CN106309935A - Compound capsule containing dendrobium candicum - Google Patents
Compound capsule containing dendrobium candicum Download PDFInfo
- Publication number
- CN106309935A CN106309935A CN201610717583.9A CN201610717583A CN106309935A CN 106309935 A CN106309935 A CN 106309935A CN 201610717583 A CN201610717583 A CN 201610717583A CN 106309935 A CN106309935 A CN 106309935A
- Authority
- CN
- China
- Prior art keywords
- parts
- compound
- herba dendrobii
- compound capsule
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a compound capsule containing dendrobium candicum. The compound is prepared from, by weight, 12- 48 parts of dendrobium candicum, 5- 19 parts of radix glehniae, 6- 20 parts of dwarf lilyturf tuber, 7- 17 parts of fragrant solomonseal rhizome, 4- 16 parts of mulberry leaf and 3- 12 parts of propolis. The specified compound capsule would significantly enhance human immunity, and reduce the blood fat. The compound consists of six specific components. Compared to other herbal combination, or one or two substitutions for the components in the compound, the compound produces better effect on enhancement of human immunity, and reduction in the blood fat. It's easy to produce the compound for application, facilitating to industrialized production. The consumption method is convenient and safe, suitable for popularity.
Description
Technical field
The present invention relates to medical-care health food field, be specifically related to a kind of compound capsule containing Herba Dendrobii.
Technical background
Herba Dendrobii, supplementing QI and nourishing YIN, for monarch drug in side, it is aided with Radix Glehniae, to strengthen the merit of supplementing QI and nourishing YIN, is for ministerial drug,
Radix Ophiopogonis, Rhizoma Polygonati Odorati, nourishing YIN to relieve dryness, hold concurrently with heat clearing away, be to be allowed to medicine for assistant.All medicines share, and play the merit of supplementing QI and nourishing YIN heat clearing away altogether, and have
Preferably immunoregulation effect.Iron and bor on compound has nourishing YIN and clearing away heat, promotes the production of body fluid and moisturizes, the effect strengthened the spleen and stomach.Wherein iron sheet maple
Bucket sweet in the mouth, returns stomach, kidney channel, enriching yin and nourishing kidney, and liver body must be supported, and has effect of tonifying kidney and nourishing liver, and the hepatic and renal YIN deficiency, dysfunction of the spleen in transportation be height
One of different TCM syndrome types of lipidemia.Rhizoma Polygonati Odorati sweet in the mouth, has nourishing YIN to relieve dryness, the effect of promoting the production of body fluid to quench thirst, thinks it in " book on Chinese herbal medicine justice "
To " polyorexia person has prompt effect especially ", research is it has also been found that Rhizoma Polygonati Odorati has blood fat reducing, alleviates dynamic atherosis effect.Though Chinese medicine
Without the name of disease of " hyperlipemia ", but of long standing and well established to the understanding of cream fat.Lee Cyprinus carpio thinks that " deficiency of kidney yin, then cream fat is not hidden, and knows and oozes
In blood, kidney yin lose the most then the kidney failing to nourish the liver and catharsis dereliction of duty ", illustrate that deficiency of YIN deficiency of the kidney is one of pathogenesis of cream lipidemia." Plain Questions passages through which vital energy circulates
Another matter " cloud: " eat in stomach, transporting essential substances in solution, upper defeated in spleen, spleen-QI transporting the essence to the whole body, be above attributed to lung, regulating fluid apssage, under defeated bladder, water Tianjin
Four cloth, the Five Classics is parallel." illustrating that The spleen has the function to transport and transform nutrients, defeated cloth essence of water and grain is lacked of proper care in the five internal organs and passages through which vital energy circulates, taste, then cream fat can be caused to become silted up
Long-pending.And iron and bor on compound just has YIN nourishing and supports Tianjin, the effect strengthened the spleen and stomach.And mainly there is treating both the principal and the secondary aspects of a disease at the same time, toxic and side effects
Little, the advantage of wide spectrum blood fat reducing, and mechanism of action multipath, Mutiple Targets, therefore under most important theories instructs, dialectical treatmert, research
Safe and efficient blood fat reducing is important has profound significance.
