CN106343548A - Composite licoflavone blueberry juice chewable tablet and preparation method thereof - Google Patents
Composite licoflavone blueberry juice chewable tablet and preparation method thereof Download PDFInfo
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- CN106343548A CN106343548A CN201610716124.9A CN201610716124A CN106343548A CN 106343548 A CN106343548 A CN 106343548A CN 201610716124 A CN201610716124 A CN 201610716124A CN 106343548 A CN106343548 A CN 106343548A
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- licoflavone
- blueberry juice
- chewable tablet
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- composite
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- 235000003095 Vaccinium corymbosum Nutrition 0.000 title claims abstract description 58
- 235000017537 Vaccinium myrtillus Nutrition 0.000 title claims abstract description 58
- 235000021014 blueberries Nutrition 0.000 title claims abstract description 58
- 229930194248 Licoflavone Natural products 0.000 title claims abstract description 57
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 240000000851 Vaccinium corymbosum Species 0.000 title claims abstract description 55
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 53
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 45
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 32
- 229920002472 Starch Polymers 0.000 claims abstract description 16
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 16
- 239000008107 starch Substances 0.000 claims abstract description 16
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- 229930195725 Mannitol Natural products 0.000 claims abstract description 15
- 239000000594 mannitol Substances 0.000 claims abstract description 15
- 235000010355 mannitol Nutrition 0.000 claims abstract description 15
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 14
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- 238000004945 emulsification Methods 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 abstract description 3
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- 238000007873 sieving Methods 0.000 abstract 1
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
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- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
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- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 241001278898 Glycyrrhiza inflata Species 0.000 description 1
- 240000008917 Glycyrrhiza uralensis Species 0.000 description 1
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- 241000594394 Hedyotis Species 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
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- 239000002671 adjuvant Substances 0.000 description 1
- 230000003026 anti-oxygenic effect Effects 0.000 description 1
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- 229960000271 arbutin Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
- 238000007596 consolidation process Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 235000016709 nutrition Nutrition 0.000 description 1
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- 235000008935 nutritious Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention relates to a composite licoflavone blueberry juice chewable tablet and a preparation method thereof. The invention relates to a chewable tablet and a preparation method thereof, and aims at solving the technical problem that the utilization rate of liquorice roots is low. The composite licoflavone blueberry juice chewable tablet is prepared from the following raw materials by weight percent: licoflavone extract, blueberry juice, white granulated sugar, starch, maltodextrin, citric acid, magnesium stearate and mannitol. The preparation method comprises the following steps: crushing the white granulated sugar, adding the starch and the maltodextrin, uniformly mixing, then adding the licoflavone extract and the blueberry juice, uniformly stirring to obtain a soft material, sieving, and baking particles to obtain hard particles; and adding the citric acid and the mannitol into the hard particles, uniformly stirring, adding the magnesium stearate, and tableting, thus obtaining the composite licoflavone blueberry juice chewable tablet. The chewable tablet has an antioxidant effect and a bacteriostatic effect and can be used as a healthcare product.
Description
Technical field
The present invention relates to a kind of chewable tablet and preparation method thereof.
Background technology
Radix Glycyrrhizae also known as state is old, well-informed, Herba Hedyotis cantonensis, rod grass, be glycyrrhizic legume (also referred to as Glycyrrhiza uralensis Fisch.), Glycyrrhiza inflata Bat.,
Or Glycyrrhiza glabra L. root and rhizome is dried, be one of the most frequently used Important Chinese Medicinal Herbs material, be also country license medicine-food two-purpose money
Source.Principle active component in Radix Glycyrrhizae be saponinss and flavonoid, wherein liquorice flavonoids compound have antibacterial, disease-resistant
The different physiological roles such as poison, antitumor, antioxidation, liver protection, also find liquorice flavonoids compound for treatment glycosuria in recent years
Disease, prevent and treat skin photoage and also have certain effect.Liquorice flavonoids compound suffers from extensively in medical domain and food industry
General application.Due to the material containing medicinal in a large number, nutrition, health care in licoflavone, therefore, for licoflavone class
The research of compound has important practical significance.
