CN106318820A - Healthcare wine for relieving physical fatigue and preparing method thereof - Google Patents
Healthcare wine for relieving physical fatigue and preparing method thereof Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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Abstract
The invention is in the field of food processing, particularly healthcare wine for relieving physical fatigue and preparing method thereof. The invention is aimed at providing a healthcare wine prepared by predominantly maca in the company of traditional Chinese medicines of barbary wolfberry fruit, American ginseng, and milkvetch root. It has effects of relieving physical fatigue, including the following BPCs and white spirit: BPCs are prepared from, by weight, 1-5 parts of maca, 0.2-0.5 parts of fructus lycii, 0.2-0.5 parts of American ginseng, 0.2-0.5 parts of milkvetch root;and proper amount of white spirit. The invention has simple production technology and maca and American ginseng are extracted in normal temperature, which brings advantage of percolation into full play, not only ensuring stable functional components and acquiring higher rate of extraction; fructus lycii and milkvetch root are extracted in conventional warm water, thus their functional components are fully extracted: crude polysaccharide. In the formula, all ingredients are extracted in different ways by their functional components so as to ensure higher rate of extraction.
Description
Technical field
The invention belongs to food processing field, particularly a kind of alleviating physical fatigue health promoting wine and preparation method thereof.
Background technology
Fatigue can make work efficiency reduce, to things bradykinesia.If can not get resting and reorganizing in time after tired appearance, the time is long
Overwork will be produced and then cause going to bits.
Tired essence is a kind of physiological change, generally, can adjust through suitable rest and medicine
Reason just can be recovered or alleviate.But traditional doctor trained in Western medicine anti-fatigue medicament side effect is relatively big, and improving fatigue symptom with health food is
The most appropriate selection.Therefore, sight is transferred to improve the field of this disease phenomenon by the most many experts and scholars one after another.
The Maca wine of a great variety having in the market, but belong to bread and cheese.Production technology uses tradition
The mode soaked, owing to Lepidinm meyenii Walp itself has the zest taste of uniqueness, the mouthfeel of these Maca wines is the most poor, and can not
Ensure the function of product.Therefore, invention is based oneself upon research and development and a is integrated safety, excellent texture, the health care of clear and definite health care
Wine.
Retrieved by patent documentation and non-patent literature, and market survey, not yet it is found to have Lepidinm meyenii Walp and Fructus Lycii, west
The reported in literature of health promoting wine is obtained after the mixing of Radix Panacis Quinquefolii, the Radix Astragali.
Summary of the invention
It is an object of the invention to play Lepidinm meyenii Walp and Fructus Lycii, Radix Panacis Quinquefolii, the advantage of the Radix Astragali, it is provided that a kind of based on Lepidinm meyenii Walp,
The health promoting wine with alleviating physical fatigue effect that interpolation Chinese crude drug Fructus Lycii, Radix Panacis Quinquefolii, the Radix Astragali are made.
Alleviating physical fatigue health promoting wine of the present invention, it is characterised in that: include following crude drug and Chinese liquor:
Crude drug, by weight ratio meter: Lepidinm meyenii Walp 1～5 parts, Fructus Lycii 0.2～0.5 part, Radix Panacis Quinquefolii 0.2～0.5 part, the Radix Astragali
0.2～0.5 part；
Chinese liquor is appropriate.
Further preferably, alleviating physical fatigue health promoting wine of the present invention, it is characterised in that: include following crude drug and Chinese liquor:
Crude drug, by weight ratio meter: Lepidinm meyenii Walp 1～5 parts, Fructus Lycii 0.2～0.5 part, Radix Panacis Quinquefolii 0.2～0.5 part, the Radix Astragali
0.2～0.5 part；Chinese liquor 93.5～98.4 parts.
In technical solution of the present invention, described Chinese liquor is aromatic Chinese spirit.
Alleviating physical fatigue health promoting wine alcoholic strength is 30～38%vol.
The preparation method of alleviating physical fatigue health promoting wine of the present invention, comprises the steps:
(1) weighting raw materials；Meter by weight ratio: Lepidinm meyenii Walp 1～5 parts, Fructus Lycii 0.2～0.5 part, Radix Panacis Quinquefolii 0.2～0.5
Part, the Radix Astragali 0.2～0.5 part；
(2) pulverize Radix Panacis Quinquefolii, Lepidinm meyenii Walp, the Radix Astragali, at least cross 20 mesh sieves；
(3) Radix Panacis Quinquefolii, Lepidinm meyenii Walp extracting solution are prepared: take step (2) gained Radix Panacis Quinquefolii, Lepidinm meyenii Walp uses Chinese liquor percolation, obtains diafiltration
Liquid, Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution is filtered to obtain in percolate cold preservation；
(4) prepare the Radix Astragali, Fructus Lycii extracting solution: take Fructus Lycii and step (2) the gained Radix Astragali, add 10～20 times amount water soakings
Extract, filter to obtain the Radix Astragali, Fructus Lycii extracting solution；
(5) step (3) gained Radix Panacis Quinquefolii, Lepidinm meyenii Walp extracting solution, step (4) the gained Radix Astragali, Fructus Lycii extracting solution, adds Chinese liquor and adjusts
Whole alcoholic strength is to setting.
