CN106266886A - A kind of compositions with immunological enhancement and preparation method thereof - Google Patents
A kind of compositions with immunological enhancement and preparation method thereof Download PDFInfo
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- CN106266886A CN106266886A CN201610663361.3A CN201610663361A CN106266886A CN 106266886 A CN106266886 A CN 106266886A CN 201610663361 A CN201610663361 A CN 201610663361A CN 106266886 A CN106266886 A CN 106266886A
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- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/50—Methods involving additional extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Abstract
The invention discloses a kind of compositions with immunological enhancement, it is that the raw material comprising following weight proportioning is prepared from: 1 20 parts of Fructus Jujubae, Rhizoma Dioscoreae 1 20 parts, 1 40 parts of Poria, Rhizoma Polygonati 1 40 parts, 1 20 parts of Fructus Hordei Germinatus, Fructus Crataegi 1 20 parts, Fructus Alpiniae Oxyphyllae 1 30 parts.Effect experiment shows, the present composition can strengthen the immunologic function of hypoimmunity mice, Clinical controlled trial result proves that it can substantially reduce the times of common cold of immunocompromised crowd further, there is significant immunological enhancement, food, health product or medicine can be further prepared into, have broad application prospects.
Description
Technical field
The present invention relates to a kind of compositions with immunological enhancement and preparation method thereof, belong to field of medicaments.
Background technology
Immunity is the physiological reaction of body identification Self substances and a kind of protectiveness getting rid of Self substances, has maintenance certainly
Body is stable, prevent infection and the effect of immune surveillance.The height of body's immunity directly influence body resistance against diseases and
Production capacity.Immunologic hypofunction is the initiating agent of multiple disease, it is possible to produces in multiple disease course and increases the weight of the state of an illness.
Immunologic hypofunction is different according to pathogenic factor, can be divided into constitutional and Secondary cases two class.Constitutional is congenital
Educating complete caused, great majority are relevant with heredity, multiple are born in child；Secondary cases is then by infection or medicines such as virus, antibacterial, funguses
Thing, tumor, fatigue, insomnia, malnutrition, pressure are excessive etc., and reason causes, it is seen that in the crowd at various ages, majority body after being ill
Weak, easily send out infectious disease person and belong to Secondary cases hypoimmunity.The most conventional immunostimulant mainly includes aluminium hydroxide, honeybee
Glue, thymosin etc., in view of immunostimulant kind is few, apply limited, and there is the situations such as most untoward reaction, many researcheres
Gradually sight is focused on the field of Chinese medicines, develops, with characteristics of Traditional Chinese Medicine, there is regulation immunocompetence, the exempting from of enhancing human body immunity power
Epidemic disease reinforcing agent.
Therefore, with the Chinese crude drug of integration of edible and medicinal herbs as raw material, it is provided that a kind of strengthen immune effect clearly, without obvious toxic-side effects
Medicine, health product or food, become a problem demanding prompt solution.
Summary of the invention
It is an object of the invention to provide a kind of compositions with immunological enhancement and preparation method thereof.
The invention provides a kind of compositions with immunological enhancement, it is the raw material system comprising following weight proportioning
For forming: Fructus Jujubae 1-20 part, Rhizoma Dioscoreae 1-20 part, Poria 1-40 part, Rhizoma Polygonati 1-40 part, Fructus Hordei Germinatus 1-20 part, Fructus Crataegi 1-20 part, Fructus Alpiniae Oxyphyllae
Core 1-30 part.
Further, it is that the raw material comprising following weight proportioning is prepared from: Fructus Jujubae 5-10 part, Rhizoma Dioscoreae 10-20 part, Fu
Siberian cocklebur 20-40 part, Rhizoma Polygonati 20-30 part, Fructus Hordei Germinatus 5-10 part, Fructus Crataegi 10 parts, Fructus Alpiniae Oxyphyllae 10 parts.