Radix Glehniae (Glehnialittoralis) is the dry root of samphire glehnia littoralis.Nature and flavor hardship sweet, micro-, it is slightly cold.
The Pharmacopoeia of the People's Republic of China is recorded: nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid, for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound
Yearningly.Radix Glehniae has the pharmacological action such as immunomodulating, anticancer, antioxidation.Experimentation shows, Radix Glehniae crude polysaccharides can significantly increase
The cellular immunization of reinforcing YIN-essence void mice and humoral immune function, increase the quantity of hemolysin, strengthens delayed super quick
Reaction, Radix Glehniae decoction pieces polysaccharide and Radix Glehniae crude polysaccharides all have the huge effect biting thin full phagocytic function of enhancing to normal mouse.Real
The water extract-alcohol precipitation preparation issuing after examination and approval existing Radix Glehniae all can suppress thromboxane A2 under various dosage, can promote again the conjunction of prostacyclin
Become.
Have another name called dwarf lilyturf, book band grass, Radix Ophiopogonis, Radix Ophiopogonis Radix Ophiopogonis (Ophiopogonjaponicus), for Liliaceae dwarf lilyturf
Belong to perennial evergreen herbaceous plant.Nature and flavor hardship sweet, micro-, it is slightly cold.The Pharmacopoeia of the People's Republic of China is recorded: YIN nourishing and the production of body fluid promoting, lung moistening
Clear away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Modern doctor
Research shows, Radix Ophiopogonis has immunologic enhancement: can dramatically increase the spleen weight of mice, strengthens the phagocytosis of macrophage
Effect, the murine interleukin that antagonism is caused by cyclophosphamide reduces.To retting conditions accelerator induced mice intraperitoneal mastocyte
Granule is inhibited, has inhibitory action to the histamine in mastocyte is free.
Rhizoma Polygonati Odorati is the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati (Polygonatumodoratum (Mill.) Druce).Nature and flavor
Sweet, be slightly cold.The Pharmacopoeia of the People's Republic of China is recorded: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Hinder for lung stomach-Yin, cough caused by dryness-heat, dry pharynx
Thirsty, interior-heat is quenched one's thirst.Impact on immunologic function: mice Immune Function after Burn reduces, and Rhizoma Polygonati Odorati alcohol extraction thing is to burned mice
Gavage, can make the hemolysin amount of burned mice, macrophage phagocytic function and spleen lymphocyte proliferation functional rehabilitation to normal water
Flat.
Folium Mori, have another name called " Herba adianti myriosori ", are the leaves of Moraceae Mulberry plant Mulberry (Morus alba L.).China's national health
It is medicine-food two-purpose product that portion announced Folium Mori in 1993.Pharmacopeia is recorded, and Folium Mori are sweet, bitter, cold.Return lung, Liver Channel, can dispelling wind and heat pathogens, clearly
Lung is moisturized, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.Shennong's Herbal claims Folium Mori
For " Radix Rhodiolae ", have enrich blood, dispelling wind, heat radiation, the liver benefiting ventilation, effect of antihypertensive diuretic.Modern a large amount of pharmaceutical research proves
Many pharmacological actions such as Folium Mori tool blood fat reducing, blood pressure lowering, removing free radical, antibacterial and disease-resistant, anticancer.Since ancient times,
The traditional Chinese medical science just using Folium Mori as treatment hyperlipidemia application in TCM in clinic.Modern age doctor also often by Folium Mori compatibility in Chinese medicine compound
It is applied to clinic.
Propolis is the resin that Apis gathers from plant spore or trunk, is mixed into the secretions of palatine gland on it, wax gland
A kind of colloidal solid thing with aromatic odor processed.Pharmacopeia is recorded, propolis bitter, acrid, cold.Return spleen, stomach warp, can qi-restoratives
Weak, change turbid fat, only quench one's thirst；External removing toxic substances and promoting subsidence of swelling, restrains granulation promoting.For body void senilism, hyperlipemia, quench one's thirst；External treatment skin chap
Split, burn and scald.Recent studies proves, abundant contained by propolis and the bioactive substance of uniqueness so that it is have enhancing immunity,
The several functions such as blood fat reducing, blood sugar lowering, antibacterial, antiinflammatory, antipruritic, antioxidation, antitumor, has medical treatment widely, protects human body
Strong effect, has become the focus of various countries' scientific research, and becomes emerging health product and extremely praise highly.
