CN1062739C - Medicine for preventing sexual disease - Google Patents
Medicine for preventing sexual disease Download PDFInfo
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- CN1062739C CN1062739C CN97109241A CN97109241A CN1062739C CN 1062739 C CN1062739 C CN 1062739C CN 97109241 A CN97109241 A CN 97109241A CN 97109241 A CN97109241 A CN 97109241A CN 1062739 C CN1062739 C CN 1062739C
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- medicine
- std
- preventing sexual
- disease
- acyclovir
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Abstract
The present invention relates to medicine for preventing sexual diseases, which is particularly to suitable to prevent condyloma acuminatum. The present invention comprises iodophor, and is characterized in that the medicine for preventing sexual diseases also comprises aciclovir essentially. The medicine for preventing sexual diseases is broad-spectrum, sterilizing and antiviral medicine, is used for cleaning and sterilizing vaginae and preventing sexual infectious diseases, and can particularly prevent condyloma acuminatum effectively. The cross infection of STD can be prevented or greatly reduced.
Description
The invention belongs to medicine for preventing sexual disease.
From world wide, the infection rate and the sickness rate of sexually transmitted disease (STD) rise year by year, popular scope constantly enlarges, the extent of injury is on the rise, the spread of aids that is called as " 20 century plague " is rapid, causes global shock, present, in some Hesperian diseases constitute, sexually transmitted disease (STD) is occupied critical role, and its sickness rate almost accounts for the over half of various infectious disease sums.The popular advantage of sexually transmitted disease (STD) is sick plants to gonorrhea, accounts for 60% of whole sexually transmitted disease (STD)s.Secondly be condyloma acuminatum, nongonococcal urethritis.There are 200,000,000 gonorrhea new patients in the whole world every year approximately, and wherein most patient is failed to report.2% is infected in the total population of sex life ability is arranged, with the sexual contactee 50-90% of gonorrhea patient can be infected.China's std patient pre-peaceful liberation period is many, and number of patients reached more than 1,000 ten thousand people in 1949.After liberation, Party and government attach great importance to prevention and treatment of venereal diseases work, basic disappearance sexually transmitted disease (STD) in 1964.
Sexually transmitted disease (STD) is revivable in China the eighties, nearly 30,000 people of national patient in 1986, nineteen ninety reaches 200,000 people, in particular locality, in special populations such as open city, tourist spot, drugs distribution centre, the infection rate of sexually transmitted disease (STD) and sickness rate have reached higher level.Secondly the morbidity of mahjong city is few effect ethnic mimority area at most on the south China's sexually transmitted disease (STD), and the case in each province and city, the Yangtze river basin increases the fastest.From the whole nation, the morbidity by the city to rural area, south north, coastal upcountry the diffusion spread.This spreading rapidly, involve wide, sickness rate is high, the general susceptible of crowd, this causes huge psychological impact to the resident that sexuality is arranged.
At present, considerable work has been done to prevention, treatment sexually transmitted disease (STD) by health ministry health and epidemic prevention department, but sexually transmitted disease (STD) is not still had artificial immunity both at home and abroad up to now, and the specific drug of prevention of STD is not arranged yet.How let us everyone strengthen self-special protection, the erosion of prevention of STD, this problem seems and becomes more and more important and give prominence to.
At present, both at home and abroad the method for prevention of STD mainly be 1. use condom 2. oral antibiotic 3. use spermicide.These three kinds of methods can be played a role to the prevention of sexually transmitted disease (STD), but respectively some shortcomings are arranged.Condom generally is to adopt latex material to make now.Easily break, and when using, make the male reduce the degree of sexual excitation, and have groups of people to use the back irritated, a lot of male are reluctant to use.Oral antibiotic prophylaxis: bibliographical information is arranged, take antibiotics preventability disease transmission when contacting by bacterial std patient with gonorrhea, syphilis etc.Yet, indiscriminately abuses preventative antibiotic have the drug-fast danger of antibiotics takes place, and the sexually transmitted disease (STD) that oral antibiotic is caused by virus condyloma acuminatum, AIDS etc. is without any preventive effect.Use spermicide: bibliographical information is arranged, use spermicide, for venereal disease infection the preventive effect of 25-60% is arranged, but effect is not as using condom obvious.
