CN106344608A - Applications of ozonized oil in dairy stock culture - Google Patents
Applications of ozonized oil in dairy stock culture Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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Abstract
The invention relates to applications of ozonized oil in prevention and treatment of dairy stock diseases as well as combined medication of medicines for treating dairy stock diseases. The invention particularly relates to applications of ozonized oil in prevention and treatment of endometritis, mastitis and placental retention of dairy stock by virtue of administration routes, such as breast and uterus perfusion.
Description
Technical field
The invention belongs to veterinary drug technical field, be related to ozone carburetion alone or in combination medication be used in dairy stock cultivation prevention and
Treatment disease.Specifically related to ozone carburetion prevents and treats dairy stock endometrium by the route of administration of breast and uterine perfusion etc.
Inflammation, mastitiss, placenta retention.
Background technology
Velio bocci outlines in " ozone therapy " book and can play many using the ozone gas of low dosage
Beneficial functions, and have no side effect, i.e. ozone therapy (" the oxygen-ozone therapy " writing see velio bocci, Beijing
University Hospital publishing house, 2004).Ozone therapy can be realized by multiple route of administration, and produces not for various disease
Same effect.Ozone carburetion external is used for the treating for skin disease medicine such as decubital ulcer and ulcer as antibacterial, deodorizer.Therefore,
Know that ozone has oxidation and antibacterial action.Direct for ozone carburetion gavage is used for controlling of the gastritis that helicobacter pylori causes
Treat.Muscle or subcutaneous injection ozone gas are treating slow viruss hepatitis and vascular conditions.Vagina is passed directly into ozone gas
Inflammation and bacterium infection can be cured.Ozone gas are directly mixed in vitro with the blood of certain volume, then feed back to patient
It is referred to as autologous hemotherapy, human internal environment can be nursed one's health, reduce sensitivity and the enhancing human body immunity power of body.Rectum is direct
Blowing ozone's gas can improve Parkinsonian symptom (see lamberto re, mohamed n. mawsouf, silvia
Menendez, olga s. leon, gregorio m. the sanchez, " ozone that and frank hernandez writes
Therapy:clinical and basic evidence of its therapeutic potential ", archives
Of medical research, 2008,39:17-26).Abdominal cavity can cardioprotection obstruct from Acute myocardial to ozone gas
Damage (clara di filippo, margherita luongo, the raffaele marfella, franca of plug
Ferraraccio, biagio lettieri, annalisa capuano, francesco rossi, michele d'
" the oxygen/ozone protects the heart from acute myocardial infarction that amico writes
through local increase of enos activity and endothelial progenitor cells
Recruitment ", naunyn-schmied arch pharmacol, 2010,382:287 291).From structure, although
Ozone carburetion and ozone gas (: o-o-o) it is not same substance, but ozone carburetion is by obtaining to oily addition ozone,
Therefore there is ozonide structure in the molecule thereof, the functional similarity with ozone gas.Any of the above route of administration all shows ozone
Directly can be absorbed by organisms in the way of gas and function.The function of ozone gas may by three below approach Lai
Realize: (1), ozone pass through biochemical reaction in vivo, generate material (the hydroxyl radical free radical oh of similar active oxygen-, super oxygen cloudy
Ion o2 -Deng), extensively affect body oxidation-reduction system；(2), ozone can cause endothelial progenitor cells to assemble and promote an oxygen
Change the generation of nitrogen (no), play vasodilatory effect；(3), ozone can inducing bone marrow stem cell to vascular injury site, promote
Enter injured blood vessel reconstruction, but concrete mechanism is still not clear.
There is many defects in above-mentioned route of administration: contact with too many material on the way it is difficult to ensure that gas enters having of body
Effect concentration.If giving the excessive body that easily induces to produce uncomfortable reaction, and operating process being loaded down with trivial details, along with the course for the treatment of is longer, patient
Difficult to accept.Especially autologous hemotherapy, 2～3 times weekly, continuous 10 weeks be a course for the treatment of.The present invention is with oil and ozone addition
Mode, obtains ozone carburetion.Also can preserve steadily in the long term under normal conditions；Fixing quantity ozone carburetion can also enter body, thus
Avoid being administered by other administering modes, artificially cause dose improper.