Preferably, it is that the raw material comprising following weight proportioning is prepared from: 10 parts of Fructus Jujubae, Rhizoma Dioscoreae 20 parts, 25 parts of Poria,
Rhizoma Polygonati 20 parts, 5 parts of Fructus Hordei Germinatus, Fructus Crataegi 10 parts, Fructus Alpiniae Oxyphyllae 10 parts.
Further, it is possibly together with the raw material of following weight proportioning: 100 parts of Semen Phaseoli, Semen Maydis 100 parts.
Further, it is by primary powder, water or the extractive with organic solvent of each weight proportion raw material, add pharmaceutically or
The preparation that in health product, acceptable adjuvant or complementary composition are prepared from, or add food adjuvant or other food and prepare
Food, or be directly prepared as food.
Further, described preparation is oral formulations.
Further, described oral formulations is enteral nutrition agent, powder, granule, tablet, capsule, pill, suspendible
Agent or mixture.
Further, described food is that nutrition is stuck with paste.
Nutrition of the present invention is stuck with paste, can one or more are prepared as instant for base material with corn, beans, Semen Juglandis etc.
Stick with paste.
Wherein, described corn includes but not limited to rice, Semen setariae, Semen Tritici aestivi, Herba bromi japonici, Semen Coicis, fructus zizaniae caduciflorae, Semen Sesami, Semen Maydis.
Wherein, described beans includes but not limited to Bowl bean, Semen phaseoli radiati, Semen Phaseoli.
The invention provides the preparation method of a kind of described compositions, comprise the steps: a, take the former of each weight proportion
Material；B, directly beat powder, or add water or organic solvent extraction, concentrate, obtain extract；C, add pharmaceutically or can in health product
The adjuvant accepted or complementary composition, or add food adjuvant or other food, or directly it is prepared as food, to obtain final product.
Further, the preparation of described extract comprises the steps: to take the raw material of each weight proportion, and the backflow that adds water carries
Take, filter, concentrated filtrate, to obtain final product.
Further, the preparation of described extract also comprises the steps: that concentrating the filtrate to relative density is 1.25g/
Ml, adds ethanol and makes alcohol content reach 80%v/v, standing separation, collect supernatant, concentrate.
The invention provides described compositions, in preparation, there is the use in the medicine of immunological enhancement, health product or food
On the way.
The invention provides a kind of compositions with immunological enhancement.Inventor by commonly using righting prescription to the traditional Chinese medical science
Carry out statistical analysis, in conjunction with Clinical Experience, form the present composition.Said composition is by seven kinds of integration of edible and medicinal herbs Chinese drug-treated group
Becoming, with Rhizoma Polygonati as monarch, invigorating the spleen and replenishing QI, with Fructus Jujubae, Rhizoma Dioscoreae and Poria as minister, invigorating the spleen and replenishing QI has spleen invigorating concurrently, makes benefit and oiliness, mountain
Short, bristly hair or beard, Fructus Hordei Germinatus are assistant, strengthen function of invigorating spleen, and each taste raw material complements each other, and play synergistic function.Effect experiment shows that it can increase
The immunologic function of strong hypoimmunity mice, Clinical controlled trial result proves that it can substantially reduce immunocompromised crowd's further
Times of common cold, has significant immunological enhancement.Traditional application method of Chinese medicine, preparation method letter are followed in said composition preparation
Single, can be applicable to food, health food or medicine and prepare.
Obviously, according to the foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, without departing from
Under the present invention above-mentioned basic fundamental thought premise, it is also possible to make the amendment of other various ways, replace or change.
The detailed description of the invention of form by the following examples, remakes the most specifically the foregoing of the present invention
Bright.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below.All based on foregoing of the present invention
The technology realized belongs to the scope of the present invention.
Detailed description of the invention
The raw material, the equipment that use in the specific embodiment of the invention are known product, obtain by buying commercially available prod.
