CN106389380A - Preparation method of medicinal hard shell capsules - Google Patents
Preparation method of medicinal hard shell capsules Download PDFInfo
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- CN106389380A CN106389380A CN201611156767.9A CN201611156767A CN106389380A CN 106389380 A CN106389380 A CN 106389380A CN 201611156767 A CN201611156767 A CN 201611156767A CN 106389380 A CN106389380 A CN 106389380A
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- capsule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- General Preparation And Processing Of Foods (AREA)
- Jellies, Jams, And Syrups (AREA)
Abstract
The invention relates to a preparation method of medicinal hard shell capsules. The method comprises the following steps: heating distilled water to 50-60 DEG C by using a water bath pot I, adding weighed ultralow-viscosity alginate while continuously stirring until a transparent solution is formed, heating 2 parts of distilled water to 70-80 DEG C by using a water bath pot, adding a small amount of glycerin, and respectively adding weighed carrageenan and CMC while continuously stirring until a transparent solution is formed. The medicinal hard shell capsules prepared through the method have the advantages of good formability, standard level reaching of the thickness and the brittleness of the walls of the capsules, and lowest cost, and the preparation method of the healthy and safe plant medicinal hard shell capsules has highest economic benefit.
Description
Technical field
The present invention relates to a kind of preparation method of hard capsules for medicament use.
Background technology
After there is " toxic capsule " event in recent years, plant capsule for medicine replaces the trend of animal gelatin capsule more and more brighter
Aobvious, vegetable polysaccharidess capsule for medicine even more becomes a kind of " coat of pure natural " of medicine, becomes necessarily becoming of pharmaceutical market development
Gesture.Plant capsule Jin Ren China's medicine and functional food market, not only can improving product brand value at home, and can plus
The internationalization paces of fast domestic preparation, make the exported product of China's medicine or functional food manufacturing enterprise quickly incorporate west special
Culture and advocate in natural trend.Research vegetable polysaccharidess making capsule for medicine replacement gelatine capsule can have preferably controls curative effect
Really, it is respectively the proportioning of sodium alginate, CMC and carrageenan using vegetable polysaccharidess and optimal moulding process reduces production cost,
Minimum to reach throwing people's cost, prepare healthy and safe plant amedica hollow and hard capsule, economic benefit highest.Used by vegetable polysaccharidess
The medicinal hollow and hard capsule that certain optimised process makes, is a kind of natural plants capsule, will replace animal gelatin capsule.
Content of the invention
The present invention proposes a kind of preparation method of hard capsules for medicament use.
A kind of preparation method of hard capsules for medicament use, comprises the following steps：
（1）It is heated to 50～60 DEG C with water-bath I distilled water, lower the ultralow viscosity alginate weighing up is added being stirred continuously
Until forming clear solution, with water-bath, 2 parts of distilled water are heated to 70～80 DEG C simultaneously；First it is separately added into a small amount of glycerol,
Lower respectively the carrageenan weighing up and CMC are added until forming clear solution being stirred continuously；
（2）Respectively 3 parts of clear solutions are mixed to form homogeneous clear solution, move in water-bath, heat 30min, be allowed to fill
Divide and dissolve uniformly glue；
（3）Then mixed solution is moved to water-bath, after standing 40min, remove the foam on liquid level, make glue clear standby；
（4）First pigment is configured to the pigment aqueous solution of certain percentage composition, then adds after polysaccharide CL and filtered
Pigment aqueous solution, stirring several minutes make after uniformly, place into water-bath insulation；
（5）The moulding process of composite capsule, with capsule die, tringle is soaked in people's glue and is stained with rubidium capsule blank；
（6）The tringle first choosing appropriate gauge is fixed in template, with appropriate liquid Tween 80 lubrication；
（7）Again mould is steadily held, upper end is immersed downwards in glue, treat glue whole submergence tringle 6～8 S, that is, slowly
Template is lifted, leaves glue liquid surface, then put people 5% calcium chloride solution calcification, make the glue rapid shaping outside capsule die；
（8）Again mould is dug, upset makes cooling for several times, the speed dipping in glue typically impregnates and in rear mold with 5～6/rain is
Preferably；
（9）Calcification, drying：With 10% CaCl, solution calcification 10 15S then be placed in clear water 5 S about soaking and washing；
（10）It is dried using calorstat, using the hot-air evaporation solvent moisture of flowing, make capsule shells drying and moulding；
（11）The capsule that takes out from thermostatic drying chamber will place 10min, makes moisture in glycerol absorption air, thus profit
Capsule；
（12）Encase dried mould with napkin, in case sweat is got wet capsule shells on hand, prune according to designated length；
（13）Obtain final product after the capsule body being successful and capsule cap fit.