China's Licorice enriches, and eats with a long history, but the processing stage for Radix Glycyrrhizae is very low, the profit of Licorice
With processing still in simple Raw material processing.The product of Radix Glycyrrhizae exploitation at present is concentrated mainly on GANGCAO GAO, licorice spray, glycyrrhizic acid powder
Deng glycyrrhizin based article, it is applied to for soy sauce, cure food, marine products rare delicacies product as a kind of sweeting agent and contains Sal food
Product, and as the food additive in the products such as confection, beverage, chocolate, play the function of increasing fragrance, improve local flavor.
But but abandoned, in waste residue, causes the serious waste of Licorice to the liquorice flavonoids compound in Radix Glycyrrhizae, and utilization rate is low,
There is not been reported for the food developing for the Flavonoid substances in Radix Glycyrrhizae at present.
Content of the invention
The invention aims to the low technical problem of the utilization rate of solution Radix Glycyrrhizae, provide a kind of licoflavone composite blueberry
Juice chewable tablet and preparation method thereof.
The licoflavone composite blueberry juice chewable tablet of the present invention, be by weight percentage by 2.5%～12.5% Radix Glycyrrhizae
Flavonoid extract, 1%～3% blueberry juice, 25%～30% white sugar, 5%～20% starch, 15%～30% Fructus Hordei Germinatus paste
The Mannitol of essence, 0.5%～1.5% citric acid, 0.5%～1.5% magnesium stearate and 1.5%～50.5% is made.
The preparation method of above-mentioned licoflavone composite blueberry juice chewable tablet, sequentially includes the following steps:
First, weigh by weight percentage 2.5%～12.5% licoflavone extractum, 1%～3% blueberry juice, 25%
～30% white sugar, 5%～20% starch, 15%～30% maltodextrin, 0.5%～1.5% citric acid, 0.5%～
1.5% magnesium stearate and 1.5%～50.5% Mannitol；
2nd, white sugar powder is broken to 100 mesh～120 mesh；To add after white sugar powder, starch, maltodextrin mix homogeneously
Licoflavone extractum and blueberry juice, are stirred for uniformly, obtaining soft material；
20 mesh sieves crossed by the soft material that step 2 is obtained, and obtain soft grit, then granule is placed in baking in 50～70 DEG C of baking ovens
Do to water content 4%～6%, obtain hard particles；
3rd, in hard particles add step one weigh citric acid, Mannitol, mix homogeneously, add step one title
The magnesium stearate taking, with tabletting machine, obtains licoflavone composite blueberry juice chewable tablet.
The licoflavone composite blueberry juice chewable tablet of the present invention be a facilitate consumer to eat and carry, have certain
The product of health care.Blue berry wild fruit sweet and sour, unique flavor, nutritious, it is described as " king of sarcocarp ", be a kind of anthocyanin
The wild acinus of rich content, the present invention utilizes blue berry wild fruit juice and licoflavone extractum and starch, maltodextrin, Fructus Citri Limoniae
Acid, magnesium stearate, Mannitol compound, and make chewable tablet, can strengthen the oxidation resistance of chewable tablet, improve chewable tablet simultaneously
Color and luster, increases the refrigerant local flavor of chewable tablet and improves chewiness.This product has antibiotic property, can eliminate oral cavity to a certain extent
Abnormal flavour, has certain health care, meets the allegro life style of modern society, and suitable various people eat, and are fine
Casual health food.The research and development of this product are for the deep processing important in inhibiting of liquorice flavonoids compound, yellow by Radix Glycyrrhizae
Ketone extractum 100% is used for food manufacturing, compensate for the blank of the deep processed product of liquorice flavonoids compound, is conducive to Radix Glycyrrhizae to provide
The scientific utilization in source.
The licoflavone composite blueberry juice chewable tablet sweet mouthfeel of the present invention is suitable, smooth exquisiteness, any surface finish rounding, color
Pool uniformly, assumes purplish pink, has Radix Glycyrrhizae and the distinctive delicate fragrance of blue berry, delicious, chewiness is good, long shelf-life, added value
Height, can be used as casual health food.
