CN106390032A - Traditional Chinese medicine preparation for treating liver-depression qi stagnation syndrome and preparation method - Google Patents
Traditional Chinese medicine preparation for treating liver-depression qi stagnation syndrome and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating liver-depression qi stagnation syndrome and a preparation method. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 60-120 parts of radix bupleuri, 200-400 parts of radix curcumae, 200-400 parts of radix rubiae, 200-400 parts of herba cistanche, 200-400 parts of semen cuscutae, 200-400 parts of raspberry, 200-400 parts of mulberry fruit, 200-400 parts of stir-fried jujube kernel, 170-230 parts of flos albiziae, 70-130 parts of safflower, 170-230 parts of Chinese yam, 170-230 parts of glossy privet fruit, 300-500 parts of hawthorn, 90-150 parts of radix rehmanniae praeparata, 30-90 parts of corn cervi pantotrichum, 30-90 parts of bergamot, 0.001-0.002 part of stevioside and 0.001-0.003 part of sodium benzoate. The traditional Chinese medicine preparation disclosed by the invention has the functions of soothing liver and removing depression and conditioning thoroughfare and conception vessels, realizes a remarkable effect, can be taken for long term and is easily acceptable to patients.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine preparation treating the depressed card of liver depression and preparation method.
Background technology
In daily life, often hear that a word is gloomy, have in the heart a fire, and seemingly have a strand gas, do not spit out, do not swallow
Go, this is the performance of liver-qi depression in fact, it was found that Chang Rongyi feels gloomy people, with insomnia, antimigraine, pharyngo-laryngitis chronica,
The diseases such as chronic gastritis, the proliferation of mammary gland, depression have close relationship.The physique of this class people, belongs to traditional Chinese medical science obstruction of the circulation of vital energy body more
Matter.This kind of state is slowly lasting, by mood onset or sway the emotion, then affects normal life, patient suffering is abnormal, and body and mind is subject to
Tired；The people of obstruction of the circulation of vital energy physique, often depressed, feel depressed, or excited, being irritable and getting angry easily, or nervous, anxious or many
Anxious sentimental, it is easily upset, often feel and fear or afraid of one's shadow often have breast and two side of body portion distending pains, sense uncomfortable in chest, often sigh without reason,
Bottleneck throat often feels there is foreign matters from being blocked, typically many insomnias；At present, Chinese medicine liver depression depressed card research report is increasing, because
Its Small side effects is accepted by vast liver depression depressed card patient, using modern science and technology equipment and method, inquires into the depressed card of liver depression
Etiology and pathogenesis, screening verification active drug, develop Chinese medicine preparation with strong points, that curative effect affirmative, formulation are easy, be currently urgently
The key issue solving.
Content of the invention
For solving above-mentioned technical problem, the present invention provides a kind of Chinese medicine preparation treating the depressed card of liver depression, by following weight
The raw material of part is made：Radix bupleuri 60-120 part, root tuber of aromatic turmeric 200-400 part, madder 200-400 part, saline cistanche 200-400 part, the seed of Chinese dodder
200-400 part, raspberry 200-400 part, mulberry fruit 200-400 part, stir-baked SEMEN ZIZIPHI SPINOSAE 200-400 part, Flos Albiziae 170-230 part, red
Flower 70-130 part, Chinese yam 170-230 part, fruit of glossy privet 170-230 part, hawthorn 300-500 part, prepared rhizome of rehmannia 90-150 part, pilose antler 30-
90 parts, bergamot 30-90 part, stevioside 0.001-0.002 part, Sodium Benzoate 0.001-0.003 part；
The present invention also provides a kind of preparation method of the Chinese medicine preparation treating the depressed card of liver depression, and its preparation process is：
（1）Take raw material radix bupleuri, root tuber of aromatic turmeric, madder, saline cistanche, the seed of Chinese dodder, raspberry, prepared rhizome of rehmannia, pilose antler pulverizer to pulverize, pulverize
Fineness 60-80 mesh, obtains raw material powder, standby；
（2）Raw material mulberry fruit, stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae, safflower, Chinese yam, the fruit of glossy privet, hawthorn pulverizer is taken to pulverize, smashing fineness
100-120 mesh, obtains raw material powder, standby；
（3）Raw material bergamot pulverizer is taken to pulverize, smashing fineness 50-60 mesh, obtain raw material powder, standby；
（4）By step（1）Gained raw material powder and step（2）Gained raw material powder and（3）Gained raw material powder adds raw material gross weight
8-12 times of water, soaks 0.5-2 hour, heating distillation 2-6 hour, collects volatile oil, obtain distillate, the dregs of a decoction add raw material gross weight
The decocting of 4-8 times of amount boils 1-2 time, and the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters and must filter
Liquid, filtrate is concentrated into 85-95 DEG C and surveys the clear cream that relative density is 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling
Even, 0 to 6 DEG C refrigeration 20-30 hour, filter, decompression filtrate recycling ethanol to no alcohol taste, filtrate be concentrated into 50-60 DEG C relatively close
Spend the medicinal extract for 1.15-1.25, standby；
（5）By step（4）Middle gained medicinal extract is put in Agitation Tank, adds the purified water of medicinal extract weight 3-6 times amount to be heated to seething with excitement,
Stirring 15-25 minute, micro-boiling rises insulation 10-15 minute, forms liquid, places, is cooled to room temperature, standby；
（6）Stevioside, Sodium Benzoate is taken to be respectively crushed into 500-600 mesh, standby；
（7）By step（5）Middle gained liquid adds the stevioside after pulverizing, Sodium Benzoate dissolving stirring, so that liquid is mixed,
Filtered with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then adjust pH
For 6.5-7.0, obtain joining liquid, standby；
（8）By step（7）Middle gained joins the clean vial packing of liquid, using ultra high temperature short time sterilization, obtains final product treatment liver depression
The Chinese medicine preparation of depressed card.
