CN1063057C - 抗病毒抗细菌中药复方制剂 - Google Patents
抗病毒抗细菌中药复方制剂 Download PDFInfo
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- CN1063057C CN1063057C CN 96122920 CN96122920A CN1063057C CN 1063057 C CN1063057 C CN 1063057C CN 96122920 CN96122920 CN 96122920 CN 96122920 A CN96122920 A CN 96122920A CN 1063057 C CN1063057 C CN 1063057C
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- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 claims abstract description 10
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- 239000000284 extract Substances 0.000 claims description 11
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- 241000180649 Panax notoginseng Species 0.000 claims description 6
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 6
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 6
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- 239000000047 product Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
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- 239000000825 pharmaceutical preparation Substances 0.000 description 2
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- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
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Abstract
本发明涉及一种以植物提取物为有效成份制成的具有广谱抗菌功效的复方医药制剂。本发明所述的抗病毒抗细菌中药复方制剂主要含有以下成份(重量百分比)：氯原酸5-50%、黄芩甙10-75%、鱼腥草素0.5-15%、齐墩果酸2.5-40%。
本发明所述配方的有机组合，经临床验证，具有清热解毒，广谱抗细菌、抗真菌，抗病菌、消炎镇痛、镇静等多种功效，疗效确切，毒副作用小。
Description
本发明涉及一种以植物提取物为有效成份制成的具有广谱抗菌功效的复方医药制剂。
中国专利申请CN1044760A(申请号89106021.9)公开了一种“双黄连粉针剂制备工艺，”由双花、黄芩、连翘三味中药经提取精制而成，该发明主要是用酸碱法醇处理提取精制黄芩中的有效成份黄芩甙，双花、连翘用水醇处理，将两部分混合制成双黄连粉针剂半成品，然后经配制成适当浓度的水溶液，再运用冷冻干燥法除其中水分，制成疏松固体状的双黄连粉针剂。
本发明的目的旨在提供一种以植物提取物为主要有效成分的、具有广谱抗菌功效的复方医药制剂。
本发明所述的九黄素制剂主要含有以下成份(重量百分比)：氯原酸5-50％、黄芩甙10-75％、鱼腥草素0.5-15％、齐墩果酸2.5-40％。
在上述配方中，所述的氯原酸可采用商品氯原酸，也可采用金银花等中药材提取而制得的产品原液(或提取物)；所述的黄芩甙可采用商品黄芩甙，也可采用黄芩提取物；所述的齐墩果酸可为商品齐墩果酸，也可为金银花、连翘等中药的提取物。除上述成份外，配方中还可加入三七叶皂甙5-50％，黄连大黄藤提取物0.5-10％，黄柏提取物1-15％，上述提取物均为水醇提取物。
本发明所述配方中的氯原酸为金银花主要抗菌活性物，黄芩甙为黄芩中主要生理活性物，鱼腥草素为鱼腥草中抗菌有效成份，齐墩果酸为金银花、连翘等许多中药的抗菌有效成份之一，三七叶皂甙为三七叶主要有效成份，以上成份的有机组合，经临床验证，具有清热解毒，广谱抗细菌、抗真菌，抗病毒、消炎镇痛、镇静等多种功效，疗效确切，毒副作用小。
本发明所述的制剂为糖浆剂、胶囊剂、乳剂、散剂、丸剂、栓剂、针剂、粉针剂等多种临床应用剂型。
实施例：
1、取氯原80g，黄芩甙60g，鱼腥草素20g，齐墩果酸10g，三七叶皂甙30g，加药用辅料适量，混合，制粒，压片，得成品1000片含九黄素提取物200mg。
2、取甘油、明胶、水按70∶20∶10的比例配成基质。加热熔化后加氯原酸10g，黄芩甙150g，鱼腥草素30g，齐墩果酸60g，拌匀，保温使成液状，倒入已涂过液体石腊的栓模中，冷却刮平，得栓剂1000粒，每粒含九黄素提取物250mg。
3、取氯原酸15g，黄芩甙20g，鱼腥草素15g，齐墩果酸10g，三七叶皂甙40g，蒸馏水溶解，1N NaoH调PH至7，加甘露醇适量，粗滤，无菌过滤，分装，冷冻干燥，扎盖，包装，得1000支冻干粉针成品，每支含九黄素提取物100mg。
Claims (4)
1．一种抗病毒抗细菌中药复方制剂，其特征在于主要含有以下成份(重量百分比)：氯原酸5-50％、黄芩甙10-75％、鱼腥草素0.5-15％、齐墩果酸2.5-40％。
2．按照权利要求1所述的抗病毒抗细菌中药复方制剂，其特征在于还含有三七叶皂甙5-50％。
3．按照权利要求1所述的抗病毒抗细菌中药复方制剂，其特征在于还含有黄连大黄藤提取物0.5-10％。
4．按照权利要求1所述的抗病毒抗细菌中药复方制剂，其特征在于还含有黄柏提取物1-15％。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96122920 CN1063057C (zh) | 1996-09-26 | 1996-09-26 | 抗病毒抗细菌中药复方制剂 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96122920 CN1063057C (zh) | 1996-09-26 | 1996-09-26 | 抗病毒抗细菌中药复方制剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1179948A CN1179948A (zh) | 1998-04-29 |
| CN1063057C true CN1063057C (zh) | 2001-03-14 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96122920 Expired - Lifetime CN1063057C (zh) | 1996-09-26 | 1996-09-26 | 抗病毒抗细菌中药复方制剂 |
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| Country | Link |
|---|---|
| CN (1) | CN1063057C (zh) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6632459B2 (en) | 2000-12-11 | 2003-10-14 | Nutricia N.V. | Chlorogenic acid and an analog thereof for immune system stimulation |
| KR100893065B1 (ko) | 2007-07-02 | 2009-04-15 | 경북대학교 산학협력단 | 클로로겐산을 유효 성분으로 함유하는 항균용 조성물 |
-
1996
- 1996-09-26 CN CN 96122920 patent/CN1063057C/zh not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1179948A (zh) | 1998-04-29 |
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