Existing report uses Herba Dendrobii to treat hyperlipidaemic conditions, at the existing compound capsule containing Herba Dendrobii
In, Chinese patent 200410025479.0 discloses a kind of compound recipe whole-tortoise-turtle Tiepi Fengdou Granule for nourishing yin and the index side of electuary
Method, wherein active component is in addition to Herba Dendrobii, is also added into QUANGUI, Trionyx sinensis (Wiegmann), Radix Panacis Quinquefolii, Radix Ophiopogonis, Rhizoma Polygonati Odorati and xylitol totally 7
Taste medicine, but the prior art is high except cost of material, is only also loosely its roughing to be prepared as electuary, describes this and join
Side has Yin-nourishing and body fluid promoting function, does not carry out the processing in commercial production meaning, does not tests toxicological assessment test
And the effect for the treatment of hypertension.In addition Chinese patent 201410029075.2 discloses a kind of honey refining Herba Dendrobii ball, wherein
Containing Herba Dendrobii, Rhizoma Dioscoreae, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Radix Panacis Quinquefolii, Rhizoma Polygonati Odorati, Mel, then this honey refining ball is unfavorable for absorption of human body, and effect is not
Good.The application applicant is found by lot of experiments, by Herba Dendrobii and above-mentioned Radix Glehniae, Radix Ophiopogonis, Rhizoma Polygonati Odorati, Folium Mori and honeybee
Glue coordinates with specific proportioning, makes capsule and can play the effect being obviously enhanced immunity, and possesses excellent prevention and treatment height
The effect of blood lipid disorder.
Summary of the invention
It is an object of the invention to provide a kind of enhancing immunity, the answering containing Herba Dendrobii of blood fat reducing aspect excellent effect
Side's capsule.
The foregoing invention purpose of the present invention is achieved by the following technical solution:
A kind of compound capsule containing Herba Dendrobii, it is characterised in that it is as follows that described compound capsule contains by weight
Raw material: 12-48 part Herba Dendrobii, 5-19 part Radix Glehniae, 6-20 part Radix Ophiopogonis, 7-17 part Rhizoma Polygonati Odorati, 4-16 part Folium Mori and 3-12 part honeybee
Glue.
Preferably, described compound capsule contains following raw material by weight: 20-40 part Herba Dendrobii, 8-16 part north are husky
Ginseng, 10-15 part Radix Ophiopogonis, 10-14 part Rhizoma Polygonati Odorati, 8-12 part Folium Mori and 5-10 part propolis.
It is highly preferred that described compound capsule contains following raw material by weight: 15-30 part Herba Dendrobii, 10-15 part north
Radix Adenophorae (Radix Glehniae), 12-14 part Radix Ophiopogonis, 12-14 part Rhizoma Polygonati Odorati, 10-12 part Folium Mori and 6-8 part propolis.
Most preferably, described compound capsule contains following raw material by weight: 20 parts of Herba Dendrobii, 12 portions of Radix Glehniaes,
12 parts of Radix Ophiopogonis, 12 portions of Rhizoma Polygonati Odorati, 10 parts of Folium Mori and 7 parts of propolis.
Further, the present invention provides the preparation method of the above-mentioned compound capsule containing Herba Dendrobii, it is characterised in that institute
State preparation method to comprise the steps:
Step one, raw material pre-treatment step
(1) Radix Glehniae, Radix Ophiopogonis, Rhizoma Polygonati Odorati, four medical materials of Folium Mori being mixed by by formula, water carries three times, each 2h, filters mixed
Close, concentrated extracting solution；
(2) Herba Dendrobii, the size-reduced machine of propolis are pulverized, and cross 100 mesh sieves, standby；
Step 2, mixing
Concentrated solution is mixed with Herba Dendrobii powder, propolis powder；
Step 3, dry, pulverizing
The mixture of step 2 being put vacuum drying oven be dried, temperature controls below 80 DEG C；The most size-reduced machine
Pulverize, cross 80 mesh sieves；
Step 4, fill out capsule, pressing plate, sterilizing and packaging
Progressively carry out capsule filling, Aluminium-coating Packer carries out aluminum-plastic packaged, with co-60 radiation sterilizing and after the assay was approved
Packaging is dispatched from the factory.