Preferably in scheme, a kind of described Chinese medicine preparation treating the depressed card of liver depression, by the raw material system of following weight portion
Become：90 parts of radix bupleuri, 300 parts of root tuber of aromatic turmeric, 300 parts of madder, 300 parts of saline cistanche, 300 parts of the seed of Chinese dodder, 300 parts of raspberry, mulberry fruit 300
Part, 300 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 200 parts of Flos Albiziae, 100 parts of safflower, 200 parts of Chinese yam, 200 parts of the fruit of glossy privet, 400 parts of hawthorn, prepared rhizome of rehmannia
120 parts, 60 parts of pilose antler, 60 parts of bergamot, 0.0015 part of stevioside, 0.002 part of Sodium Benzoate；
Its preparation process is：
（1）Take raw material radix bupleuri, root tuber of aromatic turmeric, madder, saline cistanche, the seed of Chinese dodder, raspberry, prepared rhizome of rehmannia, pilose antler pulverizer to pulverize, pulverize
Fineness 80 mesh, obtains raw material powder, standby；
（2）Raw material mulberry fruit, stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae, safflower, Chinese yam, the fruit of glossy privet, hawthorn pulverizer is taken to pulverize, smashing fineness
100 mesh, obtain raw material powder, standby；
（3）Raw material bergamot pulverizer is taken to pulverize, smashing fineness 60 mesh, obtain raw material powder, standby；
（4）By step（1）Gained raw material powder and step（2）Gained raw material powder and（3）Gained raw material powder adds raw material gross weight
12 times of water, soaks 0.5 hour, heating distillation 4 hours, collects volatile oil, obtains distillate, the dregs of a decoction add the 6 of raw material gross weight
Decocting again boils 2 times, and the time is 0.6 hour, merges decoction liquor and volatile oil and distillate, filters to get filtrate, filtrate is concentrated into
Survey the clear cream that relative density is 1.00 for 85 DEG C, add 85% appropriate amount of ethanol after cooling, stir evenly, 5 DEG C refrigerate 20 hours, filter, filtrate
To no alcohol taste, filtrate is concentrated into the medicinal extract that 60 DEG C of relative densities are 1.25 to decompression recycling ethanol, standby；
（5）By step（4）Middle gained medicinal extract is put in Agitation Tank, adds the purified water of medicinal extract weight 6 times amount to be heated to seething with excitement, stirs
Mix 15 minutes, micro-boiling rises insulation 10 minutes, form liquid, place, be cooled to room temperature, standby；
（6）Stevioside, Sodium Benzoate is taken to be respectively crushed into 600 mesh, standby；
（7）By step（5）Middle gained liquid adds the stevioside after pulverizing, Sodium Benzoate dissolving stirring, so that liquid is mixed,
Stirring was filtered with centrifuge after 15 minutes, at 60 DEG C, carried out twice homogenization under the conditions of 20MPa, then adjusted pH for 7.0, obtained
To joining liquid, standby；
（8）By step（7）Middle gained joins the clean vial packing of liquid, using ultra high temperature short time sterilization, obtains final product treatment liver depression
The Chinese medicine preparation of depressed card.
Used by the present invention, the pharmacology of Chinese medicine material medicine is as follows：
Radix bupleuri：Meridian distribution of property and flavor：Hardship, is slightly cold, Return liver, gallbladder channel；Indication：In inducing sweat, soothing the liver, rise sun；For cold, fever,
Fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, prolapse of the anus.
