CN106344607A - Applications of ozonized oil in treatment of nerve injuries - Google Patents
Applications of ozonized oil in treatment of nerve injuries Download PDFInfo
- Publication number
- CN106344607A CN106344607A CN201610935376.0A CN201610935376A CN106344607A CN 106344607 A CN106344607 A CN 106344607A CN 201610935376 A CN201610935376 A CN 201610935376A CN 106344607 A CN106344607 A CN 106344607A
- Authority
- CN
- China
- Prior art keywords
- oil
- ozone
- fatty acid
- injection
- acid ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to applications of ozonized oil in treatment of nerve injuries as well as combined medication of medicines for treating nerve injuries. The ozonized oil can be used for effectively preventing and treating various nerve injuries, mainly including optic nerve injury, spine nerve injury, oculomotor nerve injury and other cerebral nerve injuries by virtue of an oral administration route and modes of intraperitoneal injection, enema, gavage, intravenous injection, subcutaneous injection, intramuscular injection and suppository administration.
Description
Technical field
The invention belongs to pharmaceutical technology field and in particular to ozone carburetion be used for nerve injury treatment and with treatment nerve
The combination therapies damaging.
Background technology
Velio bocci outlines in " ozone therapy " book and can play many using the ozone gas of low dosage
Beneficial functions, and have no side effect, i.e. ozone therapy (" the oxygen-ozone therapy " writing see velio bocci, Beijing
University Hospital publishing house, 2004).Ozone therapy can be realized by multiple route of administration, and produces not for various disease
Same effect.Ozone carburetion external is used for the treating for skin disease medicine such as decubital ulcer and ulcer as antibacterial, deodorizer.Therefore,
Know that ozone has oxidation and antibacterial action.Direct for ozone carburetion gavage is used for controlling of the gastritis that helicobacter pylori causes
Treat.Muscle or subcutaneous injection ozone gas are treating slow viruss hepatitis and vascular conditions.Vagina is passed directly into ozone gas
Inflammation and bacterium infection can be cured.Ozone gas are directly mixed in vitro with the blood of certain volume, then feed back to patient
It is referred to as autologous hemotherapy, human internal environment can be nursed one's health, reduce sensitivity and the enhancing human body immunity power of body.Rectum is direct
Blowing ozone's gas can improve Parkinsonian symptom (see lamberto re, mohamed n. mawsouf, silvia
Menendez, olga s. leon, gregorio m. the sanchez, " ozone that and frank hernandez writes
Therapy:clinical and basic evidence of its therapeutic potential ", archives
Of medical research, 2008,39:17-26).Abdominal cavity can cardioprotection obstruct from Acute myocardial to ozone gas
Damage (clara di filippo, margherita luongo, the raffaele marfella, franca of plug
ferraraccio, biagio lettieri, annalisa capuano, francesco rossi, michele d'
" the oxygen/ozone protects the heart from acute myocardial infarction that amico writes
through local increase of enos activity and endothelial progenitor cells
Recruitment ", naunyn-schmied arch pharmacol, 2010,382:287 291).From structure, although
Ozone carburetion and ozone gas (: o-o-o) it is not same substance, but ozone carburetion is by obtaining to oily addition ozone,
Therefore there is ozonide structure in the molecule thereof, the functional similarity with ozone gas.Any of the above route of administration all shows ozone
Directly can be absorbed by organisms in the way of gas and function.The function of ozone gas may by three below approach Lai
Realize: (1), ozone pass through biochemical reaction in vivo, generate material (the hydroxyl radical free radical oh of similar active oxygen-, super oxygen cloudy
Ion o2 -Deng), extensively affect body oxidation-reduction system；(2), ozone can cause endothelial progenitor cells to assemble and promote an oxygen
Change the generation of nitrogen (no), play vasodilatory effect；(3), ozone can inducing bone marrow stem cell to vascular injury site, promote
Enter injured blood vessel reconstruction, but concrete mechanism is still not clear.
