CN106309762A - Feed premix medicine material for treating porcine circovirus infection - Google Patents

Feed premix medicine material for treating porcine circovirus infection Download PDF

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CN106309762A
CN106309762A CN201610869103.0A CN201610869103A CN106309762A CN 106309762 A CN106309762 A CN 106309762A CN 201610869103 A CN201610869103 A CN 201610869103A CN 106309762 A CN106309762 A CN 106309762A
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parts
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radix
porcine circovirus
infection
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毛华养
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
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    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/43—Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention relates to a feed premix medicine material for treating porcine circovirus infection, belongs to the technical field of veterinary medicine and solves the treatment problem of the porcine circovirus infection. The feed premix medicine material is characterized by being prepared from the following traditional Chinese medicine in parts by weight through combination: 15 parts of perillaseeds, 15 parts of radix codonopsis, 15 parts of honeysuckle flowers, 15 parts of isatis roots, 10 parts of semen raphani, 15 parts of felwort, 15 parts of radix rehmanniae, 15 parts of seed of Chinese dodders, 10 parts of cortex moutan, 10 parts of folium isatidis, 20 parts of radix scutellariae, 10 parts of rhizoma polygoni cuspidate, 10 parts of seaweed and 8 parts of liquorice roots.

Description

A kind of feedstuff premix spice of Infection of Porcine circovirus
Technical field
The present invention relates to the medicine of pig circular ring virus, particularly to the medicine combined with Chinese medicine, belong to Medicine technology field.
Background technology
Pig circular ring virus (porcinecircovirus, PCV) at taxonomy Shang Shu porcine circovirus section Circovirus, for One of known minimum animal virus.Virion diameter 14-17nm, in 20 body symmetrical structures, containing covalence closed The ring-type minus-strand dna of sub-thread, Genome Size is about 1.76kb.The resistance of PCV physical and chemical factor to external world is quite strong, even if Also can survive a period of time in the hot environment of the sour environment of PH3 and 72 DEG C, chloroform give non-inactivation, without hemagglutination activity.Existing Known PCV has PCV1 and PCV2.PCV1 is the virus of non-pathogenic.PCV2 is pathogenic virus.PCV2 is had stronger by pig Susceptibility, infected pigs can discharge virus in the refuses such as nose liquid, feces, and direct oral cavity, respiratory tract approach infect all ages and classes Pig.Being most commonly that pig is gradual to become thin or growth retardation, this is also clinical foundation, other symptoms necessary to diagnosis PMWS Have anorexia, spirit is depressed, be slow in action, palor, dyspnea fluffy and disorderly by hair, the respiratory disorder that is characterized of cough.
1974, German Tischer found, pig circular ring virus (PCV) is icosahedral symmetry, without cyst membrane, sub-thread ring Shape DNA viruses.A diameter of 17 nm of virion, are the minimum animal viruss having now been found that.PCV resistance to external world is relatively By force, it is not inactivated for a long time in the sour environment of pH 3.This virus is insensitive to chloroform, processes one at 56 DEG C or 70 DEG C The section time is not inactivated.Also can survive a period of time in hot environment.The many animals such as not coagulation cattle, sheep, pig, chicken and people's is red Cell.
Pig circular ring virus belongs to porcine circovirus section Circovirus, and virion size is 14～25nm, average diameter 17 Nm, icosahedron symmetrically, without cyst membrane, genome is sub-thread cyclic DNA, is made up of DNA (deoxyribonucleic acid), in the tissue Suspension density is 1.37 cm3, and sedimentation coefficient is 52S, is the minimum animal virus having now been found that.PCV copies as rolling ring again Mode processed, first passes through the replication form (RF) of a double-strand, is then transcribed and encoding proteins by the replication form of double-strand.This duplication side Formula is identical with the copy mode of Chicken Anemia Virus (CAV) (CAV).
With the presence of PCV particle in sick pig's nasal mucosa, bronchus, lungs, tonsil, kidney, spleen and small intestinal.Thymus, All having this virus in the lymphoid tissue of spleen, mesentery, bronchus etc., wherein in lungs and lymph node, recall rate is higher.Show The immune system of PCV serious infringement pig: virus accompanies with monocytes/macrophages, histiocyte and thymus macrophage, Cause affected pig body condition to decline, form immunosuppressant.Cause immunodeficiency due to immunosuppressant, its clinical manifestation is: to low cause The microorganism of characteristic of disease or attenuated vaccine can be diseases induced；Repeat to fall ill to treatment unresponsiveness；To vaccination the most fully Immunne response；A brood of pig has more than one the morbidity of unaccountable birth phase and death occur；Swinery have simultaneously multiple Disease syndrome occurs.These features are substantially all generation in various degree in the swinery of PMWS.