Root tuber of aromatic turmeric：Meridian distribution of property and flavor：Pungent, bitter, tremble with fear, Return liver, the heart, lung channel；Indication：Regulating qi to disperse stagnation, heart fire-clearing upset-relieving, cholagogic moves back
Yellow；For closed dysmenorrhea, chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsy is gone mad, jaundice urine is red.
Madder：Meridian distribution of property and flavor：Hardship, trembles with fear, return liver warp；Indication：Cool blood, hemostasis, dissolving stasis, stimulate the menstrual flow；For spitting blood, nosebleed
Blood, uterine bleeding, traumatism and bleeding, Amenorrhea stasis blocking, joint pain, tumbling and swelling.
Saline cistanche：Meridian distribution of property and flavor：Sweet, salty, temperature, return kidney, large intestine channel；Indication：Kidney-replenishing, benefiting essence-blood, relax bowel；
For impotence, infertile, soreness and weakness of waist and knees, muscles and bones is powerless, dry constipation of intestines.
The seed of Chinese dodder：Meridian distribution of property and flavor：Sweet, temperature, Return liver, kidney, the spleen channel；Indication：Nourishing liver and kidney, astringent sperm contracting urine, antiabortive, bright
Mesh, antidiarrheal；For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen
Kidney deficiency is rushed down；Control outward leucoderma.
Raspberry：Meridian distribution of property and flavor：Sweet, sour, temperature, return kidney, bladder warp；Indication：Kidney-nourishing, controlling nocturnal emission with astringent drugs, contracting urine；For kidney deficiency
The enuresis, frequent urination, impotence and premature ejaculation, emission and spermatorrhea.
Mulberry fruit：Nature and flavor：Sweet, cold in nature, return through：Enter the heart, liver and kidney channel；Function：Nourishing yin and supplementing blood, improving eyesight is promoted the production of body fluid, ease constipation；
Cure mainly：Weakness due to chronic disease, liver-kidney Yin deficiency, soreness and weakness of waist and knees, the dark tinnitus of mesh, articular instability, dry constipation of intestines, body fluid deficiency blood is few, and hectic fever is passed out semen,
Diabetes etc..
Stir-baked SEMEN ZIZIPHI SPINOSAE：Meridian distribution of property and flavor：Sweet, sour, put down, Return liver, courage, the heart channel of Hang-Shaoyin；Indication：Tonifying liver, calming heart, arrest sweating, promotes the production of body fluid；With
In restlessness of asrhenia type and insomnia, horrified to much dream, body void hidrosis, injury thirst.
Flos Albiziae：Meridian distribution of property and flavor：Sweet, put down, the thoughts of returning home, Liver Channel；Indication：Resolving stagnation for tranquilization, for confused and worried, melancholy mistake
Sleep.
Safflower：Meridian distribution of property and flavor：Pungent, temperature, the thoughts of returning home, Liver Channel；Indication：Invigorate blood circulation, blood stasis removing analgesic；For Amenorrhea, bitterly
Warp, lochia, note of the ancient Chinese lump in the abdomen lump in the abdomen, injury from falling down, sore swell and ache curative.
Chinese yam：Meridian distribution of property and flavor：Sweet, put down, returns spleen, lung, kidney channel；Indication：Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying；
For spleen eating less, endless diarrhea, the deficiency syndrome of the lung is breathed with cough, emission due to the kidney deficiency, under band, frequent micturition, and abnormal heat is quenched one's thirst；Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney；
For spleen eating less, loose stool of having loose bowels, leukorrhea.
The fruit of glossy privet：Meridian distribution of property and flavor：Sweet, bitter, cold, returns liver and kidney channel；Indication：Nourishing liver and kidney, improving eyesight black hair；For dizzy
Dizzy tinnitus, soreness and weakness of waist and knees, poliosis, mesh is secretly failed to understand.
Hawthorn：Meridian distribution of property and flavor：Sour, sweet, tepor, returns spleen, stomach, Liver Channel；Indication：Food digesting stomach fortifying, scattered stasis；For
Meat stagnation, gastral cavilty turgor, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, hernia pain；Hyperlipidemia；Jiaoshan Hill
Short, bristly hair or beard promoting digestion effect strengthens；For meat stagnation, rush down dysentery is not well.
Prepared rhizome of rehmannia：Meridian distribution of property and flavor：Sweet, tepor, return liver and kidney channel；Indication：Nourishing yin and supplementing blood, beneficial essence fills out marrow；For liver kidney
The deficiency of Yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat is passed out semen, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis,
Dizziness, tinnitus, poliosis.
