RU2333748C1 - Method for prevention of omphalophlebitis and navel gangrene in newborn calves - Google Patents

Abstract

FIELD: medicine, veterinary.

SUBSTANCE: invention concerns veterinary. The method involves cutting navel cord at the distance of 10-15 cm from abdominal wall by disinfected tool, extrusion of residual blood from the navel cord, processing external navel part with 5% alcohol iodine solution, adherence to veterinary sanitation rules during calving, sustaining cleanness in natal section, and application of visceral novocain blockade for calf. Additionally, calving cows undergo immunisation twice, 1.5 months before calving, by animal escherichiosis vaccine Coli-Vac K99 with 15 day interval, with the first dose of 10 cm³ and the dose of 15 cm³. Simultaneously 5 ml of ligfolum is administrated twice intramuscularly to each animal. During visceral Novocain blockade the calves born of those cows receive single intramuscular injection of ligfolum in the dose of 0.1 ml per kg of body weight in 2-4 hours after birth. Right after birth internal navel part is cleansed by 5% alcohol iodine solution with syringe.

EFFECT: obtaining more strain specific immunity of cows before calving, high level of specific colostral immunity of calves ensuring reduced omphalophlebitis and navel gangrene incidence by calves.

7 tbl, 4 ex

Description

The invention relates to the field of veterinary medicine, relates to a method for the prevention of omphalophlebitis and umbilical cord gangrene in newborn calves.

Omphalophlebitis is an inflammation of the umbilical vein. It is recorded mainly in ruminants, because when tearing off the umbilical cord, the veins contract to a lesser extent than arteries. It proceeds as a wound infection due to the ingress of various microflora through the untreated umbilical cord. The disease may be accompanied by bacteremia and septicemia.

Clinical signs of omphalophlebitis are usually noted on 2-3 days of calf life. At the beginning of the disease, oppression, rejection of colostrum, an increase in body temperature by 0.5-1.5 ° C are observed. At the base of the umbilical cord, palpation reveals an inflammatory, painful swelling of a test consistency. Subsequently, pain extends to the lower and lateral walls of the abdomen. On palpation of the umbilicus, hardening is recorded with a thickness of a pencil, finger or a child’s cam, which is not fused to the skin covering it and can be traced to the entrance to the abdominal cavity. The disease is accompanied by diarrhea, which may be absent at the onset of the disease.

The prognosis is doubtful, since if it is not possible to localize the process, the infection begins to enter the liver and other parenchymal organs, as well as metastatically into the joints and tendon sheaths, which can lead to pyosepticemia / 1, 2 /.

Umbilical cord gangrene - wet necrosis of the umbilical stump. The umbilical cord stump undergoes dry necrosis (mummification) and disappears on day 4-8, the umbilicus turns into a scar and epithelizes. When infectious agents penetrate the stump from the external environment (less often by the hematogenous route), the process of mummification is delayed and wet necrosis develops. The inflamed umbilical cord is swollen and painful, turns into a wet, purulent mass of dirty brown color. At the same time, there is a risk of infection spreading to the inner stump of the umbilical cord / 1, 3 /.

Anatomically, the umbilical cord or umbilical cord is a tube formed by an aqueous membrane in which ruminants pass two arteries and two veins and a urinary duct connecting the top of the bladder with the allantois cavity.

Under normal conditions for the rupture of the umbilical cord, the umbilical cord vagina remains for a fairly large extent, the width of the palm. The vessels inside it usually rupture in the abdominal ring or slightly below it, and after the blood has expired, they all thrombose and then obliterate.

In calves, the increment of the vessels to the umbilical ring is very loose and weak, and two ruptured umbilical arteries, contracting after tension during rupture due to their elasticity, are pulled into the abdominal cavity and thus are completely protected from external pollution and infection. And two ruptured umbilical veins, due to less elasticity, contract little, but when their diameter is insignificant, they fall pretty well, and their openings are largely covered by scraps of vascular intima. The remainder of the torn cord - the umbilical cord stump - for the most part consists of the umbilical cord vagina alone, which satisfactorily covers the ends of the vessels and protects them from infections (i.e., the umbilical cord vagina is connected with the umbilical veins). In addition, the base of the remainder of the umbilical cord in the calf is covered by a thick skin vagina. If the vessels of the calf rupture slightly below the abdominal ring, then their ends are still well covered and protected by this collar.

