CN106266129A - A kind of blue a kind of reed mentioned in ancient books granule preparing process - Google Patents
A kind of blue a kind of reed mentioned in ancient books granule preparing process Download PDFInfo
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- CN106266129A CN106266129A CN201610733924.1A CN201610733924A CN106266129A CN 106266129 A CN106266129 A CN 106266129A CN 201610733924 A CN201610733924 A CN 201610733924A CN 106266129 A CN106266129 A CN 106266129A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a kind of blue a kind of reed mentioned in ancient books granule preparing process, comprise the following steps: (1) decocting；(2) precipitate with ethanol；(3) it is spray-dried；(4) pelletize.The present invention is optimized improvement to whole blue a kind of reed mentioned in ancient books granule preparing process, have adjusted proportioning raw materials, carries water, the technological parameter of precipitate with ethanol, spray drying step is optimized design, and after strict screening design, defining drying aids and the kind of adjuvant and consumption, when solving spray drying, material glues the problem of wall, caking, and step is simple, process stabilizing, easily implementing, production efficiency is high, and loss of effective components is few, the granule opaque prepared is crisp, dissolubility and good fluidity, powder is few, and moisture is suitable.
Description
Technical field
The present invention relates to Chinese medicine preparation production technical field, especially relate to a kind of blue a kind of reed mentioned in ancient books granule preparing process.
Background technology
Blue a kind of reed mentioned in ancient books granule is Radix Isatidis, Radix Scutellariae, Fructus Gardeniae, Cortex Phellodendri, the extracted granule being processed into of Semen Sterculiae Lychnophorae Chinese medicine of the five flavours,
Remove contamination gastric heat, removing pathogenic heat from blood and toxic substance from the body with Radix Isatidis, let out excess-fire, dehumidifying heat with Radix Scutellariae, the fire of lung heat clearing and large intestine, with Fructus Gardeniae clearing away heat-fire,
Removing pathogenic heat from blood and toxic substance from the body, strengthens heat-clearing and toxic substances removing, removing heat from blood detumescence with Cortex Phellodendri, opens a surname waste gas, stagnated fire of coming down in torrents with Semen Sterculiae Lychnophorae, and all medicines share, and play altogether
Heat-clearing and toxic substances removing, the merit of relieving sore throat and diminishing swelling, can be used for the pharyngalgia caused by acute pharyngitis, lung excess of the stomach heat syndrome, dry pharynx, the pharyngeal disease such as scorching hot.
Medicinal liquid extraction, spray drying and dry granulation are main three steps producing blue a kind of reed mentioned in ancient books granule, and it directly affects life
Produce efficiency and product quality.Current blue a kind of reed mentioned in ancient books particulate manufacturing method, also exists medicinal liquid extracting cycle long, the problems such as extraction ratio is low,
During spray drying, material wall easy to stick, caking, the problems such as dry mass is poor, material incomplete mixing during dry granulation, be difficult to granulating,
Powder is many, and granular mass is poor.
Summary of the invention
The present invention is to solve the problems referred to above existing for blue a kind of reed mentioned in ancient books granule preparing process of prior art, it is provided that a kind of
Step is simple, and process stabilizing is easily implemented, and loss of effective components is few, and can be effectively improved material in spray-drying process and glue wall journey
Degree, beneficially blue a kind of reed mentioned in ancient books granule preparing process of preparations shaping, prepared granule opaque is crisp, dissolubility and good fluidity, and powder is few,
Moisture is suitable.
To achieve these goals, the present invention is by the following technical solutions:
A kind of blue a kind of reed mentioned in ancient books granule preparing process of the present invention, comprises the following steps:
(1) decocting: by 13 ~ 16 parts of Radix Isatidis, 10 ~ 13 parts of Radix Scutellariaes, 13 ~ 16 portions of Fructus Gardeniaes, 5 ~ 7 portions of Cortex Phellodendris, the weight of 3 ~ 6 parts of Semen Sterculiae Lychnophoraes
After the amount various raw material of part stoichiometry, boiling obtains decoction liquor, and it is 1.10 ~ 1.15 that decoction liquor is evaporated to relative density
(50 DEG C of heat are surveyed), obtains concentrated solution.
