CN106378217A - Micro-fluidic chip capable of producing two kinds of droplets including oil-water-oil droplets and water-oil-water droplets - Google Patents
Micro-fluidic chip capable of producing two kinds of droplets including oil-water-oil droplets and water-oil-water droplets Download PDFInfo
- Publication number
- CN106378217A CN106378217A CN201611110081.6A CN201611110081A CN106378217A CN 106378217 A CN106378217 A CN 106378217A CN 201611110081 A CN201611110081 A CN 201611110081A CN 106378217 A CN106378217 A CN 106378217A
- Authority
- CN
- China
- Prior art keywords
- hole
- oil
- water
- micro
- radius
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
Abstract
The invention relates to a micro-fluidic chip capable of producing two kinds of droplets including oil-water-oil droplets and water-oil-water droplets. The micro-fluidic chip comprises a first hydrophobic layer, a second hydrophobic layer, a first hydrophillic layer and a second hydrophillic layer; a first through hole, a second through hole, a third through hole and a fourth through hole penetrate through the surface of the first hydrophobic layer; a fifth through hole, a sixth through hole, a seventh through hole and an eighth through hole penetrate through the surface of the second hydrophobic layer; a first microchannel unit is formed in the left part of the upper surface of the second hydrophobic layer; a second microchannel unit is formed in the right part of the upper surface of the second hydrophobic layer; a ninth through hole, a tenth through hole, an eleventh through hole and a twelfth through hole penetrate through the surface of the first hydrophillic layer; and a cross channel is formed in the lower surface of the first hydrophillic layer. The micro-fluidic chip solves the problem that at present, no micro-fluidic chip integrating two or more materials can prepare both the oil-water-oil droplets and the water-oil-water droplets exists and is suitable for the fields of biological detection, drug screening, cell research, material synthesis and the like.
Description
Technical field
The present invention relates to micro-fluidic chip, specifically a kind of miniflow generating oil-water-You Heshui-two kinds of drops of oil-water
Control chip.
Background technology
Micro-fluidic chip is the sample preparation being related in the fields such as biological and chemical, separation, mixing, reaction and to detect
Integrated or be substantially integrated into one piece several square centimeters Deng basic operation unit（Even more little）Chip on, rely on chip on micro-pipe
The functional devices such as road, micro-valve, reservoir, microelectrode, micro- detecting element and adapter control fluid to run through whole system, in order to take
For a kind of technology platform of standard biologic or chemical laboratory various functions, laboratory on the piece that is therefore otherwise known as（lab-on-a-
chip）.Micro-fluidic chip can carry out function the sampling of normal experiment, dilution, concentration, mixing, separation, reaction and detection etc.
Integration, miniaturization, rapid and portability etc..
Drop micro-fluidic chip adopts discontinuous flow technology, generates highly monodispersed nanoliter level to a grade drop of ascending to heaven, and
Correlational study is carried out for unit with drop.Compare continuous stream micro-fluidic chip, drop micro-fluidic chip overcomes cross-contamination
Shortcoming, and efficiently quick Parallel testing and experiment are possibly realized, achievable high throughput testing.Drop micro-fluidic chip exists
The fields such as biological detection, drug screening, cell research and materials synthesis have wide application potential.
By the retrieval discovery to prior art, the preparation of water-oil-water and oil-two kinds of drops of water-oil all can be using double
T-shape structure（Okushima S et al, Langmuir 20:9905-9908）With double " ten " type structure（Abate AR et
al, Lab Chip 11:253-258）.The hydrophilic and hydrophobic property of the inner surface of chip has non-to the formation of drop and stably
Often important effect, the formation of water-oil drops needs the inner surface of chip to have hydrophobicity, and the formation of oil-water drop needs
The inner surface of chip has hydrophilic.Therefore, the first half preparing water-oil-water drop chip needs hydrophobic surface, and later half
Part needs water-wetted surface；The first half preparing oil-water-oil drops chip needs water-wetted surface, and latter half needs to dredge
Water surface.
