CN106310145A - 一种用于治疗痔疮的外涂药物及其制备方法 - Google Patents
一种用于治疗痔疮的外涂药物及其制备方法 Download PDFInfo
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Abstract
本发明涉及中药技术领域,具体公开了一种用于治疗痔疮的外涂药物,同时还公开了其制备方法。该治疗痔疮的外涂药物由以下重量份数的原料药制成:芒硝、三七粉、蟾酥、半夏、胆南星、五倍子、冰片、苍术、白芷、防风、红花、明矾、莪术、黄柏、赤芍、丹皮、百部、蝉蜕、大黄、枳壳、马齿苋、地榆、紫草、地肤子、石菖蒲、荆芥、甘草、白鲜皮、人工麝香。本发明提供的治疗痔疮的外涂药物,经以上原料药合理配伍,具有活血凉血、清热燥湿、去水消肿、收敛止痛效果,通过涂抹于患处,可以有效治疗外痔。并且,本发明提供的治疗痔疮的外涂药物为无色液体,不用担心在使用时会污染内衣,使用非常方便。
Description
技术领域
本发明涉及中药技术领域,具体涉及一种用于治疗痔疮的外涂药物,同时还涉及其制备方法。
背景技术
痔是人体直肠末端粘膜下和肛管皮肤下静脉丛发生扩张和屈曲所形成的柔软静脉团,是一种常见的肛肠疾病,又名痔疮、痔核、痔病、痔疾等。任何年龄都可发病,但随着年龄增长,发病率逐渐增高。
痔按发生部位的不同分为内痔、外痔、混合痔。在肛管皮肤与直肠黏膜的连接处有一条锯齿状的可见的线叫肛管齿状线。在齿状线以上的为内痔,是肛垫的支持结构、静脉丛及动静脉吻合支发生病理改变或移位,被覆直肠黏膜,由于内括约肌收缩,肛垫以Y型沟分为左侧、右前侧、右后侧三块,因此内痔常见于左侧、右前侧及右后侧;在齿状线以下为外痔,被覆肛管黏膜,可分为结缔组织性外痔、静脉曲张性外痔、血栓性外痔;兼有内痔和外痔的为混合痔,是内痔通过静脉丛与相应的外痔融合,即上、下静脉丛的吻合,混合痔脱出肛门外,呈梅花状时,称为环形痔,若被括约肌嵌顿,形成嵌顿性痔。
痔疮的临床表现主要为便血,坠胀感,肿胀、疼痛等。虽然痔疮的病因复杂,但通过临床统计来看,缺少运动、久坐更容易导致痔疮。随着人们生活方式的变化,对于每个现代人来说,缺乏运动是一个共同的问题,另一个就是久坐,因此导致目前痔疮患者越来越多。采用外科手术方法治疗痔疮有一定的创伤性,再加上术后护理的不便及可能出现的并发症,许多人不易接受。目前临床治疗痔疮主要以缓解症状为主,因此越来越多的引入了中医疗法。其中涂抹中药就是常见的一种治疗方法。
发明内容
本发明的目的是提供一种用于治疗痔疮的外涂药物,具有活血凉血、清热燥湿、去水消肿、收敛止痛效果,通过涂抹于患处,可以有效治疗痔疮,特别是外痔。
本发明的目的还在于提供一种用于治疗痔疮的外涂药物的制备方法。
为了实现以上目的,本发明所采用的技术方案是:一种用于治疗痔疮的外涂药物,由以下重量份数的原料药制成:
芒硝3-8份、三七粉5-10份、蟾酥10-15份、半夏10-15份、胆南星10-15份、五倍子10-15份、冰片2-6份、苍术10-15份、白芷10-15份、防风10-15份、红花5-10份、明矾4-6份、莪术10-15份、黄柏10-20份、赤芍10-15份、丹皮10-15份、百部10-15份、蝉蜕10-15份、大黄3-8份、枳壳10-15份、马齿苋10-20份、地榆10-15份、紫草10-15份、地肤子10-15份、石菖蒲10-15份、荆芥10-15份、甘草20-30份、白鲜皮10-15份、人工麝香1-5份。