(2) precipitate with ethanol: after addition ethanol makes alcohol content reach 60 ~ 70% in concentrated solution, stand, filter, decompression recycling ethanol,
Being concentrated into relative density is that 1.07 ~ 1.10(50 DEG C of heat is surveyed), obtain extractum, and in 50 DEG C of insulations.In 50 DEG C of insulations, extractum mobility
Good, spray-drying efficiency is high.It is 1.07 ~ 1.10 that concentrated solution is concentrated into relative density, finally prepares granule uniform, and relative density is too
Little, granule is too thin, and powder is many, and energy consumption is high, and relative density is too big, and extractum thickness, drying time is long, and granule is thicker.
(3) it is spray-dried: after extractum is sieved, extractum adds beta-schardinger dextrin-, is stirring evenly and then adding into drying aids,
It is spray-dried, obtains spray powder.After being sieved by extractum, to prevent coarse grain to be mixed into, stopped nozzles, impact is spray-dried effect；This
In bright granule relatively big containing Radix Scutellariae and Fructus Gardeniae bitterness, therefore add beta-schardinger dextrin-and carry out taste masking to reduce its bitterness, β-ring simultaneously
Dextrin can improve the extractum viscous wall degree in spray-drying process.
(4) pelletize: in spray powder, add mix homogeneously after adjuvant carry out dry granulation, through granulate, sieve after i.e. obtain blue
A kind of reed mentioned in ancient books granule.
As preferably, in step (1), Fructus Gardeniae decocts after crushing, and it is 0.2 ~ 0.4cm that Radix Scutellariae and Cortex Phellodendri are cut into thickness
Thin decoction pieces decoct.Fructus Gardeniae decocts after crushing, decocts, be conducive to improving effectively after Radix Scutellariae and Cortex Phellodendri section
Constituents extraction rate.
As preferably, in step (1), boiling three times, concretely comprise the following steps: add water 12 times amount for the first time, boils extraction
2h, add water 10 times amount for the second time, boils extraction 1h, and add water 10 times amount for the third time, boils extraction 10h, merges decoction liquor.
As preferably, in step (1), control concentrating under reduced pressure temperature ＜ 80 DEG C.By controlling concentrating under reduced pressure temperature to avoid
Active component, by high temperature, ensures thickening efficiency simultaneously.
As preferably, in step (2), during decompression recycling ethanol, control thickening temperature ＜ 80 DEG C.
As preferably, in step (2), after concentrated solution adds ethanol, supersound process 20 ~ 30min in ice bath, stand 3 ~
5h.In the present invention when concentrated solution is carried out precipitate with ethanol, coordinate ice-bath ultrasonic, time of repose (conventional time of repose can be greatly shortened
For more than 12h), and the extraction ratio of effective ingredient is higher, advantageously reduces energy consumption, improves production efficiency.
As preferably, in step (3), beta-schardinger dextrin-addition is the 2 ~ 3% of extractum quality.
As preferably, in step (3), the addition of described drying aids is the 0.5 ~ 1% of extractum quality, drying aids by
The component composition of following mass percent: 20 ~ 30% Oleum menthae, 20 ~ 30% mannitol, surplus is sodium stearate.Add β-ring to stick with paste
When the row that progresses greatly is spray-dried, still there is viscous wall, agglomeration problems, by adding drying aids to solve above-mentioned lacking in the present invention
Point, drying aids is the key point of the present invention, wherein mannitol no hygroscopicity, and fast drying has antiseized effect, can make product
Moisture lowers, thus wall sticking phenomenon when improving spray drying；Oleum menthae has the effect of taste masking, it is often more important that, thin
The interparticle adhesion of the moisture generation of powder surface absorption when lotus oil can reduce spray drying and reduction spraying extract powder
The electrostatic force on surface, so that extractum energy rapid dispersion, being dried, is conducive to shortening the dry run of product particle, raw improving
Suppress wall sticking phenomenon while producing efficiency, improve and be spray-dried effect；Sodium stearate can adsorb at powder body table in spray process
Face hinders hydrone close, improves the moisture pick-up properties of powder body, and can improve the surface roughness of extract powder particle of spraying, reduction powder
Body and the time of contact of wall, thus significantly alleviate the generation of wall sticking phenomenon.Drying aids in the present invention is by each other
Synergism, the material problem of gluing wall, caking when can effectively solve to be spray-dried.