Thus, under normal conditions, the umbilical veins are well protected from microorganisms, only with a very short break in the umbilical cord during childbirth, it is possible that they become infected (omphalophlebitis).

The remains of a torn umbilical cord is a favorable environment for the propagation of microorganisms. They do not encounter obstacles to their development and penetration into the bloodstream, i.e. the main reason for omphalophlebitis is getting on the wound surface of the stump of the umbilical cord microflora located in the stalled stalls (floor, litter) and on dirty hands with improper handling of the umbilical cord.

Clinical signs of omphalophlebitis are especially noted on 2-3 days of calf life. In the beginning, oppression, rejection of colostrum, an increase in body temperature by 0.5-1.5 ° C are observed.

At the base of the umbilical cord, palpation reveals inflammatory swelling of the test consistency. In this case, the umbilical cord is moist, thickened and painful, i.e. inflammation of the umbilical cord (umbilical cord gangrene) is simultaneously recorded.

Normally, the umbilical cord stump undergoes mummification and disappears on day 4-8, the umbilicus turns into a scar and epithelizes. The umbilical cord is often contaminated and infected during childbirth if preventive measures are not taken in time (drying the umbilical stump by squeezing blood, treating 5-10% r-rum iodine, 1% r-rum potassium permanganate, 3-5% r-rum phenol or by other similar means) and the rules for caring for the umbilical cord are not followed, then the pathogen penetrates the stump from the external environment, especially in weakened newborn animals, the mummification process is delayed and the inflammatory process develops (umbilical cord gangrene).

With umbilical cord gangrene, clinical signs appear on day 2-3. The general condition is depressed, the animal stands with an elongated back, which is caused by pain in the navel. In severe cases, inflammation spreads to the umbilical region of the abdomen and umbilical vessels, as well as to the peritoneum. The umbilical cord is swollen, painful, hangs in the form of a bloody strand with a diameter of up to 1.5 cm, then the stump turns into a wet rotting mass of dirty brown color with a putrid odor.

Inflammation of the umbilical cord (umbilical cord gangrene) and inflammation of the umbilical veins (omphalophlebitis) are recorded at the same time, on the 2nd-3rd day of life of newborns; inflammation of the umbilical cord stump promotes inflammation of the umbilical veins.

The primary processing of the umbilical cord is aimed at preventing infection through the stump of the umbilical cord, achieving its quickest mummification and falling away, ensuring aseptic demarcation in relation to the tissues of the newborn and rapid epithelialization of the umbilical wound.

Anatomically, the umbilical cord vagina is associated with umbilical veins, and inflammation of the first (umbilical cord gangrene) leads to inflammation of the umbilical veins (omphalophlebitis), i.e. umbilical cord gangrene is not independently recorded.

A known method for the prevention of omphalophlebitis in calves, which consists in observing veterinary and sanitary rules in the maternity ward when providing obstetric care, according to which newborn calves are taken on fresh dry straw litter covered with clean burlap or plastic wrap, in newborns they cut off or cut the umbilical cord at a distance of 10 15 cm from the abdominal wall with a disinfected instrument. The remains of blood are squeezed out of the umbilical cord stump and its end is treated with 5-10% alcohol solution of iodine, 1% solution of potassium permanganate, 3-5% solution of phenol or other similar means / 2, 4 /.

However, this method of preventing omphalophlebitis is not effective enough, since it is not always possible to apply it in a timely manner, since calving often takes place at night, in addition, cows often lick the umbilical cord stump while licking the calf, thereby contributing to infection / 5 /. And since this method consists in processing only the outer part of the umbilical cord, it is ineffective for preventing umbilical cord gangrene.

At the same time, according to a number of researchers, compliance with veterinary and sanitary rules does not always give a preventive effect, since intrauterine toxicosis and infection of calves is possible / 6, 7 /.