Wherein, the satisfied following at least any one of step (3) described percolation condition:
Step (3) adds the Chinese liquor moistening of Chinese liquor 1～1.5 times amount；
Adding Chinese liquor wetting time described in step (3) is 1～2h；Preferably, adding Chinese liquor wetting time described in is 1h；
Step (3) described Chinese liquor alcoholic strength is 40～60%vol；
During step (3) percolation, material filling amount is the 1/3～2/3 of percolate pot, blade diameter length ratio 1:2～1:3；
During step (3) percolation, percolation after impregnating 1～2 day according to solid-liquid ratio 1:3～1:4 Chinese liquor；
Step (3) collects percolate with 5～15mL/min.kg speed；
Step (3) collects the percolate of solid-liquid ratio 1:6～1:10；
The temperature of step (3) percolate cold preservation is 0～4 DEG C；
The time of step (3) percolate cold preservation is 3～7 days；
Filter after step (3) percolate cold preservation and use filtering with microporous membrane；Preferably employ 0.2～1.0 μm microporous filter membrane mistakes
Filter.
Wherein, step (4) is prepared the Radix Astragali, Fructus Lycii extracting solution and is at least met following any one:
Step (4) described soak extraction is normal pressure extraction；
The soak extraction temperature of step (4) described soak extraction is 60～80 DEG C；
The soak extraction number of times of step (4) described soak extraction is 2～3 times (preferably 2 times)；
Each extraction time 2～5h of step (4) described soak extraction；
Step (4) described soak extraction filters gained filtrate and concentrates.
Wherein, step (5) described adjustment alcoholic strength is to 30～38%vol.
Concrete, health promoting wine preparation method of the present invention, weigh each crude drug and Chinese liquor by weight ratio, use following steps
Preparation:
1. Lepidinm meyenii Walp, Radix Panacis Quinquefolii are pulverized, cross 20 mesh sieves；
2. weigh Lepidinm meyenii Walp and Radix Panacis Quinquefolii powder, mix homogeneously, add 40～60%vol aromatic Chinese spirit profits of 1～1.5 times amount
Wet 1～2h, load percolate pot, material filling amount is the 1/3～2/3 of percolate pot, and blade diameter length ratio 1:2～1:3, according to solid-liquid ratio 1:3
～1:4 adds the 40～60%vol airtight dippings of aromatic Chinese spirit 1～2 days, start percolation, receive with 5～15mL/min.kg speed
The percolate of collection solid-liquid ratio 1:6～1:10；
3., by percolate cold preservation 3～7 days in 0～4 DEG C of cold room, 0.2～1.0 μm filtering with microporous membranes obtain Lepidinm meyenii Walp the West
Ginseng extracting solution；
4. the Radix Astragali is pulverized, cross 20 mesh sieves；
5. weigh Fructus Lycii and astragalus membranaceus powder, mix homogeneously, add the purified water of 10～20 times amount, the normal pressure when 60～80 DEG C
Extraction, extracts 2～3 times, every time extraction 2～5h, filters, merging filtrate, is concentrated to give Fructus Lycii Radix Astragali extractive solution；
6., by Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution, Fructus Lycii Radix Astragali extractive solution, add Chinese liquor and adjust alcoholic strength to setting.
In order to coordinate product different wine accuracy requirement, Chinese liquor can be added and adjust alcoholic strength.As by Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution,
Fructus Lycii Radix Astragali extractive solution joins in Chinese liquor, and adjusting alcoholic strength is 30～38%vol, and is settled to 1000L, filters, fill,
Obtain the alleviating physical fatigue health promoting wine of 30～38%vol.
The present invention uses the reason of each crude drug as follows:
Lepidinm meyenii Walp contains rich in protein, aminoacid, reducing sugar, mineral, unsaturated fatty acid, wherein linolenic acid and Asia
Oleic acid is extremely advantageous to health.MAKA dry powder rich in aminoacid (particularly branched-chain amino acid and taurine), mineral calcium,
The multiple chemical composition with antifatigue effect such as magnesium, zinc.In addition to conventional nutrients, metabolism also forms spy
Have has bioactive functional component, such as alkaloid, macamide and Lepidinm meyenii Walp alkene series matter, isothiocyanate, mustard oil
Glycosides, flavonol etc..High nutritive value, rational trophic structure and multiple there is bioactive secondary metabolite make Lepidinm meyenii Walp
Possesses plurality of health care functions.Can be used for traditionally strengthening energy, improve fertility, improve sexual function, treatment climacteric syndrome,
Rheumatism, depression, anemia, effect of the most anticancer and anti-leukemia.Modern medicine study shows, Lepidinm meyenii Walp has anti-tired
The multiple unique effects such as labor, endocrine regulation.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum, its sweet in the mouth, and property is put down.Two sources are eaten as traditional medicine
Material, is the traditional rare Chinese medicine of China, have " red treasured " laudatory title.Chemical composition mainly includes pigment, flavonoid and many
Saccharide compound, if the most also glycine betaine, vitamin C, food booth, several amino acids and various trace elements, it is the most effective
Composition is lycium barbarum polysaccharide.Confirm that Fructus Lycii has regulation body's immunity, can effectively suppress tumor growth and cell to dash forward
Become, there is resisting fatigue, slow down aging, anti-fatty liver, regulation blood fat and the effect of the aspect such as blood glucose, promotion hemopoietic function.Fructus Lycii
Son belongs to natural Chinese medicinal herb, has the medicinal and edible history of thousand of years in China, and life-time service has no side effect.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii, sweet in the mouth, micro-hardship, cool in nature.Containing more than ten kind Radix Ginsengs in Radix Panacis Quinquefolii
Saponin, a small amount of volatile oil, saccharide, aminoacid, inorganic elements etc., can regulate excitement and the suppression of central nervous system, with suppression
The most prominent；Can resisting fatigue, anti-hypoxia, enhancing body adaptation ability；Have arrhythmia, resist myocardial ischemia, strengthen cardiac muscle receipts
The effect of contracting power；There is the effect promoting adrenocortical hormone secretion；Can enhancing human body immunity function；Diuresis and hemostasis is had to make
With.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali.Slightly warm in nature, sweet in the mouth.It has now been found that it contains
There are the various trace elements such as saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper, there is protecting myocardial cell, strong
The heart, anti-stress, enhancing human body immunity power etc. act on.