进一步的,本发明的一个优选技术方案为:用于治疗痔疮的外涂药物由以下重量份数的原料药制成:
芒硝8份、三七粉5份、蟾酥15份、半夏10份、胆南星10份、五倍子15份、冰片2份、苍术15份、白芷10份、防风15份、红花5份、明矾6份、莪术15份、黄柏10份、赤芍15份、丹皮15份、百部10份、蝉蜕15份、大黄3份、枳壳15份、马齿苋20份、地榆15份、紫草15份、地肤子10份、石菖蒲15份、荆芥15份、甘草20份、白鲜皮15份、人工麝香5份。
进一步的,本发明的另一个优选技术方案为:用于治疗痔疮的外涂药物由以下重量份数的原料药制成:
芒硝3份、三七粉10份、蟾酥10份、半夏15份、胆南星15份、五倍子10份、冰片6份、苍术10份、白芷15份、防风10份、红花10份、明矾4份、莪术10份、黄柏20份、赤芍10份、丹皮10份、百部15份、蝉蜕10份、大黄8份、枳壳10份、马齿苋10份、地榆10份、紫草10份、地肤子15份、石菖蒲10份、荆芥10份、甘草30份、白鲜皮10份、人工麝香1份。
进一步的,本发明的再一个优选技术方案为:用于治疗痔疮的外涂药物由以下重量份数的原料药制成:
芒硝5份、三七粉6份、蟾酥10份、半夏10份、胆南星10份、五倍子10份、冰片5份、苍术10份、白芷15份、防风10份、红花8份、明矾5份、莪术10份、黄柏15份、赤芍10份、丹皮10份、百部10份、蝉蜕10份、大黄5份、枳壳10份、马齿苋20份、地榆10份、紫草15份、地肤子10份、石菖蒲10份、荆芥15份、甘草30份、白鲜皮10份、人工麝香3份。
本发明提供的用于治疗痔疮的外涂药物的制备方法,包括步骤:
S1:将原料药三七粉、蟾酥、半夏、胆南星、五倍子、苍术、白芷、防风、红花、莪术、黄柏、赤芍、丹皮、百部、蝉蜕、大黄、枳壳、马齿苋、地榆、紫草、地肤子、石菖蒲、荆芥、甘草、白鲜皮混合,然后向混合原料药中加入10-15倍重量的水,加热煮沸10-20分钟,之后过滤去渣,得到提取液,再向所述提取液中加入人工麝香,然后用活性炭脱色2-4次,至无色为止,得到脱色后的提取液;
S2:向所述脱色后的提取液中加入芒硝、冰片、明矾,然后蒸发浓缩至液体体积的1/3-1/2,得到治疗痔疮的外涂药物。
本发明提供的用于治疗痔疮的外涂药物中采用的各味中药的性味及功效介绍如下。芒硝:咸、苦,寒,清火消肿,外治痔疮肿痛;三七粉:性温,味甘微苦,具有止血、散瘀、定痛作用;蟾酥:甘辛,温,解毒,消肿;半夏:消疖肿,消肿止痛;胆南星:苦寒、微辛,凉,止血定痛,消肿;五倍子:味酸,涩,性寒,止血,解毒;冰片:辛,苦,凉,消肿止痛;苍术:辛、苦,温,清热燥湿、化浊、止痛;白芷:性温,味辛,气芳香,微苦,祛风湿,活血排脓,生肌止痛;防风:味辛、甘,性微温,胜湿止痛;红花:辛,温,活血通经,祛瘀止痛;明矾:性味酸涩,寒,有抗菌作用、收敛作用;莪术:祛瘀止痛;黄柏:味苦,性寒,清热解毒,泻火燥湿;赤芍:苦,微寒,清热凉血,活血祛瘀;丹皮:即牡丹皮,苦、辛,微寒,清热凉血、活血化淤;百部:甘、苦,微温,杀虫;蝉蜕:甘,寒,散风除热,治疗疔肿毒疮;大黄:苦,寒,活血祛瘀;枳壳:苦、辛、酸、温,去水消肿;马齿苋:性寒,味甘酸,清热利湿、解毒消肿、消炎;地榆:苦、酸、涩,微寒,凉血止血,清热解毒,消肿敛疮;紫草:性寒,味甘、咸,清热解毒、凉血活血;地肤子:性寒,味辛、苦,清热利湿,祛风止痒;石菖蒲:辛、苦,温,活血,散风,去湿;荆芥:味辛,微苦,性微湿,解表散风,透疹,消疮,止血;甘草:甘,平,益气补中,缓急止痛,泻火解毒,调和诸药;白鲜皮:清热燥湿,祛风解毒;人工麝香:镇痛、消肿。