The prototype of the invention is a method for the prevention of omphalophlebitis in calves / 8 /. In newborns, the umbilical cord is cut off or cut off at a distance of 10-15 cm from the abdominal wall with a disinfected tool. The remains of blood are squeezed out of the umbilical cord stump and its external part is treated with 5% alcohol solution of iodine. In the first 2-4 hours of life, along with the use of generally accepted veterinary-sanitary rules, calves are treated with visceral novocaine blockade - in the middle of the upper third of the right hungry fossa, the hair is cut off and the skin is lubricated with tincture of iodine. A warm (38–40 ° C) 0.5% solution of novocaine is added to the sterile syringe at the rate of 1 ml per 1 kg of the animal’s body weight and 300 thousand units of streptomycin are dissolved in it. 2-3 cm from the end of the transverse process of the 3rd or 4th lumbar vertebra towards the left knee pierce the abdominal wall with a needle, attach a syringe and slowly inject the solution into the abdominal cavity. When correctly inserted, the moment of penetration of the needle into the cavity feels like a failure, tilting the needle to the sides does not cause pain, and the solution flows freely from the syringe. After injection of the solution, the abdominal wall is slightly pressed near the puncture site and the needle is removed, and the puncture site is smeared with iodine solution.

The disadvantage of this method is that only the outer part of the umbilical stump is treated with an iodine alcohol solution. This method of prevention does not prevent possible intrauterine infection and infection of calves during the birth of E. coli (one of the etiological factors of omphalophlebitis).

The technical result of the invention is to increase the effectiveness of the prevention of omphalophlebitis and umbilical cord gangrene in calves.

The technical result is achieved by immunization of deep-shelled cows with a vaccine against animal Escherichiosis (Koli-Vak K99) with the simultaneous use of the drug ligfol, an additional single use of this drug, visceral novocaine blockade of newborn calves and treatment of both the external and internal (vagina) parts of the umbilical cord.

Ligfol is a complex preparation, which includes humic acids obtained by hydrolysis of natural (wood) lignin, sodium pyrophosphate decahydrate, sodium chloride and demineralized water. The valeopositive effects of ligfol are based on immuno-antioxidant mechanisms, including the antiradical activity of immunocompetent organs / 9 /.

The method is as follows. 1.5 months prior to calving, they are immunized twice with an interval of 15 days with a vaccine against colibacillosis of animals Coli-Wack K99 / 10 /. The first dose is 10 cm ³ and the second is 15 cm ³ , and at the same time, ligfol is administered intramuscularly at a dose of 5 ml per animal. In newborn calves, the umbilical cord is cut off with a disinfected instrument at a distance of 10-15 cm from the abdominal wall, blood is squeezed out of the umbilical cord and treated with 5% alcohol solution of iodine both the outer and inner parts of the umbilical stump. Within 2-4 hours after birth, calves are injected intramuscularly with ligfol at a dose of 0.1 ml / kg body weight and visceral novocaine blockade is used: a warm (38-40 ° C) 0.5% novocaine solution is collected in a sterile syringe at the rate of 1 ml per 1 kg of animal body weight and 300 thousand units of streptomycin are dissolved in it. 2-3 cm from the end of the transverse process of the 3rd or 4th lumbar vertebra towards the left knee pierce the abdominal wall with a needle, attach a syringe and slowly inject the solution into the abdominal cavity. When correctly inserted, the moment of penetration of the needle into the cavity feels like a failure, tilting the needle to the sides does not cause pain, and the solution flows freely from the syringe. After injection of the solution, the abdominal wall is slightly pressed near the puncture site and the needle is removed, and the puncture site is smeared with iodine solution.

Prevention of omphalophlebitis and umbilical cord gangrene in newborn calves using the proposed method was carried out on 44 calves. The production test showed high efficiency and feasibility of the proposed method.

Example 1. The rationale for the treatment of the external and internal parts of the umbilical cord for the prevention of omphalophlebitis and gangrene of the umbilical cord in calves.

In a farm that was long dysfunctional in omphalophlebitis and umbilical gangrene, 40 dry cows were selected according to the principle of body weight, number of lactation and clinical condition, of which two groups of 20 animals each were formed.

Newborn calves were taken on a fresh, dry straw bed, covered with a clean burlap, the umbilical cord was cut at a distance of 10-15 cm from the abdominal wall with a disinfected tool.

