CN106380475A - 一种噻吩并[2,3‑d]嘧啶类化合物及其制备方法和应用 - Google Patents
一种噻吩并[2,3‑d]嘧啶类化合物及其制备方法和应用 Download PDFInfo
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- CN106380475A CN106380475A CN201610742168.9A CN201610742168A CN106380475A CN 106380475 A CN106380475 A CN 106380475A CN 201610742168 A CN201610742168 A CN 201610742168A CN 106380475 A CN106380475 A CN 106380475A
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- 0 CC1(*)C=CC(c([o]2)nnc2Sc2nc(*)nc3c2c(*)c(N)[s]3)=CC=C1 Chemical compound CC1(*)C=CC(c([o]2)nnc2Sc2nc(*)nc3c2c(*)c(N)[s]3)=CC=C1 0.000 description 5
- ATBAHRVSYHPSKU-UHFFFAOYSA-N CCc1cc(c(Sc2nnc(-c(cc3)ccc3OC)[o]2)nc(C(F)(F)F)n2)c2[s]1 Chemical compound CCc1cc(c(Sc2nnc(-c(cc3)ccc3OC)[o]2)nc(C(F)(F)F)n2)c2[s]1 ATBAHRVSYHPSKU-UHFFFAOYSA-N 0.000 description 2
- AAMONFHANPFCQQ-UHFFFAOYSA-N CCC(C1)Sc2c1c(Sc1nnc(-c3ccccc3Cl)[o]1)nc(C(F)(F)F)n2 Chemical compound CCC(C1)Sc2c1c(Sc1nnc(-c3ccccc3Cl)[o]1)nc(C(F)(F)F)n2 AAMONFHANPFCQQ-UHFFFAOYSA-N 0.000 description 1
- SWCNDYKWZVASHY-UHFFFAOYSA-N CCc1c(C)[s]c2c1c(Sc1nnc(-c(cc3)ccc3OC)[o]1)nc(C(F)(F)F)n2 Chemical compound CCc1c(C)[s]c2c1c(Sc1nnc(-c(cc3)ccc3OC)[o]1)nc(C(F)(F)F)n2 SWCNDYKWZVASHY-UHFFFAOYSA-N 0.000 description 1
- YHLDZCGWPKTBRM-UHFFFAOYSA-N CCc1cc(c(Sc2nnc(-c(cccc3)c3Cl)[o]2)nc(C(F)(F)F)n2)c2[s]1 Chemical compound CCc1cc(c(Sc2nnc(-c(cccc3)c3Cl)[o]2)nc(C(F)(F)F)n2)c2[s]1 YHLDZCGWPKTBRM-UHFFFAOYSA-N 0.000 description 1
- ZMNKZLJBUMCSFE-UHFFFAOYSA-N COC1=CCCC=C1c([o]1)nnc1S Chemical compound COC1=CCCC=C1c([o]1)nnc1S ZMNKZLJBUMCSFE-UHFFFAOYSA-N 0.000 description 1
- ODIMDXTZXYDQMN-UHFFFAOYSA-N COc(cc1)ccc1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCC1)c1[s]2 Chemical compound COc(cc1)ccc1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCC1)c1[s]2 ODIMDXTZXYDQMN-UHFFFAOYSA-N 0.000 description 1
- BZQHOHARXRSLIW-UHFFFAOYSA-N COc(cc1)ccc1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCCC1)c1[s]2 Chemical compound COc(cc1)ccc1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCCC1)c1[s]2 BZQHOHARXRSLIW-UHFFFAOYSA-N 0.000 description 1
- JIHKMRPSPKTDCZ-UHFFFAOYSA-N COc1cc(-c([o]2)nnc2Sc2nc(C(F)(F)F)nc3c2c(CCC2)c2[s]3)ccc1 Chemical compound COc1cc(-c([o]2)nnc2Sc2nc(C(F)(F)F)nc3c2c(CCC2)c2[s]3)ccc1 JIHKMRPSPKTDCZ-UHFFFAOYSA-N 0.000 description 1
- AKJLLQRWTHIGHL-UHFFFAOYSA-N COc1ccccc1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCC1)c1[s]2 Chemical compound COc1ccccc1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCC1)c1[s]2 AKJLLQRWTHIGHL-UHFFFAOYSA-N 0.000 description 1
- RMMJMLXXZPKXGO-UHFFFAOYSA-N O=Cc(cccc1)c1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCC1)c1[s]2 Chemical compound O=Cc(cccc1)c1-c([o]1)nnc1Sc1nc(C(F)(F)F)nc2c1c(CCC1)c1[s]2 RMMJMLXXZPKXGO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
Claims (11)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201610742168.9A CN106380475B (zh) | 2016-08-26 | 2016-08-26 | 一种噻吩并[2,3‑d]嘧啶类化合物及其制备方法和应用 |
Applications Claiming Priority (1)
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CN201610742168.9A CN106380475B (zh) | 2016-08-26 | 2016-08-26 | 一种噻吩并[2,3‑d]嘧啶类化合物及其制备方法和应用 |
Publications (2)
Publication Number | Publication Date |
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CN106380475A true CN106380475A (zh) | 2017-02-08 |
CN106380475B CN106380475B (zh) | 2018-03-09 |
Family
ID=57917440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201610742168.9A Active CN106380475B (zh) | 2016-08-26 | 2016-08-26 | 一种噻吩并[2,3‑d]嘧啶类化合物及其制备方法和应用 |
Country Status (1)
Country | Link |
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CN (1) | CN106380475B (zh) |
-
2016
- 2016-08-26 CN CN201610742168.9A patent/CN106380475B/zh active Active
Non-Patent Citations (3)
Title |
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XIN JIAN SONG等: "Facile synthesis of novel fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazole", 《CHINESE CHEMICAL LETTERS》 * |
高慧等: "4-(5-芳基-1,3,4-噻二唑-2-基硫代)-2-三氟甲基噻吩并[2,3-d]嘧啶的合成", 《湖北民族学院学报(自然科学版)》 * |
高慧等: "四氢苯并[4,5]噻吩并[2,3-d]嘧啶含氟衍生物的合成、晶体结构及抗肿瘤活性", 《精细化工》 * |
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CN106380475B (zh) | 2018-03-09 |
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Address after: 445000 No. 39 College Road, Enshi Tujia and Miao Autonomous Prefecture, Hubei Province Patentee after: HUBEI MINZU University Address before: 445000 No. 39 College Road, Enshi Tujia and Miao Autonomous Prefecture, Hubei Province Patentee before: Hubei Institute For Nationalities |
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Effective date of registration: 20211227 Address after: 430070 12499, 12th floor, Huagong science and technology industry building, 243 Luoyu Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Wuhan Bochuang blueprint Pharmaceutical Technology Co.,Ltd. Address before: 445000 No. 39 College Road, Enshi Tujia and Miao Autonomous Prefecture, Hubei Province Patentee before: HUBEI MINZU University |