As preferably, in step (3), the process conditions of spray drying are: inlet temperature 180 ~ 195 DEG C, leaving air temp 80
~95℃.For avoiding effective ingredient by high temperature and to ensure drying effect, efficiency, spray drying temperature controls 180 ~ 195
DEG C, it being spray-dried leaving air temp and control at 80 ~ 95 DEG C, the granularity, the hardness that prepare are suitable, and good fluidity.
As preferably, in step (4), the addition of described adjuvant is the 20 ~ 25% of spray powder quality, and adjuvant is by following matter
The component composition of amount percentage ratio: 3 ~ 5% magnesium stearate, 5 ~ 10% steviosin, 3 ~ 5% Gypsum Fibrosum, surplus is dextrin.Adjuvant is also this
Bright inventive point, wherein magnesium stearate is lubricant, beneficially grain forming；Steviosin is as correctives, and its sweet taste is pure, after
Taste is good to eat, after taking, is not absorbed by the body, and does not produce heat, and nontoxic, safe and reliable；Gypsum Fibrosum can improve each component to be mixed
Close uniformity, pelletize the easiest, and Gypsum Fibrosum can reduce the generation of flour in pelletization, and when ensureing to pelletize, granule is equal
Even, fine and smooth, be conducive to improving granulate quality；Dextrin is main molding adjuvant, and grain forming is good, prepares granule opaque pine
Crisp, dissolubility is good, and moisture is suitable.The each component of adjuvant in the present invention is the most collaborative, can be effectively improved granulate quality.
Therefore, there is advantages that and whole blue a kind of reed mentioned in ancient books granule preparing process is optimized improvement, adjust
Proportioning raw materials, carries water, the technological parameter of precipitate with ethanol, spray drying step is optimized design, and through strict screening design
After define drying aids and the kind of adjuvant and consumption, when solving spray drying, material glues the problem of wall, caking, step letter
Single, process stabilizing, easily to implement, production efficiency is high, and loss of effective components is few, and the granule opaque prepared is crisp, dissolubility and flowing
Property is good, and powder is few, and moisture is suitable.
Detailed description of the invention
Below by detailed description of the invention, the present invention will be further described.