There is many defects in above-mentioned route of administration: contact with too many material on the way it is difficult to ensure that gas enters having of body
Effect concentration.If giving the excessive body that easily induces to produce uncomfortable reaction, and operating process being loaded down with trivial details, along with the course for the treatment of is longer, patient
Difficult to accept.Especially autologous hemotherapy, 2～3 times weekly, continuous 10 weeks be a course for the treatment of.The present invention is with oil and ozone addition
Mode, obtains ozone carburetion, then this oil is wrapped up with enteric coated capsule, can overcome the shortcomings directly using ozone gas.
Both ensured that ozone carburetion was not contacted with extraneous any material, also can preserve steadily in the long term under normal conditions；Can also fixing quantity ozone
Carburetion enters body, thus avoiding being administered by other administering modes, artificially causes dose improper.Ozone carburetion enteric coated capsule
Route of administration is directly to be administered orally, and body is injured minimum, operation is simple, is convenient for carrying, and has established good for its popularization
Basis.
In ozonisation oil product, ozonisation olive oil, sunflower oil, soybean oil are used for decubital ulcer as antibacterial, deodorizer
List with the topical drug of the treating for skin disease such as ulcer.But the form that ozone carburetion is made enteric coated capsule is passed through directly
Oral mode enters body and produces effect, there is no report at present.In the present invention, by ozone carburetion enteric is directly administered orally
Capsule, the mode of lumbar injection, coloclysis, gavage, intravenous injection, subcutaneous injection, intramuscular injection and suppository, medicine can be produced and make
With.
Content of the invention
The purpose of the present invention is to prevent and treat various nerve injury using ozonisation oil formulation and route of administration, preparation
Easy, with low cost.Verify by clinic application, the present invention has evident in efficacy, and oral dose is low, has no toxic side effect, effective percentage
High the advantages of.
In the present invention, why select one of various oil described in claim 1,2, two kinds and two or more,
It is because that these oily unsaturated fatty acid contents are higher, wherein the unsaturated fatty acid of walnut oil up to more than 92%, in unsaturation
At least one olefinic double bond in fatty acid structure.If by one of claim 1,2, two kinds and two or more containing insatiable hunger
One of the oil high with fatty acid and claim 3～7, two kinds and two or more surfactants mix, also can with smelly
There is additive reaction in oxygen.As long as it can be seen that there is alkene unsaturated bond in the structure of addition product with ozone, additive reaction can occur,
Unsaturated bond number is more, and reaction is more susceptible to, and more with the amount of ozone addition, and addition product can carry ozone molecule
Number is also more.
For reaching above-mentioned purpose, the technical solution used in the present invention will be carried out with reference to following Making programme and embodiment
Simple illustration.
1st, ozone gas are prepared.
2nd, prepare ozone carburetion.
3rd, prepare ozonisation olive oil enteric coated capsule.
4th, the ozone carburetion containing surfactant for the preparation.
5th, the ozone carburetion enteric coated capsule containing surfactant for the preparation.
6th, the Experiment on therapy that ozonisation Fructus Canarii albi oil capsule is hindered to optic nerve, spinal nerves damage, oculomotoriuss.
7th, the Experiment on therapy to other Cranial nerve injury as birth traumas for the ozonisation Fructus Canarii albi oil capsule.
Specific embodiment
With reference to embodiments the specific embodiment of the present invention is elaborated.
Prepared by embodiment 1 ozonisation olive oil enteric coated capsule
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, prepare ozone carburetion and ozone carburetion enteric coated capsule whole process need carry out at 20～25 DEG C it is ensured that ozonisation
Oil will not occur pyrolytic reaction.
3rd, olive oil 3kg inserts in reactor；Ozone is with 150m3/ h flow velocity adds, and total reaction time is 20 hours.Reaction
After end, residual air inactivates.
4th, obtaining ozonisation Fructus Canarii albi oil concentration is 40 mg/l, and 25 DEG C can stably preserve ten months.
5th, prepare ozonisation olive oil enteric coated capsule.