In ozonisation oil product, ozonisation olive oil, sunflower oil, soybean oil are used for decubital ulcer as antibacterial, deodorizer
List with the topical drug of the treating for skin disease such as ulcer.But ozone carburetion is given by the form of uterus and breast perfusion
Medicine and produce effect, there is no report at present.In the present invention, ozone carburetion pass through lumbar injection, intravenous injection, subcutaneous injection,
The mode of intramuscular injection and suppository is it is also possible to produce medicine effect.
Ozone is widely present in common air, has multiple biological activities, such as: cardiovascular protective effect, antioxidation
Effect, uvioresistant and radiation resistance, antimutagenic and antitumaous effect, antibacterial action, antivirus action, immunoregulation effect etc..
All have a wide range of applications in the field such as medication chemistry and food.
Content of the invention
The purpose of the present invention is to prevent and treat dairy stock endometritis, mastitiss, placenta retention using ozone carburetion,
Prepare easy, with low cost.Verify by clinic application, the present invention has evident in efficacy, and dosage is low, has no toxic side effect, effective percentage
High the advantages of.
In the present invention, why select one of various oil described in claim 1,2, two kinds and two or more,
It is because that these oily unsaturated fatty acid contents are higher, wherein the unsaturated fatty acid of walnut oil up to more than 92%, in unsaturation
At least one olefinic double bond in fatty acid structure.If by one of claim 1,2, two kinds and two or more containing insatiable hunger
One of the oil high with fatty acid and claim 3～7, two kinds and two or more surfactants mix, also can with smelly
There is additive reaction in oxygen.As long as it can be seen that there is alkene unsaturated bond in the structure of addition product with ozone, additive reaction can occur,
Unsaturated bond number is more, and reaction is more susceptible to, and more with the amount of ozone addition, and addition product can carry ozone molecule
Number is also more.
For reaching above-mentioned purpose, the technical solution used in the present invention will be carried out with reference to following Making programme and embodiment
Simple illustration.
1st, ozone gas are prepared.
2nd, prepare ozone carburetion.
3rd, prepare ozonisation olive oil.
4th, the ozone carburetion containing surfactant for the preparation.
5th, the clinical effectiveness of cow endometritis treated by ozonisation olive oil.
6th, the clinical effectiveness of mammitis of cow treated by ozonisation olive oil.
7th, the clinical effectiveness of milk goat clinic mastitis treated by ozonisation olive oil.
8th, the clinical effectiveness of milch cow placenta retention treated by ozonisation olive oil.
Specific embodiment
Following non-limiting examples are used for the present invention is described.
The preparation of embodiment 1 ozonisation olive oil
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, the whole process preparing ozone carburetion need be carried out at 20～25 DEG C it is ensured that ozone carburetion will not occur pyrolysis anti-
Should.
3rd, olive oil 3kg inserts in reactor；Ozone is with 150m3/ h flow velocity adds, and total reaction time is 20 hours.Reaction
After end, residual air inactivates.
4th, obtaining ozonisation Fructus Canarii albi oil concentration is 40 mg/l, and 25 DEG C can stably preserve ten months.
The preparation of embodiment 2 ozonisation olive oil, soybean oil and Oleum Arachidis hypogaeae semen miscella
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, prepare ozone carburetion whole process to carry out at 20～25 DEG C it is ensured that ozone carburetion will not occur pyrolysis anti-
Should.
3rd, olive oil 1kg, soybean oil 1kg and Oleum Arachidis hypogaeae semen 1kg insert in reactor；Ozone is with 150m3/ h flow velocity adds, always
Response time is 20 hours.After reaction terminates, residual air inactivates.