Embodiment 1
(1) decocting: by 13kg Radix Isatidis, 10kg Radix Scutellariae, 13kg Fructus Gardeniae, 5kg Cortex Phellodendri, the weight proportion metering of 3kg Semen Sterculiae Lychnophorae is each
Plant raw material, Fructus Gardeniae is crushed, after Radix Scutellariae and Cortex Phellodendri are cut into the thin decoction pieces that thickness is 0.2cm, each raw material mixing and water adding is decocted
Decocting three times, concretely comprise the following steps: add water 12 times amount for the first time, boil extraction 2h, add water 10 times amount for the second time, boils extraction 1h,
Add water 10 times amount for the third time, boils extraction 10h, merges decoction liquor, decoction liquor is evaporated to relative density and is 1.10(50 DEG C
Heat is surveyed), obtain concentrated solution, during concentrating under reduced pressure, control concentrating under reduced pressure temperature ＜ 80 DEG C；
(2) precipitate with ethanol: after addition ethanol makes alcohol content reach 60% in concentrated solution, supersound process 20min in ice bath, stand 3h, mistake
Filter, decompression recycling ethanol, being concentrated into relative density is that 1.07(50 DEG C of heat is surveyed), obtain extractum, and in 50 DEG C of insulations, recovered under reduced pressure second
During alcohol, control thickening temperature ＜ 80 DEG C；
(3) it is spray-dried: after extractum is sieved, extractum is incorporated as the beta-schardinger dextrin-of extractum quality 2%, adds after stirring
Enter the drying aids of extractum quality 0.5%, be spray-dried, inlet temperature 180 DEG C during spray drying, leaving air temp 80 DEG C, obtain spray drying
Powder, wherein drying aids is made up of the component of following mass percent: 20% Oleum menthae, 20% mannitol, and surplus is stearic acid
Sodium,；
(4) pelletize: after adding the adjuvant of spray powder quality 20% in spray powder, mix homogeneously carries out dry granulation, through granulate, mistake
I.e. obtaining blue a kind of reed mentioned in ancient books granule after sieve, wherein adjuvant is made up of the component of following mass percent: 3% magnesium stearate, 5% steviosin, 3% stone
Cream, surplus is dextrin.
Embodiment 2
(1) decocting: by 16kg Radix Isatidis, 13kg Radix Scutellariae, 16kg Fructus Gardeniae, 7kg Cortex Phellodendri, the weight proportion metering of 6kg Semen Sterculiae Lychnophorae is each
Plant raw material, Fructus Gardeniae is crushed, after Radix Scutellariae and Cortex Phellodendri are cut into the thin decoction pieces that thickness is 0.4cm, each raw material mixing and water adding is decocted
Decocting three times, concretely comprise the following steps: add water 12 times amount for the first time, boil extraction 2h, add water 10 times amount for the second time, boils extraction 1h,
Add water 10 times amount for the third time, boils extraction 10h, merges decoction liquor, decoction liquor is evaporated to relative density and is 1.15(50 DEG C
Heat is surveyed), obtain concentrated solution, during concentrating under reduced pressure, control concentrating under reduced pressure temperature ＜ 80 DEG C；
(2) precipitate with ethanol: after addition ethanol makes alcohol content reach 70% in concentrated solution, supersound process 30min in ice bath, stand 5h, mistake
Filter, decompression recycling ethanol, being concentrated into relative density is that 1.10(50 DEG C of heat is surveyed), obtain extractum, and in 50 DEG C of insulations, recovered under reduced pressure second
During alcohol, control thickening temperature ＜ 80 DEG C；
(3) it is spray-dried: after extractum is sieved, extractum is incorporated as the beta-schardinger dextrin-of extractum quality 3%, adds after stirring
Enter the drying aids of extractum quality 1%, be spray-dried, inlet temperature 195 DEG C during spray drying, leaving air temp 95 DEG C, obtain spray drying
Powder, wherein drying aids is made up of the component of following mass percent: 30% Oleum menthae, 30% mannitol, and surplus is stearic acid
Sodium,；
(4) pelletize: after adding the adjuvant of spray powder quality 25% in spray powder, mix homogeneously carries out dry granulation, through granulate, mistake
I.e. obtaining blue a kind of reed mentioned in ancient books granule after sieve, wherein adjuvant is made up of the component of following mass percent: 5% magnesium stearate, 10% steviosin, 5% stone
Cream, surplus is dextrin.