Further, the present invention provides the above-mentioned compound capsule containing Herba Dendrobii to be applied to preparation enhancing body immunity
The purposes of the medicine of function.
Further, the present invention provides the above-mentioned compound capsule containing Herba Dendrobii to be applied to prepare the use of blood lipid-lowering medicine
On the way.
Using technical scheme, compare existing this kind of Chinese medicine preparation and compare, it has the advantage that
1, described formula has the effect significantly strengthening body immunity, also has excellent in terms of blood fat reducing simultaneously
Effect；
2, containing the compound recipe combination of 6 kinds of specific components during the combination of this compound recipe, it is compared other Chinese medicine composition, or compares
These 6 kinds combination in replace 1 to 2 taste Chinese medicine other combination for listing enhancing immunity in terms of, all have in terms of blood fat reducing
There is more excellent effect；
3, the preparation method of the application is simple, it is simple to industrialized production, product taking convenience, safety, is suitable for universal
Promote.
Detailed description of the invention
In order to explain technique scheme further, the application spy is specifically described with following embodiment, but the application
It is not limited to this.
One, preparation embodiment
Preparation embodiment 1: the formula of each component is: 20 parts of Herba Dendrobii, 12 portions of Radix Glehniaes, 12 parts of Radix Ophiopogonis, 12 portions of Rhizoma Polygonati Odorati,
10 parts of Folium Mori and 7 parts of propolis.
Prepare compound capsule as follows: Radix Glehniae, Radix Ophiopogonis, Rhizoma Polygonati Odorati, four medical materials of Folium Mori are mixed by by formula,
Water carries three times, each 2h, filters mixing, concentrated extracting solution；Herba Dendrobii, the size-reduced machine of propolis are pulverized, crosses 100 mesh
Sieve, standby；Concentrated solution is mixed with Herba Dendrobii powder, propolis powder；Mixture being put vacuum drying oven be dried, temperature controls
Below 80 DEG C；The most size-reduced machine is pulverized, and crosses 80 mesh sieves；Progressively carry out capsule filling, Aluminium-coating Packer carry out aluminum-plastic packaged,
Dispatch from the factory with co-60 radiation sterilizing and packing after the assay was approved.
Preparation embodiment 2: except the formula of each component is: 48 parts of Herba Dendrobii, 19 parts of Radix Glehniaes, 20 parts of Radix Ophiopogonis, 17 parts of jade
Outside bamboo, 16 parts of Folium Mori and 12 parts of propolis, remaining is with preparation embodiment 1.
Preparation embodiment 3: except the formula of each component is: 12 parts of Herba Dendrobii, 5 portions of Radix Glehniaes, 6 parts of Radix Ophiopogonis, 7 portions of Rhizoma Polygonati Odorati, 4
Outside part Folium Mori and 3 parts of propolis, remaining is with preparation embodiment 1.
Preparation embodiment 4: except the formula of each component is: 48 parts of Herba Dendrobii, 19 parts of Radix Glehniaes, 20 parts of Radix Ophiopogonis, 7 parts of jade
Outside bamboo, 4 parts of Folium Mori and 3 parts of propolis, remaining is with preparation embodiment 1.
Preparation embodiment 5: except the formula of each component be 12 parts of Herba Dendrobii, 5 portions of Radix Glehniaes, 6 parts of Radix Ophiopogonis, 17 portions of Rhizoma Polygonati Odorati,
Outside 16 parts of Folium Mori and 12 parts of propolis, remaining is with preparation embodiment 1.
Comparative examples A: except the formula of each component is 20 parts of Herba Dendrobii, 12 portions of Radix Glehniaes, 12 portions of Radix Ophiopogonis, 12 portions of Rhizoma Polygonati Odorati
With 7 parts of propolis, remaining is with preparation embodiment 1.
Comparative examples B: except the formula of each component is: 20 parts of Herba Dendrobii, 12 parts of Radix Glehniaes, 12 parts of Radix Ophiopogonis, 12 parts of jade
Bamboo and 10 parts of Folium Mori, remaining is with preparation embodiment 1.