4th, obtaining ozonisation miscella concentration is 40mg/l, and 25 DEG C can stably preserve ten months.
Embodiment 3 contains the preparation of the ozonisation olive oil of surfactant
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, prepare ozone carburetion whole process to carry out at 20～25 DEG C it is ensured that ozone carburetion will not occur pyrolysis anti-
Should.
3rd, olive oil 3kg inserts in reactor, is slowly added to sorbitan monooleate polyoxyethylene ether (Tween 80)
20ml, mixes, ozone is with 150m3/ h flow velocity adds, and total reaction time is 20 hours.After reaction terminates, residual air inactivates.
4th, obtaining ozonisation Fructus Canarii albi oil concentration is 40 mg/l, and 25 DEG C can stably preserve ten months.
Embodiment 4 contains the ozonisation olive oil preparation of surfactant and cosurfactant
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, prepare ozone carburetion whole process to carry out at 20～25 DEG C it is ensured that ozone carburetion will not occur pyrolysis anti-
Should.
3rd, olive oil 3kg inserts in reactor, is slowly added to sorbitan monooleate polyoxyethylene ether (Tween 80)
20ml and straight alcohol 20ml, mixes, ozone is with 150m3/ h flow velocity adds, and total reaction time is 20 hours.After reaction terminates, remaining
Gas inactivates.
4th, obtaining ozonisation Fructus Canarii albi oil concentration is 40 mg/l, and 25 DEG C can stably preserve ten months.
The clinical effectiveness of embodiment 5 ozonisation olive oil treatment cow endometritis:
Experimental animal
In Yang Ling dairy cow farm 3～5 age, through milking cow, body weight about 700～850kg, is to suffer from milk through clinical diagnosises to 3～5 tires
Cattle endometritis milch cow 50.
Experimental drug
The ozonisation olive oil obtaining in the embodiment of the present invention 1；Oxytetracycline is purchased from Tianjin Xuan Yao bio tech ltd.Medication
Amount 40ml-50ml, waits warm uterine perfusion, and once a day, 3d is a course for the treatment of.
Diagnostic criteria
Vagina has moderate inflammation, hyperemia, has a small amount of floccule or purulent secretion, ectocervical swelling, hyperemia.Rectum
Check, accessible cornua uteri increases thick, Uterus wall became uneven, hydrops and have fluctuation in uterine cavity.
Therapeutic effect criterion:
Cure: after successive administration 3 times, intrauterine hydrops is excluded substantially, uterus recovers normal, neck liquid is changed into transparent and no from muddiness
Stink;It is seen that no rheuminess thing at vagina and opening of the cervix during examination per vagina;During non-heat, opening of the cervix is closed and in pink
Color.Examination per rectum uterine contraction, size and quality recover normal；Stopping treatment recovering normal heat in latter 30 days and can manually award
Essence.
Effective: after successive administration 3 times, the inviscid or viscous purulent secretion of vaginal orifice is discharged, check vagina it's too late opening of the cervix no
Rheuminess thing;Examination per rectum uterine contraction, size and quality return to normal;Stop treating in latter 30 days, just do not recover
Often heat, or recover heat but neck liquid is still not limpid or poor toughness is it is impossible to carry out artificial insemination.
Invalid: after successive administration 3 times, clinical symptoms are not improved, substantially, intrauterine hydrops is not arranged for palpation pain and swelling
Go out, and neck liquid still muddiness.
Result:
The clinical effectiveness of cow endometritis treated by table 1 ozonisation olive oil
| Group | Ill cattle (head) | Cure head number (%) | Effectively head number (%) | Invalid head number (%) | Total effective rate head (%) |
| Ozonisation olive oil | 25 | 20(80%) | 4(16%) | 1(4%) | 96% |
| Oxytetracycline | 25 | 15(60%) | 6(24%) | 4(16%) | 84% |
Result shows: compared with oxytetracycline group, ozonisation olive oil filling agent can effectively treatment cow endometritis, treatment has
Efficiency reaches 96%, and up to 80%, effect is better than oxytetracycline group to cure rate.Above test result indicate that, in this treatment cow uteri
The scorching ozonisation olive oil infusion liquid of film has anti-inflammation, adjusts uterus function, improves local blood circulation, adjustment intrauterine
Environment, increase medicine and in uterus spread, permeate and the features such as Absorption, nonirritant, enhance immunity.