Fatigue belongs to insufficiency of vital energy and blood, the weak caused deficiency syndrome of function mostly.Tonification is the general principle for the treatment of deficiency syndrome, mends
Method is to take a tonic or nourishing food to build up one's health people's bromhidrosis, blood, the deficiency of yin, yang, promotes that feeble and exhausted function is recovered, returns in balance coordination.Nourish and can make
Weakling's health level improves, and body constitution strengthens, and promotes that weak strain situation takes a favorable turn or fully recovers.The Radix Astragali is a kind of important biography
System traditional tonic medicine, is the Qi-tonifying drug that purposes is the widest, consumption is maximum, has people to be classified as QI invigorating head medicine, and the Radix Astragali also has life simultaneously
The effect nourished blood in Tianjin.Radix Panacis Quinquefolii and Radix Ginseng have cold using warming therapy other in terms of the property of medicine, and Radix Panacis Quinquefolii is most appropriate to deficiency of both QI and YIN the disease of heat
People, it is unique in that the hottest the driest, all be not suitable for Radix Ginseng treatment and vulcanize can use Radix Panacis Quinquefolii per capita." ginseng stilbene " is the traditional Chinese medical science
Classical compatibility, both of which belongs to Qi-tonifying drug, Radix Panacis Quinquefolii effect boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, Radix Astragali effect air making-up and spleen enlivening, yang invigorating
Act falls into, benefit defends consolidating superficial resistance, inducing diuresis to remove edema, promoting pus discharge and tissue regeneration strengthening, and both share the effect that can strengthen QI invigorating.Fructus Lycii effect is notable, GUYAO
Book " book on Chinese herbal medicine converges and says " is sayed: " Fructus Lycii can make gas can fill (QI invigorating), blood can mend (enriching blood), Yang Kesheng (tonifying YANG), the moon can be grown and (grow
Cloudy), (pathogenic fire reducing) can drop in fire, wind can be dispelled (dispelling the wind and dampness pathogens), has perfect magical effect also." traditional Chinese medical science thinks that gas and blood are dialectical relationships, gas is
The general of blood, blood is again the mother of gas, and Radix Astragali Radix Panacis Quinquefolii is mainly QI invigorating, and Fructus Lycii has effect of rich in nutrition concurrently.
The traditional Chinese medical science thinks that the health status of human body and the power of its " originally " have substantial connection, qi-restoratives to it is critical only that element culturing fixed folder.
So-called cultivate human body this, encourage healthy trends, essentially consist in spleen reinforcing and the kidney invigorating, ancient Chinese medicine doctor thinks the strain of human body and old and feeble controlling
Treat general provisions and be the kidney invigorating and spleen invigorating.In formula, the Radix Astragali returns spleen channel, Radix Panacis Quinquefolii and Fructus Lycii to return kidney channel, it is seen that this three's compatibility has
Well kidney and spleen invigorating effect.
MAKA dry powder has rich in aminoacid (particularly branched-chain amino acid and taurine), mineral calcium, magnesium, zinc etc. are multiple
The chemical composition of antifatigue effect.Modern medicine study shows, Lepidinm meyenii Walp has multiple unique merit such as resisting fatigue, endocrine regulation
Effect.Research finds that MAKA dry powder can be obviously prolonged mice swimming time, reduces serum urea nitrogen level, can increase the glycogen of mice
Former deposit, reduces blood lactase acid changing value before and after motion.
Lepidinm meyenii Walp, the Radix Astragali, Radix Panacis Quinquefolii, Fructus Lycii are respectively provided with good alleviating physical fatigue effect, and this product is based on Lepidinm meyenii Walp
Want Effect raw material, be aided with the Radix Astragali, Radix Panacis Quinquefolii and Fructus Lycii, cooperative reinforcing function of physical fatigue alleviation.
The present invention with natural product as raw material, pure in mouth feel, without food additive, no side effects.
Production technology of the present invention is simple, and Lepidinm meyenii Walp Radix Panacis Quinquefolii uses extract at room temperature, gives full play to the advantage of percolation, both ensured
The stablizing of functional component (such as: alkaloid, saponin), obtains again higher extraction ratio；The Fructus Lycii Radix Astragali uses conventional warm water
Extract, can fully extract functional component therein: crude polysaccharides.Technical study relevant experimental data is as follows.In formula, each raw material is pressed
According to the character of functional component, the extracting mode that categorizing selection is different, it is ensured that its higher extraction ratio.
Accompanying drawing explanation
The impact that total saponins, total alkaloids are extracted by Fig. 1 raw material granularity.
The impact that total saponins, total alkaloids are extracted by Fig. 2 Chinese liquor number of degrees.
The impact that total saponins, total alkaloids are extracted by Fig. 3 percolation speed.
The impact that total saponins, total alkaloids are extracted by Fig. 4 leachate collection volume.
The impact that crude polysaccharides is extracted by Fig. 5 extraction time.
The impact that crude polysaccharides is extracted by Fig. 6 Extracting temperature.
The impact that crude polysaccharides is extracted by Fig. 7 solid-liquid ratio.
The impact that crude polysaccharides is extracted by Fig. 8 extraction time.
Detailed description of the invention
The following is preparation method screening experiment and the functional experiment of alleviating physical fatigue health promoting wine of the present invention.