Pilose antler：Nature and flavor：Sweet, salty, temperature, return kidney, Liver Channel；Function：Invigorating kidney yang, mends marrow, strengthening the bones and muscles, adjusts punching to appoint, torr sore poison；
Cure mainly：Kidney deficiency, dizzy, deaf, mesh is dark, impotence, involuntary emission, and uterus cold infertile is thin thin, refreshing tired, chilly, spinal column crymodynia, muscles and bones impotence,
Uterine bleeding under band, the disease such as cloudy subcutaneous ulcer is not held back and prolonged illness is deficient.
Bergamot：Nature and flavor acrid, bitter, warm, enter liver, spleen, stomach, lung channel, there is liver-smoothing, qi-regulating, eliminating dampness and eliminating phlegm work(is it is adaptable to liver
Hypochondriac pain caused by the strongly fragrant stagnation of the circulation of vital energy, uncomfortable in chest, abdominal fullness and distention caused by the taste stagnation of the circulation of vital energy, indigestion and loss of appetite stomachache, belch evil of vomitting, coughing with a lot of sputum etc..
Beneficial effects of the present invention：There is soothing the liver flat strongly fragrant, coordinating Chong and Conception Vessels, drug effect is notable, can suffer from long-term taking
Person is easy to accept.
Specific embodiment
Describe technical scheme with reference to embodiment and experimental example in detail, but protection domain not limited to this.
Embodiment 1
A kind of Chinese medicine preparation treating the depressed card of liver depression, is made up of the raw material of following weight portion：120 parts of radix bupleuri, 400 parts of root tuber of aromatic turmeric,
400 parts of madder, 400 parts of saline cistanche, 400 parts of the seed of Chinese dodder, 400 parts of raspberry, 400 parts of mulberry fruit, 400 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae
230 parts, 130 parts of safflower, 230 parts of Chinese yam, 230 parts of the fruit of glossy privet, 500 parts of hawthorn, 150 parts of prepared rhizome of rehmannia, 90 parts of pilose antler, bergamot 90
Part, 0.002 part of stevioside, 0.003 part of Sodium Benzoate；
Its preparation process is：
（1）Take raw material radix bupleuri, root tuber of aromatic turmeric, madder, saline cistanche, the seed of Chinese dodder, raspberry, prepared rhizome of rehmannia, pilose antler pulverizer to pulverize, pulverize
Fineness 60-80 mesh, obtains raw material powder, standby；
（2）Raw material mulberry fruit, stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae, safflower, Chinese yam, the fruit of glossy privet, hawthorn pulverizer is taken to pulverize, smashing fineness
100-120 mesh, obtains raw material powder, standby；
（3）Raw material bergamot pulverizer is taken to pulverize, smashing fineness 50-60 mesh, obtain raw material powder, standby；
（4）By step（1）Gained raw material powder and step（2）Gained raw material powder and（3）Gained raw material powder adds raw material gross weight
8-12 times of water, soaks 0.5-2 hour, heating distillation 2-6 hour, collects volatile oil, obtain distillate, the dregs of a decoction add raw material gross weight
The decocting of 4-8 times of amount boils 1-2 time, and the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters and must filter
Liquid, filtrate is concentrated into 85-95 DEG C and surveys the clear cream that relative density is 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling
Even, 0 to 6 DEG C refrigeration 20-30 hour, filter, decompression filtrate recycling ethanol to no alcohol taste, filtrate be concentrated into 50-60 DEG C relatively close
Spend the medicinal extract for 1.15-1.25, standby；
（5）By step（4）Middle gained medicinal extract is put in Agitation Tank, adds the purified water of medicinal extract weight 3-6 times amount to be heated to seething with excitement,
Stirring 15-25 minute, micro-boiling rises insulation 10-15 minute, forms liquid, places, is cooled to room temperature, standby；
（6）Stevioside, Sodium Benzoate is taken to be respectively crushed into 500-600 mesh, standby；
（7）By step（5）Middle gained liquid adds the stevioside after pulverizing, Sodium Benzoate dissolving stirring, so that liquid is mixed,
Filtered with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then adjust pH
For 6.5-7.0, obtain joining liquid, standby；
（8）By step（7）Middle gained joins the clean vial packing of liquid, using ultra high temperature short time sterilization, obtains final product treatment liver depression
The Chinese medicine preparation of depressed card.
Usage：Oral, 2 times a day, each 15ml.
