CN106366186A - 识别hpv16阳性肿瘤细胞的单克隆抗体及其应用 - Google Patents
识别hpv16阳性肿瘤细胞的单克隆抗体及其应用 Download PDFInfo
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Abstract
Description
最初的残基 | 代表性的取代 | 优选的取代 |
Ala(A) | Val;Leu;Ile | Val |
Arg(R) | Lys;Gln;Asn | Lys |
Asn(N) | Gln;His;Lys;Arg | Gln |
Asp(D) | Glu | Glu |
Cys(C) | Ser | Ser |
Gln(Q) | Asn | Asn |
Glu(E) | Asp | Asp |
Gly(G) | Pro;Ala | Ala |
His(H) | Asn;Gln;Lys;Arg | Arg |
Ile(I) | Leu;Val;Met;Ala;Phe | Leu |
Leu(L) | Ile;Val;Met;Ala;Phe | Ile |
Lys(K) | Arg;Gln;Asn | Arg |
Met(M) | Leu;Phe;Ile | Leu |
Phe(F) | Leu;Val;Ile;Ala;Tyr | Leu |
Pro(P) | Ala | Ala |
Ser(S) | Thr | Thr |
Thr(T) | Ser | Ser |
Trp(W) | Tyr;Phe | Tyr |
Tyr(Y) | Trp;Phe;Thr;Ser | Phe |
Val(V) | Ile;Leu;Met;Phe;Ala | Leu |
Claims (16)
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Cited By (4)
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CN109021097A (zh) * | 2017-06-08 | 2018-12-18 | 艾托金生物医药(苏州)有限公司 | 一种识别hpv18和/或hpv45的单克隆抗体及其应用 |
CN110196332A (zh) * | 2019-05-22 | 2019-09-03 | 艾托金生物医药(苏州)有限公司 | 一种检测多亚型hpv e7蛋白的方法及其应用 |
CN111217905A (zh) * | 2019-11-18 | 2020-06-02 | 安徽环球基因科技有限公司 | 一种重组兔单克隆抗体的制备方法 |
WO2023184862A1 (zh) * | 2022-03-29 | 2023-10-05 | 深圳吉诺因生物科技有限公司 | Hpv抗原表位及其鉴定方法、应用 |
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CA1324331C (en) * | 1987-07-11 | 1993-11-16 | Tilman Oltersdorf | Monoclonal antibodies against e7 protein of human type 16 papillomavirus, a process for their preparation, and their use |
EP2357197A1 (en) * | 2010-02-16 | 2011-08-17 | Österreichische Akademie der Wissenschaften | Anti-HPV E7 antibodies |
CN102443060A (zh) * | 2010-10-13 | 2012-05-09 | 上海泽润生物科技有限公司 | 一种抗hpv的抗体、其制备方法和应用 |
CN103130890A (zh) * | 2011-11-28 | 2013-06-05 | 常小迦 | Hpv16e7单克隆抗体、相关杂交瘤细胞株和应用 |
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2015
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CA1324331C (en) * | 1987-07-11 | 1993-11-16 | Tilman Oltersdorf | Monoclonal antibodies against e7 protein of human type 16 papillomavirus, a process for their preparation, and their use |
EP2357197A1 (en) * | 2010-02-16 | 2011-08-17 | Österreichische Akademie der Wissenschaften | Anti-HPV E7 antibodies |
CN102443060A (zh) * | 2010-10-13 | 2012-05-09 | 上海泽润生物科技有限公司 | 一种抗hpv的抗体、其制备方法和应用 |
CN103130890A (zh) * | 2011-11-28 | 2013-06-05 | 常小迦 | Hpv16e7单克隆抗体、相关杂交瘤细胞株和应用 |
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CN109021097A (zh) * | 2017-06-08 | 2018-12-18 | 艾托金生物医药(苏州)有限公司 | 一种识别hpv18和/或hpv45的单克隆抗体及其应用 |
CN110196332A (zh) * | 2019-05-22 | 2019-09-03 | 艾托金生物医药(苏州)有限公司 | 一种检测多亚型hpv e7蛋白的方法及其应用 |
CN111217905A (zh) * | 2019-11-18 | 2020-06-02 | 安徽环球基因科技有限公司 | 一种重组兔单克隆抗体的制备方法 |
WO2023184862A1 (zh) * | 2022-03-29 | 2023-10-05 | 深圳吉诺因生物科技有限公司 | Hpv抗原表位及其鉴定方法、应用 |
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