The clinical effectiveness of mammitis of cow treated by embodiment 6 ozonisation olive oil
The clinical test of pesticide effectiveness:
1 test method
1.1 test milch cows: test of cure Yang Ling periphery cattle farm occurs acute, subacute and latent mammitises 120 cases
(taking ill breast district as a example), different degrees of red and swollen heat pain in acute, subacute mastitiss ill breast district, and milk is thin, send out
Yellow, grumeleuse or pus occur, milk yield is decreased obviously.Detected, will be examined using " California, USA mastitiss test (cmt) " method
Survey the cattle that suffers from that result is " ++ " or more and list latent mammitises test in.
1.2 Therapeutic Method: 120 cases, it is divided into test group and matched group, cleans breast with disinfectant solution, disease breast is squeezed net,
With 75% alcohol swab sterilization nipple, by papillary duct injection of medicine, massage cream area a moment, 3 days courses for the treatment of, observation and treatment are imitated
Really.Test group 90, the ozonisation olive oil using embodiment 1 irrigates breast, once a day, each loml;Matched group 30,
Using lactogenic spirit injectant (ammonia section XiLin sodium, cloxacillin sodium breast injection, norbrook company of Britain produce), daily 2
Secondary, each 5.og.
1.3 Outcome measure: carry out bacteriology checking before and after treatment, itemized record illness milch cow pathology table in therapeutic process
Existing, and judge curative effect of medication by following standards:
Recovery from illness: breast is red, swollen, hot, pain disappears, and milk perusal is normal, and milk production is gone up, and pathogen is turned out cloudy.
Clinical cure: breast is red, swollen, hot, pain disappears, and milk perusal is normal, and milk production is gone up, but pathogen is not complete
Entirely turn out cloudy.
Effective: breast is red, swollen, hot, alleviation of pain light, perusal milk character is taken on a new look or is tended to normal, and milk production has been returned
Rise.
Invalid: breast is red, swollen, hot, bitterly do not have remarkable improvement or more serious, milk abnormal, and milk production declines.
Latent mammitises judge criterion of cure: strong positive (+++) or positive (++) switch to negative (-) or suspicious (±).Have
Effect: strong positive (+++) or positive (++) switch to weakly positive (+).Invalid: unchanged after medication.
2 therapeutic outcomes
Table 1 test group and the matched group clinic test of pesticide effectiveness
| Result of the test | The breast perfusion preparation of embodiment 1 | Lactogenic spirit |
| Treatment case | 90 | 30 |
| Recovery from illness (example) | 80 | 10 |
| Clinical cure (example) | 8 | 9 |
| Effectively (example) | 2 | 5 |
| Invalid (example) | 0 | 6 |
| Cure rate (%) | 89% | 33% |
| Total clinical cure rate (%) | 98% | 63% |
The clinical effect trial result of table 1 shows, the ozonisation olive oil of the embodiment of the present invention 1 preparation irrigates breast and comparison medicine
Thing lactogenic spirit is compared, and clinical total cure rate and effective percentage are significantly higher.
3 conclusions
Test of pesticide effectiveness result illustrate, the embodiment of the present invention 1 preparation ozonisation olive oil perfusion breast treatment Gram-negative and
Positive microbial acute, subacute and latent mammitises effect is significant, cure rate is high, and easy to use and safety has preferably
Clinical value.