Embodiment 2
A kind of Chinese medicine preparation treating the depressed card of liver depression, is made up of the raw material of following weight portion：90 parts of radix bupleuri, 300 parts of root tuber of aromatic turmeric, madder
300 parts of grass, 300 parts of saline cistanche, 300 parts of the seed of Chinese dodder, 300 parts of raspberry, 300 parts of mulberry fruit, 300 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae 200
Part, 100 parts of safflower, 200 parts of Chinese yam, 200 parts of the fruit of glossy privet, 400 parts of hawthorn, 120 parts of prepared rhizome of rehmannia, 60 parts of pilose antler, 60 parts of bergamot,
0.0015 part of stevioside, 0.002 part of Sodium Benzoate；
Its preparation process is：
（1）Take raw material radix bupleuri, root tuber of aromatic turmeric, madder, saline cistanche, the seed of Chinese dodder, raspberry, prepared rhizome of rehmannia, pilose antler pulverizer to pulverize, pulverize
Fineness 60-80 mesh, obtains raw material powder, standby；
（2）Raw material mulberry fruit, stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae, safflower, Chinese yam, the fruit of glossy privet, hawthorn pulverizer is taken to pulverize, smashing fineness
100-120 mesh, obtains raw material powder, standby；
（3）Raw material bergamot pulverizer is taken to pulverize, smashing fineness 50-60 mesh, obtain raw material powder, standby；
（4）By step（1）Gained raw material powder and step（2）Gained raw material powder and（3）Gained raw material powder adds raw material gross weight
8-12 times of water, soaks 0.5-2 hour, heating distillation 2-6 hour, collects volatile oil, obtain distillate, the dregs of a decoction add raw material gross weight
The decocting of 4-8 times of amount boils 1-2 time, and the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters and must filter
Liquid, filtrate is concentrated into 85-95 DEG C and surveys the clear cream that relative density is 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling
Even, 0 to 6 DEG C refrigeration 20-30 hour, filter, decompression filtrate recycling ethanol to no alcohol taste, filtrate be concentrated into 50-60 DEG C relatively close
Spend the medicinal extract for 1.15-1.25, standby；
（5）By step（4）Middle gained medicinal extract is put in Agitation Tank, adds the purified water of medicinal extract weight 3-6 times amount to be heated to seething with excitement,
Stirring 15-25 minute, micro-boiling rises insulation 10-15 minute, forms liquid, places, is cooled to room temperature, standby；
（6）Stevioside, Sodium Benzoate is taken to be respectively crushed into 500-600 mesh, standby；
（7）By step（5）Middle gained liquid adds the stevioside after pulverizing, Sodium Benzoate dissolving stirring, so that liquid is mixed,
Filtered with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then adjust pH
For 6.5-7.0, obtain joining liquid, standby；
（8）By step（7）Middle gained joins the clean vial packing of liquid, using ultra high temperature short time sterilization, obtains final product treatment liver depression
The Chinese medicine preparation of depressed card.
Usage：Oral, 2 times a day, each 15ml.
Embodiment 3
A kind of Chinese medicine preparation treating the depressed card of liver depression, is made up of the raw material of following weight portion：60 parts of radix bupleuri, 200 parts of root tuber of aromatic turmeric, madder
200 parts of grass, 200 parts of saline cistanche, 200 parts of the seed of Chinese dodder, 200 parts of raspberry, 200 parts of mulberry fruit, 200 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae 170
Part, 70 parts of safflower, 170 parts of Chinese yam, 170 parts of the fruit of glossy privet, 300 parts of hawthorn, 90 parts of prepared rhizome of rehmannia, 30 parts of pilose antler, 30 parts of bergamot, sweet
0.001 part of synanthrin, 0.001 part of Sodium Benzoate；
Its preparation process is：
（1）Take raw material radix bupleuri, root tuber of aromatic turmeric, madder, saline cistanche, the seed of Chinese dodder, raspberry, prepared rhizome of rehmannia, pilose antler pulverizer to pulverize, pulverize
Fineness 60-80 mesh, obtains raw material powder, standby；
（2）Raw material mulberry fruit, stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae, safflower, Chinese yam, the fruit of glossy privet, hawthorn pulverizer is taken to pulverize, smashing fineness
100-120 mesh, obtains raw material powder, standby；
（3）Raw material bergamot pulverizer is taken to pulverize, smashing fineness 50-60 mesh, obtain raw material powder, standby；
（4）By step（1）Gained raw material powder and step（2）Gained raw material powder and（3）Gained raw material powder adds raw material gross weight
8-12 times of water, soaks 0.5-2 hour, heating distillation 2-6 hour, collects volatile oil, obtain distillate, the dregs of a decoction add raw material gross weight
The decocting of 4-8 times of amount boils 1-2 time, and the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters and must filter
Liquid, filtrate is concentrated into 85-95 DEG C and surveys the clear cream that relative density is 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling
Even, 0 to 6 DEG C refrigeration 20-30 hour, filter, decompression filtrate recycling ethanol to no alcohol taste, filtrate be concentrated into 50-60 DEG C relatively close
Spend the medicinal extract for 1.15-1.25, standby；
（5）By step（4）Middle gained medicinal extract is put in Agitation Tank, adds the purified water of medicinal extract weight 3-6 times amount to be heated to seething with excitement,
Stirring 15-25 minute, micro-boiling rises insulation 10-15 minute, forms liquid, places, is cooled to room temperature, standby；
（6）Stevioside, Sodium Benzoate is taken to be respectively crushed into 500-600 mesh, standby；
（7）By step（5）Middle gained liquid adds the stevioside after pulverizing, Sodium Benzoate dissolving stirring, so that liquid is mixed,
Filtered with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then adjust pH
For 6.5-7.0, obtain joining liquid, standby；
（8）By step（7）Middle gained joins the clean vial packing of liquid, using ultra high temperature short time sterilization, obtains final product treatment liver depression
The Chinese medicine preparation of depressed card.
Usage：Oral, 2 times a day, each 15ml.
Chinese medicine preparation Ureteral Calculus liver depression of the present invention depressed card patient 45, clinical report is as follows：
1st, physical data
Clinical observation liver depression depressed card patient 45, wherein male 20, female 25, the shortest course of disease half a year, the longest 5 years, age 35-
70 years old, average age 47.5 years old.
2nd, diagnostic criteria
Symptoms include：Stagnant, depression and stagnation of QI is dredged in liver mistake, and with depressed emotion, happiness is sighed, and chest side of body or less abdominal distension are vexed to alter bitterly, female breast distending pain,
Irregular menstruation, veins string.
3rd, treatment method
Using Chinese medicine preparation of the present invention treatment, oral Chinese medicine preparation of the present invention, 2 times a day, each 15ml, is within 7 days a course for the treatment of.
4th, efficacy evaluation
Cure：Symptom disappears.
Effectively：Clinical symptom relief.
Invalid：Clinical symptoms are no improved or are increased.
5th, treatment results
In clinical treatment liver depression depressed card patient 45, cure 37 and account for 82.2%, take a turn for the better 8 and account for 17.8%, invalid 0, always have
Efficiency is 100%.
6th, model case
Case 1：Female, 32 years old, patient main suit's irregular menstruation was as long as half a year, delayed, the depressed card of liver depression, intermenstrual bleeding, dizzy through row
Dizzy, endocrine disturbance, examine for：Liver depression is depressed, oral two courses for the treatment of of Chinese medicine preparation of the present invention, and symptom is clearly better, and this is administered orally again
Two courses for the treatment of of invention Chinese medicine preparation, clinical cure.
Case 2：Female, 28 years old, the depressed card of liver depression 3 years in the no obvious inducement of patient main suit, difficulty falling asleep, early awakening,
Agitation, anxious state of mind irritability, menstrual period are too short, Hypomenorrhea, examine for：Liver depression is depressed, oral one course for the treatment of of Chinese medicine preparation of the present invention,
Patient symptom substantially mitigates, and two courses for the treatment of of oral traditional Chinese medicine preparation, and symptom is clearly better, and of the present invention Chinese medicine preparation two is administered orally again
The course for the treatment of, clinical cure.
Case 3：Man, 38 years old, depression in patients 1 year, dizziness, belch, chest side of body altered pain, poor appetite, bitter taste, and tongue is purple dark, arteries and veins
String is puckery, examine for：Liver depression is depressed, oral two courses for the treatment of of Chinese medicine preparation of the present invention, and symptom is clearly better, and of the present invention Chinese medicine system is administered orally again
Two courses for the treatment of of agent, clinical cure.
Case 4：Man, 43 years old, dizziness, belch, chest side of body altered pain, poor appetite, bitter taste to patient over the past half year, and tongue is purple dark, veins string
Puckery, examine for：Liver depression is depressed, oral two courses for the treatment of of Chinese medicine preparation of the present invention, and symptom is clearly better, and of the present invention Chinese medicine preparation is administered orally again
Two courses for the treatment of, clinical cure.
It should be pointed out that the specific embodiment more representational example that is the present invention is it is clear that the skill of the present invention
Art scheme is not limited to above-described embodiment, can also have many variations；Those of ordinary skill in the art, clearly public with present invention institute
What what written description that open or according to file was undoubted obtained, all it is considered as this patent scope of the claimed.
Claims (6)
1. a kind of Chinese medicine preparation treating the depressed card of liver depression it is characterised in that：It is made up of the raw material of following weight portion：Radix bupleuri 60-
120 parts, root tuber of aromatic turmeric 200-400 part, madder 200-400 part, saline cistanche 200-400 part, seed of Chinese dodder 200-400 part, raspberry 200-
400 parts, mulberry fruit 200-400 part, stir-baked SEMEN ZIZIPHI SPINOSAE 200-400 part, Flos Albiziae 170-230 part, safflower 70-130 part, Chinese yam 170-
230 parts, fruit of glossy privet 170-230 part, hawthorn 300-500 part, prepared rhizome of rehmannia 90-150 part, pilose antler 30-90 part, bergamot 30-90 part,
Stevioside 0.001-0.002 part, Sodium Benzoate 0.001-0.003 part.
2. a kind of Chinese medicine preparation treating the depressed card of liver depression according to claim 1 preparation method it is characterised in that：Its
Preparation process is：
（1）Take raw material radix bupleuri, root tuber of aromatic turmeric, madder, saline cistanche, the seed of Chinese dodder, raspberry, prepared rhizome of rehmannia, pilose antler pulverizer to pulverize, pulverize
Fineness 60-80 mesh, obtains raw material powder, standby；
（2）Raw material mulberry fruit, stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae, safflower, Chinese yam, the fruit of glossy privet, hawthorn pulverizer is taken to pulverize, smashing fineness
100-120 mesh, obtains raw material powder, standby；
（3）Raw material bergamot pulverizer is taken to pulverize, smashing fineness 50-60 mesh, obtain raw material powder, standby；
（4）By step（1）Gained raw material powder and step（2）Gained raw material powder and（3）Gained raw material powder adds raw material gross weight
8-12 times of water, soaks 0.5-2 hour, heating distillation 2-6 hour, collects volatile oil, obtain distillate, the dregs of a decoction add raw material gross weight
The decocting of 4-8 times of amount boils 1-2 time, and the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters and must filter
Liquid, filtrate is concentrated into 85-95 DEG C and surveys the clear cream that relative density is 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling
Even, 0 to 6 DEG C refrigeration 20-30 hour, filter, decompression filtrate recycling ethanol to no alcohol taste, filtrate be concentrated into 50-60 DEG C relatively close
Spend the medicinal extract for 1.15-1.25, standby；
（5）By step（4）Middle gained medicinal extract is put in Agitation Tank, adds the purified water of medicinal extract weight 3-6 times amount to be heated to seething with excitement,
Stirring 15-25 minute, micro-boiling rises insulation 10-15 minute, forms liquid, places, is cooled to room temperature, standby；
（6）Stevioside, Sodium Benzoate is taken to be respectively crushed into 500-600 mesh, standby；
（7）By step（5）Middle gained liquid adds the stevioside after pulverizing, Sodium Benzoate dissolving stirring, so that liquid is mixed,
Filtered with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then adjust pH
For 6.5-7.0, obtain joining liquid, standby；
（8）By step（7）Middle gained joins the clean vial packing of liquid, using ultra high temperature short time sterilization, obtains final product treatment liver depression
The Chinese medicine preparation of depressed card.
3. a kind of Chinese medicine preparation treating the depressed card of liver depression according to claim 2 preparation method it is characterised in that：Its
Preparation process is：
（1）Take raw material radix bupleuri, root tuber of aromatic turmeric, madder, saline cistanche, the seed of Chinese dodder, raspberry, prepared rhizome of rehmannia, pilose antler pulverizer to pulverize, pulverize
Fineness 80 mesh, obtains raw material powder, standby；
（2）Raw material mulberry fruit, stir-baked SEMEN ZIZIPHI SPINOSAE, Flos Albiziae, safflower, Chinese yam, the fruit of glossy privet, hawthorn pulverizer is taken to pulverize, smashing fineness
100 mesh, obtain raw material powder, standby；
（3）Raw material bergamot pulverizer is taken to pulverize, smashing fineness 60 mesh, obtain raw material powder, standby；
（4）By step（1）Gained raw material powder and step（2）Gained raw material powder and（3）Gained raw material powder adds raw material gross weight
12 times of water, soaks 0.5 hour, heating distillation 4 hours, collects volatile oil, obtains distillate, the dregs of a decoction add the 6 of raw material gross weight
Decocting again boils 2 times, and the time is 0.6 hour, merges decoction liquor and volatile oil and distillate, filters to get filtrate, filtrate is concentrated into
Survey the clear cream that relative density is 1.00 for 85 DEG C, add 85% appropriate amount of ethanol after cooling, stir evenly, 5 DEG C refrigerate 20 hours, filter, filtrate
To no alcohol taste, filtrate is concentrated into the medicinal extract that 60 DEG C of relative densities are 1.25 to decompression recycling ethanol, standby；
（5）By step（4）Middle gained medicinal extract is put in Agitation Tank, adds the purified water of medicinal extract weight 6 times amount to be heated to seething with excitement, stirs
Mix 15 minutes, micro-boiling rises insulation 10 minutes, form liquid, place, be cooled to room temperature, standby；
（6）Stevioside, Sodium Benzoate is taken to be respectively crushed into 600 mesh, standby；
（7）By step（5）Middle gained liquid adds the stevioside after pulverizing, Sodium Benzoate dissolving stirring, so that liquid is mixed,
Stirring was filtered with centrifuge after 15 minutes, at 60 DEG C, carried out twice homogenization under the conditions of 20MPa, then adjusted pH for 7.0, obtained
To joining liquid, standby；
（8）By step（7）Middle gained joins the clean vial packing of liquid, using ultra high temperature short time sterilization, obtains final product treatment liver depression
The Chinese medicine preparation of depressed card.