Brief description
Fig. 1 is the In Vitro Bacteriostasis design sketch of the chewable tablet of test 2 preparation；
The In Vitro Bacteriostasis design sketch of the chewable tablet of Fig. 2 contrast test one preparation；
The In Vitro Bacteriostasis design sketch of the chewable tablet of Fig. 3 contrast test two preparation；
Specific embodiment
Specific embodiment one: the licoflavone composite blueberry juice chewable tablet of present embodiment be by weight percentage by
2.5%～12.5% licoflavone extractum, 1%～3% blueberry juice, 25%～30% white sugar, 5%～20% starch,
15%～30% maltodextrin, 0.5%～1.5% citric acid, 0.5%～1.5% magnesium stearate and 1.5%～
50.5% Mannitol is made.
Specific embodiment two: the preparation side of the licoflavone composite blueberry juice chewable tablet described in specific embodiment one
Method, sequentially includes the following steps:
First, weigh by weight percentage 2.5%～12.5% licoflavone extractum, 1%～3% blueberry juice, 25%
～30% white sugar, 5%～20% starch, 15%～30% maltodextrin, 0.5%～1.5% citric acid, 0.5%～
1.5% magnesium stearate and 1.5%～50.5% Mannitol；
2nd, white sugar powder is broken to 100 mesh～120 mesh；To add after white sugar powder, starch, maltodextrin mix homogeneously
Licoflavone extractum and blueberry juice, are stirred for uniformly, obtaining soft material；
3rd, the soft material that step 2 obtains is crossed 20 mesh sieves, obtain soft grit, then granule is placed in 50～70 DEG C of baking ovens
Dry to water content 4%～6%, obtain hard particles；
4th, in hard particles add step one weigh citric acid, Mannitol, mix homogeneously, add step one title
The magnesium stearate taking, with tabletting machine, obtains licoflavone composite blueberry juice chewable tablet.
Specific embodiment three: present embodiment is yellow from the Radix Glycyrrhizae described in step one unlike specific embodiment two
The preparation method of ketone extractum, sequentially includes the following steps:
First, Radix Glycyrrhizae tuber pulverized 60 mesh sieves, obtained Radix Glycyrrhizae powder；
2nd, it is 1:(30～50 by solid-liquid ratio) that Radix Glycyrrhizae powder is placed in the ethanol that ethanol mass concentration is 70%～90% is molten
In liquid, mix homogeneously, use high cut disperse emulsification device, shearing rotating speed be 10000～16000r/min under conditions of shearing 3～
5min, is then again heated to 60 DEG C～80 DEG C extraction 30～60min, is cooled to room temperature, centrifugation, obtains crude extract；
3rd, licoflavone crude extract is concentrated it in 40～60 DEG C of rotary evaporations to amass as original 1/5～1/10, be obtained sweet
Careless Flavonoid extract.
Other are identical with specific embodiment two.
The extractum obtaining under conditions of present embodiment is viscous pasty state, and the flavone compound in Radix Glycyrrhizae is at utmost
Retain.
Specific embodiment four: present embodiment weighs 12% from step one unlike specific embodiment two or three
Licoflavone extractum, 2.5% blueberry juice, 28% white sugar, 15% starch, 20% maltodextrin, 1% citric acid,
1% magnesium stearate and 20.5% Mannitol.Other identical with specific embodiment two or three.
Flavone compound in extractum and the Arbutin in blue berry, protein, anthocyanin and other adjuvants, by mutual
Between chemical action, improve anti-oxidation function and bacteria resistance function.
Specific embodiment five: in step 3 unlike one of present embodiment and specific embodiment two to four, dry
The temperature of case is 60 DEG C, dries to water content 5%.Other identical one of with specific embodiment two to four.
With following verification experimental verification beneficial effects of the present invention:
Test 1: prepare licoflavone concentrated extract first, specifically comprise the following steps that
First, Radix Glycyrrhizae tuber pulverized 60 mesh sieves, obtained Radix Glycyrrhizae powder；
2nd, Radix Glycyrrhizae powder being placed in solid-liquid ratio is mix homogeneously in the ethanol solution that 1: 40, concentration of alcohol is 90%, with height
Shearing dispersion and emulsion device is extracted, and shearing rotating speed is 10000r/min, and shear time is 5min, 60 DEG C of extraction 30min, cooling
To room temperature, centrifugation, obtain crude extract；
3rd, licoflavone crude extract is concentrated into the 1/10 of original volume in 45 DEG C of rotary evaporations, prepared licoflavone extractum.
