CN106389271A - Skin-care antibacterial lotion as well as preparation method and applications thereof - Google Patents
Skin-care antibacterial lotion as well as preparation method and applications thereof Download PDFInfo
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- CN106389271A CN106389271A CN201610458841.6A CN201610458841A CN106389271A CN 106389271 A CN106389271 A CN 106389271A CN 201610458841 A CN201610458841 A CN 201610458841A CN 106389271 A CN106389271 A CN 106389271A
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a skin-care antibacterial lotion as well as a preparation method and applications of the skin-care antibacterial lotion. The skin-care antibacterial lotion is prepared from the following components in parts by weight: 80-90 parts of animal and plant extracting solution, 10-15 parts of glycerinum, 0.3-0.7 part of menthol, 1-3 parts of eucalyptus oil, and 0.5-5 parts of essence, wherein the animal and plant extracting solution is prepared from the following components in parts by weight: 8-12 parts of herba lobeliae chinensis, 3-7 parts of honeysuckle flowers, 6-10 parts of radix codonopsis, 2-7 parts of toad skin, 1-4 parts of gekko chinensis, and the balance of alcohol. The skin-care antibacterial lotion is externally applied to the skin, has the functions of resisting bacteria, relieving itching, moisturizing the skin, and cooling the skin, is a good product for skin care, sterilization, living and travel, and especially has killing effects for staphylococcus aureus and escherichia coli; the extracting solution of the skin-care antibacterial lotion is light brown liquid, is transparent, has no sedimentation, has cool and refreshing fragrance, and has the pH being 5.5-6.5. The external-use spray is free of any toxic or side effect, is convenient to use, is stable in sterilizing effect, and takes effect rapid, and the effect achieves 100% after 2 minutes.
Description
Technical field
Present invention relates particularly to a kind of skin protection antimicrobial fluid and preparation method and application.
Background technology
Antibacterial, is can to make certain micro-organisms (antibacterial, funguses, yeast, algae and virus etc.) within a certain period of time
Growth or breeding be maintained at necessary chemical substance below horizontal.Antibacterial is that a class has the new of antibacterial and bactericidal property
Auxiliary agent.
Antibacterial is generally divided into mineral-type and organic two big class.The former is filled out with silver, zinc, copper etc. as main material with inorganic
Expect for carrier, to make inorganic antiseptic, resistance to elevated temperatures is good.The latter with esters, alcohols, phenols as primary raw material, heat-resisting quantity
Relatively low, typically below 200 DEG C, it is 250 DEG C individually, sterilizing time is short, occasionally has the phenomenons such as precipitation.
Commonly using test strain is：Staphylococcus aureuses (gram positive bacteria), escherichia coli (gram negative bacteria) etc..
Escherichia coli (Escherichia coli, E.coli) are Gram-negative brevibacterium, under the conditions of normal perch not
Cause a disease.If but entering gallbladder, bladder etc. and can cause inflammation.Amount reproduction in intestinal, several accounts for the 1/3 of feces dry weight.Large intestine
Bacillus is strong compared with other Bacterium entericum to hot resistance, and 55 DEG C still have part antibacterial to deposit for 15 minutes through heating in 60 minutes or 60 DEG C
Live.Escherichia coli have morbid substance (virulence factor), specifically include：Endotoxin, pod membrane, type excretory system, adhesin is with outward
Toxin etc..
Staphylococcus aureuses (Staphyloccocus aureus) are a kind of important pathogen of the mankind, are under the jurisdiction of Portugal
Grape Coccuss (Staphylococcus), have the another name of " thermophilic meat bacterium ", are the representatives of gram positive bacteria, can cause many serious
Infection and alimentary toxicosis.
Therefore, the sterilization effect of escherichia coli and staphylococcus aureuses is as fields such as measurement medicine, food, water quality
One of the important indicator of safety, also serve as one of important indicator of skin degerming sterilizing.
Content of the invention
Goal of the invention：The present invention provides a kind of skin protection antimicrobial fluid and preparation method and application.