The first group (control) included dead cows that were not immunized. 2-4 hours after birth, calves obtained from these cows were given a single visceral novocaine blockade, and immediately after birth, the outer part of the umbilical cord was treated with 5% alcohol solution of iodine. The second (experimental) group included dry cows, which were also not vaccinated. 2-4 hours after birth, calves obtained from these cows were given a single visceral blockade, and immediately after birth, the outer and inner part of their umbilical cord was treated with 5% alcohol solution of iodine. The inner part of the umbilical cord was treated with iodine solution using disposable syringes. The calf at the time of the treatment was in the dorsal position. The calves obtained from the above cows were monitored for 14 days, the time of onset of clinical signs of omphalophlebitis, the duration and severity of the disease were recorded. Body weight was determined on days 1 and 14. The results of the experiment are presented in table 1.

Table 1 The effectiveness of the prevention of omphalophlebitis and umbilical cord gangrene in newborn calves when processing the vagina of the umbilical cord No. P / P Indicators Calves from cows the first group second group one. The number of calves, goals (%) 20 (100) 20 (100) 2. Of them, he got sick with omphalophlebitis, goals (%)
Start day
Duration, day 2 (10.0)
3.0
8 2 (10.0)
3,5
5,0 3. Of them, he got sick with omphalophlebitis and gangrene umbilical cord
Start day
Duration, day 1 (5.0)
2
9 -
-
- four. Body weight on the 1st day, kg 36.0 35.8 5. Body weight on the 14th day, kg 37.8 38.1 6. Weight gain, kg 1.8 2.0 7. The average daily weight gain, g 129 143

Table 1 shows that the effectiveness of prophylaxis when treating both the outer and inner parts of the umbilical stump with 5% alcohol solution of iodine is 90.0%, and in calves with only the outer part of the umbilical cord, 85%. In addition, the calves of the second group of the gangrene umbilical cord were not ill, and omphalophlebitis was ill on average 0.5 days later, the duration of the disease was 3 days less. The average daily weight gain over 14 days was 14 g more.

Example 2. The rationale for the immunization of dry cows for the prevention of omphalophlebitis and umbilical cord gangrene in newborn calves.

In a farm that was long dysfunctional in omphalophlebitis and umbilical gangrene, 40 dry cows were selected according to the principle of body weight, number of lactation and clinical condition, of which two groups of 20 animals each were formed. The first group included animals that were not immunized. The second group included dry cows, which were 1.5 months before calving immunized with the vaccine against colibacillosis Kolya-Vak K99, according to the instructions for the use of biological product / 9 /.

Newborn calves of both groups were taken on fresh, dry straw bedding, covered with clean burlap. The umbilical cord was cut at a distance of 10-15 cm from the abdominal wall with a disinfected instrument, blood was squeezed out of the umbilical cord stump. Two to four hours after birth, calves of both groups were once treated with visceral novocaine blockade and treated with 5% iodine solution. In calves obtained from cows of the first group, only the outer part of the umbilical cord was treated, and from the second, the outer and inner parts were treated.

The results of the experiment are presented in table 2.

table 2 The effectiveness of the prevention of omphalophlebitis in newborn calves when immunizing dry cows against escherichiosis No. P / P Indicators Calves from cows the first group second group one. The number of calves, goals (%) 20 (100) 20 (100) 2. Of them, he got sick with omphalophlebitis, goals (%)
Start day
Duration, day 3 (15.0)
3.0
8 2 (10.0)
3,5
6 3 Of them, he got sick with omphalophlebitis and gangrene umbilical cord
Start day
Duration, day 1 (5.0)
2
9 -
-
- four. Body weight on the 1st day, kg 36.0 36,2 5. Body weight on the 14th day, kg 37.8 38.3 6. Weight gain, kg 1.8 2.1 7. The average daily weight gain, g 129 150

From table 2 it is seen that the effectiveness of the above method for the prevention of omphalophlebitis and umbilical cord gangrene in calves of the first group is 85%, and in calves of the second group - 90%.

Calves of the second group obtained from immunized animals fell ill on average 0.5 days later and were sick 2 days less, and the average daily weight gain for 14 days was 21 g more.

Example 3. The rationale for the use of ligfol dry cows.

On the farm, which was long dysfunctional in omphalophlebitis and umbilical cord gangrene, 40 dry cows were selected according to the principle of analogues in body weight, number of lactation and clinical condition, of which two groups of 20 animals each were formed. All cows were immunized with the Koli-Vak K99 vaccine against Escherichiosis 1.5 months before calving according to the instructions for the use of a biological product. A second group of cows for 1.5 months prior to calving twice immunized animals ehsherihioza vaccine Coli K99-Wack at intervals of 15 days, the first dose was 10 cm ^3, and the second - 15 cm ^3, simultaneously doubly ligfol administered intramuscularly at a dose of 5 ml per animal.