Infection of Porcine circovirus is most commonly that pig is gradual and becomes thin or growth retardation, and this is also that diagnosis PMWS institute is required Clinic foundation, other symptoms have anorexia, spirit depressed, be slow in action, palor, dyspnea fluffy and disorderly by hair, coughing is The respiratory disorder of feature.The symptom of less discovery is diarrhoea and central nervous system disorder.Sickness rate is typically the lowest and case fatality rate The highest.Body surface superficial popliteal lymph nodes enlargement, the lymph node of swelling can be touched sometimes, particularly superficial inguinal lymph nodes；Anemia With visual mucosa jaundice.Above-mentioned all clinical symptoms may be can not see a pig, but the morbidity visible all of disease of swinery Shape.Gastric ulcer, drowsiness, central nervous system disorder and sudden death are the most rare.Most PCV2 are subclinical infections.One As clinical symptoms may be relevant with secondary infection, or be entirely by caused by secondary infection.At improper ventilation, too gather around Squeeze, air is dirty, when raising together with and infect the factors such as other cause of diseases, the state of an illness substantially increases the weight of, and general case fatality rate is 10%～30%.
Prophylactico-therapeutic measures: experiment veterinary biological safety measure: treat in earnest and introduce a fine variety work, introduce a fine variety and accidentally break out epidemic disease often The main cause of feelings.The replacement gilt introduced should carry out strict quarantine, and the breeding boar bought, seminal fluid must be without II type annulus Virus infects.
Prophylactico-therapeutic measures: improve feeding and management, minimizing stress, reasonable preparation daily ration.Note ventilating with warming, keep pig house to do Dry, improve the air quality of pig house, reduce ammonia concentration.Injection must follow good health and sterilization custom.
Epidemic prevention immunity: pig B type circular virus vulnerable period the most do not inject stress be bigger vaccine, such as baby swine paratyphoid Vaccine, foot-and-mouth disease vaccine, asthma vaccine etc., some can lean on the bacterial infectious disease of chemoprophylaxis, such as pig erysipelas, Pulmonis Sus domestica Epidemic disease, pig streptococcicosis, baby swine paratyphoid etc., can suspend vaccine injection.Reduce ammonia concentration.
Summary of the invention
In order to tackle the difficulty of Infection of Porcine circovirus treatment, in order to overcome the Western medicine such as antibiotic to weaken pig immune system Shortcoming.Hunting circovirus infection with Chinese medicine viewpoint analysis, belong to outer by damp, liver-heat of suffering from a deficiency of the kidney, stagnation of QI causing phlegm retention, treatment should be with Heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating, temperature compensation Liver and kidney, the Chinese medicine combined treatment of dispelling pathogenic wind and eliminating phlegm, it is therefore desirable to be fabricated to be mixed into by medicine and raise The premix material of material.
The feedstuff premix spice of a kind of Infection of Porcine circovirus is to combine by following each Chinese medicine quality part ratio: Fructus Perillae 15 Part, Radix Codonopsis 15 parts, Flos Lonicerae 15 parts, Radix Isatidis 15 parts, Semen Raphani 10 parts, Radix Gentianae 15 parts, 15 parts of the Radix Rehmanniae, Semen Cuscutae 15 parts, Cortex Moutan 10 parts, Folium Isatidis 10 parts, Radix Scutellariae 20 parts, Rhizoma Polygoni Cuspidati 10 parts, Sargassum 10 parts, 8 parts of Radix Glycyrrhizae.
The most first analyze the property of medicine feature of each Chinese medicine in the feedstuff premix spice of a kind of Infection of Porcine circovirus.Chinese medicine Fructus Perillae There is expectorant sending down the abnormal ascending QI, relieving cough and relieving asthma, moisten cardiopulmonary, control QI rising in reverse order uncomfortable in chest, constipation function.Flos Lonicerae is described as heat-clearing and toxic substances removing from ancient times Good medicine；Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not injure one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also Kind removing summer-heat blood poison, in various febrile diseases, such as fever of the body, dermexanthesis, sends out tumor.Effect of Radix Isatidis and effect: Radix Isatidis be Isatis indigotica Fort. and The grass root of Folium Isatidis or the rhizome of acanthaceous vegetable acanthaceous indigo and root；Effect of Radix Isatidis is: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, sore-throat relieving are only Bitterly, the effect of Radix Isatidis is to control influenza, epidemic encephalitis, encephalitis b, pneumonia etc..Effect of Semen Raphani and effect: cure mainly therapeutic method to keep the adverse QI flowing downwards Dingchuan, disappear Food reduces phlegm；Control cough phlegm