Technical scheme：The solution of the present invention is former based on motherland's medical science understanding pathogenetic to inflammation and treatment
Then, achieve with reference to modern pharmacological research, theoretical by traditional Chinese medical science prescription, skim the cream off milk so as to the effect of play antibacterial.The present invention is one
Plant skin protection antimicrobial fluid, described skin protection antimicrobial fluid is by following component by weight：Animals and plants extracting solution：80-90 part；
Glycerol：10-15 part；Mentholum：0.3-0.7 part；Oleum Eucalypti：1-3 part；Essence：0.5-5 part；Wherein, in described animals and plants extracting solution
Including：Herba Lobeliae Chinensis：8-12 part；Flos Lonicerae：3-7 part；Radix Codonopsis：6-10 part；Cutis Bufonis：2-7 part；Gekko Swinhonis：1-4 part, remaining content is
Ethanol.
As optimization：Described essence includes：Mosquito-repellent perfume essence, delicate fragrance essence, Fructus Citri Limoniae essence, Mint Essence, perfume (or spice)
Flos Hierochloes adoratae essence, lavandula angustifolia essence etc..
As optimization：The purity of described glycerol is 95%, and the purity of Mentholum is >=95%, the purity of Oleum Eucalypti is >=
70%.
A kind of preparation method of the skin protection antimicrobial fluid described in basis, comprises the steps：
(1), by this 5 kinds of animals and plants medical materials of Herba Lobeliae Chinensis, Flos Lonicerae, Radix Codonopsis, Cutis Bufonis and Gekko Swinhonis, with 5-10 times amount 30%-
80% alcohol reflux is secondary, each 1-3 hour, filtration, and filtrate recycling ethanol is simultaneously concentrated into relative density for 1.05-
The clear paste of 1.35g/ml (temperature is 35 DEG C -55 DEG C)；
(2), add ethanol to alcohol content to reach about 70%-80%, stir evenly, stand overnight, take supernatant；
(3), add the activated carbon low rate mixing 10-30 minute of 3-8%, stand >=3 hours, 200 mesh filter；
(4), add essence：Need individually to add essence mosquito-repellent perfume essence, delicate fragrance essence, lemon by product odor type
Lemon essence, Mint Essence, Herba Cymbopogonis Citrari essence, lavandula angustifolia essence etc.；
(5), put in container in the formula for a product ratio of antimicrobial fluid, mixing and stirring, stand 24 hours；
(6), by semi-finished product detect qualified after, make finished product in sub-bottling；Put in storage after the assay was approved.
A kind of application of the skin protection antimicrobial fluid described in basis, described skin protection antimicrobial fluid is sprayed in right amount, is applied in skin correlation
Position, and retain more than 15 minutes, can Reusability；Wherein, baby should not be used in and directly smears skin, skin injury, ethanol
Allergy sufferers, pregnant and lying-in women use with caution.
Beneficial effect：It is used for skin outside the present invention, there is antibacterial, antipruritic, skin moistening, refrigerant effect, be skin nursing, kill
Staphylococcus aureuses, escherichia coli are especially had killing action by bacterium, the non-defective unit of travelling at home；And, deposit in shady and cool dry
Dry, child is difficult to take place, inflammable；The extracting solution of skin protection antimicrobial fluid is light brown liquid, transparent, no precipitate；Containing refrigerant virtue
Fragrance, pH is 5.5-6.5.Externally applied spray of the present invention is without any side effects, easy to use, and stable sterilization effect is rapid-action, and 2
100% is reached during minute.
It is an advantage of the invention that：With the increasingly raising of modernization of Chinese medicine degree, in herbal pharmacology and fitochemical studies
On the basis of, increasing Effective Component of Chinese Medicine or effective site are proved to definite curative effect and are purified, the present invention
It is exactly to apply and raw, its scientific and technical content height in this development, be the herbal species of modernization, no any poison pair
Effect, easy to use, rapid-action, effect stability.
Specific embodiment
With reference to specific embodiment, the present invention will be described in detail.
Specific embodiment one：
A kind of skin protection antimicrobial fluid, described skin protection antimicrobial fluid is by following component by weight：Animals and plants are extracted
Liquid：80 parts；Glycerol：10 parts；Mentholum：0.3 part；Oleum Eucalypti：1 part；Essence：0.5 part；Wherein, wrap in described animals and plants extracting solution
Include：Herba Lobeliae Chinensis：8 parts；Flos Lonicerae：3 parts；Radix Codonopsis：6 parts；Cutis Bufonis：2 parts；Gekko Swinhonis：1 part, remaining content is ethanol.