Newborn calves of both groups were taken on fresh, dry straw bedding, covered with clean burlap. The umbilical cord was cut at a distance of 10-15 cm from the abdominal wall with a disinfected instrument, blood was squeezed out of the umbilical cord stump. In 2-4 hours after birth, calves of both groups were once treated with visceral novocaine blockade and treated with 5% iodine solution of the outer and inner parts of the umbilical cord. Calves obtained from cows of the second group, during the period of visceral novocaine blockade - 2-4 hours after birth - were injected intramuscularly with ligfol at a dose of 0.1 ml / kg body weight. The calves were under clinical observation for 14 days, the time of manifestation of clinical signs of omphalophlebitis, the duration of the disease were recorded, and attention was paid to inflammatory edema in the umbilical region in the lower and lateral wall of the abdomen, soreness of the umbilical rings and navel, its thickening. With gangrenous inflammation of the umbilical stump, attention was paid to its color, humidity, swelling and soreness. Body weight was determined on days 1 and 14.

The results of the experiment are presented in table 3.

Table 3 The effectiveness of the prevention of omphalophlebitis in calves when immunizing dry cows in combination with ligfol No. P / P Indicators Calves from cows the first group second group one. The number of calves, goals (%) 20 (100) 20 (100) 2. Of them, he got sick with omphalophlebitis, goals (%)
Start day
Duration, day 2 (10.0)
3
6 1 (5.0)
four
5.5 3. Of them, he got sick with omphalophlebitis and gangrene umbilical cord, goals (%)
Start day
Duration, day -
-
- -
-
- four. Body weight on the 1st day, kg 36,2 35.8 5. Body weight on the 14th day, kg 38.3 39.9 6. Weight gain, kg 2.1 4.1 7. The average daily weight gain, g 150 293

As can be seen from table 3, the prophylactic efficacy of vaccination in combination with ligfol was 95%, and when immunizing cows without the drug - 90%.

Calves obtained from cows immunized with ligfol and simultaneously treated with this drug with intraperitoneal administration of novocaine fell ill on average 1 day later and were sick 0.5 days less, and the average daily weight gain for 14 days was 143 g more .

The effect of immunization of cows in combination with ligfol on the titer of agglutinins to the Escherichia antigen are presented in table 4.

Table 4 Agglutinin titer for Escherichia antigen in cows and calves obtained from them Study Dates Groups Escherichia antigen antibody titer Dead cows Before vaccination 1 group 1: 45.0 2 group 1: 43.8 2 weeks after vaccination 1 group 1: 67.9 2 group 1: 106.3 Newborn calves obtained from cows 1 day after birth ^1st group 1: 85.0 ^2nd group 1: 131.3 2 day after birth ^1st group 1: 106.5 ^2nd group 1: 65.0 3 day after birth ^1st group 1: 60.0 ^2nd group 1: 71.8 14 days after birth ^1st group 1: 20.0 ^2nd group Neg.

As can be seen from table 4, before vaccination, dry cows revealed agglutinins for escherichiosis, antigens in the titer from 1: 43.8 to 1:45, which are a consequence of the circulation of the causative agent of colibacteriosis in adult animals. Two weeks after vaccination, an increase in antibody titers was observed in animals of both groups. However, in cows that were given the vaccine against Escherichiosis in combination with ligfol, the agglutinin titer was 1.6 times higher than in animals that were vaccinated without the drug.

In calves obtained from cows that were given the vaccine in combination with ligfol, the titer of agglutinins to the Escherichia antibody exceeded that in calves obtained from immunized cows without a drug 1.5 times on the first day of life, 1.6 times on day 2 , on day 3 - 1.2 times. On day 14 after birth, agglutinins to the escherichiogenic antigen were not found in these animals.

Thus, double administration of dry ligfol cows in combination with vaccination and once intramuscular administration of this drug to calves contributed to the creation of more intense specific immunity in cows before calving and the formation of a high level of specific colostral immunity in calves obtained from them, which contributed to a decrease in the incidence of calves with omphalophlebitis and gangrene umbilical cord.