Prepare water-oil-water at present and the chip of oil-two kinds of drops of water-oil typically adopts a kind of material, the table of homogenous material
Face hydrophobe property is fixing, and this is accomplished by, to its modifying surface, thus bringing following problem：First, surface modification
Process comparatively laborious, but also will in modifying process to do not need modification part protect.Second, changing through surface
As time goes on the surface hydrophobe property of property can slowly return to originally intrinsic hydrophobe property.Therefore, if sending out
Can either the preparing oil-water-oil drops and can prepare water-oil-water drop again of bright a kind of two or more material integrated
Micro-fluidic chip, then can effectively overcome the problems referred to above.But have no such a drop micro-fluidic chip at present.
Content of the invention
The present invention can either prepare oil-water-oil in order to solve to there is no at present a kind of two or more material integrated
Drop can prepare the problem of the micro-fluidic chip of water-oil-water drop again, there is provided one kind can generate oil-water-You Heshui-oil-
The micro-fluidic chip of two kinds of drops of water.
The present invention adopts the following technical scheme that realization：
The micro-fluidic chip of oil-water-You Heshui-two kinds of drops of oil-water can be generated, including the first hydrophobic layer, the second hydrophobic layer,
One hydrophilic layer, the second hydrophilic layer；
Wherein, the first hydrophobic layer, the second hydrophobic layer, the first hydrophilic layer, the second hydrophilic layer stack gradually together from top to bottom；
The surface insertion of the first hydrophobic layer offers first through hole, the second through hole, third through-hole, fourth hole；
The surface insertion of the second hydrophobic layer offers fifth hole, clematis stem hole, the 7th through hole, the 8th through hole；
The upper surface left part of the second hydrophobic layer offers the first micro-channel units；It is circular that described first micro-channel units include first
Shrinkage pool, rectangular channel, long straight channel；Rectangular channel is around the first circular shrinkage hole setting and convex in the middle part of the left side of rectangular channel
Go out and be formed with the second circular shrinkage hole；Long straight channel is connected with square crossing in the middle part of the right edge of rectangular channel；A left side for long straight channel
End is connected with the first circular shrinkage hole；The right-hand member of long straight channel is connected with fifth hole；
The upper surface right part of the second hydrophobic layer offers the second micro-channel units；Described second micro-channel units include U；
U is arranged around clematis stem hole, and the opening of U is towards a left side；Protrude in the middle part of the right edge of U and be formed with the 3rd
Circular shrinkage hole；The two ends of U are connected with the 7th through hole and the 8th through hole respectively；
Second circular shrinkage hole is located at the underface of first through hole；First circular shrinkage hole is located at the underface of the second through hole；Clematis stem
Hole position is in the underface of third through-hole；3rd circular shrinkage hole is located at the underface of fourth hole；
The surface insertion of the first hydrophilic layer offers the 9th through hole, the tenth through hole, the 11st through hole, the 12nd through hole；
The lower surface of the first hydrophilic layer offers crisscrossing channels；Four ends of crisscrossing channels respectively with the 9th through hole, the tenth lead to
Hole, the 11st through hole, the 12nd through hole connection；9th through hole is located at the underface of fifth hole；Tenth through hole is located at clematis stem
The underface in hole；11st through hole is located at the underface of the 7th through hole；Tenth two-way hole position is in the underface of the 8th through hole.
Specific work process includes：First, the forming process of oil-water-oil drops：Aqueous phase is successively through fourth hole, the 3rd circle
Shape shrinkage pool flow to U, is then divided into two through U：First flow to ten through the 7th through hole, the 11st through hole successively
Font passage, second flow to crisscrossing channels through the 8th through hole, the 12nd through hole successively.First via oil phase is successively through threeway
Hole, clematis stem hole, the tenth through hole flow to crisscrossing channels, then formation oil-water drop mixed with water.Oil-water drop is successively
It flow to long straight channel through the 9th through hole, fifth hole.Second road binders mutually leads to through first through hole, the second circular shrinkage hole, rectangle successively
Road flow to long straight channel, is then mixed to form oil-water-oil drops with oil-water drop.Oil-water-oil drops are circular through first successively
Shrinkage pool, the second through hole flow outwardly.2nd, the forming process of water-oil-water drop：Oil phase is recessed through first through hole, the second circle successively
Hole, rectangular channel flow to long straight channel.First via aqueous phase flow to long straight channel through the second through hole, the first circular shrinkage hole successively, so
It is mixed to form water-oil drops afterwards with oil phase.Water-oil drops flow to crisscrossing channels through fifth hole, the 9th through hole successively.Second
Road aqueous phase flow to U through fourth hole, the 3rd circular shrinkage hole successively, is then divided into two through U：First successively
It flow to crisscrossing channels through the 7th through hole, the 11st through hole, second flow to cross through the 8th through hole, the 12nd through hole successively
Passage.Second road aqueous phase and water-oil drops are mixed to form water-oil-water drop in crisscrossing channels.Water-oil-water drop is successively
Flow outwardly through the tenth through hole, clematis stem hole, third through-hole.