One, Lepidinm meyenii Walp Radix Panacis Quinquefolii extracts experiment of single factor
(1) impact that total saponins, total alkaloids are extracted by raw material granularity
Lepidinm meyenii Walp and Radix Panacis Quinquefolii are respectively crushed into 5 kinds of different-grain diameters, are 5mm, 2.5mm, 1.6mm (12 mesh), 0.9mm respectively
(20 mesh), 0.3mm (60 mesh).Accurately weigh the pueraria root powder 30g and Radix Panacis Quinquefolii powder 3g of different-grain diameter, with pueraria root powder and the west of particle diameter
Radix Panacis Quinquefolii powder mix homogeneously, with the 60%vol Chinese liquor moistening 2h that solid-liquid ratio is 1:1, fills percolation post, impregnates 24h, with 0.6mL/min
The speed of left and right collects percolate 198mL.Detection total saponins, the content of total alkaloids, calculate extraction ratio, and result is shown in Fig. 1.
As shown in Figure 1, along with the reduction of raw material pulverizing granularity, the surface area of raw material increases, with the contact area phase of solvent
Should increase, beneficially the dissolution of functional component, total saponins, the extraction ratio of total alkaloids gradually rise.But, if raw material mistake
Carefully, bed material is the closeest, hinders percolation operation.Raw material granularity is when 20 mesh, and functional component extraction rate reached is to higher level, again
Can guarantee that the compactness of percolation material is moderate, conveniently carry out percolation.Therefore, during percolation, raw material granularity is chosen as 20 mesh.
(2) impact that total saponins, total alkaloids are extracted by the Chinese liquor number of degrees
Accurately weigh pueraria root powder 30g and Radix Panacis Quinquefolii powder 3g, the mix homogeneously being crushed to 20 mesh, weigh 5 parts, use 33mL respectively
30,40,50,60,68%vol Chinese liquor moistening 2h, fill percolation post, impregnate 24h, collect with the speed of about 0.5mL/min and ooze
Filtrate 198mL.Detection total saponins, the content of total alkaloids, calculate extraction ratio, and result is shown in Fig. 2.
As shown in Figure 2, along with the rising of the Chinese liquor number of degrees, total saponins, total alkaloids all present first raise, the most stable, right
After the process that slightly lowers.Total saponins extraction ratio, when the Chinese liquor number of degrees are 50%vol, reaches maximum 44.37%；Total alkaloids
Extraction ratio is reaching maximum 58.87% when the Chinese liquor number of degrees are 60%vol.When the Chinese liquor number of degrees are 50%vol, total alkaloids
Extraction ratio also is able to reach 57.93%.Therefore the Chinese liquor number of degrees selecting 40%vol, 50%vol, 60%vol to be orthogonal experiment.
(3) impact that total saponins, total alkaloids are extracted by percolation speed
Accurately weigh pueraria root powder 30g and Radix Panacis Quinquefolii powder 3g, the mix homogeneously being crushed to 20 mesh, weigh 5 parts, use 33mL
50%vol Chinese liquor moistening 2h, fills percolation post, impregnates 24h, respectively with 0.2,0.3,0.4,0.5, the speed of 0.6mL/min collects
Percolate 198mL.Detection total saponins, the content of total alkaloids, calculate extraction ratio, and result is shown in Fig. 3.
From the figure 3, it may be seen that percolation speed is less on the impact of total saponins, total alkaloids extraction ratio, total soap during 0.3mL/min
When glycosides, total alkaloids extraction ratio are the most of a relatively high, therefore selecting 0.2mL/min, 0.3mL/min, 0.4mL/min is orthogonal experiment
Percolation speed.
(4) impact that total saponins, total alkaloids are extracted by leachate collection volume
Accurately weigh pueraria root powder 30g and Radix Panacis Quinquefolii powder 3g, the mix homogeneously being crushed to 20 mesh, weigh 5 parts, use 33mL
50%vol Chinese liquor moistening 2h, fills percolation post, impregnates 24h, percolation speed 0.3mL/min, collect respectively percolate 198,264,
330,396,462mL (percolate volume is followed successively by the 6 of material, 8,10,12,14 times).Detection total saponins, the containing of total alkaloids
Amount, calculates extraction ratio, and result is shown in Fig. 4.
As shown in Figure 4, the extraction ratio of functional component is affected very big, along with leachate collection volume by leachate collection volume
Be continuously increased, the extraction ratio of functional component raises, and progressivelyes reach stable.When leachate collection volume reaches 10 times, effect
Composition has had dissolved out significant portion, total saponins extraction rate reached to 81.83%, total alkaloids extraction rate reached to 75.11%, then increases
Adding leachate collection volume, the extraction ratio elevated-levels of functional component slows down.Therefore selecting 8 times, 10 times, 12 times is orthogonal experiment
Percolate collected volume.
Two, Lepidinm meyenii Walp Radix Panacis Quinquefolii extracts orthogonal experiment
On the basis of experiment of single factor, determine using the Chinese liquor number of degrees, percolation speed, leachate collection volume as orthogonal reality
Test the factor of optimization.3 factors respectively select three preferable levels, use L9 (34) orthogonal table, carry out orthogonal experiment.Three preferably
0.2,0.3,0.4mL/min 40,50,60%vol level is respectively the Chinese liquor number of degrees:, percolation speed:, leachate collection volume: 8,
10,12 times, the gauge outfit design of orthogonal experiment is shown in Table 1, and Orthogonal experiment results is as shown in table 2.