The effect of immunization of cows in combination with ligfol on indicators of natural resistance are presented in table 5.

Table 5 Indices of natural resistance in cows and calves obtained from them Study Dates Groups LASK, mcg / ml BASK,% CASK,% heme. Dead cows Before vaccination 1 group 1.15 98.10 3.18 2 group 1.35 91.70 3.56 2 weeks after vaccination 1 group 0.50 90.95 2.43 2 group 0.44 95.07 3.37 Newborn calves obtained from cows 1 day after birth ^1st group 0.40 79.41 5.11 ^2nd group 0.41 84.14 5.59 2 day after birth ^1st group 0.48 95.05 4.60 ^2nd group 0.48 95.12 5.19 3 day after birth ^1st group 0.27 92.21 3.99 ^2nd group 0.49 96,42 4.19 14 days after birth ^1st group 0.53 89.57 4.64 ^2nd group 0.61 93.10 5.11

As can be seen from table 5, before vaccination of dry cows, lysozyme activity of blood serum (LASK) ranged from 1.15 to 1.35 μg / ml, bactericidal activity of blood serum (BASK) ranged from 91.7 to 98.1%, complementary activity blood serum (CASK) - from 3.18 to 3.56% heme. Two weeks after vaccination, the LASK, BASK and KASK indicators decreased, however, the decrease in bactericidal and complementary activity of blood serum in cows immunized with ligfol was less pronounced. In calves obtained from cows that were given the vaccine in combination with ligfol, the BASK and CASK values on day 1 after birth were superior to those in calves obtained from immunized cows without the drug. On days 3 and 14, all of the above indicators of natural resistance of calves obtained from cows immunized in combination with ligfol were higher than in calves obtained from immunized cows without a preparation.

The effect of immunization of cows on indicators of cellular immunity are presented in table 6.

Table 6 Indicators of phagocytic activity of leukocytes, phagocytic number and phagocytic index in cows and calves obtained from them Study Dates Groups FAL,% Ff FI Dead cows Before vaccination 1 group 81.8 4.35 5.33 2 group 78.7 4.48 5.74 2 weeks after vaccination 1 group 94.0 6.08 6.69 2 group 93.8 6.98 7.44 Newborn calves obtained from cows 1 day after birth ^1st group 89.6 3.91 4.32 ^2nd group 92.3 4.24 4,58 2 day after birth ^1st group 88.8 3.46 3.84 ^2nd group 90.5 4.04 4.46 3 day after birth ^1st group 95.6 3.92 4.00 ^2nd group 90.6 3,59 4.20 14 days after birth ^1st group 95.6 4.46 4,50 ^2nd group 95.0 3.93 4.10

Table 6 shows that in the background study (before vaccination), the leukocyte phagocytic activity (FAL) ranged from 78.8 to 81.8%, the phagocytic number (PS) ranged from 4.35 to 4.48, and the phagocytic index ( FI) - 5.33 to 5.74. Two weeks after revaccination, the growth of the studied parameters was recorded, but it was more pronounced in cows, which were given the vaccine in combination with ligfol.

In calves obtained from cows that were immunized in combination with ligfol, the phagocytic activity of leukocytes, phagocytic number and phagocytic index were 1 and 2 days higher than in calves obtained from vaccinated cows without preparation.

Example 4. The rationale for effectiveness.

In a farm that was long dysfunctional in omphalophlebitis and umbilical gangrene, 44 dry cows were selected according to the principle of body weight, number of lactation and clinical condition, of which two groups were formed, including 20 and 24 animals.

The first group (control) included dead cows that were not immunized. The second (experimental) group included dry cows, which were immunized with a vaccine against animal Escherichiosis (Koli-Vak K99) according to the instructions for the use of a biological product in combination with ligfol, which was administered twice simultaneously with the vaccine at a dose of 5 ml per animal.