The preparation of embodiment 1 present composition
Take Fructus Jujubae 10kg, Rhizoma Dioscoreae 20kg, Poria 20kg, Rhizoma Polygonati 30kg, Fructus Hordei Germinatus 5kg, Fructus Crataegi 5kg, Fructus Alpiniae Oxyphyllae 10kg, use water
Reflux, extract, 2 times, adds 12 times of volumes for the first time, and second time adds 10 times of volumes, every time backflow 2 hours, filters, and merges filter
Liquid, is concentrated into relative density 1.25g/ml, adds ethanol and makes alcohol content reach 80%v/v, stands and solid-liquid separation, take supernatant, return
Receive ethanol, concentrate, be dried, extract obtained pulverized 60 mesh sieves, and obtained extract powder 27kg of the present invention.Health care can be subsequently used for
Prepared by product, food or medicine.
The preparation of embodiment 2 present composition
Take Fructus Jujubae 10kg, Rhizoma Dioscoreae 20kg, Poria 25kg, Rhizoma Polygonati 20kg, Fructus Hordei Germinatus 5kg, Fructus Crataegi 10kg, Fructus Alpiniae Oxyphyllae 10kg, use
Water reflux, extract, 2 times, adds 10 times of volumes for the first time, and second time adds 8 times of volumes, every time backflow 2 hours, filters, and merges filter
Liquid, concentrate drying, extract obtained pulverize 60 mesh sieves, obtain extract powder 20kg of the present invention.Health product, food can be subsequently used for
Prepared by product or medicine.
The preparation of embodiment 3 present composition
Take Fructus Jujubae 15kg, Rhizoma Dioscoreae 15kg, Poria 25kg, Rhizoma Polygonati 30kg, Fructus Hordei Germinatus 5kg, Fructus Crataegi 5kg, Fructus Alpiniae Oxyphyllae 5kg, add
60%v/v ethanol water reflux, extract, 3 times, adds 8 times of volumes, second time and third time for the first time and adds 6 times of volumes respectively,
Every time backflow 1～2 hour, filters, merging filtrate, reclaims ethanol, concentrates, is dried, extract obtained pulverizing, obtains the present invention and carry
Take thing powder 15kg.Health product, food or medicine can be subsequently used for prepare.
The preparation that embodiment 4 present composition nutrition is stuck with paste
Take Fructus Jujubae 10kg, Rhizoma Dioscoreae 20kg, Poria 25kg, Rhizoma Polygonati 20kg, Fructus Hordei Germinatus 5kg, Fructus Crataegi 10kg, Fructus Alpiniae Oxyphyllae 10kg, steam
Ripe, it is dried, co-grinding, obtains raw material mixed powder；With Semen Phaseoli 100kg, Semen Maydis 100kg, cook, be dried, co-grinding, obtain base material
Mixed powder；Raw material, base material mixed powder are sufficiently mixed, obtain nutrition of the present invention and stick with paste.
Beneficial effects of the present invention is proved below by way of experimental example.
The impact on hypoimmunity mice immunologic function of experimental example 1 present composition
KM mice 80, is divided into 8 groups by body weight stratified random, and respectively suspensoid matched group (gives 0.5% Calculus Bovis from Northwest of China stilbene
Glue), model control group (giving 0.5% tragacanth), positive controls (giving krestin), the present composition full side group
(giving the extract powder according to embodiment 2 preparation), Rhizoma Dioscoreae group, Rhizoma Polygonati group, Radix Ginseng group, (above-mentioned single raw material is equal for Fructus Alpiniae Oxyphyllae group
It is prepared as extract powder) according to embodiment 2 method.Gavage gives trial drug, every day 1 time, continuous 14d.Except suspensoid compares
Outside group, be administered the 8th, 10,12d give cyclophosphamide normal saline solution by 25mg/kg lumbar injection, cause immunocompromised.The
13d, 14d lumbar injection 6% starch solution respectively；1h after being administered to 14d last, lumbar injection 5% chicken red blood cell physiology salt
Aqueous suspensions 1ml, after 30min, cervical dislocation puts to death animal, through abdominal cavity saline injection 2ml, and gently rubs abdominal part.Cut after 1min
Opening abdominal part, draw abdominal cavity washing liquid 1ml, average mark drips on 2 microscope slides, puts into wet box, 37 DEG C of incubation 30min.After in life
Rinsing in reason saline, dry, and fix with 1:1 acetone-methanol solution, 4% (v/v) Giemsa-PBS dyes 3min, distilled water
Rinsing is dried, microscopy, calculates phagocytic percentage.Result is as shown in table 1.