Next prepares blueberry juice: wild blueberry is thawed, squeezes the juice, juice filtered through gauze, and obtain blueberry juice.
The licoflavone extractum of this test 1 preparation and blueberry juice are used for following licoflavone composite blueberry juice chewable tablet
Preparation.
Test 2: the preparation method of the licoflavone composite blueberry juice chewable tablet of this test, sequentially include the following steps:
First, weigh the licoflavone extractum of 1g, the blueberry juice of 0.4g, 7g white sugar, 2g starch, the maltodextrin of 4g,
The Mannitol of the citric acid of 0.2g, the magnesium stearate of 0.2g and 5.2g；
2nd, white sugar powder is broken to 120 mesh；Licoflavone will be added after white sugar powder, starch, maltodextrin mix homogeneously
Extractum and blueberry juice, are stirred for uniformly, obtaining soft material；
3rd, the soft material hand pressure that step 2 obtains is crossed 20 mesh sieves, obtain soft grit, then granule is laid on iron pan
It is placed in drying 10min in 60 DEG C of baking ovens, period is stirred material in three times and makes its uniform drying, obtains hard particles；Hard particles
Water content be 5%；
4th, 20 sieve granulate will be crossed again, and so that the material of caking is loosed off in hard particles and add step one to weigh
Citric acid, Mannitol, mix homogeneously, add the magnesium stearate that step one weighs, with tabletting machine, obtain licoflavone multiple
Close blueberry juice chewable tablet.
The licoflavone composite blueberry juice chewable tablet of this test preparation, sweet mouthfeel is suitable, smooth exquisiteness, and any surface finish is justified
Whole, uniform color, assume purplish pink, have Radix Glycyrrhizae and the distinctive delicate fragrance of blue berry, delicious, chewiness is good.
Do contrast test with test 2 simultaneously:
Contrast test one, from unlike test 2, is added without licoflavone extractum in step one and two, other and test 2
Identical.Preferably, local flavor is light, easily loose, has powder sense, and chewiness is poor for the chewable tablet color that contrast test one is produced.
Contrast test two, from unlike test 2, is not added with blueberry juice in step one and two, other identical with test 2.Contrast
The chewable tablet color that test two is produced is poor, section consolidation, and chewiness is preferable.
It is compared it is known that licoflavone concentrated extract exists by testing the sensory evaluation of the chewable tablet of 2 and contrast test
There is in chewable tablet manufacturing process the effect strengthening local flavor, bonding each adjunct ingredient, improve chewiness.Blueberry juice has and improves nozzle
Chewing piece color and luster makes the effect that chewable tablet is more attractive, increases fragrant, make even tissue.
The antioxidant activity of the chewable tablet that determination test 2 and contrast test one and contrast test two produce, its data such as table 1
Shown.
The antioxidation activity in vitro of table 1 chewable tablet
As it can be seen from table 1 the antioxygenic property of the licoflavone composite blueberry juice chewable tablet of test 2 is than contrast test one
Greatly improve with the chewable tablet of contrast experiment two, and it can also be seen that add licoflavone concentrated extract to significantly improve blue berry
The anti-oxidation function of juice, has the effect of Synergistic.Therefore licoflavone composite blueberry juice chewable tablet antioxidant effect is best.
The inhibitory action to Aspergillus niger of the chewable tablet that determination test 2 and contrast test one and contrast test two produce,
Its fungistatic effect is as shown in Figure 1,2 and 3.Wherein, Fig. 1 is the fungistatic effect figure of the chewable tablet of test 2；Fig. 2 is contrast test one
The fungistatic effect figure of the chewable tablet of preparation；Fig. 3 is the fungistatic effect figure of the chewable tablet of contrast test two preparation.Can from Fig. 1,2 and 3
To find out, the bacteriostasis being not added with the chewable tablet of licoflavone extractum in contrast test one are inconspicuous, and blue berry fungistatic effect is described
Bad, and the chewable tablet being not added with blueberry juice in contrast test two has certain fungistatic effect, its minimal inhibitory concentration is
0.138mg/ml (in terms of licoflavone), antibacterial circle diameter is 8.63mm, illustrates that Radix Glycyrrhizae has certain fungistatic effect, but does not show
Write, and test the fungistatic effect of the licoflavone extractum of 2 preparations and blueberry juice composite chewable tablet preferably, its minimal inhibitory concentration is
0.105mg/ml (in terms of licoflavone) and the inhibition zone 14.89mm of 6.58mg/ml (in terms of Anthocyanin from Blueberry), its bacteriostasis
Significantly improve than the chewable tablet of contrast test one and contrast test two, licoflavone concentrated extract and blue berry have collaborative antibacterial
Effect.
