CN106265560A - A kind of Sobering-up buccal tablet and preparation method thereof - Google Patents
A kind of Sobering-up buccal tablet and preparation method thereof Download PDFInfo
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- CN106265560A CN106265560A CN201610583446.0A CN201610583446A CN106265560A CN 106265560 A CN106265560 A CN 106265560A CN 201610583446 A CN201610583446 A CN 201610583446A CN 106265560 A CN106265560 A CN 106265560A
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- buccal tablet
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- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 52
- 239000006189 buccal tablet Substances 0.000 title claims abstract description 52
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 150000004676 glycans Chemical class 0.000 claims abstract description 103
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 102
- 239000005017 polysaccharide Substances 0.000 claims abstract description 102
- 239000000284 extract Substances 0.000 claims abstract description 65
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 58
- 235000013311 vegetables Nutrition 0.000 claims abstract description 51
- 239000000463 material Substances 0.000 claims abstract description 50
- 239000000203 mixture Substances 0.000 claims abstract description 33
- 235000013351 cheese Nutrition 0.000 claims abstract description 26
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 25
- 239000000741 silica gel Substances 0.000 claims abstract description 25
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 25
- 239000011230 binding agent Substances 0.000 claims abstract description 20
- 241000208340 Araliaceae Species 0.000 claims abstract description 13
- 241000190633 Cordyceps Species 0.000 claims abstract description 13
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 13
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 13
- 235000008434 ginseng Nutrition 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 241000196324 Embryophyta Species 0.000 claims description 55
- 239000006228 supernatant Substances 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 19
- 239000000843 powder Substances 0.000 claims description 19
- 238000000605 extraction Methods 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 14
- 239000011812 mixed powder Substances 0.000 claims description 14
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 12
- 239000002244 precipitate Substances 0.000 claims description 12
- 229920002774 Maltodextrin Polymers 0.000 claims description 11
- 239000005913 Maltodextrin Substances 0.000 claims description 11
- 229940035034 maltodextrin Drugs 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 238000007796 conventional method Methods 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 8
- 238000007908 dry granulation Methods 0.000 claims description 6
- 101100383903 Mus musculus Cisd3 gene Proteins 0.000 claims description 3
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims 1
- 210000004185 liver Anatomy 0.000 abstract description 21
- 230000006378 damage Effects 0.000 abstract description 9
- 230000008520 organization Effects 0.000 abstract description 5
- 230000035622 drinking Effects 0.000 abstract description 4
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 241000700159 Rattus Species 0.000 description 21
- 229960004756 ethanol Drugs 0.000 description 18
- 230000000694 effects Effects 0.000 description 13
- 230000037396 body weight Effects 0.000 description 7
- 238000003304 gavage Methods 0.000 description 7
- 238000003305 oral gavage Methods 0.000 description 7
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000009467 reduction Effects 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241000256844 Apis mellifera Species 0.000 description 3
- 235000012907 honey Nutrition 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000002311 liver mitochondria Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010016825 Flushing Diseases 0.000 description 1
- 206010019837 Hepatocellular injury Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of Sobering-up buccal tablet, its raw material is made up of the component of following weight portion: vegetable polysaccharides extract 55 60 parts, Mel 10 15 parts, 5 10 parts of cheese, binding agent 5 10 parts, micropowder silica gel 12 parts；Described vegetable polysaccharides extract be mixed by the mass ratio of 1: 1: 1 by Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii after, extract what the active polysaccharide material in mixture was prepared from.The Sobering-up buccal tablet of the present invention, for protection to liver after drinking, reduces the ethanol damage to liver organization, has no side effect human body, have be convenient for carrying, all-ages.Additionally, the invention also discloses the preparation method of a kind of Sobering-up buccal tablet.
Description
Technical field
The invention belongs to health product technology field, be specifically related to a kind of Sobering-up buccal tablet, the invention still further relates to this Sobering-up buccal tablet
Concrete preparation method.
