weight of green element, 1 parts by weight of Shitake Mushroom P.E, 2 parts by weight of honeysuckle flower extract.
In other embodiments provided by the invention, in parts by weight, the anti-ageing composition of whitening includes: saskatoon original
3 parts by weight of anthocyanidin, 1.8 parts by weight of Shitake Mushroom P.E, 0.5 parts by weight of honeysuckle flower extract.
In other embodiments provided by the invention, in parts by weight, the anti-ageing composition of whitening includes: saskatoon original
6 parts by weight of anthocyanidin, 0.7 parts by weight of Shitake Mushroom P.E, 1 parts by weight of honeysuckle flower extract.
Preferably, saskatoon procyanidine the preparation method comprises the following steps: saskatoon is crushed, 15~30 times of body is added
The ethyl alcohol that product percent concentration is 60%~80%, extracts 30~150min at 55~85 DEG C, extracts 2~4 times, takes extracting solution
It purified, dried, obtain saskatoon procyanidine.
In some embodiments provided by the invention, saskatoon procyanidine the preparation method comprises the following steps: by saskatoon powder
180 mesh are broken to, the ethyl alcohol that the concentration of volume percent for being added 15 times is 75% extracts 120min at 70 DEG C, extracts 3 times, take
Extracting solution is purified, is dried, and saskatoon procyanidine is obtained.
Preferably, purifying are as follows: saskatoon extracting solution is adsorbed with HPD750 macroreticular resin, then with 50%~
70% ethyl alcohol is eluted, and eluent is collected.
Preferably, dry are as follows: be evaporated under reduced pressure gained eluent, then do concentrate progress vacuum refrigeration
It is dry, obtain saskatoon procyanidine.
The present invention also provides a kind of cosmetics, including saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flower extract
With auxiliary material acceptable on cosmeceutical.
In embodiment provided by the invention, the dosage form of cosmetics is Essence, cosmeceutical in Essence of the invention
Upper acceptable auxiliary material includes VC, niacinamide, propylene glycol, moisturizer, thickener, 1,2- hexylene glycol, Sensiva SC50, rose
Hydrosol, EDTA-2Na, pH adjusting agent and water.
Preferably, in terms of mass percentage, dosage of each component in cosmetics are as follows:
Preferably, moisturizer is ethoxy urea, ceramide, Sodium Hyaluronate, levulan, allantoin, reed fragrant plant oil, mountain
One or more of pears sugar alcohol or glycine betaine.
Preferably, thickener is one in xanthan gum, seaweed glue, guar gum, chitosan, Arabic gum or tara gum
Kind is several.
Preferably, pH adjusting agent is the one or two of citric acid or triethanolamine.
Preferably, the pH value of cosmetics of the present invention is 5~5.5.
Preferably, the preparation method of Essence includes the following steps:
Thickener and EDTA-2Na are added to the water and are heated to 80~85 DEG C, stirring makes it sufficiently be dissolved to clear,
Obtain solution A；
Propylene glycol, niacinamide, moisturizer, 1,2- hexylene glycol and Sensiva SC50 are mixed, solution B is obtained；
The temperature of solution A is down to 60~65 DEG C, solution B is added, stirs evenly and makes it completely dissolved, heat preservation 30~
35min；
40~45 DEG C are down to temperature, saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flower extract and VC is added,
Stirring cools down after keeping the temperature 10~15min to being completely dissolved；
When temperature is down to 25 DEG C, it is slowly added to pH adjusting agent and adjusts pH to 5~5.5；It is eventually adding rose, is stirred
Uniform standing 18 afterwards~for 24 hours, obtain Essence.
The present invention provides a kind of anti-ageing composition of whitening and cosmetics.The anti-ageing composition of the whitening is spent by saskatoon original
Green element, Shitake Mushroom P.E and honeysuckle flower extract composition.The present invention at least has one of following advantage:
1, with saskatoon procyanidine for main functional active components, addition mushroom mentions the anti-ageing composition of whitening of the present invention
Object and honeysuckle flower extract are taken, Shitake Mushroom P.E, honeysuckle flower extract and saskatoon procyanidine are used in compounding, and play collaboration
The effect of synergy makes product of the invention have apparent whitening anti-aging effect.
2, Essence of the present invention is free of preservative, but has anti-corrosion effect, and added 1,2- hexylene glycol has excellent
Broad spectrum antibiotic activity, and Sensiva SC50 can obviously increase the antibiotic effect of 1,2- ethylene glycol, rose have antibacterial at
Point, by synergistic function, favorable anti-corrosion effect, and this three also have good skin moisture-keeping performance, highly-safe, nothing
Stimulation.