Comparative examples C: except the formula of each component is: 20 parts of Herba Dendrobii, 12 parts of Radix Glehniaes, 12 parts of Radix Ophiopogonis, 12 parts of jade
Bamboo, remaining same preparation embodiment 1.
Two, toxicological study test
1, experiment purpose: evaluate the safety of iron and bor on compound.
2, laboratory sample and character: content is particulate powder, capsule
3, experimental technique:
3.1 acute oral toxicity tests:
3.1.1 laboratory animal: NIH mice, body weight 18-22g, male and female half and half.
3.1.2 dosage and medication: use Horn ' s method, at random mice is divided into 4 dosage groups (21.5g/kg,
10g/kg, 4.64g/kg, 2.15g/kg), preparation embodiment 1 iron and bor on compound gavage on an empty stomach once, is observed one week.
3.2Ames tests: Salmonella typhimurium back mutation is tested.
3.3 mouse marrow cell micro nuclear tests:
3.3.1 laboratory animal NIH mice, body weight 20-22g.
3.3.2 dosage and medication: set 2.5,5.0 and three dosage groups of 10.0g/kg body weight, and set matched group.Often
Organize 10 mices, female, male half and half.Interval 24h is used to give to prepare embodiment 1 iron and bor on compound.After last is administered, 6h puts to death
Mice, takes its bone marrow of sternum film-making, and methanol is fixed, and Gimsa dyes.
3.4 mouse inbred strain:
3.4.1 laboratory animal ICR mice, body weight 30～35g.
3.4.2 dosage and medication: set 2.5,5.0 and three dosage groups of 10.0g/kg body weight, and set matched group.Often
Organize 6 male mices, incite somebody to action and prepare embodiment 1 iron and bor on compound gavage, continuous 5 days.Within 35th day, put to death mice, take epididymis, mirror
Inspection.Record rate of teratosperm.
4, experimental result
Chmice acute per os maximum tolerated dose bisexuality is not all higher than 20.0g/kg, belongs to nontoxic；Salmonella reversion test, mice
Micronucleus test and mouse inbred strain result are feminine gender, do not show mutagenicity.
Three, enhancing immunity function test
1, experiment purpose: by contrast experiment, evaluates and strengthens functional trial.
2, laboratory sample and character: content is particulate powder, capsule
3, experimental technique:
3.1 laboratory animals: ICR mice, female, body weight 20 ± 2g.
3.2 dose design: experiment sets three dosage groups and negative control group (deionized water).Low middle high three dosage are respectively
Be 0.5,1.0,3.0g/kg body weight, be equivalent to the 5 of people's recommended amounts, 10 and 30 times, prepare embodiment 1 iron and bor on compound gavage
Give sample.The dosage used by sample obtained by comparative examples A, B, C is middle dosage 1.0g/kg.
3.3 experimental techniques:
3.3.1 conversion test；
3.3.2 sheep red blood cell (SRBC) (SRBC) inducing mouse DTH (the foot sole of the foot thickens method)；
3.3.3 mice hemolysin test；
3.3.4 antibody-producting cell detection (Jerne improves slide method)；
3.3.5 Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell test；
3.3.6 mice carbonic clearance is tested；
3.3.7NK cytoactive detection；
3.3.8 internal organs/body weight ratio.
4, experimental result
This experiment sets basic, normal, high three dosage groups, is respectively equivalent to 5,10,30 times of the actual intake of people, sets simultaneously
Negative control group (deionized water), within continuous 29-32 days, per os gives the Herba Dendrobii prepared by preparation embodiment 1 of various dose
Capsule.Test result indicate that: such as table 1, table 2 and table 3, preparation three dosage groups of iron and bor on compound prepared by embodiment 1 are little
Mouse lymphotactin multiplication capacity optical density difference is the most significantly raised, 24 hours and the 0 hour thickness in foot sole of the foot portion about middle dosage group mice
Degree difference is significantly raised；Middle and high dosage group mice hemolysis plaque number is the most significantly raised；High dose group Turnover of Mouse Peritoneal Macrophages gulps down
The phagocytic percentage biting chicken red blood cell is significantly raised, the phagocytosis of middle and high dosage group Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell
Index is the most significantly raised, and difference all has significance.Under equal experiment condition, obtained by comparative examples A of Isodose, B
Sample, mouse lymphocyte multiplication capacity optical density difference does not shows significantly raised, 24 hours and 0 hour, foot sole of the foot portion about mice
Thickness difference is less than the iron and bor on compound experimental group of middle dosage group；Mice hemolysis plaque number rises the same low dose group of index, little
The phagocytic percentage of Mus peritoneal macrophage phagocytosis chicken red blood cell is less than with the Herba Dendrobii glue prepared by the embodiment 1 of dosage group
Capsule.Sample obtained by comparative examples C, all experiment indexes are below the low dose group prepared by embodiment.