Background technology
Along with social pressure and the change of living habit, increasing people hits the bottle in recent years, and excessive consumption of alcohol causes
Body aging degree is aggravated, and liver metabolism pressure increases, a large amount of free radicals produced in metabolism and negative oxygen ion attack cells film,
Cause hepatocellular damage.Secondly the noxious substance produced, as acetaldehyde etc. causes the activity reduction of protein, the work of antioxidase
Power declines.Therefore, drink and hepatic tissue causes major injury, chronic alcoholism will form alcoholic liver, hepatitis, liver group that What is more
Knit meeting fibrosis, and then be converted into hepatocarcinoma, the health of the hepatopathy caused of the drinking serious threat mankind.
Vegetable polysaccharides is as active substance topmost in medicine-food two-purpose plant, and it has good oxidation resistance,
Can suppress increasing of free radical, improve immunity of organisms, antibiont suddenlys change, and can be formed on liver film top layer simultaneously and be effectively protected
Layer, the hindered alcohol damage to liver organization.Have Activities of Some Plants polyoses extract at present to protect at food as functional product
Strong field obtains application, but does not also have the application in alcohol-neutralize healthy product, therefore, it is necessary to exploitation one is many containing plant
The Sobering-up buccal tablet of sugar extract, for reducing the ethanol damage to liver organization.
Summary of the invention
A kind of Sobering-up buccal tablet that the present invention provides, for reducing the ethanol damage to liver organization.
First purpose of the present invention is to provide a kind of Sobering-up buccal tablet, and its raw material is made up of the component of following weight portion: plant
Thing polyoses extract 55-60 part, Mel 10-15 part, cheese 5-10 part, binding agent 5-10 part, micropowder silica gel 1-2 part；Described plant
Thing polyoses extract be mixed by the mass ratio of 1: 1: 1 by Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii after, extract the polysaccharide in mixture and live
Property material is prepared from.
Preferably, the Sobering-up buccal tablet that the present invention provides, its raw material is made up of the component of following weight portion: vegetable polysaccharides extracts
Thing 55 parts, Mel 13 parts, 7 parts of cheese, binding agent 8 parts, micropowder silica gel 1 part.
Preferably, the Sobering-up buccal tablet that the present invention provides, its raw material is made up of the component of following weight portion: vegetable polysaccharides extracts
Thing 60 parts, Mel 15 parts, 5 parts of cheese, binding agent 6 parts, micropowder silica gel 2 parts.
Preferably, the Sobering-up buccal tablet that the present invention provides, its raw material is made up of the component of following weight portion: vegetable polysaccharides extracts
Thing 58 parts, Mel 10 parts, 5 parts of cheese, binding agent 10 parts, micropowder silica gel 1 part.
Preferably, binding agent described in above-mentioned Sobering-up buccal tablet is maltodextrin.
Present invention also offers the preparation method of a kind of Sobering-up buccal tablet, specifically implement according to following steps:
Step 1, weighs Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii by the mass ratio of 1: 1: 1, and is mixed into plant mixture；
Step 2, extracts the active polysaccharide material in plant mixture, and is dried by active polysaccharide material, obtain plant many
Sugar extract；
Step 3, weighs each component respectively by following weight portion: vegetable polysaccharides extract 55-60 part, Mel 10-15 part, milk
Cheese 5-10 part, binding agent 5-10 part, micropowder silica gel 1-2 part；
Step 4, after being processed by the vegetable polysaccharides extract microwave sterilizating weighed, with the Mel weighed, cheese, binding agent mixes
Close, and dry granulation technology prepares material powder routinely；
Step 5, material powder microwave sterilizating according to a conventional method；
Step 6, adds the micropowder silica gel weighed in the material powder after microwave sterilizating, mixing, after in tabletting machine
Shape, obtain Sobering-up buccal tablet.