(1), the preparation of capsule material: the ratio by weight 3:3:1:1 weighs water, gelatin, glycerol and glutinous rice flour or starch falls
Enter in glue tank, during colloidal sol, temperature is first arranged to 75 DEG C, start to add water when temperature reaches 60 DEG C, add water 10 minutes, use handss
Touching has micro- boiling hot sensation, is initially added into glycerol, stirs 2 minutes, takes 2 times from glue pot bottom, refund in glue tank, rapidly plus gelatin,
Mixing time is 2 hours, and after stirring, temperature is set as 60 DEG C, standing de-bubbled 8 hours.
(2), pressing is adopted to prepare ozonisation olive oil enteric coated capsule, capacity 0.25ml.
22 DEG C of glue capsules of room temperature, rubber thickness is 0.7mm, and capacity is 0.25ml, and prepared soft capsule cools down 8 in rotating cage
Hour, come out of steamer, be drying to obtain ozonisation olive oil enteric coated capsule, standby in 4 DEG C of lucifuge cold preservations.
The enteric coated capsule preparation of embodiment 2 ozonisation olive oil, soybean oil and Oleum Arachidis hypogaeae semen miscella
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, prepare ozone carburetion and ozone carburetion enteric coated capsule whole process need carry out at 20～25 DEG C it is ensured that ozonisation
Oil will not occur pyrolytic reaction.
3rd, olive oil 1kg, soybean oil 1kg and Oleum Arachidis hypogaeae semen 1kg insert in reactor；Ozone is with 150m3/ h flow velocity adds, always
Response time is 20 hours.After reaction terminates, residual air inactivates.
4th, obtaining ozonisation miscella concentration is 40mg/l, and 25 DEG C can stably preserve ten months.
5th, prepare ozonisation miscella enteric coated capsule.
(1), the preparation of capsule material: the ratio by weight 3:3:1:1 weighs water, gelatin, glycerol and glutinous rice flour or starch falls
Enter in glue tank, during colloidal sol, temperature is first arranged to 75 DEG C, start to add water when temperature reaches 60 DEG C, add water 10 minutes, use handss
Touching has micro- boiling hot sensation, is initially added into glycerol, stirs 2 minutes, takes 2 times from glue pot bottom, refund in glue tank, rapidly plus gelatin,
Mixing time is 2 hours, and after stirring, temperature is set as 60 DEG C, standing de-bubbled 8 hours.
(2), pressing is adopted to prepare ozonisation miscella enteric coated capsule, capacity 0.25ml.
22 DEG C of glue capsules of room temperature, rubber thickness is 0.7mm, and capacity is 0.25ml, and prepared soft capsule cools down 8 in rotating cage
Hour, come out of steamer, be drying to obtain ozonisation miscella enteric coated capsule, standby in 4 DEG C of lucifuge cold preservations.Embodiment 3 contains surfactant
Ozonisation olive oil enteric coated capsule preparation
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, prepare ozone carburetion and ozone carburetion enteric coated capsule whole process need carry out at 20～25 DEG C it is ensured that ozonisation
Oil will not occur pyrolytic reaction.
3rd, olive oil 3kg inserts in reactor, is slowly added to sorbitan monooleate polyoxyethylene ether (Tween 80)
20ml, mixes, ozone is with 150m3/ h flow velocity adds, and total reaction time is 20 hours.After reaction terminates, residual air inactivates.
4th, obtaining ozonisation Fructus Canarii albi oil concentration is 40 mg/l, and 25 DEG C can stably preserve ten months.
5th, the ozonisation olive oil enteric coated capsule containing surfactant for the preparation.
(1), the preparation of capsule material: the ratio by weight 3:3:1:1 weighs water, gelatin, glycerol and glutinous rice flour or starch falls
Enter in glue tank, during colloidal sol, temperature is first arranged to 75 DEG C, start to add water when temperature reaches 60 DEG C, add water 10 minutes, use handss
Touching has micro- boiling hot sensation, is initially added into glycerol, stirs 2 minutes, takes 2 times from glue pot bottom, refund in glue tank, rapidly plus gelatin,
Mixing time is 2 hours, and after stirring, temperature is set as 60 DEG C, standing de-bubbled 8 hours.
(2), pressing is adopted to prepare ozonisation olive oil enteric coated capsule, capacity 0.25ml.