Embodiment 3
(1) decocting: by 15kg Radix Isatidis, 12kg Radix Scutellariae, 14kg Fructus Gardeniae, 6kg Cortex Phellodendri, the weight proportion metering of 5kg Semen Sterculiae Lychnophorae is each
Plant raw material, Fructus Gardeniae is crushed, after Radix Scutellariae and Cortex Phellodendri are cut into the thin decoction pieces that thickness is 0.3cm, each raw material mixing and water adding is decocted
Decocting three times, concretely comprise the following steps: add water 12 times amount for the first time, boil extraction 2h, add water 10 times amount for the second time, boils extraction 1h,
Add water 10 times amount for the third time, boils extraction 10h, merges decoction liquor, decoction liquor is evaporated to relative density and is 1.12(50 DEG C
Heat is surveyed), obtain concentrated solution, during concentrating under reduced pressure, control concentrating under reduced pressure temperature ＜ 80 DEG C；
(2) precipitate with ethanol: after addition ethanol makes alcohol content reach 65% in concentrated solution, supersound process 25min in ice bath, stand 4h, mistake
Filter, decompression recycling ethanol, being concentrated into relative density is that 1.08(50 DEG C of heat is surveyed), obtain extractum, and in 50 DEG C of insulations, recovered under reduced pressure second
During alcohol, control thickening temperature ＜ 80 DEG C；
(3) it is spray-dried: after being sieved by extractum, extractum is incorporated as the beta-schardinger dextrin-of extractum quality 2 ~ 3%, after stirring
Add the drying aids of extractum quality 0.7%, be spray-dried, inlet temperature 182 DEG C during spray drying, leaving air temp 85 DEG C, obtain spray
Dry powder, wherein drying aids is made up of the component of following mass percent: 25% Oleum menthae, 25% mannitol, and surplus is stearic acid
Sodium,；
(4) pelletize: after adding the adjuvant of spray powder quality 22% in spray powder, mix homogeneously carries out dry granulation, through granulate, mistake
I.e. obtaining blue a kind of reed mentioned in ancient books granule after sieve, wherein adjuvant is made up of the component of following mass percent: 4% magnesium stearate, 7% steviosin, 4% stone
Cream, surplus is dextrin.
The blue a kind of reed mentioned in ancient books particulates' properties index prepared by the present invention is as follows:
Character: light yellow to brown yellow granule, taste is sweet, micro-hardship.
Moisture :≤5%.
Every bag (4.0g/ bag ± 7%) contains jasminoidin: >=95mg.
Microbiological indicator: bacterial population≤70/g, yeast≤10g/, escherichia coli and the demodicid mite that lives do not detect.
Each index all meets national regulation.
Embodiment described above is the one preferably scheme of the present invention, not makees the present invention any pro forma
Limit, on the premise of without departing from the technical scheme described in claim, also have other variant and remodeling.
Claims (10)
1. blue a kind of reed mentioned in ancient books granule preparing process, it is characterised in that comprise the following steps:
(1) decocting: by 13 ~ 16 parts of Radix Isatidis, 10 ~ 13 parts of Radix Scutellariaes, 13 ~ 16 portions of Fructus Gardeniaes, 5 ~ 7 portions of Cortex Phellodendris, the weight of 3 ~ 6 parts of Semen Sterculiae Lychnophoraes
After the amount various raw material of part stoichiometry, boiling obtains decoction liquor, and it is 1.10 ~ 1.15 that decoction liquor is evaporated to relative density
(50 DEG C of heat are surveyed), obtains concentrated solution；
(2) precipitate with ethanol: after addition ethanol makes alcohol content reach 60 ~ 70% in concentrated solution, stand, filter, decompression recycling ethanol, concentrate
It is that 1.07 ~ 1.10(50 DEG C of heat is surveyed to relative density), obtain extractum, and in 50 DEG C of insulations；
(3) it is spray-dried: after extractum is sieved, extractum adds beta-schardinger dextrin-, is stirring evenly and then adding into drying aids, spraying
It is dried, obtains spray powder；
(4) pelletize: in spray powder, add mix homogeneously after adjuvant carry out dry granulation, through granulate, sieve after i.e. obtain blue a kind of reed mentioned in ancient books
Grain.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (1), Fructus Gardeniae is through broken
After decoct, Radix Scutellariae and Cortex Phellodendri are cut into the thin decoction pieces that thickness is 0.2 ~ 0.4cm and decoct.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (1), boiling three
Secondary, concretely comprise the following steps: add water 12 times amount for the first time, boil extraction 2h, add water 10 times amount for the second time, boils extraction 1h, for the third time
Add water 10 times amount, boils extraction 10h, merges decoction liquor.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (1), control decompression dense
Contracting temperature ＜ 80 DEG C.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (2), recovered under reduced pressure second
During alcohol, control thickening temperature ＜ 80 DEG C.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (2), add in concentrated solution
After entering ethanol, supersound process 20 ~ 30min in ice bath, stand 3 ~ 5h.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (3), beta-schardinger dextrin-adds
Dosage is the 2 ~ 3% of extractum quality.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (3), described being dried is helped
The addition of agent is the 0.5 ~ 1% of extractum quality, and drying aids is made up of the component of following mass percent: 20 ~ 30% Oleum menthae,
20 ~ 30% mannitol, surplus is sodium stearate.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (3), spray drying
Process conditions are: inlet temperature 180 ~ 195 DEG C, leaving air temp 80 ~ 95 DEG C.