Described essence includes：Mosquito-repellent perfume essence, delicate fragrance essence, Fructus Citri Limoniae essence, Mint Essence, Herba Cymbopogonis Citrari essence, smoke
Clothing hay-scented essence etc..
The purity of described glycerol is 95%, and the purity of Mentholum is >=95%, and the purity of Oleum Eucalypti is >=70%.
A kind of preparation method of the skin protection antimicrobial fluid described in basis, comprises the steps：
(1), by this 5 kinds of animals and plants medical materials of Herba Lobeliae Chinensis, Flos Lonicerae, Radix Codonopsis, Cutis Bufonis and Gekko Swinhonis, with the ethanol of 5 times amount 30%
Reflux, extract, is secondary, 1 hour every time, filtration, filtrate recycling ethanol and be concentrated into relative density be 1.05g/ml (temperature be 35
DEG C) clear paste；
(2), add ethanol to alcohol content to reach about 70%, stir evenly, stand overnight, take supernatant；
(3), the activated carbon low rate mixing of interpolation 3-8% 10 minutes, stand >=3 hours, and 200 mesh filter；
(4), add essence：Need individually to add essence mosquito-repellent perfume essence, delicate fragrance essence, lemon by product odor type
Lemon essence, Mint Essence, Herba Cymbopogonis Citrari essence, lavandula angustifolia essence etc.；
(5), put in container in the formula for a product ratio of antimicrobial fluid, mixing and stirring, stand 24 hours；
(6), by semi-finished product detect qualified after, make finished product in sub-bottling；Put in storage after the assay was approved.
A kind of application of the skin protection antimicrobial fluid described in basis, described skin protection antimicrobial fluid is sprayed in right amount, is applied in skin correlation
Position, and retain more than 15 minutes, can Reusability；Wherein, baby should not be used in and directly smears skin, skin injury, ethanol
Allergy sufferers, pregnant and lying-in women use with caution.
Specific embodiment two：
A kind of skin protection antimicrobial fluid, described skin protection antimicrobial fluid is by following component by weight：Animals and plants are extracted
Liquid：90 parts；Glycerol：15 parts；Mentholum：0.7 part；Oleum Eucalypti：3 parts；Essence：5 parts；Wherein, described animals and plants extracting solution includes：
Herba Lobeliae Chinensis：12 parts；Flos Lonicerae：7 parts；Radix Codonopsis：10 parts；Cutis Bufonis：7 parts；Gekko Swinhonis：4 parts, remaining content is ethanol.
Described essence includes：Mosquito-repellent perfume essence, delicate fragrance essence, Fructus Citri Limoniae essence, Mint Essence, Herba Cymbopogonis Citrari essence, smoke
Clothing hay-scented essence etc..
The purity of described glycerol is 95%, and the purity of Mentholum is >=95%, and the purity of Oleum Eucalypti is >=70%.
A kind of preparation method of the skin protection antimicrobial fluid described in basis, comprises the steps：
(1), by this 5 kinds of animals and plants medical materials of Herba Lobeliae Chinensis, Flos Lonicerae, Radix Codonopsis, Cutis Bufonis and Gekko Swinhonis, with the ethanol of 10 times amount 80%
Reflux, extract, is secondary, 3 hours every time, filtration, filtrate recycling ethanol and be concentrated into relative density be 1.35g/ml (temperature be 55
DEG C) clear paste；
(2), add ethanol to alcohol content to reach about 80%, stir evenly, stand overnight, take supernatant；
(3), the activated carbon low rate mixing of interpolation 3-8% 30 minutes, stand >=3 hours, and 200 mesh filter；
(4), add essence：Need individually to add essence mosquito-repellent perfume essence, delicate fragrance essence, lemon by product odor type
Lemon essence, Mint Essence, Herba Cymbopogonis Citrari essence, lavandula angustifolia essence etc.；
(5), put in container in the formula for a product ratio of antimicrobial fluid, mixing and stirring, stand 24 hours；
(6), by semi-finished product detect qualified after, make finished product in sub-bottling；Put in storage after the assay was approved.