22 DEG C of glue capsules of room temperature, rubber thickness is 0.7mm, and capacity is 0.25ml, and prepared soft capsule cools down 8 in rotating cage
Hour, come out of steamer, be drying to obtain the ozonisation olive oil enteric coated capsule containing surfactant, standby in 4 DEG C of lucifuge cold preservations.
Embodiment 4 contains the ozonisation olive oil enteric coated capsule preparation of surfactant and cosurfactant
1st, ozone gas are prepared.The present invention prepares ozone gas using medical oxygen by ozonator.
The dro3-a type ozone machine (power 55w) producing selected from Xi'an Derun Bio-Technology Co., Ltd.'s design.
2nd, prepare ozone carburetion and ozone carburetion enteric coated capsule whole process need carry out at 20～25 DEG C it is ensured that ozonisation
Oil will not occur pyrolytic reaction.
3rd, olive oil 3kg inserts in reactor, is slowly added to sorbitan monooleate polyoxyethylene ether (Tween 80)
20ml and straight alcohol 20ml, mixes, ozone is with 150m3/ h flow velocity adds, and total reaction time is 20 hours.After reaction terminates, remaining
Gas inactivates.
4th, obtaining ozonisation Fructus Canarii albi oil concentration is 40 mg/l, and 25 DEG C can stably preserve ten months.
5th, the ozonisation olive oil enteric coated capsule containing surfactant and cosurfactant for the preparation.
(1), the preparation of capsule material: the ratio by weight 3:3:1:1 weighs water, gelatin, glycerol and glutinous rice flour or starch falls
Enter in glue tank, during colloidal sol, temperature is first arranged to 75 DEG C, start to add water when temperature reaches 60 DEG C, add water 10 minutes, use handss
Touching has micro- boiling hot sensation, is initially added into glycerol, stirs 2 minutes, takes 2 times from glue pot bottom, refund in glue tank, rapidly plus gelatin,
Mixing time is 2 hours, and after stirring, temperature is set as 60 DEG C, standing de-bubbled 8 hours.
(2), pressing is adopted to prepare ozonisation olive oil enteric coated capsule, capacity 0.25ml.
22 DEG C of glue capsules of room temperature, rubber thickness is 0.7mm, and capacity is 0.25ml, and prepared soft capsule cools down 8 in rotating cage
Hour, come out of steamer, be drying to obtain the ozonisation olive oil enteric coated capsule containing surfactant and cosurfactant, in 4 DEG C of lucifuges
Cold preservation is standby.
The Experiment on therapy that embodiment 5 ozonisation Fructus Canarii albi oil capsule is hindered to optic nerve, spinal nerves damage, oculomotoriuss
Specific experiment process is as follows:
The clinical observation on the therapeutic effect of medicine of the present invention
1st, physical data
Collect patient totally 50
2nd, diagnostic criteria
Nerve injury mainly includes Cranial nerve injury as birth trauma, spinal nerves are damaged etc., and optic nerve injury is often accompanied by involving obital apex and regards god
Through before pipe, middle cranial fossa fracture.After patient's wound, visual deterioration occurs even blind.The visible diplopia of oculomotoriuss the wounded, upper eyelid
Sagging, platycoria, light areflexia, eyeball deflection outer lower side;Behind face, injury of acoustic nerve wound, face paralysis in different time
Paralysis.Should be treated in time.
3rd, Therapeutic Method
From the ozonisation olive oil capsule medicament of embodiment 1 preparation, use to patient's (medicine) being taken before meal, once a day, one every time, even
Continue and take 90 days.
4th, efficacy assessment standard
Effective: the recovery from illness of nerve injury symptom, recovers normal;
Take a turn for the better: nerve injury symptom mitigation, progressively takes a turn for the better;
Invalid: not reach improvement standard person;
5th, therapeutic outcome (see table):
In above-mentioned treatment, with Drug therapy patient with nerve damage of the present invention 50, effective 40 of result, obvious effective rate is 80%, good
Turn 5, improvement rate is 10%, invalid 5, total effective rate is 90%.