The clinical effectiveness of milk goat mastitiss treated by embodiment 7 ozonisation olive oil
For treating the test of milk goat clinic mastitis
Test method: Shaanxi Fuping Yang Chang, the milk goat choosing 50 clinic mastitis is tested, experimental group 25,
Matched group 25.Experimental group adopts ozonisation olive oil 1 times/day of the breast of perfusion of the embodiment of the present invention 1 preparation, each 5ml, connects
Continuous medication 1-10 days.Matched group gives dosage using enrofloxacin by sheep body weight, 2 times/day.
Judge criterion of cure: breast red, swollen, hot, pain symptoms disappear, milk perusal is normal, milk yield recovers, essence
God, appetite are normal；
Effective: breast red, swollen, hot, pain symptoms mitigate, milk floccule substantially disappears or significantly reduces, and milk yield is gone up;
Invalid: breast red, swollen, hot, pain symptoms no substantially mitigate, milk is thin or turns to be yellow, and flocculus is more apparent, and milk yield is not returned
Rise, general body state has no improvement.
Test effect:
After medication, 25 sick sheeps of experimental group cure 22, effective 2, and cure rate is 88%, and effective percentage is 96%;25 diseases of matched group
Sheep cures 14, is effectively 5, and cure rate is 56%, and effective percentage is 80%;It can be seen that, the present invention is to milk goat clinic mastitis
There is good therapeutical effect.
The clinical effectiveness of milch cow placenta retention treated by embodiment 8 ozonisation olive oil
The clinical test of pesticide effectiveness
1st, experimental animal
21 infected cattles of milch cow placenta retention are occurred as object of study with Yang Ling vaccary over 2 years, before test, infected cattle is carried out
Clinical examination, determines and is diagnosed as milch cow placenta retention disease.
2nd, test packet
Respectively 21 infected cattles are divided into 3 groups, every group 7.The ozonisation olive oil obtaining by the embodiment of the present invention 1, waits warm uterus
Perfusion, once a day, 3d is 1 course for the treatment of.Low dose group dosage 20ml of the present invention；Middle dose group dosage 40ml of the present invention;This
Bright high dose group dosage 60ml.Observe each group state of an illness treatment, and recorded.
3rd, result of the test
After each Testing Team is observed, result is as follows:
Low dose group: by carrying out low-dose drugs treatment to the milch cow of post-abortion placenta retention, after 48 hours, 7 cow heads are all incited somebody to action
Afterbirth is discharged.
Middle dose group: after the milch cow to post-abortion placenta retention carries out middle dosage Drug therapy, 7 milk after 48 hours
Afterbirth is all discharged by cattle.
High dose group: after the milch cow to post-abortion placenta retention carries out high dose medicament treatment, 7 milk after 48 hours
Cattle placenta is all discharged.
4th, conclusion and analysis
The ozonisation olive oil of the embodiment of the present invention 1 preparation, can reach the effect of clinical treatment milch cow placenta retention disease.This
Bright safe and reliable.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all essences in the present invention
Any modification, equivalent and improvement made within god and principle etc., should be included within the scope of the present invention.
Claims (8)
1. a kind of application in dairy stock cultivation for ozone carburetion is it is characterised in that oil is at least selected from olive oil, Oleum Glycines, sunflower seed
Oil, Semen Lini oil, Oleum Brassicae campestriss, Semen setariae oil, Semen Maydis oil, Fructus Maydis oil, Oleum sesami, Oleum Gossypii semen, Oleum Ricini, Oleum Arachidis hypogaeae semen, camellia oleosa seed
Oil, perilla oil, safflower oil, almond oil, hazelnut oil, walnut oil, pine-seed oil, shinyleaf yellowhorn oil, edible blend oil, cod-liver oil and fish
One of oil, by oily electrophilic addition ozone, the ozone carburetion obtaining adopts lumbar injection, intravenous injection, subcutaneous note
Penetrate, intramuscular injection, the mode of breast perfusion, uterine perfusion and suppository give, can be used in preparation prevention and treatment dairy stock uterus
Intimitiss, mastitiss, the medicine of placenta retention.