本发明提供的治疗痔疮的外涂药物,经以上原料药合理配伍,具有活血凉血、清热燥湿、去水消肿、收敛止痛效果,通过涂抹于患处,可以有效治疗痔疮,特别是外痔。经临床验证表明,本发明提供的治疗痔疮的外涂药物对外痔具有显著疗效。并且,本发明提供的治疗痔疮的外涂药物为无色液体,不用担心在使用时会污染内衣,使用非常方便。
具体实施方式
下面通过具体实施例对本发明的技术方案进行详细说明。
实施例1
本实施例提供的用于治疗痔疮的外涂药物,由以下重量份数的原料药制成:
芒硝8份、三七粉5份、蟾酥15份、半夏10份、胆南星10份、五倍子15份、冰片2份、苍术15份、白芷10份、防风15份、红花5份、明矾6份、莪术15份、黄柏10份、赤芍15份、丹皮15份、百部10份、蝉蜕15份、大黄3份、枳壳15份、马齿苋20份、地榆15份、紫草15份、地肤子10份、石菖蒲15份、荆芥15份、甘草20份、白鲜皮15份、人工麝香5份。
实施例2
本实施例提供的用于治疗痔疮的外涂药物,由以下重量份数的原料药制成:
芒硝3份、三七粉10份、蟾酥10份、半夏15份、胆南星15份、五倍子10份、冰片6份、苍术10份、白芷15份、防风10份、红花10份、明矾4份、莪术10份、黄柏20份、赤芍10份、丹皮10份、百部15份、蝉蜕10份、大黄8份、枳壳10份、马齿苋10份、地榆10份、紫草10份、地肤子15份、石菖蒲10份、荆芥10份、甘草30份、白鲜皮10份、人工麝香1份。
实施例3
本实施例提供的用于治疗痔疮的外涂药物,由以下重量份数的原料药制成:
芒硝5份、三七粉6份、蟾酥10份、半夏10份、胆南星10份、五倍子10份、冰片5份、苍术10份、白芷15份、防风10份、红花8份、明矾5份、莪术10份、黄柏15份、赤芍10份、丹皮10份、百部10份、蝉蜕10份、大黄5份、枳壳10份、马齿苋20份、地榆10份、紫草15份、地肤子10份、石菖蒲10份、荆芥15份、甘草30份、白鲜皮10份、人工麝香3份。
实施例1-3提供的用于治疗痔疮的外涂药物的制备方法,包括步骤:
S1:将原料药三七粉、蟾酥、半夏、胆南星、五倍子、苍术、白芷、防风、红花、莪术、黄柏、赤芍、丹皮、百部、蝉蜕、大黄、枳壳、马齿苋、地榆、紫草、地肤子、石菖蒲、荆芥、甘草、白鲜皮混合,然后向混合原料药中加入10-15倍重量的水,加热煮沸10-20分钟,之后过滤去渣,得到提取液,再向提取液中加入人工麝香,然后用活性炭脱色至无色为止,得到脱色后的提取液;
S2:向脱色后的提取液中加入芒硝、冰片、明矾,然后蒸发浓缩至液体体积的1/2,得到治疗痔疮的外涂药物。
每天涂抹1-2次,7天为一疗程。
分别采用实施例1-3提供的治疗痔疮的外涂药物进行了临床治疗。统计情况如下。
采用实施例1提供的治疗痔疮的外涂药物治疗外痔患者175例,其中男97例,女78例。经过一个疗程的治疗,治愈145例,症状完全消失,创面愈合良好;好转30例,症状明显改善,痔核缩小;无效0例。继续治疗一个疗程后,全部治愈。
采用实施例2提供的治疗痔疮的外涂药物治疗外痔患者167例,其中男85例,女82例。经过一个疗程的治疗,治愈151例,症状完全消失,创面愈合良好;好转16例,症状明显改善,痔核缩小;无效0例。继续治疗一个疗程后,全部治愈。