A kind of application of the skin protection antimicrobial fluid described in basis, described skin protection antimicrobial fluid is sprayed in right amount, is applied in skin correlation
Position, and retain more than 15 minutes, can Reusability；Wherein, baby should not be used in and directly smears skin, skin injury, ethanol
Allergy sufferers, pregnant and lying-in women use with caution.
Specific embodiment three：
A kind of skin protection antimicrobial fluid, described skin protection antimicrobial fluid is by following component by weight：Animals and plants are extracted
Liquid：86 parts；Glycerol：12 parts；Mentholum：0.4 part；Oleum Eucalypti：2 parts；Essence：2 parts；Wherein, described animals and plants extracting solution includes：
Herba Lobeliae Chinensis：10 parts；Flos Lonicerae：5 parts；Radix Codonopsis：8 parts；Cutis Bufonis：5 parts；Gekko Swinhonis：2 parts, remaining content is ethanol.
Described essence includes：Mosquito-repellent perfume essence, delicate fragrance essence, Fructus Citri Limoniae essence, Mint Essence, Herba Cymbopogonis Citrari essence, smoke
Clothing hay-scented essence etc..
The purity of described glycerol is 95%, and the purity of Mentholum is >=95%, and the purity of Oleum Eucalypti is >=70%.
A kind of preparation method of the skin protection antimicrobial fluid described in basis, comprises the steps：
(1), by this 5 kinds of animals and plants medical materials of Herba Lobeliae Chinensis, Flos Lonicerae, Radix Codonopsis, Cutis Bufonis and Gekko Swinhonis, with the ethanol of 8 times amount 50%
Reflux, extract, is secondary, 1.5 hours every time, filtration, filtrate recycling ethanol and be concentrated into relative density be 1.15g/ml (temperature be 50
DEG C) clear paste；
(2), add ethanol to alcohol content to reach about 75%, stir evenly, stand overnight, take supernatant；
(3), the activated carbon low rate mixing of interpolation 3-8% 20 minutes, stand >=3 hours, and 200 mesh filter；
(4), add essence：Need individually to add essence mosquito-repellent perfume essence, delicate fragrance essence, lemon by product odor type
Lemon essence, Mint Essence, Herba Cymbopogonis Citrari essence, lavandula angustifolia essence etc.；
(5), put in container in the formula for a product ratio of antimicrobial fluid, mixing and stirring, stand 24 hours；
(6), by semi-finished product detect qualified after, make finished product in sub-bottling；Put in storage after the assay was approved.
A kind of application of the skin protection antimicrobial fluid described in basis, described skin protection antimicrobial fluid is sprayed in right amount, is applied in skin correlation
Position, and retain more than 15 minutes, can Reusability；Wherein, baby should not be used in and directly smears skin, skin injury, ethanol
Allergy sufferers, pregnant and lying-in women use with caution.
It is used for skin outside the present invention, there is antibacterial, antipruritic, skin moistening, refrigerant effect, be skin nursing, sterilization, house trip
Staphylococcus aureuses, escherichia coli are especially had killing action by the non-defective unit of row；And, deposit in shady and cool drying, child is difficult
Take place, inflammable；Precipitate is effective ingredient, and wherein the extracting solution of skin protection antimicrobial fluid is light brown liquid, transparent, no precipitate；Contain
There is refrigerant fragranced, pH is 5.5-6.5.
It is an advantage of the invention that：With the increasingly raising of modernization of Chinese medicine degree, in herbal pharmacology and fitochemical studies
On the basis of, increasing Effective Component of Chinese Medicine or effective site are proved to definite curative effect and are purified, the present invention
It is exactly to apply and raw, its scientific and technical content height in this development, be the herbal species of modernization, no any poison pair
Effect, easy to use, rapid-action, effect stability.