The impact on mice delayed allergy of table 1 iron and bor on compound
Mice serum hemolytic antibody titre is reacted by table 2 iron and bor on compound
The impact on mice carbonic clearance phagocytic function of table 3 iron and bor on compound
It follows that the preparation iron and bor on compound containing special component prepared by embodiment 1 compare do not contain Folium Mori,
Comparative examples A of propolis, B and C increase significantly in terms of enhancing immunity.
Four, lipid-lowering test
Experiment is divided into high, medium and low three agent of iron and bor on compound of Normal group, model control group, preparation embodiment 1
Amount (0.8g/kg, 0.4g/kg, 0.2g/kg) group, after modeling, successive administration measures serum four TC, TG, LDL-in the 15th, 30 days
C, HDL-C level.
Route of administration: consistent with clinical route of administration.
It is administered volume: 10ml/kg (i.e. 1ml/100g body weight)；Dosage is adjusted by the increase and decrease of body weight.
The administration time limit: 30 days.
Observation index: weigh in weekly, blood sampling in time testing 15,30 days, measure serum TC, TG, HDL-C level, meter
Calculate LDL-C level (LDL-C=TC-HDL-C-TG/2.2).
Experimental result
1. the modeling impact on hypercholesterolemiaanimal animal model Serum Lipids in Experimental HypercholesterolemicRats in 2 weeks
When SD rat models 2 weeks, compared with Normal group, model control group and each administration group Serum TC, TG,
LDL-C, HDL-C significantly raise (p < 0.01).After SD rat models successfully, compared with model control group project, each administration group is big
Mus serum TC, TG, LDL-C, HDL-C there was no significant difference.
Table 4 high lipid food causes the hypercholesterolemiain in rats model blood lipid level when modeling 2 weeks
Note: compare with Normal group,ΔP ＜ 0.05,ΔΔP ＜ 0.01
2. it is administered the impact on hypercholesterolemiaanimal animal model Serum Lipids in Experimental HypercholesterolemicRats in 15 days
After modeling successfully, SD rat gives to prepare the iron and bor on compound of embodiment 1, comparative examples group A, B, C.15 days
Time, compared with Normal group, model control group TC, TG, HDL-C significantly raise (p < 0.01～0.05).With model control group
Compare, iron and bor on compound group (0.8,0.4 and 0.2g kg-1), A group, the TC of C group significantly reduce, iron and bor on compound group
(0.8,0.4 and 0.2g kg-1) and A group LDL-C significantly reduce.
3. it is administered the impact on hypercholesterolemiaanimal animal model Serum Lipids in Experimental HypercholesterolemicRats in 30 days
SD rat be administered 30 days time, compared with Normal group, model control group TC, TG, HDL-C significantly raise (p <
0.01～0.05).Compared with model control group, the iron and bor on compound group (0.8,0.4 and 0.2g kg of preparation embodiment 1-1)、
A group, B group TC significantly reduce；Iron and bor on compound group (0.8,0.4 and 0.2g kg-1), A group, B group LDL-C significantly reduce.
Contrast whole administration process, iron and bor on compound group (0.8,0.4 and 0.2g kg-1) when being administered 15 days and 30 days
All demonstrate the function of blood fat reducing, and the effect of middle and high dosage group becomes apparent from.Compared with model control group, control group A, B, C
Also show that reduction Serum TC, the effect of LDL-C, but effectiveness is significantly lower than iron and bor on compound group (0.8,0.4 and
0.2g·kg-1).The iron and bor on compound of the description of test present invention has certain auxiliary lipid-lowering function.