采用实施例3提供的治疗痔疮的外涂药物治疗外痔患者204例,其中男117例,女87例。经过一个疗程的治疗,治愈185例,症状完全消失,创面愈合良好;好转19例,症状明显改善,痔核缩小;无效0例。继续治疗一个疗程后,全部治愈。
Claims (5)
1.一种用于治疗痔疮的外涂药物,其特征在于,由以下重量份数的原料药制成:
芒硝3-8份、三七粉5-10份、蟾酥10-15份、半夏10-15份、胆南星10-15份、五倍子10-15份、冰片2-6份、苍术10-15份、白芷10-15份、防风10-15份、红花5-10份、明矾4-6份、莪术10-15份、黄柏10-20份、赤芍10-15份、丹皮10-15份、百部10-15份、蝉蜕10-15份、大黄3-8份、枳壳10-15份、马齿苋10-20份、地榆10-15份、紫草10-15份、地肤子10-15份、石菖蒲10-15份、荆芥10-15份、甘草20-30份、白鲜皮10-15份、人工麝香1-5份。
2.根据权利要求1所述的用于治疗痔疮的外涂药物,其特征在于,由以下重量份数的原料药制成:
芒硝8份、三七粉5份、蟾酥15份、半夏10份、胆南星10份、五倍子15份、冰片2份、苍术15份、白芷10份、防风15份、红花5份、明矾6份、莪术15份、黄柏10份、赤芍15份、丹皮15份、百部10份、蝉蜕15份、大黄3份、枳壳15份、马齿苋20份、地榆15份、紫草15份、地肤子10份、石菖蒲15份、荆芥15份、甘草20份、白鲜皮15份、人工麝香5份。
3.根据权利要求1所述的用于治疗痔疮的外涂药物,其特征在于,由以下重量份数的原料药制成:
芒硝3份、三七粉10份、蟾酥10份、半夏15份、胆南星15份、五倍子10份、冰片6份、苍术10份、白芷15份、防风10份、红花10份、明矾4份、莪术10份、黄柏20份、赤芍10份、丹皮10份、百部15份、蝉蜕10份、大黄8份、枳壳10份、马齿苋10份、地榆10份、紫草10份、地肤子15份、石菖蒲10份、荆芥10份、甘草30份、白鲜皮10份、人工麝香1份。
4.根据权利要求1所述的用于治疗痔疮的外涂药物,其特征在于,由以下重量份数的原料药制成:
芒硝5份、三七粉6份、蟾酥10份、半夏10份、胆南星10份、五倍子10份、冰片5份、苍术10份、白芷15份、防风10份、红花8份、明矾5份、莪术10份、黄柏15份、赤芍10份、丹皮10份、百部10份、蝉蜕10份、大黄5份、枳壳10份、马齿苋20份、地榆10份、紫草15份、地肤子10份、石菖蒲10份、荆芥15份、甘草30份、白鲜皮10份、人工麝香3份。
5.一种权利要求1-4任一所述的用于治疗痔疮的外涂药物的制备方法,其特征在于,包括步骤:
S1:将原料药三七粉、蟾酥、半夏、胆南星、五倍子、苍术、白芷、防风、红花、莪术、黄柏、赤芍、丹皮、百部、蝉蜕、大黄、枳壳、马齿苋、地榆、紫草、地肤子、石菖蒲、荆芥、甘草、白鲜皮混合,然后向混合原料药中加入10-15倍重量的水,加热煮沸10-20分钟,之后过滤去渣,得到提取液,再向所述提取液中加入人工麝香,然后用活性炭脱色2-4次,至无色为止,得到脱色后的提取液;
S2:向所述脱色后的提取液中加入芒硝、冰片、明矾,然后蒸发浓缩至液体体积的1/3-1/2,得到治疗痔疮的外涂药物。
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