Preferably, the extracting method of active polysaccharide material in described plant mixture, specifically include following steps:
By plant mixture freeze-day with constant temperature 12h at 55-60 DEG C, then pulverize, and cross 40-50 mesh sieve, obtain plant and mix
Close powder；
The plant mixed-powder weighing certain mass adds distilled water, and every kilogram of plant mixed-powder adds 20 liters of steamings
Distilled water, mixing, 900W microwave extraction 4-5min in microwave oven, obtain polysaccharide extraction liquid；
Polysaccharide extraction liquid stands and is cooled to room temperature, is centrifuged 5min in 600r/min, room temperature, collects supernatant；
According to supernatant: dehydrated alcohol=1: the volume ratio of 4, in supernatant, add dehydrated alcohol, and in 4 DEG C of standings
18-24h, after be centrifuged 10-15min in 5000r/min, room temperature, collect precipitate, described precipitate is active polysaccharide material；
Active polysaccharide material is dried in 60 DEG C, obtains vegetable polysaccharides extract.
Preferably, in the preparation method of above-mentioned Sobering-up buccal tablet, the condition of described microwave sterilizating is to make under 900W, 2450MHZ
Use 2-3min.
The Sobering-up buccal tablet of the present invention, can stop ethanol is acetaldehyde by oxidation of ethanol, and stops ethanol to produce in metabolic process
Raw substantial amounts of free radical and negative oxygen ion, secondly shielding acetaldehyde and blood or histiocytic contact, be used for after drinking liver
Dirty protection, reduces the ethanol damage to liver organization, has no side effect human body, have be convenient for carrying, all-ages；Add
Cheese and Mel can wrap up ethanol molecule so that it is do not absorbed by cell, directly got rid of body while protection gastric mucosa by body
Outward.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in detail, but should not be construed as the restriction of the present invention.
One Sobering-up buccal tablet of the present invention, is made up of the component of following weight portion: vegetable polysaccharides extract 55-60 part, Mel
10-15 part, cheese 5-10 part, binding agent 5-10 part, micropowder silica gel 1-2 part, wherein binding agent is maltodextrin；Described plant is many
Sugar extract be mixed by the mass ratio of 1: 1: 1 by Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii after, extract the active polysaccharide thing in mixture
Matter is prepared from.
Present invention also offers the using method of a kind of Sobering-up buccal tablet, Sobering-up buccal tablet 0.5-1h before drinking takes or drinks
The most immediately take, and each take 0.6-0.8g, 4-6h interval time that adjacent twice is taken.
Meanwhile, based on same inventive concept, present invention also offers the preparation method of a kind of Sobering-up buccal tablet, specifically according to
Following steps are implemented:
Step 1, weighs Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii by the mass ratio of 1: 1: 1, and is mixed into plant mixture.
Step 2, extracts the active polysaccharide material in plant mixture, and is dried by active polysaccharide material, obtain plant many
Sugar extract, wherein, the extracting method of active polysaccharide material in plant mixture, specifically include following steps:
Step 2.1, by plant mixture freeze-day with constant temperature 12h at 55-60 DEG C, then pulverizes, and crosses 40-50 mesh sieve,
To plant mixed-powder.
Step 2.2, the plant mixed-powder weighing certain mass adds distilled water, and every kilogram of plant mixed-powder adds
Enter 20 liters of distilled water, mixing, 900W microwave extraction 4-5min in microwave oven, obtain polysaccharide extraction liquid.
Step 2.3, polysaccharide extraction liquid stands and is cooled to room temperature, is centrifuged 5min in 600r/min, room temperature, collects supernatant.
Step 2.4, according to supernatant: dehydrated alcohol=1: the volume ratio of 4, adds dehydrated alcohol in supernatant, and
Stand 18-24h in 4 DEG C, after be centrifuged 10-15min in 5000r/min, room temperature, collect precipitate, described precipitate is polysaccharide
Active substance.