The Experiment on therapy to other Cranial nerve injury as birth traumas for the embodiment 6 ozonisation Fructus Canarii albi oil capsule
Be presented herein below patient use medicine of the present invention clinical statisticses data:
For further illustrating the effect of the present invention, applicant will be as follows for clinical drug performance summary of the present invention:
1st, clinical data: 2006-2015, applicant accepts Cranial nerve injury as birth trauma patient for medical treatment and amounts to 80, wherein, and male 45, female
Property 35, the oldest person 78 years old, reckling 33 people, course of disease elder 10 years, the shortest person 2 years.
2nd, clinical symptoms cardinal symptom is hemiplegia, facial hemiparalysiss, slobbering, slurred speech, numb limbs and tense tendons, action
Inconvenience, minor symptom is slight Hypertension, dizziness headache, poor appetite shortness of breath, insomnia forgetfulness, breathes hard, lethargy are depressed, stool
Intensive, urine is crimson.
3rd, Therapeutic Method: take medicine of the present invention once a day, early 1 capsule of (medicine) being taken before meal, warm water is sent down, 90 days one
The course for the treatment of.
4th, criterion:
Cure: cardinal symptom is improved completely, and minor symptom 90% disappears.
Effective: cardinal symptom is improved, minor symptom more than 70%.
Effective: cardinal symptom mitigates, minor symptom disappearance half.
Invalid: symptom has no mitigation.
5th, curative effect statistics: 96% healing, general medication takes effect for 10 days, and effectively severe one more than 30 sky was effective, two months in 7 days for the lighter
Cardinal symptom is improved completely, and minor symptom disappears substantially, has no recurrence within 5 years so far.
Curative effect statistical result: cure 77, effective 2, effective 1, invalid 0.
6th, model case:
1) single x, man, 46 years old, are diagnosed as cerebral concussion sequela during first visit.Symptom: cranium pressure is higher, dizzy feeling of fullness in the head, upset, long
Phase has a sleepless night, and memory degradation is taken medicine of the present invention and returned to normal for 3 months.Take capsule 2 times afterwards each week,
Body returns to one's perfect health, normally goes to work.
2) hole xx, man, 60 years old, because cerebral infarction is in hospital, there are sequela, slurred speech, numb limbs and tense tendons after treatment, action is not
Just, dizziness headache, is diagnosed as Cranial nerve injury as birth trauma, takes medicine of the present invention 3 months after discharge, and all symptoms disappear.
3) all xx, female, 35 years old, suffer from cerebral thrombosiss, after discharge, have sequela, cardinal symptom is: upset, arrhythmia,
Dizzy headache, Hyperlipidemia, handicapped, take medicine of the present invention 30 days, body returns to one's perfect health, and normally goes to work.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention is made with other forms, appoints
What those skilled in the art possibly also with the disclosure above technology contents changed or be modified as equivalent variations etc.
Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit according to the present invention is entered to above example
Row modification, or equivalent is carried out to wherein some technical characteristics.All within the spirit and principles in the present invention, made appoint
What modification, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (9)
1. a kind of application in nerve injury for ozone carburetion is it is characterised in that oil is at least selected from olive oil, Oleum Glycines, sunflower seed
Oil, Semen Lini oil, Oleum Brassicae campestriss, Semen setariae oil, Semen Maydis oil, Fructus Maydis oil, Oleum sesami, Oleum Gossypii semen, Oleum Ricini, Oleum Arachidis hypogaeae semen, camellia oleosa seed
Oil, perilla oil, safflower oil, almond oil, hazelnut oil, walnut oil, pine-seed oil, shinyleaf yellowhorn oil, edible blend oil, cod-liver oil and fish
One of oil, by oily electrophilic addition ozone, the ozone carburetion obtaining make the Oryza glutinosa that capacity is 0.1～0.75ml or
Starch material enteric coated capsule, contained with 2～100ml vial, with the dosage of 0.1 ~ 100ml, be administered by oral route and adopt
The mode of lumbar injection, coloclysis, gavage, intravenous injection, subcutaneous injection, intramuscular injection and suppository gives, and can be used in preparation pre-
Anti- and treatment optic nerve, spinal nerves are damaged, oculomotoriuss are hindered and the medicine of other Cranial nerve injury as birth trauma.