dyspnea, stagnation of QI due to dyspepsia, abdominal distention uncomfortable in chest, weight after dysentery.The medical value of Radix Gentianae: heat clearing and damp drying, eliminating pathogen in the liver gallbladder Fire；For heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire；For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, eczema scabies.Radix Codonopsis is put down, sweet in the mouth, micro- Acid；Return spleen, lung meridian；Invigorating the spleen and replenishing QI, strengthening spleen and tonifying lung；For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency cough, interior-heat disappears Yearningly；Effect: 1. build up resistance；Radix Codonopsis has excitation to nervous system, can enhancing body resistance；2. blood pressure lowering, can expand Open peripheral vessels and reduce blood pressure.Radix Rehmanniae clearing away heat and cooling blood, promoting blood circulation and hemostasis, YIN nourishing and the production of body fluid promoting.Semen Cuscutae effect: the solid bladder of kidney tonifying, is suitable for In all because of kidney qi do not fill, uncontrol of the urinary bladder and the enuresis that causes, with soreness of waist pain, meet the coolest cold and cool then frequent micturition urgency and the heeltap not To the greatest extent, just without diseases such as urethralgia.Cortex Moutan, acrid in the mouth is bitter, cool in nature；GUIXIN, liver, kidney, lung meridian.Heat clearing away；Promoting blood circulation to remove blood stasis.Main warm febrile disease enters Blood system；Send out speckle；Tell nosebleed；Pathogenic bacteria later stage hot Fu Yin brimful of tears distributes heat；Deficiency of YIN osteopyrexia and fever；Amenorrhea due to stagnation of blood；Dysmenorrhea；Carbuncle skin ulcer Poison；Fall and flutter the pain of injury；Beriberoid pyretic arthralgia.Folium Isatidis is called: blue buttocks leaf, LANYE, Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) leaf, indigo-blue leaf, Folium Isatidis；Function cures mainly: heat clearing away Removing toxic substances, cooling blood for hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute lung Scorching.Effect of Rhizoma Polygoni Cuspidati and effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm, for arthralgia, jaundice due to damp-heat, amenorrhea, Lump in the abdomen, Rhizoma Polygoni Cuspidati water decoction is to staphylococcus aureus, A type or group B streptococcus, escherichia coli and herpes simplex virus, stream Influenza Virus etc. all have inhibitory action.The root of Radix Scutellariae can be used as medicine, bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive etc. Effect.Cure mainly epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, Effect of hypertension Sargassum and effect: Sargassum has another name called gloiopeltis, Nori, Zostera marina, big Herba Artemisiae, sea root vegetables, zostera marina, effect of Sargassum Being heat clearing away, hard masses softening and resolving, softening the hard mass, expectorant, diuretic detumescent, the effect of Sargassum is to control thyromegaly, viral lymph node under neck Swollen.Radix Glycyrrhizae function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, and Radix Glycyrrhizae is used in the mixing formula of plurality of Chinese, and energy coordinating the actions of various ingredients in a prescription is dissolved Effect of toxic reaction between medicine.
The feedstuff premix spice beneficial effect of the invention of a kind of Infection of Porcine circovirus is: a kind of Infection of Porcine circovirus Feedstuff premix spice, by hunting circovirus infection with Chinese medicine viewpoint analysis, belongs to outer by damp, liver-heat of suffering from a deficiency of the kidney, stagnation of QI expectorant Resistance, takes to be combined as medicine with heat-clearing and toxic substances removing, depressed liver-energy dispersing and QI regulating, temperature compensation Liver and kidney, the Chinese medicine of dispelling pathogenic wind and eliminating phlegm, and be fabricated to raise Material premix spice, feeding is convenient, and therapeutic effect is notable.
Detailed description of the invention
The feedstuff premix spice of lower a kind of Infection of Porcine circovirus of surface analysis is suitable for pig and takes the amount of feeding as embodiment It is further described.
The feedstuff premix spice of a kind of Infection of Porcine circovirus is applied to pig and feeds with treatment, pig every day of every hundred jin of weight Take dose be a dosage unit be to combine by following each Chinese medicine quality part ratio: Fructus Perillae 15 grams, Radix Codonopsis 15 grams, Flos Lonicerae 15 grams, Radix Isatidis 15 grams, Semen Raphani 10 grams, Radix Gentianae 15 grams, 15 grams of the Radix Rehmanniae, Semen Cuscutae 15 grams, Cortex Moutan 10 grams, Folium Isatidis 10 Gram, Radix Scutellariae 20 grams, Rhizoma Polygoni Cuspidati 10 grams, Sargassum 10 grams, 8 grams of Radix Glycyrrhizae.Using method: each Chinese medicine mixing crushed into powder is directly added section Feedstuff mix homogeneously.The amount of feeding: every hundred jin of pigs feed a dosage every day, even feed a week and can cure.

Claims (2)

1. a feedstuff premix spice for Infection of Porcine circovirus, is characterized in that combining by following each Chinese medicine quality part ratio: Fructus Perillae 15 parts, Radix Codonopsis 15 parts, Flos Lonicerae 15 parts, Radix Isatidis 15 parts, Semen Raphani 10 parts, Radix Gentianae 15 parts, 15 parts of the Radix Rehmanniae, Semen Cuscutae 15 parts, Cortex Moutan 10 parts, Folium Isatidis 10 parts, Radix Scutellariae 20 parts, Rhizoma Polygoni Cuspidati 10 parts, Sargassum 10 parts, 8 parts of Radix Glycyrrhizae.
The feedstuff of a kind of Infection of Porcine circovirus the most according to claim 1 premixes spice, and it is applied to pig and feeds with treating, Pig every day of every hundred jin of weight take dose be a dosage unit be to combine by following each Chinese medicine quality part ratio: Fructus Perillae 15 grams, Radix Codonopsis 15 grams, Flos Lonicerae 15 grams, Radix Isatidis 15 grams, Semen Raphani 10 grams, Radix Gentianae 15 grams, 15 grams of the Radix Rehmanniae, Semen Cuscutae 15 Gram, Cortex Moutan 10 grams, Folium Isatidis 10 grams, Radix Scutellariae 20 grams, Rhizoma Polygoni Cuspidati 10 grams, Sargassum 10 grams, 8 grams of Radix Glycyrrhizae.
CN201610869103.0A 2016-09-30 2016-09-30 Feed premix medicine material for treating porcine circovirus infection Withdrawn CN106309762A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102846866A (en) * 2012-08-28 2013-01-02 郑州后羿制药有限公司 Chinese medicine composition for prevention and control of porcine circovirus disease and preparation method thereof

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