The gauge outfit design of table 1 orthogonal experiment
Table 2 total saponins, total alkaloids percolation L9 (34) Orthogonal experiment results
The range analysis of raw material seepage pressure effects total saponins orthogonal experiment and variance analysis are shown in Table 3, table 4.By range analysis table 3
Understanding, the power that these 3 factors affect total saponins extraction ratio is followed successively by: percolation volume (C) the ＞ Chinese liquor number of degrees (A) ＞ percolation speed
(B)；Optimal conditions is A3B3C3, it may be assumed that Chinese liquor number of degrees 60%vol, percolation speed 0.4mL/min, percolate collected volume are 12
Times.From analysis of variance table 4, the Chinese liquor number of degrees (A), percolation volume (C) extremely notable (the P ＜ of impact on total saponins extraction ratio
0.01), and percolation speed (B) is notable (P ＞ 0.10) on the impact of total saponins extraction ratio.
The range analysis of raw material seepage pressure effects total alkaloids orthogonal experiment and variance analysis are shown in Table 5, table 6.By range analysis
Table 5 understands, and the power that these 3 factors affect total alkaloids extraction ratio is followed successively by: percolation volume (C) the ＞ Chinese liquor number of degrees (A) ＞ oozes
Speed of filtering (B)；Optimal conditions is A2B1C3, it may be assumed that Chinese liquor number of degrees 50%vol, percolation speed 0.2mL/min, percolate collected volume
It it is 12 times.From analysis of variance table 6, the Chinese liquor number of degrees (A), percolation volume (C) notable (P of impact on total alkaloids extraction ratio
＜ 0.10), and percolation speed (B) is not notable (P ＞ 0.10) on the impact of total alkaloids extraction ratio.
From Orthogonal experiment results, the optimal conditions that total saponins extracts is A3B3C3, the optimal conditions of total alkaloids extraction
It is A2B1C3.In 3 factors, percolation speed (B) is minimum on the impact of two kinds of constituents extraction, in order to improve the efficiency of production, selects
Percolation speed faster, i.e. B3.The Chinese liquor number of degrees are chosen as 50%vol.When leachate collection volume is 10 times, functional component extracts
Rate can meet requirement, and in order to reduce solvent load, leachate collection volume is chosen as 10 times.So final extraction conditions is
A2B3C2, it may be assumed that concentration of alcohol 50%, percolation speed 0.4mL/min, percolate collected volume are 10 times, this condition in confirmatory experiment
Lower total saponins extraction ratio is 81.7%, total alkaloids extraction ratio is 75.8%.
Table 3 total saponins percolation orthogonal experiment range analysis
Table 4 total saponins percolation orthogonal experiment variance analysis
Table 5 total alkaloids percolation orthogonal experiment range analysis
Table 6 total alkaloids percolation orthogonal experiment variance analysis
Three, Fructus Lycii astragalus extraction experiment of single factor
(1) extraction time impact on coarse polysaccharide extractive rate
Being 1:15 and at Extracting temperature 70 DEG C at solid-liquid ratio, extract twice, each extraction time is respectively at 1h, 2h, 3h, 4h
The extraction of crude polysaccharides is carried out under time.Detection crude polysaccharides content, calculates coarse polysaccharide extractive rate, and result is shown in Fig. 5.
As seen from Figure 5, being continuously increased of heat time heating time, coarse polysaccharide extractive rate linearly rises between 1～3h, 3h with
Rear extraction ratio increase inconspicuous, long extraction time can increase energy consumption, therefore select 2h, 3h, 4h as orthogonal experiment time
Between.
(2) Extracting temperature impact on coarse polysaccharide extractive rate
It is 1:20 at solid-liquid ratio, extracts twice, under the conditions of each extraction time 2h, respectively at 60 DEG C, 70 DEG C, 80 DEG C, 90
DEG C carry out the extraction of crude polysaccharides.Detection crude polysaccharides content, calculates coarse polysaccharide extractive rate, and result is shown in Fig. 6.
As seen from Figure 6, along with the continuous rising of Extracting temperature, extraction ratio is constantly increasing, increasing degree before 80 DEG C
Ratio is more significant, but declines after 80 DEG C, and higher temperature likely activity and structure to polysaccharide has a certain impact, and also has
High temperature also can consume the substantial amounts of energy and be unfavorable for large-scale factorial praluction, select 70 DEG C, 80 DEG C, 90 DEG C as extract crude polysaccharides
Orthogonal experiment temperature.
(3) solid-liquid ratio impact on coarse polysaccharide extractive rate
Under Extracting temperature 70 DEG C and extraction time 2h, extract twice, respectively at 1:10,1:15,1:20,1:25 solid-liquid ratio
Under carry out the extraction of crude polysaccharides.Detection crude polysaccharides content, calculates coarse polysaccharide extractive rate, and result is shown in Fig. 7.
As seen from Figure 7, along with the increase of solid-liquid ratio, the extraction ratio of polysaccharide almost straight line upwards increases, but increases after 1:20
Long inconspicuous, it is contemplated that the biggest solid-liquid ratio is unfavorable for industrialized production.Therefore solid-liquid ratio is selected to make at 1:15,1:20,1:25
Solid-liquid ratio for relatively orthogonal experiment.
Four, Fructus Lycii astragalus extraction orthogonal experiment
On the basis of experiment of single factor, determine and optimize as orthogonal experiment using Extracting temperature, solid-liquid ratio, extraction time
Factor.3 factors respectively select three preferable levels, use L9 (34) orthogonal table, carry out orthogonal experiment.Three preferable levels are respectively
2,3,4h for Extracting temperature: 70,80,90 DEG C, solid-liquid ratio: 1:15,1:20,1:25, extraction time:, the gauge outfit of orthogonal experiment sets
Meter is shown in Table 7, and Orthogonal experiment results is as shown in table 8.