Step 2.5, is dried active polysaccharide material in 60 DEG C, obtains vegetable polysaccharides extract.
Step 3, weighs each component respectively by following weight portion: vegetable polysaccharides extract 55-60 part, Mel 10-15 part, milk
Cheese 5-10 part, binding agent 5-10 part, micropowder silica gel 1-2 part；
Step 4, after being processed by the vegetable polysaccharides extract microwave sterilizating weighed, with the Mel weighed, cheese, binding agent mixes
Close, and dry granulation technology prepares material powder routinely；
Step 5, material powder microwave sterilizating according to a conventional method；
Step 6, adds the micropowder silica gel weighed in the material powder after microwave sterilizating, mixing, after in tabletting machine
Shape, obtain Sobering-up buccal tablet.
Preferably, one Sobering-up buccal tablet of the present invention, including following example:
Embodiment 1
The Sobering-up buccal tablet of embodiment 1, its raw material is made up of the component of following weight portion: vegetable polysaccharides extract 55 parts, honeybee
Honey 13 parts, 7 parts of cheese, binding agent 8 parts, micropowder silica gel 1 part, described vegetable polysaccharides extract is by Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii
After mass ratio by 1: 1: 1 mixes, extract what the active polysaccharide material in mixture was prepared from, specifically according to following steps
Implement:
Step 1, weighs Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii by the mass ratio of 1: 1: 1, and is mixed into plant mixture.
Step 2, extracts the active polysaccharide material in plant mixture, and is dried by active polysaccharide material, obtain plant many
Sugar extract, wherein, the extracting method of active polysaccharide material in plant mixture, specifically include following steps:
Step 2.1, by plant mixture freeze-day with constant temperature 12h at 55 DEG C, then pulverizes, and crosses 40 mesh sieves, obtains plant
Mixed-powder.
Step 2.2, weighs the plant mixed-powder of 2 kilograms, adds 40 liters of distilled water, and mixing, in microwave oven, 900W is micro-
Ripple extracts 4min, obtains polysaccharide extraction liquid.
Step 2.3, polysaccharide extraction liquid stands and is cooled to room temperature, is centrifuged 5min in 600r/min, room temperature, collects supernatant.
Step 2.4, according to supernatant: dehydrated alcohol=1: the volume ratio of 4, adds dehydrated alcohol in supernatant, and
Stand 24h in 4 DEG C, after be centrifuged 10min in 5000r/min, room temperature, collect precipitate, described precipitate is active polysaccharide thing
Matter.
Step 2.5, is dried active polysaccharide material in 60 DEG C, obtains vegetable polysaccharides extract.
Step 3, weighs each component respectively by following weight portion: vegetable polysaccharides extract 55 parts, Mel 13 parts, 7 parts of cheese,
Maltodextrin 8 parts, micropowder silica gel 1 part；
Step 4, after being processed by the vegetable polysaccharides extract microwave sterilizating weighed, with the Mel weighed, cheese, maltodextrin
Mixing, and dry granulation technology prepares material powder routinely；
Step 5, material powder microwave sterilizating according to a conventional method；
Step 6, adds the micropowder silica gel weighed in the material powder after microwave sterilizating, mixing, after in tabletting machine
Shape, obtain Sobering-up buccal tablet.
Embodiment 2
The Sobering-up buccal tablet of embodiment 1, its raw material is made up of the component of following weight portion: vegetable polysaccharides extract 60 parts, honeybee
Honey 15 parts, 5 parts of cheese, maltodextrin 6 parts, micropowder silica gel 2 parts, described vegetable polysaccharides extract is by Cordyceps ginseng, Rhizoma Dioscoreae and hundred
After closing by the mass ratio mixing of 1: 1: 1, extract what the active polysaccharide material in mixture was prepared from, specifically according to following step
Rapid enforcement:
Step 1, weighs Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii by the mass ratio of 1: 1: 1, and is mixed into plant mixture.