Claims (5)
1. a kind of licoflavone composite blueberry juice chewable tablet it is characterised in that this chewable tablet be by weight percentage by 2.5%～
12.5% licoflavone extractum, 1%～3% blueberry juice, 25%～30% white sugar, 5%～20% starch, 15%～
30% maltodextrin, 0.5%～1.5% citric acid, 0.5%～1.5% magnesium stearate and 1.5%～50.5% sweet
Dew alcohol is made.
2. a kind of method of the licoflavone composite blueberry juice chewable tablet described in preparation claim 1 is it is characterised in that the method,
Sequentially include the following steps:
First, weigh by weight percentage 2.5%～12.5% licoflavone extractum, 1%～3% blueberry juice, 25%～
30% white sugar, 5%～20% starch, 15%～30% maltodextrin, 0.5%～1.5% citric acid, 0.5%～
1.5% magnesium stearate and 1.5%～50.5% Mannitol；
2nd, white sugar powder is broken to 100 mesh～120 mesh；Radix Glycyrrhizae will be added after white sugar powder, starch, maltodextrin mix homogeneously
Flavonoid extract and blueberry juice, are stirred for uniformly, obtaining soft material；
3rd, the soft material that step 2 obtains is crossed 20 mesh sieves, obtain soft grit, then granule is placed in drying in 50～70 DEG C of baking ovens
To water content 4%～6%, obtain hard particles；
4th, in hard particles add step one weigh citric acid, Mannitol, mix homogeneously, add what step one weighed
Magnesium stearate, with tabletting machine, obtains licoflavone composite blueberry juice chewable tablet.
3. a kind of preparation method of licoflavone composite blueberry juice chewable tablet according to claim 2 is it is characterised in that walk
The preparation method of the licoflavone extractum described in rapid one, sequentially includes the following steps:
First, Radix Glycyrrhizae tuber pulverized 60 mesh sieves, obtained Radix Glycyrrhizae powder；
2nd, by solid-liquid ratio be 1:(30～50) Radix Glycyrrhizae powder is placed in the ethanol solution that ethanol mass concentration is 70%～90%
In, mix homogeneously, use high cut disperse emulsification device, shearing rotating speed be 10000～16000r/min under conditions of shearing 3～
5min, is then again heated to 60 DEG C～80 DEG C extraction 30～60min, is cooled to room temperature, centrifugation, obtains crude extract；
3rd, licoflavone crude extract is concentrated it in 40～60 DEG C of rotary evaporations and amass as original 1/5～1/10, prepared Radix Glycyrrhizae is yellow
Ketone extractum.
4. a kind of licoflavone composite blueberry juice chewable tablet according to Claims 2 or 3 preparation method it is characterised in that
Weigh in step one 12% licoflavone extractum, 2.5% blueberry juice, 28% white sugar, 15% starch, 20% Fructus Hordei Germinatus paste
The Mannitol of essence, 1% citric acid, 1% magnesium stearate and 20.5%.
5. a kind of licoflavone composite blueberry juice chewable tablet according to Claims 2 or 3 preparation method it is characterised in that
In step 3, the temperature of baking oven is 60 DEG C, dries to water content 5%.
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Cited By (1)
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| CN109123504A (en) * | 2018-08-23 | 2019-01-04 | 杭州高峰蓝莓种植有限公司 | A kind of blueberry powder formula of chewable tablets and preparation method thereof |
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| CN109123504A (en) * | 2018-08-23 | 2019-01-04 | 杭州高峰蓝莓种植有限公司 | A kind of blueberry powder formula of chewable tablets and preparation method thereof |
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