The gauge outfit design of table 7 orthogonal experiment
Table 8 crude polysaccharides water carries L9 (34) Orthogonal experiment results
Table 9 crude polysaccharides water proposes orthogonal experiment variance analysis
As shown in Table 8, the extraction optimum condition of crude polysaccharides is A2B2C2: Extracting temperature 80 DEG C, extraction time 3h, extraction material
Liquor ratio 1:20.In confirmatory experiment, an extraction ratio adds up to be 69.1%.Analysis of variance table 9 understands, and 3 factors are to crude polysaccharides
The impact of extraction ratio is not notable (P ＞ 0.10).
Five, the Fructus Lycii astragalus extraction number of times impact on coarse polysaccharide extractive rate
The optimal conditions drawn according to orthogonal experiment, is i.e. 1:20 bar at Extracting temperature 80 DEG C, extraction time 3h, solid-liquid ratio
Under part, extract 3 times, every time detection crude polysaccharides content, calculate coarse polysaccharide extractive rate.Result is as shown in Figure 8: extraction ratio is the most for the first time
Up to 71.6%, second time drops to 10.2%, and third time is 2.97%.Third time is worth almost without extracting, and determines
Extraction time is twice.
From the point of view of functional component, stability experiment testing result, alkaloid in alleviating physical fatigue health promoting wine of the present invention
With saponin good stability, and detection method degree of variation is less.Product efficacy is notable, has bigger market development potential.
Six, the anti-fatigue effect experiment of alleviating physical fatigue health promoting wine of the present invention
1 material and method
Sample: experiment uses 3.5 times of concentrated solutions, and alcoholic strength is 15% (v/v).The front base liquor of experiment adds distilled water and is configured to
15% (v/v) base liquor, then make solvent preparation tested material, stored refrigerated by 15% (v/v) base liquor.
Dosage choice and tested material give mode: experiment sets 4.76ml/kg.BW, 9.52ml/kg.BW, 14.29ml/
Tri-dosage groups of kg.BW (are equivalent to the 10 of human body recommended amounts, 20,30 times).Take 3.5 times of concentrated solutions tested material 60ml,
119ml, 179ml, the base liquor of (v/v) mixes to 250ml first to add 15% successively, and refrigerator-freezer preserves, and is finished and joins.Every day presses 20ml/
Kg.BW per os gavage gives once, gives 30 days the most continuously.Separately set 15% (v/v) base liquor matched group and distilled water blank is right
According to group.Experiment is divided into one, two, three, four groups, often 50 animals of group.
1.1 swimming with a load attached to the body experiments: the microfuse of mouse tail root load 5% body weight of one group of each dosage group will be tested,
Mice is put into during experiment water temperature 25 ± 1.0 DEG C, the swimming trunk went swimming of depth of water 30cm, and mice starts to death record from swimming
Time, calculate mice swimming time.
1.2 serum ureas measure: the mice testing two groups of each dosage groups is put into not swimming with a load attached to the body in the water of temperature 30 DEG C
90min, after rest 60min, pulls out eyeball and takes a blood sample about 0.5ml, takes serum and operates by test kit description, full-automatic with AU400
The kit measurement serum urea content that biochemistry analyzer and diagnosis company limited of Germany's Olympus (European) provide.
1.3 hepatic glycogen measure: by test the mice last of three groups of each dosage groups to tested material 30min after, put to death dynamic immediately
Thing takes liver and blots with filter paper after normal saline rinses, and weighs about 100mg liver, by " health food inspection and assessment technique
Specification " anthrone method in (version in 2003) measures the content of hepatic glycogen.
1.4 blood lactase acid measure: will test the mice of four groups of each dosage groups, do not bear a heavy burden at the water went swimming of temperature 30 DEG C
Stop after 10min.Plasma lactate method: after 0min and swimming, rest 20min respectively takes a blood sample 20 μ l, respectively before swimming, after swimming
After adding 50 μ l hemolytic agents vibration mixings, then with SBA-40C type bio-sensing analysis-e/or determining.Measurement result is multiplied by extension rate
3.5 are Serum lactic acid content.
2 experimental results
The impact on the mice burden swimming time of the 2.1 alleviating physical fatigue health promoting wine:
From table 10, the walking weight load of 15% (v/v) base liquor matched group compares with distilled water matched group, examines through T
Test difference without significance different (P > 0.05).Walking weight load and 15% (v/v) base liquor matched group of three dosage group mices compare,
Analysis of variance, middle and high dosage group can significantly extend the mice burden swimming time (P < 0.05, P < 0.05).
The impact on the mice burden swimming time of the table 10 alleviating physical fatigue health promoting wine
2.2 alleviating physical fatigue health promoting wine are on the impact of serum urea after mouse movement:
From table 11,15% (v/v) base liquor control group mice post exercise serum urea compares with distilled water matched group,
Through T inspection no significant difference (P > 0.05).Serum urea after three dosage group mouse movements and the comparison of 15% (v/v) base liquor
Group compares, Analysis of variance, and the serum urea of dosage group low, middle significantly reduces (P < 0.05, P < 0.05).
Table 11 alleviating physical fatigue health promoting wine is on the impact of serum urea after mouse movement
The impact on Mouse Liver glycogen content of the 2.3 alleviating physical fatigue health promoting wine:
From table 12, the hepatic glycogen content of 15% (v/v) base liquor control group mice compares with distilled water matched group, through T
Inspection no significant difference (P > 0.05).Hepatic glycogen content and 15% (v/v) base liquor matched group of three dosage group mices compare,
Analysis of variance, middle and high dosage group hepatic glycogen significantly raises (P < 0.05, P < 0.01).