Step 2, extracts the active polysaccharide material in plant mixture, and is dried by active polysaccharide material, obtain plant many
Sugar extract, wherein, the extracting method of active polysaccharide material in plant mixture, specifically include following steps:
Step 2.1, by plant mixture freeze-day with constant temperature 12h at 58 DEG C, then pulverizes, and crosses 45 mesh sieves, obtains plant
Mixed-powder.
Step 2.2, weighs the plant mixed-powder of 1 kilogram, adds 20 liters of distilled water, and mixing, in microwave oven, 900W is micro-
Ripple extracts 5min, obtains polysaccharide extraction liquid.
Step 2.3, polysaccharide extraction liquid stands and is cooled to room temperature, is centrifuged 5min in 600r/min, room temperature, collects supernatant.
Step 2.4, according to supernatant: dehydrated alcohol=1: the volume ratio of 4, adds dehydrated alcohol in supernatant, and
Stand 20h in 4 DEG C, after be centrifuged 10min in 5000r/min, room temperature, collect precipitate, described precipitate is active polysaccharide thing
Matter.
Step 2.5, is dried active polysaccharide material in 60 DEG C, obtains vegetable polysaccharides extract.
Step 3, weighs each component respectively by following weight portion: vegetable polysaccharides extract 60 parts, Mel 15 parts, 5 parts of cheese,
Maltodextrin 6 parts, micropowder silica gel 2 parts；
Step 4, after being processed by the vegetable polysaccharides extract microwave sterilizating weighed, with the Mel weighed, cheese, maltodextrin
Mixing, and dry granulation technology prepares material powder routinely；
Step 5, material powder microwave sterilizating according to a conventional method；
Step 6, adds the micropowder silica gel weighed in the material powder after microwave sterilizating, mixing, after in tabletting machine
Shape, obtain Sobering-up buccal tablet.
Embodiment 3
The Sobering-up buccal tablet of embodiment 1, its raw material is made up of the component of following weight portion: vegetable polysaccharides extract 58 parts, honeybee
Honey 10 parts, 5 parts of cheese, maltodextrin 10 parts, micropowder silica gel 1 part, described vegetable polysaccharides extract is by Cordyceps ginseng, Rhizoma Dioscoreae and hundred
After closing by the mass ratio mixing of 1: 1: 1, extract what the active polysaccharide material in mixture was prepared from, specifically according to following step
Rapid enforcement:
Step 1, weighs Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii by the mass ratio of 1: 1: 1, and is mixed into plant mixture.
Step 2, extracts the active polysaccharide material in plant mixture, and is dried by active polysaccharide material, obtain plant many
Sugar extract, wherein, the extracting method of active polysaccharide material in plant mixture, specifically include following steps:
Step 2.1, by plant mixture freeze-day with constant temperature 12h at 60 DEG C, then pulverizes, and crosses 50 mesh sieves, obtains plant
Mixed-powder.
Step 2.2, weighs the plant mixed-powder of 5 kilograms, adds 100 liters of distilled water, and mixing, in microwave oven, 900W is micro-
Ripple extracts 4min, obtains polysaccharide extraction liquid.
Step 2.3, polysaccharide extraction liquid stands and is cooled to room temperature, is centrifuged 5min in 600r/min, room temperature, collects supernatant.
Step 2.4, according to supernatant: dehydrated alcohol=1: the volume ratio of 4, adds dehydrated alcohol in supernatant, and
Stand 18h in 4 DEG C, after be centrifuged 12min in 5000r/min, room temperature, collect precipitate, described precipitate is active polysaccharide thing
Matter.
Step 2.5, is dried active polysaccharide material in 60 DEG C, obtains vegetable polysaccharides extract.