Based on said process, the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water of the present invention
By the brand new using integrated bi-material, oil-water-oil drops can not only be prepared, and water-oil-water can be prepared
Drop, thus effectively overcomes the various problems that surface modification is brought.
The present invention efficiently solve there is no at present a kind of two or more material integrated can either prepare oil-water-
Oil drops can prepare the problem of the micro-fluidic chip of water-oil-water drop again it is adaptable to biological detection, drug screening, cell are ground
Study carefully and the fields such as materials synthesis.
Brief description
Fig. 1 is the structural representation of the first hydrophobic layer in the present invention.
Fig. 2 is the structural representation of the second hydrophobic layer in the present invention.
Fig. 3 is the structural representation of the first hydrophilic layer in the present invention.
In figure：1- first hydrophobic layer, 2- second hydrophobic layer, 3- first hydrophilic layer, 4- second hydrophilic layer, 101- first leads to
Hole, 102- second through hole, 103- third through-hole, 104- fourth hole, 201- fifth hole, 202- clematis stem hole, 203- the 7th
Through hole, 204- the 8th through hole, 205- first circular shrinkage hole, 206- rectangular channel, the long straight channel of 207-, 208- second is circular recessed
Hole, 209-U shape passage, 210- the 3rd circular shrinkage hole, 301- the 9th through hole, 302- the tenth through hole, 303- the 11st through hole, 304-
12nd through hole, 305- crisscrossing channels.
Specific embodiment
The micro-fluidic chip of oil-water-You Heshui-two kinds of drops of oil-water can be generated, hydrophobic including the first hydrophobic layer 1, second
Layer the 2, first hydrophilic layer 3, the second hydrophilic layer 4；
Wherein, the first hydrophobic layer 1, the second hydrophobic layer 2, the first hydrophilic layer 3, the second hydrophilic layer 4 are sequentially laminated on one from top to bottom
Rise；
The surface insertion of the first hydrophobic layer 1 offers first through hole 101, the second through hole 102, third through-hole 103, fourth hole
104；
The surface insertion of the second hydrophobic layer 2 offers fifth hole 201, clematis stem hole 202, the 7th through hole 203, the 8th through hole
204；
The upper surface left part of the second hydrophobic layer 2 offers the first micro-channel units；Described first micro-channel units include the first circle
Shape shrinkage pool 205, rectangular channel 206, long straight channel 207；Rectangular channel 206 is arranged around the first circular shrinkage hole 205, and rectangle leads to
Protrude in the middle part of the left side in road 206 and be formed with the second circular shrinkage hole 208；In the right edge of long straight channel 207 and rectangular channel 206
Portion's square crossing connection；The left end of long straight channel 207 is connected with the first circular shrinkage hole 205；The right-hand member and the 5th of long straight channel 207
Through hole 201 connects；
The upper surface right part of the second hydrophobic layer 2 offers the second micro-channel units；Described second micro-channel units include U
209；U 209 is arranged around clematis stem hole 202, and the opening of U 209 is towards a left side；In the right edge of U 209
Portion protrudes and is formed with the 3rd circular shrinkage hole 210；The two ends of U 209 are connected with the 7th through hole 203 and the 8th through hole 204 respectively
Logical；
Second circular shrinkage hole 208 is located at the underface of first through hole 101；First circular shrinkage hole 205 is just being located at the second through hole 102
Lower section；Clematis stem hole 202 is located at the underface of third through-hole 103；3rd circular shrinkage hole 210 be located at fourth hole 104 just under
Side；
The surface insertion of the first hydrophilic layer 3 offers the 9th through hole 301, the tenth through hole 302, the 11st through hole 303, the tenth two-way
Hole 304；
The lower surface of the first hydrophilic layer 3 offers crisscrossing channels 305；Four ends of crisscrossing channels 305 respectively with the 9th through hole
301st, the tenth through hole 302, the 11st through hole 303, the 12nd through hole 304 connect；9th through hole 301 is located at fifth hole 201
Underface；Tenth through hole 302 is located at the underface in clematis stem hole 202；11st through hole 303 be located at the 7th through hole 203 just under
Side；12nd through hole 304 is located at the underface of the 8th through hole 204.