A kind of blue a kind of reed mentioned in ancient books granule preparing process the most according to claim 1, it is characterised in that in step (4), described adjuvant
Addition is spray powder quality 20 ~ 25%, adjuvant is made up of the component of following mass percent: 3 ~ 5% magnesium stearate, 5 ~
10% steviosin, 3 ~ 5% Gypsum Fibrosum, surplus is dextrin.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109893507A (en) * | 2019-03-15 | 2019-06-18 | 湖南德康制药股份有限公司 | A kind of preparation method of granule that treating acpuei pharyngitis |
| CN115869359A (en) * | 2021-09-28 | 2023-03-31 | 扬子江药业集团有限公司 | Blue scutellaria extract and its use |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456229A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of donkey hide gelatin effervescent granules for nourishing blood |
| CN1456230A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of six component rehmannia root pills |
| CN1616032A (en) * | 2004-09-23 | 2005-05-18 | 内蒙古伊泰医药科技开发有限责任公司 | Process for preparing granular preparation for treating pharyngeal disease and method for controlling quality |
| CN101181404A (en) * | 2007-11-28 | 2008-05-21 | 南京海陵中药制药工艺技术研究有限公司 | Buccal tablets for curing pharynx sickness as well as preparation method |
-
2016
- 2016-08-28 CN CN201610733924.1A patent/CN106266129A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456229A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of donkey hide gelatin effervescent granules for nourishing blood |
| CN1456230A (en) * | 2003-02-12 | 2003-11-19 | 毛友昌 | Preparation of six component rehmannia root pills |
| CN1616032A (en) * | 2004-09-23 | 2005-05-18 | 内蒙古伊泰医药科技开发有限责任公司 | Process for preparing granular preparation for treating pharyngeal disease and method for controlling quality |
| CN101181404A (en) * | 2007-11-28 | 2008-05-21 | 南京海陵中药制药工艺技术研究有限公司 | Buccal tablets for curing pharynx sickness as well as preparation method |
Non-Patent Citations (4)
| Title |
|---|
| 张强，武凤兰: "《药剂学》", 31 January 2005, 北京大学医学出版社 * |
| 杨明: "《中药药剂学》", 31 August 2008, 上海科学技术出版社 * |
| 缪勇，臧广州: "《中草药植物提取与深加工新技术实用手册 第3卷》", 30 April 2004, 天津电子出版社 * |
| 谢秀琼: "《现代中药制剂新技术》", 30 June 2004, 化学工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109893507A (en) * | 2019-03-15 | 2019-06-18 | 湖南德康制药股份有限公司 | A kind of preparation method of granule that treating acpuei pharyngitis |
| CN115869359A (en) * | 2021-09-28 | 2023-03-31 | 扬子江药业集团有限公司 | Blue scutellaria extract and its use |
| CN115869359B (en) * | 2021-09-28 | 2024-03-19 | 扬子江药业集团江苏龙凤堂中药有限公司 | Radix Scutellariae extract and its application |
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