Step 3, weighs each component respectively by following weight portion: vegetable polysaccharides extract 58 parts, Mel 10 parts, 5 parts of cheese,
Maltodextrin 10 parts, micropowder silica gel 1 part；
Step 4, after being processed by the vegetable polysaccharides extract microwave sterilizating weighed, with the Mel weighed, cheese, maltodextrin
Mixing, and dry granulation technology prepares material powder routinely；
Step 5, material powder microwave sterilizating according to a conventional method；
Step 6, adds the micropowder silica gel weighed in the material powder after microwave sterilizating, mixing, after in tabletting machine
Shape, obtain Sobering-up buccal tablet.
Below the dispelling effects of alcohol of Sobering-up buccal tablet of the present invention is further described, it should be noted that the present invention is relieved the effect of alcohol
The formula of buccal tablet and embodiment 1-3 all can reach effect, owing to the effect between each formula is similar, relieves the effect of alcohol with embodiment 1 below
It is described in detail as a example by the formula of buccal tablet and preparation method.
In order to detect the content of vegetable polysaccharides in the polysaccharide extraction liquid of the multistage microwave amplifier of Sobering-up buccal tablet of the present invention, below profit
The vegetable polysaccharides content in embodiment 1 is measured with phend-sulphuric acid.
According to the data creating glucose standard curve shown in table 1, this glucose standard curve equation is y=15.620x-
0.0032, wherein R2=0.9987, error is in allowed band, and normal equation can use.
By extract in embodiment 1, vegetable polysaccharides extract being configured to 1mg/mL solution, then dilution 15 times, takes 2mL
Diluent, is separately added into 1mL 6% (v/v) phenol solution, 5mL concentrated sulphuric acid, and room temperature places 20min, after in 490nm at survey extinction
Value is 0.936, according to glucose standard curve equation and the reduction formula of total sugar, calculates the plant extracted in embodiment 1 many
In sugar extract, total sugar content is 79.17%.
Wherein, the reduction formula of total sugar is as follows:
Total sugar content=glucose content × diluted sample multiple × 0.9 × 100% in sample
Wherein, 0.9 is the conversion factor of monosaccharide and vegetable polysaccharides extract.
Table 1 Phenol sulfuric acid procedure surveys total sugar content Specification Curve of Increasing
In order to verify the dispelling effects of alcohol of vegetable polysaccharides in Sobering-up buccal tablet of the present invention further, carry out following zoopery:
60 healthy rats are randomly divided into 5 groups, respectively matched group, ethanol model group, vegetable polysaccharides low content group, plant
Content group and vegetable polysaccharides high-load group in thing polysaccharide.After adaptability is raised, matched group gavage normal saline, other groups are by every thousand
The ratio of gram body weight rat oral gavage 8ml is to rat oral gavage Chinese liquor (56%vol), and 30min before gavage Chinese liquor, and vegetable polysaccharides is low
In content group, vegetable polysaccharides, content group and vegetable polysaccharides high content component An not every kg body weight rat oral gavage 100mg, 200mg
With the ratio of 500mg to the polysaccharide extraction liquid of the above-mentioned multistage microwave amplifier of rat oral gavage.Containing raising rat 21d according to a conventional method,
22d extracts eyeball and takes blood, and place after death takes whole liver, measures the change of liver performance figure, and above-mentioned each parameter all takes often in group
The meansigma methods of all rat, result is as shown in table 2.
As can be seen from Table 2, after gavage Chinese liquor 21d, compared with matched group, the body of rat in 4 groups of gavage Chinese liquor
Weight average has reduction, but in the 3 of gavage vegetable polysaccharides groups, it is less that rat body weight reduces, and illustrates that the use of vegetable polysaccharides is permissible
Slow down the phenomenon of the rat body weight reduction that ethanol causes.