For showing the nonirritant of the present invention, the Skin Irritation Test of invention is as follows：The test day before yesterday, by rabbit
Back spinal column diamond wool cuts, and unhairing scope is 3cm*3cm2, during test, take tested material about 0.5ml to be applied to side unhaired hide
On skin, opposite side skin of unhairing, as blank, application area 2.5cm*2.5cm, is smeared once daily, continuously smears 14
My god, smear latter 4 hours, cleaned with warm water, remove residue, 24 as a child observed results, press《Disinfection technology standard》(2002
Version) in table 2-11 scoring, check plot is equally processed with test block.Press at the end of experiment《Disinfection technology standard》In (version in 2002)
Table 2-12 carries out skin irritation strength grading.Experimental result is shown in Table 1；Experiment conclusion is as follows：Sample multiple intact skin to rabbit
Irritant reaction integral mean value is 0, and stimulus intensity is nonirritant.
Table 1 tested material is to rabbit multiple intact skin irritation test result
For showing the antibacterial effect of the present invention, microbial indicators detected result of the present invention is as shown in table 2, table 3.
Table 2 microbial indicators detected result
| Inspection project | Hygiene value | Detected value |
| Total number of bacterial colonies (cfu/ml) | ≤200 | ＜ 1 |
| Straight bacterium total plate count (cfu/ml) | ≤100 | ＜ 1 |
| Pathogenic pyogenic baeceria | Must not detect | Do not detect |
| Coliform | Must not detect | Do not detect |
Table 3 is to test organismss bactericidal effect
The present invention is not limited to above-mentioned preferred forms, and anyone can show that under the enlightenment of the present invention other are various
The product of form, however, making any change in its shape or structure, every have skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (5)
1. a kind of skin protection antimicrobial fluid it is characterised in that：Described skin protection antimicrobial fluid is by following component by weight：Dynamic
Plant extraction liquid：80-90 part；Glycerol：10-15 part；Mentholum：0.3-0.7 part；Oleum Eucalypti：1-3 part；Essence：0.5-5 part；Its
In, described animals and plants extracting solution includes：Herba Lobeliae Chinensis：8-12 part；Flos Lonicerae：3-7 part；Radix Codonopsis：6-10 part；Cutis Bufonis：2-7 part；
Gekko Swinhonis：1-4 part, remaining content is ethanol.
2. skin protection antimicrobial fluid according to claim 1 it is characterised in that：Described essence includes：Mosquito-repellent perfume essence,
Delicate fragrance essence, Fructus Citri Limoniae essence, Mint Essence, Herba Cymbopogonis Citrari essence, lavandula angustifolia essence etc..
3. skin protection antimicrobial fluid according to claim 1 it is characterised in that：The purity of described glycerol is 95%, Mentholum
Purity is >=95%, and the purity of Oleum Eucalypti is >=70%.
4. the skin protection antimicrobial fluid described in a kind of any one according to claim 1-3 preparation method it is characterised in that：Including as follows
Step：
(1), by this 5 kinds of animals and plants medical materials of Herba Lobeliae Chinensis, Flos Lonicerae, Radix Codonopsis, Cutis Bufonis and Gekko Swinhonis, with 5-10 times amount 30%-80%
Alcohol reflux is secondary, each 1-3 hour, filtration, and filtrate recycling ethanol is simultaneously concentrated into relative density for 1.05-1.35g/ml
The clear paste of (temperature is 35 DEG C -55 DEG C)；
(2), add ethanol to alcohol content to reach about 70%-80%, stir evenly, stand overnight, take supernatant；
(3), add the activated carbon low rate mixing 10-30 minute of 3-8%, stand >=3 hours, 200 mesh filter；
(4), add essence：Need individually to add essence mosquito-repellent perfume essence, delicate fragrance essence, NINGMENGXIANG by product odor type
Essence, Mint Essence, Herba Cymbopogonis Citrari essence, lavandula angustifolia essence etc.；
(5), put in container in the formula for a product ratio of antimicrobial fluid, mixing and stirring, stand 24 hours；
(6), by semi-finished product detect qualified after, make finished product in sub-bottling；Put in storage after the assay was approved.
5. a kind of application of skin protection antimicrobial fluid according to claim 1 it is characterised in that：Will be appropriate for described skin protection antimicrobial fluid
Spray, be applied in skin region of interest, and retain more than 15 minutes, can Reusability；Wherein, baby should not be used in and directly smears skin
Skin, skin injury, alcohol intolerance person, pregnant and lying-in women use with caution.
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