Described first hydrophobic layer 1, the second hydrophobic layer 2 are all made using polydimethylsiloxane；Described first hydrophilic layer 3,
Second hydrophilic layer 4 is all made using glass.
Described rectangular channel 206, U 209 are all with fillet.
Described first through hole 101, the second through hole 102, third through-hole 103, fourth hole 104, fifth hole the 201, the 6th
Through hole 202, the 7th through hole 203, the 8th through hole 204, the 9th through hole 301, the tenth through hole 302, the 11st through hole the 303, the 12nd
Through hole 304 is manhole.
The thickness of described first hydrophobic layer 1, the thickness of the second hydrophobic layer 2, the thickness of the first hydrophilic layer 3, the second hydrophilic layer 4
Thickness be 2mm；The width of described rectangular channel 206, the width of long straight channel 207, the width of U 209, cross
The width of passage 305 is 0.2mm.
The radius of described fillet is 0.5mm.
The radius of described first circular shrinkage hole 205, the radius of the second circular shrinkage hole 208, the radius of the 3rd circular shrinkage hole 210
It is 0.2mm.
The radius of described first through hole 101, the radius of the second through hole 102, the radius of third through-hole 103, fourth hole 104
Radius be 0.5mm；The radius of described fifth hole 201, the radius in clematis stem hole 202, the radius of the 7th through hole 203,
The radius of eight through holes 204, the radius of the 9th through hole 301, the radius of the tenth through hole 302, the radius of the 11st through hole 303, the tenth
The radius of two through holes 304 is 0.2mm.
The specific embodiment being only the present invention disclosed above, does not constitute limiting the scope of the invention, for this
For the those of ordinary skill of technical field that the present invention belongs to, under the premise of the general idea without departing from the present invention, according to the present invention
What technical scheme was made needs not move through the variations and alternatives of creative work, all should fall within the scope and spirit of the invention.
Claims (8)
1. a kind of micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water it is characterised in that：Dredge including first
Water layer（1）, the second hydrophobic layer（2）, the first hydrophilic layer（3）, the second hydrophilic layer（4）；
Wherein, the first hydrophobic layer（1）, the second hydrophobic layer（2）, the first hydrophilic layer（3）, the second hydrophilic layer（4）From top to bottom successively
Stacked together；
First hydrophobic layer（1）Surface insertion offer first through hole（101）, the second through hole（102）, third through-hole（103）,
Four through holes（104）；
Second hydrophobic layer（2）Surface insertion offer fifth hole（201）, clematis stem hole（202）, the 7th through hole（203）,
Eight through holes（204）；
Second hydrophobic layer（2）Upper surface left part offer the first micro-channel units；Described first micro-channel units include first
Circular shrinkage hole（205）, rectangular channel（206）, long straight channel（207）；Rectangular channel（206）Around the first circular shrinkage hole（205）
Setting, and rectangular channel（206）Left side in the middle part of protrude be formed with the second circular shrinkage hole（208）；Long straight channel（207）With square
Shape passage（206）Right edge in the middle part of square crossing connection；Long straight channel（207）Left end and the first circular shrinkage hole（205）Even
Logical；Long straight channel（207）Right-hand member and fifth hole（201）Connection；
Second hydrophobic layer（2）Upper surface right part offer the second micro-channel units；Described second micro-channel units include U-shaped and lead to
Road（209）；U（209）Around clematis stem hole（202）Setting, and U（209）Opening towards a left side；U
（209）Right edge in the middle part of protrude be formed with the 3rd circular shrinkage hole（210）；U（209）Two ends respectively with the 7th through hole
（203）With the 8th through hole（204）Connection；
Second circular shrinkage hole（208）Positioned at first through hole（101）Underface；First circular shrinkage hole（205）Positioned at the second through hole
（102）Underface；Clematis stem hole（202）Positioned at third through-hole（103）Underface；3rd circular shrinkage hole（210）Positioned at
Four through holes（104）Underface；
First hydrophilic layer（3）Surface insertion offer the 9th through hole（301）, the tenth through hole（302）, the 11st through hole（303）、
12nd through hole（304）；
First hydrophilic layer（3）Lower surface offer crisscrossing channels（305）；Crisscrossing channels（305）Four ends respectively with
Nine through holes（301）, the tenth through hole（302）, the 11st through hole（303）, the 12nd through hole（304）Connection；9th through hole（301）Position
In fifth hole（201）Underface；Tenth through hole（302）Positioned at clematis stem hole（202）Underface；11st through hole
（303）Positioned at the 7th through hole（203）Underface；12nd through hole（304）Positioned at the 8th through hole（204）Underface.