Table 5
Each blood lipid level organizing rat after modeling packet in 2 weeks
The impact of lipid level on hypercholesterolemia rat model in 15 days of iron and bor on compound gastric infusion
The impact on hypercholesterolemia rat model blood lipid level in 30 days of iron and bor on compound gastric infusion
A kind of compound capsule containing Herba Dendrobii of the present invention is described by concrete example, this area
Technical staff can use for reference present invention, and the link such as suitable feed change, process conditions realizes other purpose corresponding, its phase
Close and change all without departing from present disclosure, all similar replacements and change be to those skilled in the art aobvious and
It is clear to, is considered as being included within the scope of the present invention.
Claims (7)
1. the compound capsule containing Herba Dendrobii, it is characterised in that it is the most former that described compound capsule contains by weight
Material: 12-48 part Herba Dendrobii, 5-19 part Radix Glehniae, 6-20 part Radix Ophiopogonis, 7-17 part Rhizoma Polygonati Odorati, 4-16 part Folium Mori and 3-12 part propolis.
Compound capsule the most according to claim 1, it is characterised in that it is the most former that described compound capsule contains by weight
Material: 20-40 part Herba Dendrobii, 8-16 part Radix Glehniae, 10-15 part Radix Ophiopogonis, 10-14 part Rhizoma Polygonati Odorati, 8-12 part Folium Mori and 5-10 part honeybee
Glue.
Compound capsule the most according to claim 1, it is characterised in that it is the most former that described compound capsule contains by weight
Material: 15-30 part Herba Dendrobii, 10-15 part Radix Glehniae, 12-14 part Radix Ophiopogonis, 12-14 part Rhizoma Polygonati Odorati, 10-12 part Folium Mori and 6-8 part honeybee
Glue.
Compound capsule the most according to claim 1, it is characterised in that it is the most former that described compound capsule contains by weight
Material: 20 parts of Herba Dendrobii, 12 portions of Radix Glehniaes, 12 parts of Radix Ophiopogonis, 12 portions of Rhizoma Polygonati Odorati, 10 parts of Folium Mori and 7 parts of propolis.
5. according to the preparation method of the arbitrary described compound capsule of Claims 1-4, it is characterised in that described preparation method bag
Include following steps:
Step one, raw material pre-treatment step
(1) Radix Glehniae, Radix Ophiopogonis, Rhizoma Polygonati Odorati, four medical materials of Folium Mori being mixed by by formula, water carries three times, each 2h, filters mixing,
Concentrated extracting solution；
(2) Herba Dendrobii, the size-reduced machine of propolis are pulverized, and cross 100 mesh sieves, standby；
Step 2, mixing
Concentrated solution is mixed with Herba Dendrobii powder, propolis powder；
Step 3, dry, pulverizing
The mixture of step 2 being put vacuum drying oven be dried, temperature controls below 80 DEG C；The most size-reduced machine is pulverized,
Cross 80 mesh sieves；
Step 4, fill out capsule, pressing plate, sterilizing and packaging
Progressively carry out capsule filling, Aluminium-coating Packer carry out aluminum-plastic packaged, with co-60 radiation sterilizing and pack after the assay was approved
Dispatch from the factory.
6. the medicine of preparation enhancing body immunity function it is applied to according to the arbitrary described compound capsule of claim 1 to 5
Purposes.