It is the multifunctional vaginal sponge that is used to practise contraception, prevent and treat sexually transmitted disease (STD), control gynaecopathia of principal agent with the povidone iodine that Chinese patent " multifunctional vaginal sponge " 95102894.4 discloses a kind of.Povidone iodine all has very strong ability of killing and Disinfection Effect to various bacteria, mycete, virus, brood cell, infusorian etc., can effectively prevent sexually transmitted disease (STD), and life-time service does not have any toxic action.This chemical substance has been prepared into the medicine of diseases such as treatment vaginitis, the erosion of official's neck, trichomonas vaginitis now both at home and abroad.But povidone iodine can not effectively prevent the sexually transmitted disease (STD) that accounts for this virus of deputy condyloma acuminatum in the sexually transmitted disease (STD) and cause; The sponge attitude also will be taken out sponge carrier after using from vagina on the other hand, and use has inconvenience more.
The object of the present invention is to provide a kind of medicine for preventing sexual disease, it has the preventive effect of both preserving povidone iodine, the advantage that can effectively prevent condyloma acuminatum again simultaneously.
Medicine for preventing sexual disease of the present invention is characterized in that it is made up of povidone iodine and acyclovir basically, and its composition by weight is as follows:
Povidone iodine 10～1000mg available iodine 1～100mg
Acyclovir 10～200mg.
As above-mentioned medicine for preventing sexual disease, it is characterized in that its composition by weight is as follows:
Povidone iodine 80～200mg available iodine 8～20mg
Acyclovir 80～120mg.
As above-mentioned medicine for preventing sexual disease, it is characterized in that also comprising following composition by weight:
Stearic acid 1000～2000mg glyceryl monostearate 100～1000mg
Sodium lauryl sulphate 5～500mg potassium iodate 10～200mg
Glycerol 800～5000mg.
Povidone iodine of the present invention can have numerous selections, such as povidon iodine, polyethoxy ethanol povidone iodine, Iodophors, iodole ketone, povidone iodine etc.
Acyclovir: efficient, broad-spectrum antiviral agents, it can stop the DNA of virus synthetic, and normal cell is not had influence, and this product is stronger 100 times than cytosine arabinoside to the drawing together property of herpesvirus 1 type, and is stronger 10 times than idoxuridine.
Acyclovir and povidone iodine combination can be played the preventive and therapeutic effect to condyloma acuminatum, strengthen medicine effectiveness and reliability greatly.
Suppository type embodiment of the present invention is as follows.By the following component amount of getting:
Povidone iodine 100mg available iodine 10mg
Acyclovir 100mg
Adjuvant: effect
1. microcrystalline Cellulose 0.12g disperses, dilutes
2. mannitol 0.2g dispersion, refrigerant
3. the suction of carboxymethyl starch sodium CMSNa0.03g suppository is collapsed out
4. HPC 0.2g dispersion, dilution, carrying principal agent are adsorbed on the mucosa
5. lactic acid 0.02g transfers PH
6. ethanol 0.5ml solvent
7. Mentholum 5mg is refrigerant
8. magnesium stearate 0.02g is lubricated
9. silicone oil 0.5mg improves suppository surface slip, moisture resistance
10. hypromellose 0.4g parcel bolt outer surface strengthens slip, moisture resistance
Method for making:
1, with 1., 2., 3., 4. mixing in povidone iodine, acyclovir and the batching of above-mentioned component, granulates;
2, add the tabletting that 5., 6., 7., 8. is mixed of preparing burden again,, strengthen the slip and the moisture resistance of suppository with 9., 10. wrapping film-coat.
This product is a broad-spectrum sterilization, antiviral drugs, be used for the vagina cleaning, sterilization and preventing-ability infecting disease, particularly can effectively prevent condyloma acuminatum, select for use the vaginal suppository dosage form suppository to be put into the vagina deep preceding four minutes of sex partner sexual intercourse or before the longer time, suppository can discharge slowly after mucus is moistening that to provide fungicidal spectrum wide, sterilizing power is strong, and to protozoon, fungus, all effective iodine of virus and spore and antiviral drugs acyclovir, suppository can all moisteningly soften into pasty state and be diffused in the vaginal wall gradually after four minutes, reach cervix uteri, the requirement of vagina sterilizing, treat to continue to prevent that male partner STD infects intrusion vagina and uterine cavity after the sexual intercourse, prevent from or reduce STD significantly to infect mutually.