The impact on Mouse Liver glycogen of the table 12 alleviating physical fatigue health promoting wine
2.4 alleviating physical fatigue health promoting wine are on the impact of blood lactase acid level after mouse movement:
From table 13,15% (v/v) base liquor control group mice post exercise blood lactase acid area under the curve compares with distilled water
Group compares, through T inspection no significant difference (P > 0.05).The blood lactase acid area under curve of three dosage groups and 15% (v/v) base
Wine matched group compares, Analysis of variance, without significance between blood lactase acid area under curve and the base liquor matched group of three dosage groups
Difference (P > 0.05).
Table 13 alleviating physical fatigue health promoting wine is on the impact of blood lactase acid change after mouse movement
3 brief summaries
After the most continuous 30 days per os gavages of alleviating physical fatigue health promoting wine give animal, the swimming with a load attached to the body of three dosage groups
Time compares with 15% (v/v) base liquor matched group, and middle and high dosage group can significantly extend mice burden swimming time, experimental result
For the positive；Without significance difference between blood lactase acid area under the curve and 15% (v/v) base liquor matched group after three dosage group mouse movements
Different, experimental result is negative；The Mouse Liver glycogen content of three dosage groups and 15% (v/v) base liquor matched group compare, middle and high dose
Amount group can significantly raise Mouse Liver glycogen content, and experimental result is positive；The serum urea content of three dosage groups and 15% (v/
V) base liquor matched group compares, and the serum urea of dosage group low, middle significantly reduces, and experimental result is positive.As can be seen here, body is alleviated
Power fatigue health promoting wine has function of physical fatigue alleviation to animal.
Further describing the present invention below in conjunction with embodiment, the present invention is not limited only to described embodiment.
Embodiment one
1. Lepidinm meyenii Walp, Radix Panacis Quinquefolii are pulverized, cross 20 mesh sieves；
2. weigh pueraria root powder 40kg and Radix Panacis Quinquefolii powder 2kg, mix homogeneously, add the 60%vol aromatic Chinese spirit profit of 1 times amount
Wet 1h, loads percolate pot, and material filling amount is the 2/3 of percolate pot, blade diameter length ratio 1:3, adds 60%vol according to solid-liquid ratio 1:4 dense
The airtight dipping of aromatic white spirit 2 days, starts percolation, collects the percolate of solid-liquid ratio 1:8 with 5mL/min.kg speed；
3., by percolate cold preservation 7 days in 4 DEG C of cold rooms, 0.6 μm filtering with microporous membrane obtains Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution；
4. the Radix Astragali is pulverized, cross 20 mesh sieves；
5. weigh Fructus Lycii 2kg and astragalus membranaceus powder 2kg, mix homogeneously, add the purified water of 20 times amount, the normal pressure leaching when 60 DEG C
Carry, extract 2 times, extract 5h every time, filter, merging filtrate, be concentrated to give Fructus Lycii Radix Astragali extractive solution；
6., by Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution, Fructus Lycii Radix Astragali extractive solution by joining in aromatic Chinese spirit, adjust alcoholic strength
For 38%vol, and it is settled to 1000L, filters, fill, obtain the alleviating physical fatigue health promoting wine of 38%vol.
Embodiment two
1. Lepidinm meyenii Walp, Radix Panacis Quinquefolii are pulverized, cross 20 mesh sieves；
2. weigh pueraria root powder 50kg and Radix Panacis Quinquefolii powder 5kg, mix homogeneously, add the 60%vol aromatic Chinese spirit profit of 1 times amount
Wet 1h, loads percolate pot, and material filling amount is the 2/3 of percolate pot, blade diameter length ratio 1:3, adds 60%vol according to solid-liquid ratio 1:4 dense
The airtight dipping of aromatic white spirit 2 days, starts percolation, collects the percolate of solid-liquid ratio 1:10 with 10mL/min.kg speed；
3., by percolate cold preservation 7 days in 4 DEG C of cold rooms, 0.6 μm filtering with microporous membrane obtains Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution；
4. the Radix Astragali is pulverized, cross 20 mesh sieves；
5. weigh Fructus Lycii 5kg and astragalus membranaceus powder 5kg, mix homogeneously, add the purified water of 20 times amount, the normal pressure leaching when 70 DEG C
Carry, extract 2 times, extract 5h every time, filter, merging filtrate, be concentrated to give Fructus Lycii Radix Astragali extractive solution；
6., by Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution, Fructus Lycii Radix Astragali extractive solution by joining in aromatic Chinese spirit, adjust alcoholic strength
For 36%vol, and it is settled to 1000L, filters, fill, obtain the alleviating physical fatigue health promoting wine of 36%vol.
Embodiment three
1. Lepidinm meyenii Walp, Radix Panacis Quinquefolii are pulverized, cross 20 mesh sieves；
2. weigh pueraria root powder 30kg and Radix Panacis Quinquefolii powder 5kg, mix homogeneously, add the 60%vol aromatic Chinese spirit of 1.5 times amount
Moistening 1h, loads percolate pot, and material filling amount is the 2/3 of percolate pot, blade diameter length ratio 1:3, adds 60%vol according to solid-liquid ratio 1:4
The airtight dipping of aromatic Chinese spirit 2 days, starts percolation, collects the percolate of solid-liquid ratio 1:10 with 15mL/min.kg speed；
3., by percolate cold preservation 7 days in 4 DEG C of cold rooms, 0.4 μm filtering with microporous membrane obtains Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution；
4. the Radix Astragali is pulverized, cross 20 mesh sieves；
5. weigh Fructus Lycii 3kg and astragalus membranaceus powder 3kg, mix homogeneously, add the purified water of 20 times amount, the normal pressure leaching when 80 DEG C
Carry, extract 3 times, extract 4h every time, filter, merging filtrate, be concentrated to give Fructus Lycii Radix Astragali extractive solution；
6., by Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution, Fructus Lycii Radix Astragali extractive solution by joining in aromatic Chinese spirit, adjust alcoholic strength
For 35%vol, and it is settled to 1000L, filters, fill, obtain the alleviating physical fatigue health promoting wine of 35%vol.