7. it is applied to prepare the purposes of blood lipid-lowering medicine according to the arbitrary described compound capsule of claim 1 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610717583.9A CN106309935A (en) | 2016-08-23 | 2016-08-23 | Compound capsule containing dendrobium candicum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610717583.9A CN106309935A (en) | 2016-08-23 | 2016-08-23 | Compound capsule containing dendrobium candicum |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106309935A true CN106309935A (en) | 2017-01-11 |
Family
ID=57790690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610717583.9A Pending CN106309935A (en) | 2016-08-23 | 2016-08-23 | Compound capsule containing dendrobium candicum |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106309935A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211435A (en) * | 1997-09-16 | 1999-03-24 | 汪文娟 | Tiepifengdou infused powder preparation and its compounding technique |
| CN103768406A (en) * | 2014-01-22 | 2014-05-07 | 福建永耕农业开发有限公司 | Blooming dendrobium candidum pill |
| CN103860903A (en) * | 2014-03-05 | 2014-06-18 | 闫柏 | Medicinal liquor capable of reducing blood pressure, blood sugar, and blood fat |
| CN104857088A (en) * | 2015-06-14 | 2015-08-26 | 威海紫光金奥力生物技术有限公司 | Preparation method of mulberry leaf compound capsule for lowering blood glucose in assistant manner |
| CN105748947A (en) * | 2016-05-23 | 2016-07-13 | 吴子平 | Dendrobium officinale compound capsule and preparation method thereof |
-
2016
- 2016-08-23 CN CN201610717583.9A patent/CN106309935A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211435A (en) * | 1997-09-16 | 1999-03-24 | 汪文娟 | Tiepifengdou infused powder preparation and its compounding technique |
| CN103768406A (en) * | 2014-01-22 | 2014-05-07 | 福建永耕农业开发有限公司 | Blooming dendrobium candidum pill |
| CN103860903A (en) * | 2014-03-05 | 2014-06-18 | 闫柏 | Medicinal liquor capable of reducing blood pressure, blood sugar, and blood fat |
| CN104857088A (en) * | 2015-06-14 | 2015-08-26 | 威海紫光金奥力生物技术有限公司 | Preparation method of mulberry leaf compound capsule for lowering blood glucose in assistant manner |
| CN105748947A (en) * | 2016-05-23 | 2016-07-13 | 吴子平 | Dendrobium officinale compound capsule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103719498B (en) | A kind of Siberian solomonseal rhizome health-care tea improving immunity and preparation method thereof | |
| CN103734426B (en) | A kind of Fructus Corni health protection tea of improving immunity and preparation method thereof | |
| WO2021114586A1 (en) | Immune response-improving composition, preparation method and application thereof | |
| CN105031517A (en) | Dendrobium officinale healthcare tea capable of reducing blood fat, blood sugar, and blood pressure and preparation method thereof | |
| CN103301267B (en) | Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof | |
| CN106177053A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Pericarpium Citri Reticulatae | |
| CN107468747A (en) | A kind of ginseng composition for being advantageous to anticancer, anti-cancer and preparation method thereof | |
| CN106177477A (en) | A kind of health composition for blood sugar lowering, blood fat reducing and blood pressure lowering | |
| CN106177432A (en) | A kind of health composition comprising leaf of Cyclocarya paliurus Iljinskaja, Folium Mori, green tea and Rhizoma Polygonati Odorati | |
| CN107412713A (en) | Treat Chinese patent drug, dietetic food and the preparation method of autoimmune and immune related diseases | |
| CN104257763B (en) | A kind of saline cistanche water extract, preparation method and its usage | |
| CN103705578B (en) | There is blood fat reducing and Chinese medicine preparation suppressing blood glucose rising effect and preparation method thereof | |
| CN106075056A (en) | A kind of Ganoderma lucidum and preparation method improving immunity and improving gastrointestinal function | |
| CN109718307A (en) | A kind of anti-haze Qingrun tea and its preparation method and application | |
| CN108186794A (en) | A kind of Chinese medicine composition for treating malignant tumour and its preparation method and application | |
| CN103566349B (en) | A kind of pharmaceutical composition for the treatment of hyperglycemia hyperlipidemia | |
| CN106309935A (en) | Compound capsule containing dendrobium candicum | |
| CN111000949A (en) | Composition for improving subcutaneous fat type obesity and preparation method thereof | |
| CN106177476A (en) | A kind of Hyperglycemic health care compositions comprising Herba Dendrobii and Pericarpium Citri Reticulatae | |
| CN102631486B (en) | Health care composition | |
| CN102100814A (en) | Method for preparing nanometer traditional Chinese medicine for treating severe asthma and production method thereof | |
| CN106173604A (en) | A kind of Hyperglycemic health care compositions comprising Cortex Mori and Rhizoma Polygonati Odorati | |
| CN106177480A (en) | A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja and Herba Dendrobii | |
| CN104082487B (en) | A kind of health protection tea relaxed bowel | |
| CN105125693A (en) | Traditional Chinese medicine composition for treating acute gastritis and preparing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170111 |