2. oil according to claim 1 is it is characterised in that carry out mixing two-by-two and two to the oil described in claim 1
Plant the mixing to oil, by electrophilic addition ozone, the ozone carburetion obtaining makes the Oryza glutinosa that capacity is 0.1～0.75ml or shallow lake
Powder material enteric coated capsule, with 2～100ml vial contain, with the dosage of 0.1 ~ 100ml, be administered by oral route and adopt abdomen
Chamber injection, coloclysis, gavage, intravenous injection, the mode of subcutaneous injection, intramuscular injection and suppository give, and can be used in preparation prevention
Medicine with treatment optic nerve, spinal nerves damage, oculomotoriuss wound and other Cranial nerve injury as birth trauma.
3. oil according to claims 1 to 2 is it is characterised in that pass through to select nonionic surfactant, anionic surface
One of activating agent and cationic surfactant, two kinds and two or more mixing, with the oil described in claim 1～2
Any one of mixing, by electrophilic addition ozone, obtain the ozone carburetion containing surfactant make capacity be 0.1～
The Oryza glutinosa of 0.75ml or starch material enteric coated capsule, contained with 2～100ml vial, with the dosage of 0.1 ~ 100ml, by oral administration
Administration and being given by the way of lumbar injection, coloclysis, gavage, intravenous injection, subcutaneous injection, intramuscular injection and suppository,
Can be used in preparing prevention and treatment optic nerve, the medicine of spinal nerves damage, oculomotoriuss wound and other Cranial nerve injury as birth trauma.
4. surfactant according to claim 3 is it is characterised in that be selected from glycerol unsaturated fatty acid ester, polyglycereol
Unsaturated fatty acid ester, propylene glycol unsaturated fatty acid ester, sorbitan unsaturated fatty acid ester, polyoxyethylene sorbitol
Acid anhydride unsaturated fatty acid ester, polyoxyethylene unsaturated fatty acid ester, mannitol unsaturated fatty acid ester, tetramethylolmethane are unsaturated
Non- in fatty acid ester, sucrose unsaturated fatty acid ester, Polyethylene Glycol unsaturated alkyl ether and polypropylene glycol unsaturated alkyl ether
One of ionic surface active agent, two kinds and two or more.
5. surfactant according to claim 3 is it is characterised in that be selected from unsaturated fatty acid salt, unsaturated fatty acidss
Anion surfactant in alcohol sulfuric ester salt, alpha-sulfo unsaturated fatty acid ester, olefin sulphates and alkene sulfonate
A kind of, two kinds and two or more.
6. surfactant according to claim 3 is it is characterised in that be selected from the monosubstituted trimethyl of unsaturated aliphatic hydrocarbyl moiety
Ammonium salt, unsaturated aliphatic hydrocarbyl moiety two substituted dimethyl ammonium salt, unsaturated aliphatic hydrocarbyl moiety monosubstituted dimethyl benzyl ammonium salt, unsaturation
Aliphatic group monosubstituted amine acylate, unsaturated aliphatic hydrocarbyl moiety two replacement amine acylate and n- methyl diethanolamine insatiable hunger
With one kind of the cationic surfactant in fatty acid ester hydrochlorate, two kinds and two or more.
7. surfactant according to claim 3 is it is characterised in that be selected from food stage petroleum ether, Polyethylene Glycol insatiable hunger
With alkyl ether, one kind of sorbitan monoesters polyoxyethylene ether surface active agent and two or more.
8. any one ozone carburetion according to claims 1 to 7 it is characterised in that by select ethanol, propylene glycol,
One of glycerol, hexanediol, butanediol, pentanediol, butantriol, hexanetriol, two kinds and two or more mixing, by electrophilic
Addition ozone obtains the ozone carburetion containing cosurfactant and surfactant, makes the Oryza glutinosa that capacity is 0.1～0.75ml
Or starch material enteric coated capsule, with 2～100ml vial contain, with the dosage of 0.1 ~ 100ml, be administered by oral route and adopt
Given with the mode of lumbar injection, coloclysis, gavage, intravenous injection, subcutaneous injection, intramuscular injection and suppository, can be used in preparing
Prevention and treatment optic nerve, spinal nerves are damaged, oculomotoriuss are hindered and the medicine of other Cranial nerve injury as birth trauma.