3, the fragrance of Essence addition of the present invention is rose, and good water solubility can not only assign the perfume (or spice) of product pleasure
Taste, but also have keep the skin wet, moisturizing, quick anti-inflammatory, antiallergy, it is antipruritic, delay senescence etc. skin care effects, furthermore ethyl hexyl
Base glycerol can also play flavouring, fixation and steady fragrant efficiency.
4, ingredient is plant extracts the effect of product of the present invention, natural safety, non-stimulated, has apparent anti-ageing effect
Fruit can help skin to lock moisture, sufficiently improve skin vigor, solve the problems, such as that skin is obscure, prevent skin lines from generating, make
Skin smooth is rich in gloss, elasticity.
5, essence liquid preparing process of the invention is simple, is suitble to industrial production.
Specific embodiment
The invention discloses the anti-ageing composition of whitening and cosmetics, those skilled in the art can use for reference present disclosure, fit
When improvement realization of process parameters.In particular, it should be pointed out that all similar substitutions and modifications are for a person skilled in the art
It is it will be apparent that they are considered as being included in the present invention.Method of the invention and application passed through preferred embodiment into
Gone description, related personnel obviously can not depart from the content of present invention, in spirit and scope to method described herein and application
It is modified or appropriate changes and combinations, carrys out implementation and application the technology of the present invention.
In the present invention extraction process of saskatoon procyanidine used be using saskatoon fresh fruit as raw material, it is extracted,
After purifying and drying, aubergine saskatoon procyanidine powder is obtained.Also commercially available.
The extraction process of saskatoon procyanidine in the present invention are as follows:
A. it extracts: after saskatoon clean dry, being handled with pulverizer, be crushed to 180~200 mesh；Take alder leaf
Chinese bush cherry powder is placed in the boiling flask of tool plug, the ethyl alcohol that the concentration of volume percent for being added 15~30 times is 60%~80%,
Then it puts it into thermostat water bath and is stirred at 55~85 DEG C, keep the temperature 30~150min, after extracting 2~4 times, use
0.45 μm of miillpore filter is filtered, and extracting solution is obtained.
B. it purifies: extracting solution obtained by a step being adsorbed with HPD750 macroreticular resin, then with 50%~70% ethyl alcohol
It is eluted, collects eluent.
C. it dries: solution obtained in step b is evaporated under reduced pressure, concentrate is then subjected to vacuum freeze drying,
Obtain saskatoon procyanidine powder.
The specific preparation process of saskatoon procyanidine is as follows in the specific embodiment of the invention:
A. it extracts: after saskatoon clean dry, being handled with pulverizer, be crushed to 180 mesh；Take saskatoon powder
End is placed in the boiling flask of tool plug, then the ethyl alcohol that the concentration of volume percent for being added 15 times is 75% puts it into constant temperature
It is stirred at 70 DEG C in water-bath, keeps the temperature 120min, after extracting 3 times, filtered, mentioned with 0.45 μm of miillpore filter
Take liquid.
B. it purifies: extracting solution obtained by a step being adsorbed with HPD750 macroreticular resin, is then washed with 60% ethyl alcohol
It is de-, collect eluent.
C. it dries: solution obtained in step b is evaporated under reduced pressure, concentrate is then subjected to vacuum freeze drying,
Obtain saskatoon procyanidine powder.
Other raw materials or auxiliary material are available on the market in the anti-ageing composition of whitening provided by the invention and cosmetics.Its
In, Shitake Mushroom P.E, honeysuckle flower extract are purchased from hundred Hao Bo Co., Ltd of Guangzhou.
Below with reference to embodiment, the present invention is further explained:
The preparation of the anti-ageing composition of 1 whitening of embodiment
Whitening anti-apolexis composition includes the ingredient of following weight proportion in the present embodiment:
1 parts by weight of saskatoon procyanidine；
1 parts by weight of Shitake Mushroom P.E；
2 parts by weight of honeysuckle flower extract.
Preparation process are as follows: the plant extracts of above-mentioned weight proportion is mixed, whitening anti-aging composition is obtained.
The preparation of the anti-ageing composition of 2 whitening of embodiment
Whitening anti-apolexis composition includes the ingredient of following weight proportion in the present embodiment:
3 parts by weight of saskatoon procyanidine；
1.8 parts by weight of Shitake Mushroom P.E；
0.5 parts by weight of honeysuckle flower extract.