2. the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water according to claim 1, its feature
It is：Described first hydrophobic layer（1）, the second hydrophobic layer（2）All made using polydimethylsiloxane；Described first hydrophilic layer
（3）, the second hydrophilic layer（4）All made using glass.
3. the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water according to claim 1, its feature
It is：Described rectangular channel（206）, U（209）All with fillet.
4. the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water according to claim 1, its feature
It is：Described first through hole（101）, the second through hole（102）, third through-hole（103）, fourth hole（104）, fifth hole
（201）, clematis stem hole（202）, the 7th through hole（203）, the 8th through hole（204）, the 9th through hole（301）, the tenth through hole（302）、
11st through hole（303）, the 12nd through hole（304）It is manhole.
5. the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water according to claim 1, its feature
It is：Described first hydrophobic layer（1）Thickness, the second hydrophobic layer（2）Thickness, the first hydrophilic layer（3）Thickness, second hydrophilic
Layer（4）Thickness be 2mm；Described rectangular channel（206）Width, long straight channel（207）Width, U（209）'s
Width, crisscrossing channels（305）Width be 0.2mm.
6. the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water according to claim 3, its feature
It is：The radius of described fillet is 0.5mm.
7. the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water according to claim 1, its feature
It is：Described first circular shrinkage hole（205）Radius, the second circular shrinkage hole（208）Radius, the 3rd circular shrinkage hole（210）'s
Radius is 0.2mm.
8. the micro-fluidic chip generating oil-water-You Heshui-two kinds of drops of oil-water according to claim 4, its feature
It is：Described first through hole（101）Radius, the second through hole（102）Radius, third through-hole（103）Radius, fourth hole
（104）Radius be 0.5mm；Described fifth hole（201）Radius, clematis stem hole（202）Radius, the 7th through hole
（203）Radius, the 8th through hole（204）Radius, the 9th through hole（301）Radius, the tenth through hole（302）Radius, the tenth
One through hole（303）Radius, the 12nd through hole（304）Radius be 0.2mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110081.6A CN106378217B (en) | 2016-12-06 | 2016-12-06 | The micro-fluidic chip of profit oil and two kinds of drops of water profit can be generated |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110081.6A CN106378217B (en) | 2016-12-06 | 2016-12-06 | The micro-fluidic chip of profit oil and two kinds of drops of water profit can be generated |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106378217A true CN106378217A (en) | 2017-02-08 |
| CN106378217B CN106378217B (en) | 2018-04-06 |
Family
ID=57960115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611110081.6A Expired - Fee Related CN106378217B (en) | 2016-12-06 | 2016-12-06 | The micro-fluidic chip of profit oil and two kinds of drops of water profit can be generated |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106378217B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106824313A (en) * | 2017-02-23 | 2017-06-13 | 中国科学院上海微系统与信息技术研究所 | A kind of digital pcr chip and preparation method thereof |
| CN109746063A (en) * | 2017-11-06 | 2019-05-14 | 北京新羿生物科技有限公司 | Microlayer model detection system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921481A (en) * | 2012-10-31 | 2013-02-13 | 太原理工大学 | Microfluid array device |
| CN103386333A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic liquid drop production chip |
| CN104084247A (en) * | 2014-06-30 | 2014-10-08 | 北京工业大学 | Elastic wall surface micro-fluidic chip based on T-shaped micro-channel |
| CN105214746A (en) * | 2015-10-28 | 2016-01-06 | 北京工业大学 | The micro-fluidic chip that channel side wall assigned address is movable |