The present invention is health promoting wine for oral administration, and every day, the amount of drinking was 100mL, and long-term drink is i.e. up to good result.
Above example is part detailed description of the invention of the present invention, but protection scope of the present invention is not limited thereto, and appoints
What those skilled in the art is in the technical scope that the invention discloses, the change that can readily occur in or replacement, it all should belong to
In the middle of the claims of the present invention.
Claims (9)
1. alleviating physical fatigue health promoting wine, it is characterised in that: include following crude drug and Chinese liquor:
Crude drug, by weight ratio meter: Lepidinm meyenii Walp 1～5 parts, Fructus Lycii 0.2～0.5 part, Radix Panacis Quinquefolii 0.2～0.5 part, the Radix Astragali 0.2
～0.5 part；
Chinese liquor is appropriate.
Alleviating physical fatigue health promoting wine the most according to claim 1, it is characterised in that: include following crude drug and Chinese liquor:
Crude drug, by weight ratio meter: Lepidinm meyenii Walp 1～5 parts, Fructus Lycii 0.2～0.5 part, Radix Panacis Quinquefolii 0.2～0.5 part, the Radix Astragali 0.2
～0.5 part；
Chinese liquor 93.5～98.4 parts.
Alleviating physical fatigue health promoting wine the most according to claim 1 and 2, it is characterised in that: described Chinese liquor is that Luzhou-flavor is white
Wine.
4. according to the alleviating physical fatigue health promoting wine described in any one of claim 1-3, it is characterised in that: described alleviation muscle power is tired
The alcoholic strength of labor health promoting wine is 30～38%vol.
5. the preparation method of the alleviating physical fatigue health promoting wine described in claim 1, it is characterised in that: step is as follows:
(1) weighting raw materials；Meter by weight ratio: Lepidinm meyenii Walp 1～5 parts, Fructus Lycii 0.2～0.5 part, Radix Panacis Quinquefolii 0.2～0.5 part,
The Radix Astragali 0.2～0.5 part；
(2) pulverize Radix Panacis Quinquefolii, Lepidinm meyenii Walp, the Radix Astragali, at least cross 20 mesh sieves；
(3) Radix Panacis Quinquefolii, Lepidinm meyenii Walp extracting solution are prepared: take step (2) gained Radix Panacis Quinquefolii, Lepidinm meyenii Walp uses Chinese liquor percolation, obtains percolate, oozes
Lepidinm meyenii Walp Radix Panacis Quinquefolii extracting solution is filtered to obtain in filtrate cold preservation；
(4) prepare the Radix Astragali, Fructus Lycii extracting solution: take Fructus Lycii and step (2) the gained Radix Astragali, add 10～20 times amount water soakings carry
Take, filter to obtain the Radix Astragali, Fructus Lycii extracting solution；
(5) step (3) gained Radix Panacis Quinquefolii, Lepidinm meyenii Walp extracting solution, step (4) the gained Radix Astragali, Fructus Lycii extracting solution, adds Chinese liquor and adjusts wine
Precision is to setting.
The preparation method of alleviating physical fatigue health promoting wine the most according to claim 5, it is characterised in that: step (3) is described
The satisfied following at least any one of percolation condition:
Add the Chinese liquor moistening of Chinese liquor 1～1.5 times amount；
The described Chinese liquor wetting time that adds is 1～2h；Preferably, adding Chinese liquor wetting time described in is 1h；
Described Chinese liquor alcoholic strength is 40～60%vol；
During percolation, material filling amount is the 1/3～2/3 of percolate pot, blade diameter length ratio 1:2～1:3；
During percolation, percolation after impregnating 1～2 day according to solid-liquid ratio 1:3～1:4 Chinese liquor；
Percolate is collected with 5～15mL/min.kg speed；
Collect the percolate of solid-liquid ratio 1:6～1:10；
The temperature of percolate cold preservation is 0～4 DEG C；
The time of percolate cold preservation is 3～7 days；
Filter after percolate cold preservation and use filtering with microporous membrane；Preferably employ 0.2～1.0 μm filtering with microporous membranes.
The preparation method of alleviating physical fatigue health promoting wine the most according to claim 5, it is characterised in that: prepared by step (4)
The Radix Astragali, Fructus Lycii extracting solution at least meet following any one:
Step (4) described soak extraction is normal pressure extraction；
The soak extraction temperature of step (4) described soak extraction is 60～80 DEG C；
The soak extraction number of times of step (4) described soak extraction is 2～3 times；
Each extraction time 2～5h of step (4) described soak extraction；
Step (4) described soak extraction filters gained filtrate and concentrates.
The preparation method of alleviating physical fatigue health promoting wine the most according to claim 5, it is characterised in that: step (4) is described
The soak extraction number of times of soak extraction is 2 times.
The preparation method of alleviating physical fatigue health promoting wine the most according to claim 5, it is characterised in that: step (5) is described
Adjust alcoholic strength to 30～38%vol.
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| CN110144276A (en) * | 2019-05-15 | 2019-08-20 | 四川大学 | A kind of preparation process with anti-fatigue effect health liquor |
| CN110279804A (en) * | 2019-08-02 | 2019-09-27 | 怀化学院 | A kind of antifatigue rhizoma polygonati Chinese medicine composition and its health liquor |
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