Cream type embodiment of the present invention is as follows:
Povidone iodine 10g
Acyclovir 1g
Stearic acid 130g
Glyceryl monostearate 20g
Sodium lauryl sulphate 20g
Potassium iodate 5g
Glycerol 400g
Michelia essence 0.60g
Distilled water adds to 1000g
Preparation technology:
See Figure of description-process route chart.
The preparation rules
1. supplementary material is handled: povidone iodine is crossed 32 orders, removes block, and other can be dealed with on the merits of each case.
2. oil phase preparation: take by weighing stearic acid 130g, glyceryl monostearate 20g, glycerol 120g by recipe quantity, glycerol and stearic acid, glyceryl monostearate are placed rustless steel container together, be heated to whole fusions with water-bath, use the sintered filter funnel sucking filtration, filtrate continuation be heated to 80 ℃ standby.
3. water preparation: take by weighing acyclovir 1g, sodium lauryl sulphate 20g by recipe quantity, distilled water 308g water-solublely is heated to 50 ℃ and makes dissolving, adds 280g glycerol again, stirs evenly and uses sintered filter funnel sucking filtration, filtrate continuation to be heated to 80 ℃.
4. substrate emulsifying: after aqueous phase solution was heated to 80 ℃, under agitation (120 rev/mins of speeds of agitator) slowly added 80 ℃ of oil-phase solutions, continued after all adding to stir 15 minutes again, and being cooled to 40 ℃ then rapidly becomes substrate.
5. principal agent preparation: take by weighing potassium iodate 5g by recipe quantity, add water 106g and be stirred to whole dissolvings, add povidone iodine 10g again, be stirred to whole 120 mesh sieves that dissolved.
6. add principal agent, treat that substrate is cooled to 40 ℃ after, under agitation add povidone iodine, potassium iodate solution and essence, be stirred to full and uniform.
7. ointment grinds: above-mentioned ointment is crossed roller mill grind, make mastic even, fine and smooth.
8. check
9. canned: by packing instructions, with the ointment that the is up to the standards packing container sealing of packing into.
Description of the process and points for attention
1. the oil phase heating must be with water-soluble or pressure cooker, to prevent stearic acid and glycerol, monostearate carbonization.
2. emulsifying temperature, pure stearic acid fusing point is 69.2 ℃, this technological requirement two-phase temperature is 80 ℃, and is fully emulsified under fusion fully to guarantee oil phase.
3. speed of agitator must reach 120 and changes during emulsifying, to guarantee that oil phase molecule is disperseed rapidly at aqueous phase, emulsifying.
When 4. adding povidone iodine, substrate temperature must be reduced to 40 ℃, to reduce the oxidizing intensity of iodine and host material, mainly is the incompatibility of stearic acid and glyceryl monostearate.
5. must use rustless steel machine, container and instrument.
Povidone iodine and acyclovir owner want composition in this product, the broad-spectrum sterilization of tool brute force, sterilization, antivirus action.10ppm is the tool bactericidal effect.
Because this product selected topic purpose is the hygienic article that is used for the vagina local bactericidal, sterilizes and keeps the vagina cleaning.Therefore do not require that medicine sees through skin barrier and absorbed by body, bring unnecessary side effect with the exempt from customs examination user.
In view of the foregoing, this product requires 1. soluble in water 2. easily washing of ointment base material 3. can help to clean skin only.No oily substance also requires ointment base material " the short transdermal of nothing " performance to avoid pollution clothes.Main matrix is all selected the high carbon chain fatty acid material for use, and the reported in literature carbochain all has certain penetrance at the fatty acid below 10 or 10.
In this prescription, the effect of host material is described below:
1, stearic acid: this product is white or little yellow, hard and the slightly crystalline block of gloss, granule or powder.Slightly the tool Animal fat is smelly, water insoluble, is dissolved in cold ethanol, is soluble in organic solvents such as hot ethanol, ether.
Make the thickening agent of ointment in this prescription after SDS emulsifying, this product is freezing and destroy in the time of 0 ℃, instability when following in pH5～6.
2, glyceryl monostearate: this product is white or white almost, and the hard agglomerate of wax shape, powder or the lamellar of odorless, tasteless or slight fatty stink are water insoluble, dissolve in hot water ethanol, mineral oil, the expressed oi.By a small amount of soap or other surfactant, can be scattered in the hot water.This product is a non-ionic surface active agent.Can be edible, the food aspect is used a lot.