| US20160223464A1 (en) * | 2015-02-03 | 2016-08-04 | Hitech Analytical And Diagnostic Solutions, Llc | Micro-fluidic chip to perform surface plasmon resonance assays |
-
2016
- 2016-12-06 CN CN201611110081.6A patent/CN106378217B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102921481A (en) * | 2012-10-31 | 2013-02-13 | 太原理工大学 | Microfluid array device |
| CN103386333A (en) * | 2013-08-07 | 2013-11-13 | 苏州扬清芯片科技有限公司 | Micro-fluidic liquid drop production chip |
| CN104084247A (en) * | 2014-06-30 | 2014-10-08 | 北京工业大学 | Elastic wall surface micro-fluidic chip based on T-shaped micro-channel |
| US20160223464A1 (en) * | 2015-02-03 | 2016-08-04 | Hitech Analytical And Diagnostic Solutions, Llc | Micro-fluidic chip to perform surface plasmon resonance assays |
| CN105214746A (en) * | 2015-10-28 | 2016-01-06 | 北京工业大学 | The micro-fluidic chip that channel side wall assigned address is movable |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106824313A (en) * | 2017-02-23 | 2017-06-13 | 中国科学院上海微系统与信息技术研究所 | A kind of digital pcr chip and preparation method thereof |
| CN109746063A (en) * | 2017-11-06 | 2019-05-14 | 北京新羿生物科技有限公司 | Microlayer model detection system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106378217B (en) | 2018-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Xu et al. | Review of microfluidic liquid–liquid extractors | |
| EP3227023B1 (en) | Method for producing drops | |
| CN101498630B (en) | Sample pretreatment integrated chip | |
| CN107583692B (en) | Liquid drop micro-fluidic chip and preparation method thereof | |
| EP2283924B1 (en) | Inlet unit with means supporting liquid entrance into a microchannel structure | |
| DE10352535A1 (en) | A microstructured separator and method of separating liquid components from a liquid containing particles | |
| Angelescu et al. | Microfluidic capillary separation and real-time spectroscopic analysis of specific components from multiphase mixtures | |
| CN209287355U (en) | Micro-fluidic chip and device containing the micro-fluidic chip | |
| WO2004103565A2 (en) | Device and method for structuring liquids and for dosing reaction liquids into liquid compartments immersed in a separation medium | |
| CN105498875A (en) | Centrifugal micro-fluidic chip for preparing liquid drops | |
| Santos et al. | Microfluidics for pharmaceutical applications: from nano/micro systems fabrication to controlled drug delivery | |
| CN106215988B (en) | A kind of double branch roads realize the microchannel of microlayer model splitting function twice | |
| CN106378217B (en) | The micro-fluidic chip of profit oil and two kinds of drops of water profit can be generated | |
| CN207614861U (en) | Microlayer model generating means | |
| CN111330660B (en) | Centrifugal high-flux micro-droplet preparation chip | |
| DE112017004280T5 (en) | Microfluidic chip with bead integration system | |
| CN105854347A (en) | Circumferential array type micro-fluid extraction device | |
| CN105214546A (en) | A kind of concussion jetting type micro-mixer based on Pulsating Flow | |
| CN105854963A (en) | Micro-channel structure and micro-fluid chip for achieving two-dimensional fluid power accumulation by using single-way sheath liquid | |
| CN106669513B (en) | The method that concentration gradient generating means and a step generate concentration gradient | |
| CN107999153A (en) | A kind of level Four is successively decreased spacing polycylindser array structure microchannel lautertuns | |
| CN210022179U (en) | High-efficient extraction integrated device that mixes | |
| DE60007285T2 (en) | CAPILLARY LIQUID TRANSFER DEVICE INSIDE | |
| Du et al. | Liquid-based stationary phase for deterministic lateral displacement separation in microfluidics | |
| CN211837957U (en) | Chip and kit for preparing emulsion droplets |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180406 Termination date: 20211206 |