2. oil according to claim 1 is it is characterised in that carry out mixing two-by-two and two to the oil described in claim 1
Mixing kind to oil, by electrophilic addition ozone, the ozone carburetion obtaining adopt lumbar injection, intravenous injection, subcutaneous injection,
The mode of intramuscular injection, breast perfusion, uterine perfusion and suppository gives, and can be used in preparation prevention and treatment dairy stock endometrium
Inflammation, mastitiss, the medicine of placenta retention.
3. oil according to claims 1 to 2 is it is characterised in that pass through to select nonionic surfactant, anionic surface
One of activating agent and cationic surfactant, two kinds and two or more mixing, with the oil described in claim 1～2
Any one of mixing, by electrophilic addition ozone, obtain the ozone carburetion containing surfactant and adopt lumbar injection, vein
The mode of injection, subcutaneous injection, intramuscular injection, breast perfusion, uterine perfusion and suppository gives, and can be used in preparation prevention and controls
Treat dairy stock endometritis, mastitiss, the medicine of placenta retention.
4. surfactant according to claim 3 is it is characterised in that be selected from glycerol unsaturated fatty acid ester, polyglycereol
Unsaturated fatty acid ester, propylene glycol unsaturated fatty acid ester, sorbitan unsaturated fatty acid ester, polyoxyethylene sorbitol
Acid anhydride unsaturated fatty acid ester, polyoxyethylene unsaturated fatty acid ester, mannitol unsaturated fatty acid ester, tetramethylolmethane are unsaturated
Non- in fatty acid ester, sucrose unsaturated fatty acid ester, Polyethylene Glycol unsaturated alkyl ether and polypropylene glycol unsaturated alkyl ether
One of ionic surface active agent, two kinds and two or more.
5. surfactant according to claim 3 is it is characterised in that be selected from unsaturated fatty acid salt, unsaturated fatty acidss
In anion surfactant in alcohol sulfuric ester salt, alpha-sulfo unsaturated fatty acid ester, olefin sulphates and alkene sulfonate
One kind, two kinds and two or more.
6. surfactant according to claim 3 is it is characterised in that be selected from the monosubstituted trimethyl of unsaturated aliphatic hydrocarbyl moiety
Ammonium salt, unsaturated aliphatic hydrocarbyl moiety two substituted dimethyl ammonium salt, unsaturated aliphatic hydrocarbyl moiety monosubstituted dimethyl benzyl ammonium salt, unsaturation
Aliphatic group monosubstituted amine acylate, unsaturated aliphatic hydrocarbyl moiety two replacement amine acylate and n- methyl diethanolamine insatiable hunger
With one kind of the cationic surfactant in fatty acid ester hydrochlorate, two kinds and two or more.
7. surfactant according to claim 3 is it is characterised in that be selected from food stage petroleum ether, Polyethylene Glycol insatiable hunger
With alkyl ether, one kind of sorbitan monoesters polyoxyethylene ether surface active agent and two kinds.
8. any one according to claims 1 to 7 is made ozone carburetion and described any one route of administration, its
It is characterised by, this ozone carburetion can be with the medicine treating dairy stock endometritis, mastitiss, placenta retention by described approach
Thing drug combination prevents and treats dairy stock endometritis, mastitiss, placenta retention effectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610936261.3A CN106344608A (en) | 2016-11-01 | 2016-11-01 | Applications of ozonized oil in dairy stock culture |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103430797A (en) * | 2013-08-13 | 2013-12-11 | 陕西省微生物研究所 | Method for preventing and controlling fungal diseases of cucumbers |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103430797A (en) * | 2013-08-13 | 2013-12-11 | 陕西省微生物研究所 | Method for preventing and controlling fungal diseases of cucumbers |
Non-Patent Citations (1)
| Title |
|---|
| ZKHJYX: "医用臭氧在临床实践的应用", 《HTTPS://WWW.19LOU.COM/BOARD-123456802951210-THREAD-178501362742456211-1.HTML》 * |
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