The hard capsules for medicament use of the method for the invention preparation, good moldability, capsule wall thickness and friability all reach standard water
Flat, cost is minimum, prepares healthy and safe plant amedica hollow and hard capsule, economic benefit highest.
Specific embodiment
Embodiment 1.
A kind of preparation method of hard capsules for medicament use, comprises the following steps：
（1）It is heated to 50～60 DEG C with water-bath I distilled water, lower the ultralow viscosity alginate weighing up is added being stirred continuously
Until forming clear solution, with water-bath, 2 parts of distilled water being heated to 70～80 DEG C simultaneously, being first separately added into a small amount of glycerol,
Lower respectively the carrageenan weighing up and CMC are added until forming clear solution being stirred continuously；
（2）Respectively 3 parts of clear solutions are mixed to form homogeneous clear solution, move in water-bath, heat 30min, be allowed to fill
Divide and dissolve uniformly glue；
（3）Then mixed solution is moved to water-bath, after standing 40min, remove the foam on liquid level, make glue clear standby；
（4）First pigment is configured to the pigment aqueous solution of certain percentage composition, then adds after polysaccharide CL and filtered
Pigment aqueous solution, stirring several minutes make after uniformly, place into water-bath insulation；
（5）The moulding process of composite capsule, with capsule die, tringle is soaked in people's glue and is stained with rubidium capsule blank；
（6）The tringle first choosing appropriate gauge is fixed in template, with appropriate liquid Tween 80 lubrication；
（7）Again mould is steadily held, upper end is immersed downwards in glue, treat glue whole submergence tringle 6～8 S, that is, slowly
Template is lifted, leaves glue liquid surface, then put people 5% calcium chloride solution calcification, make the glue rapid shaping outside capsule die；
（8）Again mould is dug, upset makes cooling for several times, the speed dipping in glue typically impregnates and in rear mold with 5～6/rain is
Preferably；
（9）Calcification, drying：With 10% CaCl, solution calcification 10 15S then be placed in clear water 5 S about soaking and washing；
（10）It is dried using calorstat, using the hot-air evaporation solvent moisture of flowing, make capsule shells drying and moulding；
（11）The capsule that takes out from thermostatic drying chamber will place 10min, makes moisture in glycerol absorption air, thus profit
Capsule；
（12）Encase dried mould with napkin, in case sweat is got wet capsule shells on hand, prune according to designated length；
（13）Obtain final product after the capsule body being successful and capsule cap fit.
Embodiment 2.
A kind of preparation method of hard capsules for medicament use, comprises the following steps：
（1）It is heated to 50～60 DEG C with water-bath I distilled water, lower the ultralow viscosity alginate weighing up is added being stirred continuously
Until forming clear solution, with water-bath, 2 parts of distilled water being heated to 70～80 DEG C simultaneously, being first separately added into a small amount of glycerol,
Lower respectively the carrageenan weighing up and CMC are added until forming clear solution being stirred continuously；
（2）Respectively 3 parts of clear solutions are mixed to form homogeneous clear solution, move in water-bath, heat 30min, be allowed to fill
Divide and dissolve uniformly glue；
（3）Then mixed solution is moved to water-bath, after standing 40min, remove the foam on liquid level, make glue clear standby；
（4）First pigment is configured to the pigment aqueous solution of certain percentage composition, then adds after polysaccharide CL and filtered
Pigment aqueous solution, stirring several minutes make after uniformly, place into water-bath insulation；
（5）The moulding process of composite capsule, with capsule die, tringle is soaked in people's glue and is stained with rubidium capsule blank；
（6）The tringle first choosing appropriate gauge is fixed in template, with appropriate liquid Tween 80 lubrication；
（7）Again mould is steadily held, upper end is immersed downwards in glue, treat glue whole submergence tringle 6～8 S, that is, slowly
Template is lifted, leaves glue liquid surface, then put people 5% calcium chloride solution calcification, make the glue rapid shaping outside capsule die；
（8）Again mould is dug, upset makes cooling for several times, the speed dipping in glue typically impregnates and in rear mold with 5～6/rain is
Preferably；
（9）Calcification, drying：With 10% CaCl, solution calcification 10 15S then be placed in clear water 5 S about soaking and washing；
（10）It is dried using calorstat, using the hot-air evaporation solvent moisture of flowing, make capsule shells drying and moulding；
（11）The capsule that takes out from thermostatic drying chamber will place 10min, makes moisture in glycerol absorption air, thus profit
Capsule；
（12）Encase dried mould with napkin, in case sweat is got wet capsule shells on hand, prune according to designated length；
（13）Obtain final product after the capsule body being successful and capsule cap fit.