4. a kind of Chinese medicine preparation treating the depressed card of liver depression according to claim 1 it is characterised in that：By following weight portion
Raw material make：90 parts of radix bupleuri, 300 parts of root tuber of aromatic turmeric, 300 parts of madder, 300 parts of saline cistanche, 300 parts of the seed of Chinese dodder, 300 parts of raspberry,
300 parts of mulberry fruit, 300 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 200 parts of Flos Albiziae, 100 parts of safflower, 200 parts of Chinese yam, 200 parts of the fruit of glossy privet, hawthorn 400
Part, 120 parts of prepared rhizome of rehmannia, 60 parts of pilose antler, 60 parts of bergamot, 0.0015 part of stevioside, 0.002 part of Sodium Benzoate.
5. a kind of Chinese medicine preparation treating the depressed card of liver depression according to claim 1 it is characterised in that：By following weight portion
Raw material make：120 parts of radix bupleuri, 400 parts of root tuber of aromatic turmeric, 400 parts of madder, 400 parts of saline cistanche, 400 parts of the seed of Chinese dodder, 400 parts of raspberry,
400 parts of mulberry fruit, 400 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 230 parts of Flos Albiziae, 130 parts of safflower, 230 parts of Chinese yam, 230 parts of the fruit of glossy privet, hawthorn 500
Part, 150 parts of prepared rhizome of rehmannia, 90 parts of pilose antler, 90 parts of bergamot, 0.002 part of stevioside, 0.003 part of Sodium Benzoate.
6. a kind of Chinese medicine preparation treating the depressed card of liver depression according to claim 1 it is characterised in that：By following weight portion
Raw material make：60 parts of radix bupleuri, 200 parts of root tuber of aromatic turmeric, 200 parts of madder, 200 parts of saline cistanche, 200 parts of the seed of Chinese dodder, 200 parts of raspberry,
200 parts of mulberry fruit, 200 parts of stir-baked SEMEN ZIZIPHI SPINOSAE, 170 parts of Flos Albiziae, 70 parts of safflower, 170 parts of Chinese yam, 170 parts of the fruit of glossy privet, 300 parts of hawthorn,
90 parts of prepared rhizome of rehmannia, 30 parts of pilose antler, 30 parts of bergamot, 0.001 part of stevioside, 0.001 part of Sodium Benzoate.
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|---|---|---|---|---|
| CN1772158A (en) * | 2005-05-26 | 2006-05-17 | 李琦白 | Chinese medicine prepn for treating azoospermatism |
| CN104056007A (en) * | 2014-06-29 | 2014-09-24 | 苟晓龙 | Sperm promoting capsule |
| CN104146261A (en) * | 2014-09-02 | 2014-11-19 | 王叶颖 | Traditional Chinese medicine health-care product for climacterium of women and preparation method thereof |
-
2016
- 2016-11-11 CN CN201610992101.0A patent/CN106390032A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1772158A (en) * | 2005-05-26 | 2006-05-17 | 李琦白 | Chinese medicine prepn for treating azoospermatism |
| CN104056007A (en) * | 2014-06-29 | 2014-09-24 | 苟晓龙 | Sperm promoting capsule |
| CN104146261A (en) * | 2014-09-02 | 2014-11-19 | 王叶颖 | Traditional Chinese medicine health-care product for climacterium of women and preparation method thereof |
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Application publication date: 20170215 |