2-4 hours after birth, calves obtained from cows of both groups were treated with visceral novocaine blockade. Calves obtained from vaccinated animals, 2-4 hours after birth, were administered intramuscularly ligfol at a dose of 0.1 ml / kg body weight. In calves obtained from cows of the first group, immediately after birth, the outer part of the umbilical cord was treated with a 5% alcohol solution of iodine, and from the second, the outer and inner parts of the umbilical cord. The data in table 7 show that the prophylactic effectiveness of the proposed method is 95.8%, and the known - 85.0%, the calves in the first case fell ill 2 days later, recovered 3 days earlier, and their average daily weight gain in 14 days was more by 178

Table 7 The comparative effectiveness of the claimed and known methods for the prevention of omphalophlebitis in calves No. P / P Indicators Calves from cows the first group second group one. The number of calves, goals (%) 20 (100) 24 (100) 2. Of them, he got sick with omphalophlebitis, goals (%)
Start day
Duration, day 3 (15.0)
3.0
8.0 1 (4.2)
5,0
5,0 3. Of them, he got sick with omphalophlebitis and gangrene umbilical cord
Start day
Duration, day -
-
- -
-
- four. Body weight on the 1st day, kg 36.0 36.8 5. Body weight on the 14th day, kg 37.8 41.1 6. Weight gain, kg 1.8 4.3 7. The average daily weight gain, g 129 307

Thus, on the basis of experimental data, it can be concluded that the proposed method is highly preventative, due to an integrated approach combining vaccination against colibacteriosis, which creates more intense specific immunity, using an immunomodulator, visceral novocaine blockade and sanitation of both the external and internal parts of the umbilical cord.

Information sources

1. Stose Anton Otto. Veterinary obstetrics, gynecology and diseases of the newborn / Per. with him. V.V. Kong - M. L., 1931 .-- P.381.

2. Mityushin V.V. Dyspepsia of newborn calves. 2nd ed., Revised. and add. - M.: Rosagropromizdat, 1988 .-- P.73-92.

3. Veterinary obstetrics and gynecology / A.P. Studentsov, B.C. Shipilov, L.G. Subbotina, O.N. Preobrazhensky. Ed. B.C. Shipilova. - 6th ed. corrected and add. - M.: Agrogpromizdat, 1986. - S.332-333.

4. Workshop on obstetrics, gynecology and artificial insemination of farm animals / B.C. Shepilov, G.V. Zvereva, I.I. Rodnin, V.Ya. Nikitin. - M.: Agropromizdat, 1988 .-- 335 p.

5. Podkopaev V. M., Shishkov V. P. Diagnosis, treatment and prevention of diseases of newborn calves. - M .: Kolos, 1967. - S.138-139.

6. Forty B.C. On the issue of intrauterine toxicosis of calves // Clinical and biochemical studies and treatment of non-communicable diseases of farm animals. Sat scientific labor. - Omsk: Publishing House of the Omsk Agricultural Institute, 1981, p.16-18.

7. Kurilenko A.N. Krupelnik V.A. Infectious diseases of young farm animals. - M .: Kolos, 2001 .-- P.20.

8. RU 2252021 C2, 05.20.2005.

9. Manual on the use of Ligfol as an adaptogen and stress corrector in veterinary medicine / Approved by the Department of Veterinary of the Ministry of Agriculture of Russia on 05.05.2001, No. 13-4-03 / 0063.

10. Guidance on the use of a vaccine against isherichiosis of animals (Koli-Vak K88, K99, 987P, F41, TL- and TS-toxoids) / Approved by the Department of Veterinary of the Ministry of Agriculture of Russia on June 20, 1997.

Claims (1)

A method for the prevention of omphalophlebitis and umbilical cord gangrene in newborn calves, including cutting the umbilical cord at a distance of 10-15 cm from the abdominal wall with a disinfected tool, squeezing the remains of blood from the umbilical cord, treating the outer part of the umbilical cord with 5% iodine solution, observing the veterinary-sanitary rules at the hotel and cleanliness in the maternity ward, the use of a calf with a visceral novocaine blockade, characterized in that mother cows are immunized twice with an esche vaccine 1.5 months before calving ihioza animals Coli K99-Wack at intervals of 15 days, the first dose is 10 cm ^3, and the second - 15 cm ^3, simultaneously doubly ligfol intramuscularly administered at a dose of 5 ml per animal; the calves obtained from these cows during the period of visceral novocaine blockade, 2-4 hours after birth, are administered intramuscularly ligol at a dose of 0.1 ml / kg body weight, and immediately after birth, the inside of the umbilical cord is treated with 5% alcohol iodine solution.