Table 1 present composition on the impact of hypoimmunity mice Peritoneal Macrophage Phagocytosis (n=10, )
Compare with model control group, * P ＜ 0.05, * * P ＜ 0.01
Experimental result: present composition extract gives 14 in 0.4g/kg dosage gavage, is remarkably improved immunity and presses down
The phagocytic activity of Turnover of Mouse Peritoneal Macrophages processed, there was no significant difference with positive controls；Radix Ginseng group also has preferably effect, but imitates
Fruit is not as present composition group；Single medicine no significant difference compared with matched group in other compositionss.
Result above shows, the present composition has significant immunological enhancement, and effect is better than krestin, people
Ginseng.And, under identical dosage, present composition group Turnover of Mouse Peritoneal Macrophages phagocytic percentage is apparently higher than mountain
Medicine, Radix Ginseng, Fructus Alpiniae Oxyphyllae group, show that the present invention each taste raw material complements each other, played synergistic function.
The clinical observation to the immunological enhancement of immunocompromised crowd of experimental example 2 present composition
Collect 20 easy catching a cold volunteers, according to volunteer's readme, its in 2 years times of common cold between 6-15 time.By will
Hope person is randomly divided into 1 group and 2 groups.1 group is treatment group, and 2 groups is matched group.Treatment group patient's edible root every day is made according to embodiment 4
30g is stuck with paste in standby nutrition.Matched group gives the nutrition without the present composition and sticks with paste 30g (the most only by embodiment 4 base material mixed powder group
Become).Volunteer eats 3 months, 6 months, records 3 months, times of common cold in 6 months.Result such as table 2.
Table 2 present composition intervention effect to easy catching a cold crowd's times of common cold
Note: compare with matched group: * P ＜ 0.05；* P ＜ 0.01
Experimental result: edible nutrition of the present invention is stuck with paste, and can substantially reduce the times of common cold of flu Susceptible population, prove further
The present composition has preferable immunological enhancement.
Claims (12)
1. there is a compositions for immunological enhancement, it is characterized in that: it be comprise following weight proportioning raw material preparation and
Become: Fructus Jujubae 1-20 part, Rhizoma Dioscoreae 1-20 part, Poria 1-40 part, Rhizoma Polygonati 1-40 part, Fructus Hordei Germinatus 1-20 part, Fructus Crataegi 1-20 part, Fructus Alpiniae Oxyphyllae 1-
30 parts.
2. compositions as claimed in claim 1, is characterized in that: it is that the raw material comprising following weight proportioning is prepared from: big
Fructus Jujubae 5-10 part, Rhizoma Dioscoreae 10-20 part, Poria 20-40 part, Rhizoma Polygonati 20-30 part, Fructus Hordei Germinatus 5-10 part, Fructus Crataegi 10 parts, Fructus Alpiniae Oxyphyllae 10 parts.
3. compositions as claimed in claim 2, is characterized in that: it is that the raw material comprising following weight proportioning is prepared from: big
Fructus Jujubae 10 parts, Rhizoma Dioscoreae 20 parts, 25 parts of Poria, Rhizoma Polygonati 20 parts, 5 parts of Fructus Hordei Germinatus, Fructus Crataegi 10 parts, Fructus Alpiniae Oxyphyllae 10 parts.
4. the compositions as described in claims 1 to 3 any one, is characterized in that: it is possibly together with the raw material of following weight proportioning:
100 parts of Semen Phaseoli, Semen Maydis 100 parts.