9. any one according to claims 1 to 8 is made ozone carburetion and its route of administration are it is characterised in that be somebody's turn to do
Ozone carburetion can be damaged with treatment optic nerve, spinal nerves by described approach, oculomotoriuss wound and other cranial nerve are damaged
The Drug combination of wound, can prevent and treat optic nerve, spinal nerves are damaged, oculomotoriuss wound and other brain are refreshing effectively
Through damaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610935376.0A CN106344607A (en) | 2016-11-01 | 2016-11-01 | Applications of ozonized oil in treatment of nerve injuries |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610935376.0A CN106344607A (en) | 2016-11-01 | 2016-11-01 | Applications of ozonized oil in treatment of nerve injuries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106344607A true CN106344607A (en) | 2017-01-25 |
Family
ID=57863981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610935376.0A Pending CN106344607A (en) | 2016-11-01 | 2016-11-01 | Applications of ozonized oil in treatment of nerve injuries |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106344607A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103430797A (en) * | 2013-08-13 | 2013-12-11 | 陕西省微生物研究所 | Method for preventing and controlling fungal diseases of cucumbers |
-
2016
- 2016-11-01 CN CN201610935376.0A patent/CN106344607A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103430797A (en) * | 2013-08-13 | 2013-12-11 | 陕西省微生物研究所 | Method for preventing and controlling fungal diseases of cucumbers |
Non-Patent Citations (1)
| Title |
|---|
| 胥丽霞等: "医学臭氧临床治疗进展", 《中国实用神经疾病杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106309474A (en) | Application of ozonized oil in hyperplasia diseases and infertility | |
| CN106466327A (en) | Application in dermatosis, obesity and phlebothrombosises preventing and treating for the ozone carburetion | |
| CN108653320A (en) | The medical usage of ozone carburetion promotion wound, inflammation healing | |
| CN108653319A (en) | Application of the ozone carburetion in gynaecological inflammation disease | |
| CN102274174A (en) | Oil suspension agent of benzimidazole medicine | |
| CN106265722A (en) | The application in prevention and control of cancer of the ozone carburetion | |
| CN106389463A (en) | Application of ozonized oil in prevention and treatment of autoimmune disease and irritable bowel syndrome | |
| CN106860474A (en) | A kind of new application of ozone carburetion | |
| CN108653318A (en) | Application of the ozone carburetion in eye and ear disease | |
| CN106344607A (en) | Applications of ozonized oil in treatment of nerve injuries | |
| CN107569453A (en) | It is a kind of that there are the anti-ageing little Huang breasts preparation method and application for repairing jelly scald and eczema containing egg oil | |
| CN108685941A (en) | Application of the ozone carburetion in disease of digestive tract and inflammation | |
| CN106344606A (en) | Medical applications and administration route for ozonized oil | |
| CN102784216B (en) | Traditional Tibetan medicine for treating alopecia | |
| CN100382837C (en) | A medicine for treating children's excessive blink, hyperkinetic syndrome and Tottre's syndrome and method for preparing same | |
| CN102949712A (en) | Chinese and western composite medicine for treating neoplastic diseases | |
| CN101199766B (en) | Medicament for treating epileps | |
| CN106361766A (en) | Application of ozonized oil in prevention and treatment of pregnancy diseases | |
| CN106491635A (en) | Ozone carburetion and the drug combination for treating hypertension agents | |
| CN108404094A (en) | A kind of thin network analgesic antiphlogistic bee venom application conditioning cream | |
| CN108685940A (en) | Application of the ozone carburetion in infectious diseases | |
| CN108464505A (en) | A kind of new application of ozone carburetion in food, health products and drug | |
| CN105816862A (en) | Application of ulinastatin in preparation of drugs for treating prostatic cancer | |
| CN102793771B (en) | Preparation method of Tibetan drug for treating alopecia | |
| CN101559131B (en) | Traditional Chinese medicinal composition for treating scabies and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170125 |