Preparation process are as follows: the plant extracts of above-mentioned weight proportion is mixed, whitening anti-aging composition is obtained.
The preparation of the anti-ageing composition of 3 whitening of embodiment
Whitening anti-apolexis composition includes the ingredient of following weight proportion in the present embodiment:
6 parts by weight of saskatoon procyanidine；
0.7 parts by weight of Shitake Mushroom P.E；
1 parts by weight of honeysuckle flower extract.
Preparation process are as follows: the plant extracts of above-mentioned weight proportion is mixed, whitening anti-aging composition is obtained.
The measurement of 1 effect of test example
Test specimen: the anti-ageing composition of the whitening of embodiment 1-3, saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flowers
Extract.Sample to be tested plus water are diluted, final concentration of 5%.
Effect measurement test includes: scavenging ability of DPPH free radical, removes hydroxyl radical free radical ability, inhibits tyrosine enzyme activity
The measurement of sexuality, the specific method is as follows:
A. it is slow that the phosphoric acid that 4mL pH is 6.8 measurement of scavenging ability of DPPH free radical: is sequentially added into 10mL centrifuge tube
Fliud flushing, 5mL 0.4mmol/L DPPH ethanol solution, 0.1mL sample to be tested mix well.It is centrifuged after 20min
(12000rpm, 5min) takes supernatant to measure light absorption value at 517nm.Clearance rate=[1- (A1- of the sample to DPPH free radical
A2)/A3], in formula: A1 be plus example reaction after DPPH solution light absorption value, A2 is that DPPH (being replaced with dehydrated alcohol) is not added, only
Add the light absorption value of sample solution, A3 is that sample is not added, and only adds the light absorption value of DPPH aqueous solution.
B. it removes the measurement of hydroxyl radical free radical ability: being separately added into 1mL 0.4mmol/L crystal violet into 10mL centrifuge tube,
3mL 0.2mol/L pH is 7.4 phosphate buffers, 1mL 1mmol/L FeSO4Solution, 0.3mL sample to be tested, finally plus 1mL
6%H2O2.It is centrifuged (12000rpm, 5min) after placing 1h, supernatant is taken to measure light absorption value A at 584nm.Sample to hydroxyl from
By clearance rate=(A-A2)/(A2-A1) of base, in formula: light absorption value when A is sample-adding product.When A1 replaces sample by distilled water
Light absorption value, A2 are to replace sample and H with distilled water2O2When light absorption value.
C. inhibit tyrosinase activity the measurement of ability: to 10mL centrifugation in sequentially add 3mL0.05%L- tyrosine,
4mL pH is 6.8 phosphate buffers, 0.3mL sample to be tested, shakes up and heats 10min in 37 DEG C of water-baths, adds 1mL 500U/
ML tyrosinase continues to be centrifuged (12000rpm, 5min) after heating 5min, light absorption value A1 is measured under 475nm, with phosphate buffer
It is A2 instead of the light absorption value measured when sample.Inhibiting rate=1-A1/A2 of the sample to tyrosinase.
Test result is as follows:
The comparison of 1 present composition Scavenging ability of table (clearance rate/%)
| Sample | DPPH clearance rate/% | Hydroxyl radical free radical clearance rate/% |
| Example 1 group closes object | 86.6 | 88.1 |
| 2 composition of embodiment | 93.4 | 92.9 |
| 3 composition of embodiment | 91.6 | 95.7 |
| Saskatoon procyanidine | 79.5 | 82.9 |
| Shitake Mushroom P.E | 76.3 | 63.7 |
| Honeysuckle flower extract | 64.8 | 50.4 |
As shown in Table 1, the composition of embodiment 1-3 is apparently higher than each plant to the clearance rate of DPPH and hydroxyl radical free radical and mentions
The effect for taking object to be used alone, this illustrates that the present composition has preferable free radical scavenging ability, shows the present invention indirectly
Composition has good antioxygenic property, can be applied in the cosmetics of anti-aging.
2 present composition of table inhibits the comparison of tyrosine activity ability (inhibiting rate/%)
| Sample | Inhibiting rate/% |
| Example 1 group closes object | 84.9 |
| 2 composition of embodiment | 81.6 |
| 3 composition of embodiment | 90.2 |
| Saskatoon procyanidine | 75.1 |
| Shitake Mushroom P.E | 40.8 |
| Honeysuckle flower extract | 53.6 |
The composition of embodiment 1-3 is to inhibiting tyrosinase activity with certain inhibiting effect, to junket as shown in Table 2
The inhibition of propylhomoserin enzymatic activity is apparently higher than the effect that each plant extracts is used alone, this illustrates the composition energy of embodiment 1-3
Inhibit the synthesis of melanin, there is certain whitening function.
The preparation of the anti-ageing Essence of 4 whitening of embodiment
The anti-ageing Essence of whitening manufactured in the present embodiment includes the ingredient of following weight proportion:
The step of preparing above-mentioned Essence is as follows:
Thickener and EDTA-2Na are added to the water and are heated to 80 DEG C, stirring makes it sufficiently be dissolved to clear；
60 DEG C are cooled the temperature to, propylene glycol, niacinamide, moisturizer, 1,2- hexylene glycol and the ethyl being pre-mixed is added
Hexyl glycerol, stirs evenly and makes it completely dissolved, and keeps the temperature 35min；
40 DEG C are down to temperature, sequentially adds saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flower extract and VC,
Stirring cools down after keeping the temperature 15min to being completely dissolved；
When temperature is 25 DEG C, it is slowly added to pH adjusting agent and adjusts pH to 5；It is eventually adding rose, after mixing evenly
It stands for 24 hours to get the anti-ageing Essence of the whitening.
The preparation of the anti-ageing Essence of 5 whitening of embodiment
The anti-ageing Essence of whitening manufactured in the present embodiment includes the ingredient of following weight proportion:
The step of preparing above-mentioned Essence is as follows:
Thickener and EDTA-2Na are added to the water and are heated to 82 DEG C, stirring makes it sufficiently be dissolved to clear；
62 DEG C are cooled the temperature to, propylene glycol, niacinamide, moisturizer, 1,2- hexylene glycol and the ethyl being pre-mixed is added
Hexyl glycerol, stirs evenly and makes it completely dissolved, and keeps the temperature 32min；
42 DEG C are down to temperature, sequentially adds saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flower extract and VC,
Stirring cools down after keeping the temperature 12min to being completely dissolved；
When temperature is 30 DEG C, it is slowly added to pH adjusting agent and adjusts pH to 5.2；It is eventually adding rose, is stirred evenly
Stand 20h afterwards to get the anti-ageing Essence of the whitening.
The preparation of the anti-ageing Essence of 6 whitening of embodiment
The anti-ageing Essence of whitening manufactured in the present embodiment includes the ingredient of following weight proportion:
The step of preparing above-mentioned Essence is as follows:
Thickener and EDTA-2Na are added to the water and are heated to 85 DEG C, stirring makes it sufficiently be dissolved to clear；
65 DEG C are cooled the temperature to, propylene glycol, niacinamide, moisturizer, 1,2- hexylene glycol and the ethyl being pre-mixed is added
Hexyl glycerol, stirs evenly and makes it completely dissolved, and keeps the temperature 30min；
45 DEG C are down to temperature, sequentially adds saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flower extract and VC,
Stirring cools down after keeping the temperature 10min to being completely dissolved；
When temperature is 35 DEG C, it is slowly added to pH adjusting agent and adjusts pH to 5.5；It is eventually adding rose, is stirred evenly
Stand 18h afterwards to get the anti-ageing Essence of the whitening.
2 Essence measure of merit of test example
One, human skin patch
Choosing 20 ages is the health volunteer without skin disease allergies between 25-50 years old, pastes spot method: selecting and closes
The spot tester of lattice takes the essence drop of about 15 μ L embodiment of the present invention 4-6 in spot tester with closed patch experiment method,
External application special adhesive tape is covered on subject back, and each subject pastes 15 spot testers, respectively the essence of patch examination embodiment 4-6
Liquid removes tested material after 24 hours, respectively at observation dermoreaction in 0.5,6,12,24,48 hour after removal, according to " cosmetics
Hygienic practice " in dermoreaction grade scale record its result.
Test result: human skin patch test result shows all subjects by patch test, 0.5,6,12,
24, observation dermoreaction in 48 hours illustrates production of the invention wherein 0 the adverse reactions such as erythema, papule, blister occurs
Product are non-stimulated using safe.