5. the compositions as described in Claims 1 to 4 any one, is characterized in that: it is primary by each weight proportion raw material
Powder, water or extractive with organic solvent, add what acceptable adjuvant or complementary composition pharmaceutically or in health product were prepared from
Preparation, or the food that addition food adjuvant or other food are prepared from, or directly it is prepared as food.
6. compositions as claimed in claim 5, is characterized in that: described preparation is oral formulations.
7. compositions as claimed in claim 6, is characterized in that: described oral formulations is enteral nutrition agent, powder, granule
Agent, tablet, capsule, pill, suspensoid or mixture.
8. compositions as claimed in claim 5, is characterized in that: described food is that nutrition is stuck with paste.
9. a preparation method for compositions described in claim 1～8 any one, is characterized in that: comprise the steps: a, take
The raw material of each weight proportion；B, directly beat powder, or add water or organic solvent extraction, concentrate, obtain extract；C, add pharmacy
Go up or acceptable adjuvant or complementary composition in health product, or add food adjuvant or other food, or be directly prepared as
Food, to obtain final product.
10. preparation method as claimed in claim 9, is characterized in that: the preparation of described extract comprises the steps: to take each heavy
The raw material of amount proportioning, add water reflux, extract, filters, concentrated filtrate, to obtain final product.
11. preparation methoies as claimed in claim 10, is characterized in that: the preparation of described extract also comprise the steps: by
It is 1.25g/ml that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 80%v/v, standing separation, collects supernatant, dense
Contracting.
Compositions described in 12. claim 1～8 any one has the medicine of immunological enhancement, health product or food in preparation
Purposes in product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974285A (en) * | 2017-03-31 | 2017-07-25 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition and its application |
| CN107158152A (en) * | 2017-07-21 | 2017-09-15 | 四川省中医药科学院 | A kind of traditional Chinese medicine health care product composition |
| CN113068829A (en) * | 2021-03-10 | 2021-07-06 | 苏州雷允上健康养生有限公司 | Health food for invigorating spleen, promoting digestion and improving immunity, and preparation method and application thereof |
| CN114568641A (en) * | 2020-11-30 | 2022-06-03 | 内蒙古伊利实业集团股份有限公司 | Bean product composition with immunity improving effect and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101965969A (en) * | 2009-07-28 | 2011-02-09 | 成都自豪药业有限公司 | Health-care food composition with anti-fatigue and immunity-improving functions and preparation method and application thereof |
| CN105079447A (en) * | 2014-05-14 | 2015-11-25 | 成都百草和济科技有限公司 | Health care product or medicine composition capable of relieving fatigue and enhancing immunity |
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- 2016-08-12 CN CN201610663361.3A patent/CN106266886A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101965969A (en) * | 2009-07-28 | 2011-02-09 | 成都自豪药业有限公司 | Health-care food composition with anti-fatigue and immunity-improving functions and preparation method and application thereof |
| CN105079447A (en) * | 2014-05-14 | 2015-11-25 | 成都百草和济科技有限公司 | Health care product or medicine composition capable of relieving fatigue and enhancing immunity |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974285A (en) * | 2017-03-31 | 2017-07-25 | 江苏康缘药业股份有限公司 | A kind of Chinese medicine composition and its application |
| CN106974285B (en) * | 2017-03-31 | 2020-12-08 | 江苏康缘药业股份有限公司 | Traditional Chinese medicine composition and application thereof |
| CN107158152A (en) * | 2017-07-21 | 2017-09-15 | 四川省中医药科学院 | A kind of traditional Chinese medicine health care product composition |
| CN114568641A (en) * | 2020-11-30 | 2022-06-03 | 内蒙古伊利实业集团股份有限公司 | Bean product composition with immunity improving effect and application |
| CN113068829A (en) * | 2021-03-10 | 2021-07-06 | 苏州雷允上健康养生有限公司 | Health food for invigorating spleen, promoting digestion and improving immunity, and preparation method and application thereof |
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