Make stable, lubricated, anti-stick, thickening, defoamer in this prescription.Do not destroy after this product is freezing, low temperature can reach-10 ℃ and be regardless of out moisture content.The substrate of making is lower to the sensitivity of temperature Change.
3, sodium lauryl sulphate: this product belongs to sheet or powder for white or yellowish crystallization, have slight special smelly, similar fat, bitter in the mouth, Yi Rongshui.1g is dissolved in the 10ml water and forms milky white solution, and the pH value of 1% solution is 6～7, is partially soluble in ethanol.This product character is similar to soap, but insensitive to acid, and pH value is more than 5, and the surface activity effect is very strong.Pharmacopeia of Japan is selected the emulsifying agent of making hydrophilic ointment for use.
This product is an anionic emulsifier in prescription, tool de-sludging, dispersion, moistening, lubricated, barbotage.
4, glycerol: be colourless, odorless, clear and bright syrupy liq is distinguished the flavor of sweet and warmth sensation is arranged.It is neutral that aqueous solution shows, relative density 〉=1.26.The tool hygroscopicity, the moisture content of the big several times of the energy own weight of absorptance under high humidity.Do not separate out crystallization at a lower temperature.Freezing point is lower, can prevent freezing.It is neutral that 10% aqueous solution is, and can mix arbitrarily with water.
This product is made lubricated wetting agent in prescription, and is antifreeze.
5, potassium iodate: white crystals or powder, odorless, it is little puckery to distinguish the flavor of.This product is dissolved in water, and is almost insoluble in ethanol.
In prescription, make the stabilizing agent of iodine.
Cream of the present invention is encapsulated in the little toothpaste type packing container, screws on pipe during use and inserts the vagina depths, injects medicine, and medicine is very fast to be diffused in mucus in cervix uteri and the vaginal wall, and rapid release available iodine and acyclovir, reaches sterilization, disinfectant effect.Still can continue to keep bacteriocidal concentration after the sexual life, prevent unclean thalline intrusion vagina of male and uterine cavity, prevent the mutual infection of sexually transmitted disease (STD).
Creme prescription of the present invention is compared with suppository, and it is good to have lubricity, the advantage such as foreign sense in the use, to skin, mucous membrane nonirritant and Toxicity.
Claims (3)
1, a kind of medicine for preventing sexual disease is characterized in that it is made up of povidone iodine and acyclovir basically, and its composition by weight is as follows: povidone iodine 10～1000mg available iodine 1～100mg acyclovir 10～200mg.
2, medicine for preventing sexual disease as claimed in claim 1 is characterized in that its composition by weight is as follows: povidone iodine 80～200mg available iodine 8～20mg acyclovir 80～120mg.
3, as claim 1,2 described medicine for preventing sexual disease, it is characterized in that also comprising following composition by weight: stearic acid 1000～2000mg glyceryl monostearate 100～1000mg sodium lauryl sulphate 5～500mg potassium iodate 10～200mg glycerol 800～5000mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97109241A CN1062739C (en) | 1997-06-12 | 1997-09-12 | Medicine for preventing sexual disease |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97109136.6 | 1997-06-12 | ||
| CN97109136 | 1997-06-12 | ||
| CN97109241A CN1062739C (en) | 1997-06-12 | 1997-09-12 | Medicine for preventing sexual disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1202359A CN1202359A (en) | 1998-12-23 |
| CN1062739C true CN1062739C (en) | 2001-03-07 |
Family
ID=25744319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97109241A Expired - Fee Related CN1062739C (en) | 1997-06-12 | 1997-09-12 | Medicine for preventing sexual disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1062739C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1086915C (en) * | 1999-04-22 | 2002-07-03 | 钱建民 | Mucous membrane cleaning disinfectant and its producing technology |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131535A (en) * | 1995-03-22 | 1996-09-25 | 李宏伟 | Multifunctional vaginal sponge |
-
1997
- 1997-09-12 CN CN97109241A patent/CN1062739C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131535A (en) * | 1995-03-22 | 1996-09-25 | 李宏伟 | Multifunctional vaginal sponge |
Non-Patent Citations (1)
| Title |
|---|
| 《医药导报》1993年第12卷第1期 1993.1.31 梅旭辉等，阿昔洛韦的临床应用 * |
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| Publication number | Publication date |
|---|---|
| CN1202359A (en) | 1998-12-23 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |