CN106413751A - 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 - Google Patents

用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 Download PDF

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Publication number
CN106413751A
CN106413751A CN201580027437.7A CN201580027437A CN106413751A CN 106413751 A CN106413751 A CN 106413751A CN 201580027437 A CN201580027437 A CN 201580027437A CN 106413751 A CN106413751 A CN 106413751A
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cancer
ser
antibody
ccr4
leu
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CN201580027437.7A
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Chinese (zh)
Inventor
林家扬
陈士浩
李丽芬
S·坡特鲁里
D·希利
M·马歇尔
泽田尚树
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Kyowa Kirin Co Ltd
Pfizer Corp SRL
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Kyowa Hakko Kirin Co Ltd
Pfizer Corp SRL
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CN201580027437.7A 2014-05-21 2015-05-15 用于治疗癌症的抗ccr4抗体和4‑1bb激动剂的组合 Pending CN106413751A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462001534P 2014-05-21 2014-05-21
US62/001,534 2014-05-21
PCT/US2015/031081 WO2015179236A1 (en) 2014-05-21 2015-05-15 Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer

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CN106413751A true CN106413751A (zh) 2017-02-15

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US (1) US10023649B2 (cg-RX-API-DMAC10.html)
EP (1) EP3145956A1 (cg-RX-API-DMAC10.html)
JP (1) JP2017517506A (cg-RX-API-DMAC10.html)
KR (1) KR20170004006A (cg-RX-API-DMAC10.html)
CN (1) CN106413751A (cg-RX-API-DMAC10.html)
AU (1) AU2015264528A1 (cg-RX-API-DMAC10.html)
BR (1) BR112016026993A2 (cg-RX-API-DMAC10.html)
CA (1) CA2949214A1 (cg-RX-API-DMAC10.html)
IL (1) IL248540A0 (cg-RX-API-DMAC10.html)
MX (1) MX2016015181A (cg-RX-API-DMAC10.html)
RU (1) RU2016146993A (cg-RX-API-DMAC10.html)
WO (1) WO2015179236A1 (cg-RX-API-DMAC10.html)

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WO2019072274A1 (zh) * 2017-10-12 2019-04-18 瑞阳(苏州)生物科技有限公司 一种激动型4-1bb单克隆抗体
WO2019141268A1 (zh) * 2018-01-22 2019-07-25 江苏恒瑞医药股份有限公司 抗4-1bb抗体、其抗原结合片段及其医药用途
WO2019196868A1 (en) * 2018-04-10 2019-10-17 Wuxi Biologics (Shanghai) Co., Ltd. A monoclonal antibody against human 4-1bb, method for preparing the same, and use thereof
CN111278858A (zh) * 2017-07-11 2020-06-12 指南针制药有限责任公司 结合人cd137的激动剂抗体及其用途
US11365260B2 (en) 2017-10-12 2022-06-21 Reyoung (Suzhou) Biology Science & Technology Co., Ltd Agonistic 4-1BB monoclonal antibody
CN115003691A (zh) * 2020-01-13 2022-09-02 西托戴恩股份有限公司 用于治疗ccr5阳性转移癌的ccr5结合剂

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KR20180103150A (ko) * 2016-01-25 2018-09-18 화이자 인코포레이티드 암을 치료하기 위한 ox40 작용제 및 4-1bb 작용제 단클론 항체의 조합
EP3471754A1 (en) 2016-06-20 2019-04-24 Kymab Limited Anti-pd-l1 antibodies
AU2017363337B2 (en) * 2016-11-23 2021-07-01 Translational Drug Development, Llc Benzamide and active compound compositions and methods of use
CA3039772C (en) 2017-01-06 2020-08-25 Eutilex Co., Ltd. Anti-human 4-1bb antibodies and uses thereof
KR102144658B1 (ko) * 2017-03-29 2020-08-14 시오노기세이야쿠가부시키가이샤 암 치료용 의약 조성물
EP4461825A3 (en) 2017-06-09 2024-11-20 Providence Health & Services - Oregon Tumor-infiltrating t-cells for use in the treatment of cancer
WO2019089753A2 (en) 2017-10-31 2019-05-09 Compass Therapeutics Llc Cd137 antibodies and pd-1 antagonists and uses thereof
SG11202004105TA (en) 2017-11-06 2020-06-29 Rapt Therapeutics Inc Anticancer agents
WO2019100052A2 (en) 2017-11-20 2019-05-23 Compass Therapeutics Llc Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
WO2019109238A1 (en) 2017-12-05 2019-06-13 Lyvgen Biopharma Co., Ltd. Anti-cd137 antibodies and uses thereof
KR102836393B1 (ko) * 2018-03-13 2025-07-22 에프. 호프만-라 로슈 아게 4-1bb 작용제와 항-cd20 항체의 치료 조합
CA3103629A1 (en) 2018-06-15 2019-12-19 Flagship Pioneering Innovations V, Inc. Increasing immune activity through modulation of postcellular signaling factors
CA3107019A1 (en) 2018-07-23 2020-01-30 Magenta Therapeutics, Inc. Use of anti-cd137 antibody drug conjugate (adc) in allogeneic cell therapy
AU2020263959B2 (en) 2019-04-24 2026-01-22 Heidelberg Pharma Research Gmbh Amatoxin antibody-drug conjugates and uses thereof
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
EP3966252A4 (en) 2019-05-10 2023-01-25 Lyvgen Biopharma Holdings Limited HUMANIZED ANTI-CD137 ANTIBODIES AND THEIR USES
EP4076434A1 (en) 2019-12-17 2022-10-26 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
KR20220137054A (ko) * 2020-02-04 2022-10-11 젠맵 에이/에스 요법에 사용하기 위한 항체
EP4103285A2 (en) * 2020-02-14 2022-12-21 Jounce Therapeutics, Inc. Antibodies and fusion proteins that bind to ccr8 and uses thereof
CA3184366A1 (en) 2020-06-29 2022-01-06 Darby Rye Schmidt Viruses engineered to promote thanotransmission and their use in treating cancer
EP4228627A4 (en) * 2020-10-13 2024-11-06 Board of Regents, The University of Texas System COMBINATORIAL IMMUNOTHERAPEUTIC METHODS AND COMPOSITIONS FOR THE TREATMENT OF PANCREATIC DUCT ADENOCARCINOMA
AU2022246895A1 (en) 2021-03-31 2023-10-19 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
KR20240049794A (ko) 2021-06-07 2024-04-17 프로비던스 헬스 앤드 서비시즈 - 오레곤 Cxcr5, pd-1, 및 icos 발현 종양 반응성 cd4 t 세포 및 그의 용도
EP4363059A1 (en) 2021-06-29 2024-05-08 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
TW202309097A (zh) 2021-07-14 2023-03-01 美商建南德克公司 抗ｃ－ｃ模體趨化因子受體８（ｃｃｒ８）抗體及其使用方法
EP4598946A1 (en) 2022-10-05 2025-08-13 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
US20240269251A1 (en) 2023-01-09 2024-08-15 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
US20250215087A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg depleting agent

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