Compared with ethanol model group, in vegetable polysaccharides, the liver weight of content group and vegetable polysaccharides high-load group rat shows
Write higher, its P ＜ 0.05, illustrate that vegetable polysaccharides in Sobering-up buccal tablet of the present invention has the effect of certain anti-oxidative damage, have
It is beneficial to reduce the ethanol damage to liver, can improve the ethanol infringement to body, and effect when the usage amount of vegetable polysaccharides is higher
Effect is obvious.
Table 2 rat body weight, liver weight and the measurement result of liver organ coefficient
Note: ▲ represent the P ＜ 0.05 compared with matched group；* the P ＜ 0.05. compared with ethanol model group is represented
For verifying the effects of dispelling effects of alcohol and protecting liver of Sobering-up buccal tablet of the present invention, 36 healthy rats are randomly divided into 3 groups, the most right
According to group, ethanol model group, Sobering-up buccal tablet group.Matched group gavage normal saline, other groups are by every kg body weight rat oral gavage 8ml's
Ratio is to rat oral gavage Chinese liquor (56%vol), and 30min before gavage Chinese liquor, and Sobering-up buccal tablet group is filled by every kg body weight rat
The ratio of stomach 200mg is to rat oral gavage Sobering-up buccal tablet.
Put to death after raising rat 21d according to a conventional method, take liver, clear up unnecessary connective tissue, with the normal saline of 4 DEG C
Rinse, after water suction, take liver 1.0g, shred again with 4 DEG C of normal saline flushings 2-3 time, add homogenate Jie of 4 DEG C with 1: 10 (w/v)
Matter, is homogenized in ice-water bath, abandons precipitation after being centrifuged 8-10min with 2000rpm, and supernatant is centrifuged 15-20min with 15000rpm
After, abandon supernatant, precipitation homogenate medium cleans 2-3 time, adds homogenate medium mixing and i.e. prepare mitochondrion in the most backward precipitation
Solution, wherein, described homogenate medium contains 0.25mol/L sucrose, the Tris-HCl solution of 0.1mol/L, pH=7.4.
Measuring SOD vigor, GSH, Cyt C and MDA content in rat liver mitochondria, result is as shown in table 3, with matched group
Comparing, in ethanol model group, the content of MDA dramatically increases, and SOD vigor, GSH and Cyt C content significantly reduce；Simultaneously by right
According to group, ethanol model group data respectively compared with the data of Sobering-up buccal tablet group, the increasing degree of MDA content in Sobering-up buccal tablet group
The least, the reduction amplitude of SOD vigor and Cyt C content is less, illustrates that the vegetable polysaccharides composition in Sobering-up buccal tablet of the present invention can
To slow down Alcohol on Rat Liver dirty SOD vigor, Cyt C and the impact of MDA content, be conducive to the damage slowing down ethanol to liver.
SOD vigor, the measurement result of GSH, Cyt C and MDA content in table 3 rat liver mitochondria
Note: ▲ represent the P ＜ 0.05 compared with matched group；* the P ＜ 0.05. compared with ethanol model group is represented
Although preferred embodiments of the present invention have been described, but those skilled in the art once know basic creation
Property concept, then can make other change and amendment to these embodiments.So, claims are intended to be construed to include excellent
Select embodiment and fall into all changes and the amendment of the scope of the invention.
Obviously, those skilled in the art can carry out various change and the modification essence without deviating from the present invention to the present invention
God and scope.So, if these amendments of the present invention and modification belong to the scope of the claims in the present invention and equivalent technologies thereof
Within, then the present invention is also intended to comprise these change and modification.
Claims (8)
1. a Sobering-up buccal tablet, it is characterised in that its raw material is made up of the component of following weight portion: vegetable polysaccharides extract 55-
60 parts, Mel 10-15 part, cheese 5-10 part, binding agent 5-10 part, micropowder silica gel 1-2 part；Described vegetable polysaccharides extract be by
After Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii are by the mass ratio mixing of 1: 1: 1, the active polysaccharide material extracted in mixture is prepared from
's.