Two, the anti-ageing efficacy test of whitening
Choose 120 female volunteers, be divided into 4 groups, every group of age between 20-55 years old, trial edition after morning and evening face cleaning
The Essence of inventive embodiments 4-6 and control group are used continuously 1 month, are examined before and after use using VISA skin analyzer
It surveys and compares.Note, comparative example are to be not added saskatoon procyanidine, Shitake Mushroom P.E and honeysuckle flower extract, it is other with it is real
It is identical to apply example 6.As a result as follows:
The anti-ageing efficacy test result of 3 whitening of table
As shown in Table 3, compared with the control group, Essence prepared by 4-6 of the embodiment of the present invention has significantly more beauty
White anti-ageing effect illustrates that the anti-ageing composition of whitening of the invention can help skin to lock moisture, sufficiently improves skin vigor, solve
The obscure problem of skin, prevents microgroove from generating, and makes skin smooth rich in gloss, elasticity.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (8)
1. a kind of anti-ageing composition of whitening, which is characterized in that in parts by weight, the anti-ageing composition of whitening is by the following raw material group
At: 1~6 parts by weight of saskatoon procyanidine, 0.7~1.8 parts by weight of Shitake Mushroom P.E, 0.5~2 weight of honeysuckle flower extract
Part.
2. the anti-ageing composition of whitening according to claim 1, which is characterized in that the preparation of the saskatoon procyanidine
Method are as follows: crush saskatoon, the ethyl alcohol that the concentration of volume percent for being added 15~30 times is 60%~80%, 55~85
30~150min is extracted at DEG C, is extracted 2~4 times, is taken extracting solution to be purified, dried, obtain saskatoon procyanidine.
3. a kind of cosmetics, which is characterized in that including saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flower extract and change
The upper acceptable auxiliary material of cosmetic；
In parts by weight, ingredient is made of the following raw material the effect of the cosmetics: 1~6 parts by weight of saskatoon procyanidine,
0.7~1.8 parts by weight of Shitake Mushroom P.E, 0.5~2 parts by weight of honeysuckle flower extract.
4. cosmetics according to claim 3, which is characterized in that the dosage form of the cosmetics is Essence, the essence
Acceptable auxiliary material includes VC, niacinamide, propylene glycol, moisturizer, thickener, 1,2- hexylene glycol, ethyl on cosmeceutical in liquid
Hexyl glycerol, rose, EDTA-2Na, pH adjusting agent and water.
5. cosmetics according to claim 4, which is characterized in that in terms of mass percentage, each group in the cosmetics
Divide dosage are as follows:
The pH adjusting agent is the one or two of citric acid or triethanolamine, and the pH value of the cosmetics is 5~5.5.
6. cosmetics according to claim 4, which is characterized in that the moisturizer is ethoxy urea, ceramide, transparent
One or more of matter acid sodium, levulan, allantoin, reed fragrant plant oil, D-sorbite or glycine betaine.
7. cosmetics according to claim 4, which is characterized in that the thickener be xanthan gum, seaweed glue, guar gum,
One or more of chitosan, Arabic gum or tara gum.
8. cosmetics according to any one of claims 4 to 7, which is characterized in that the preparation method packet of the Essence
Include following steps:
Thickener and EDTA-2Na are added to the water and are heated to 80~85 DEG C, stirring makes it sufficiently be dissolved to clear, obtains
Solution A；
Propylene glycol, niacinamide, moisturizer, 1,2- hexylene glycol and Sensiva SC50 are mixed, solution B is obtained；
The temperature of the solution A is down to 60~65 DEG C, the solution B is added, stirs evenly and makes it completely dissolved, heat preservation 30~
35min；
40~45 DEG C are down to temperature, saskatoon procyanidine, Shitake Mushroom P.E, honeysuckle flower extract and VC, stirring is added
To being completely dissolved, cool down after keeping the temperature 10~15min；
When temperature is down to 25 DEG C, it is slowly added to pH adjusting agent and adjusts pH to 5~5.5；It is eventually adding rose, is stirred evenly
Afterwards stand 18~for 24 hours, obtain the Essence.
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| CN113230152A (en) * | 2021-05-14 | 2021-08-10 | 杭州万融茶界科技有限公司 | Composition with whitening and anti-aging functions and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03246209A (en) * | 1990-02-21 | 1991-11-01 | Nippon Create Kk | Cosmetic |
-
2016
- 2016-12-05 CN CN201611103878.3A patent/CN106420507B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03246209A (en) * | 1990-02-21 | 1991-11-01 | Nippon Create Kk | Cosmetic |
Non-Patent Citations (2)
| Title |
|---|
| 818那些欲罢不能的百元级A醇产品;糊奔奔;《https://weibo.com/p/2304186bb5ac540102vk2u》;网页来源;20150228;网页正文 |
| 桤叶唐棣原花青素的提取与抗氧化性能的;王晴晴;《中国优秀硕士学位论文全文数据库 工程科技1辑》;20150215(第2期);第12页第1.2.2.5部分以及第16页第1.3部分，第20页第2.14.1部分 |
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