Claims (1)
1. a kind of preparation method of hard capsules for medicament use is it is characterised in that comprise the following steps：
（1）It is heated to 50～60 DEG C with water-bath I distilled water, lower the ultralow viscosity alginate weighing up is added being stirred continuously
Until forming clear solution, with water-bath, 2 parts of distilled water are heated to 70～80 DEG C simultaneously；It is separately added into a small amount of glycerol,
It is stirred continuously and lower add the carrageenan weighing up and CMC until forming clear solution respectively；
（2）Respectively 3 parts of clear solutions are mixed to form homogeneous clear solution, move in water-bath, heat 30min, be allowed to fill
Divide and dissolve uniformly glue；
（3）Then mixed solution is moved to water-bath, after standing 40min, remove the foam on liquid level, make glue clear standby；
（4）First pigment is configured to the pigment aqueous solution of certain percentage composition, then adds after polysaccharide CL and filtered
Pigment aqueous solution, stirring several minutes make after uniformly, place into water-bath insulation；
（5）The moulding process of composite capsule, with capsule die, tringle is soaked in people's glue and is stained with rubidium capsule blank；
（6）The tringle first choosing appropriate gauge is fixed in template, with appropriate liquid Tween 80 lubrication；
（7）Again mould is steadily held, upper end is immersed downwards in glue, treat glue whole submergence tringle 6～8 S, that is, slowly
Template is lifted, leaves glue liquid surface, then put people 5% calcium chloride solution calcification, make the glue rapid shaping outside capsule die；
（8）Again mould is dug, upset makes cooling for several times, the speed dipping in glue typically impregnates and in rear mold with 5～6/rain is
Preferably；
（9）Calcification, drying：With 10% CaCl, solution calcification 10 15S then be placed in clear water 5 S about soaking and washing；
（10）It is dried using calorstat, using the hot-air evaporation solvent moisture of flowing, make capsule shells drying and moulding；
（11）The capsule that takes out from thermostatic drying chamber will place 10min, makes moisture in glycerol absorption air, thus profit
Capsule；
（12）Encase dried mould with napkin, in case sweat is got wet capsule shells on hand, prune according to designated length；To make
Successfully obtain final product after capsule body and capsule cap fit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611156767.9A CN106389380A (en) | 2016-12-15 | 2016-12-15 | Preparation method of medicinal hard shell capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611156767.9A CN106389380A (en) | 2016-12-15 | 2016-12-15 | Preparation method of medicinal hard shell capsules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106389380A true CN106389380A (en) | 2017-02-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611156767.9A Pending CN106389380A (en) | 2016-12-15 | 2016-12-15 | Preparation method of medicinal hard shell capsules |
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| CN (1) | CN106389380A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108926486A (en) * | 2017-05-27 | 2018-12-04 | 兰州平山机械制造有限公司 | Hard Capsules production fixed length socket unit |
-
2016
- 2016-12-15 CN CN201611156767.9A patent/CN106389380A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108926486A (en) * | 2017-05-27 | 2018-12-04 | 兰州平山机械制造有限公司 | Hard Capsules production fixed length socket unit |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170215 |
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| WD01 | Invention patent application deemed withdrawn after publication |