Sobering-up buccal tablet the most according to claim 1, it is characterised in that its raw material is made up of the component of following weight portion: plant
Thing polyoses extract 55 parts, Mel 13 parts, 7 parts of cheese, binding agent 8 parts, micropowder silica gel 1 part.
Sobering-up buccal tablet the most according to claim 1, it is characterised in that its raw material is made up of the component of following weight portion: plant
Thing polyoses extract 60 parts, Mel 15 parts, 5 parts of cheese, binding agent 6 parts, micropowder silica gel 2 parts.
Sobering-up buccal tablet the most according to claim 1, it is characterised in that its raw material is made up of the component of following weight portion: plant
Thing polyoses extract 58 parts, Mel 10 parts, 5 parts of cheese, binding agent 10 parts, micropowder silica gel 1 part.
5. according to the Sobering-up buccal tablet described in any one of claim 1-4, it is characterised in that described binding agent is maltodextrin.
6. according to the preparation method of the Sobering-up buccal tablet described in any one of claim 1-5, it is characterised in that specifically according to following step
Rapid enforcement:
Step 1, weighs Cordyceps ginseng, Rhizoma Dioscoreae and Bulbus Lilii by the mass ratio of 1: 1: 1, and is mixed into plant mixture；
Step 2, extracts the active polysaccharide material in plant mixture, and is dried by active polysaccharide material, obtain vegetable polysaccharides and carry
Take thing；
Step 3, weighs each component respectively by following weight portion: vegetable polysaccharides extract 55-60 part, Mel 10-15 part, cheese 5-
10 parts, binding agent 5-10 part, micropowder silica gel 1-2 part；
Step 4, after being processed by the vegetable polysaccharides extract microwave sterilizating weighed, with the Mel weighed, cheese, binding agent mixes,
And dry granulation technology prepares material powder routinely；
Step 5, material powder microwave sterilizating according to a conventional method；
Step 6, adds the micropowder silica gel weighed in the material powder after microwave sterilizating, mixing, after in tabletting machine shape,
Obtain Sobering-up buccal tablet.
The preparation method of Sobering-up buccal tablet the most according to claim 6, it is characterised in that in described plant mixture, polysaccharide is lived
The extracting method of property material, specifically includes following steps:
By plant mixture freeze-day with constant temperature 12h at 55-60 DEG C, then pulverize, and cross 40-50 mesh sieve, obtain plant mixed powder
End；
The plant mixed-powder weighing certain mass adds distilled water, and every kilogram of plant mixed-powder adds 20 liters of distillations
Water, mixing, 900W microwave extraction 4-5min in microwave oven, obtain polysaccharide extraction liquid；
Polysaccharide extraction liquid stands and is cooled to room temperature, is centrifuged 5min in 600r/min, room temperature, collects supernatant；
According to supernatant: dehydrated alcohol=1: the volume ratio of 4, in supernatant, add dehydrated alcohol, and stand 18-in 4 DEG C
24h, after be centrifuged 10-15min in 5000r/min, room temperature, collect precipitate, described precipitate is active polysaccharide material；
Active polysaccharide material is dried in 60 DEG C, obtains vegetable polysaccharides extract.
The preparation method of Sobering-up buccal tablet the most according to claim 6, it is characterised in that the condition of described microwave sterilizating is
2-3min is acted under 900W, 2450MHZ.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266367A (en) * | 2011-07-19 | 2011-12-07 | 三峡大学 | Medicinal composition for treating alcoholic liver injury |
| CN102715390A (en) * | 2012-05-03 | 2012-10-10 | 湖北炎帝农业科技股份有限公司 | Liver-protecting functional food and preparation method thereof |
| CN104739896A (en) * | 2015-03-06 | 2015-07-01 | 吉林省现代中药工程研究中心有限公司 | Composite fungal intercellular polysaccharide composition with liver protecting function and preparation method |
| CN105747203A (en) * | 2016-02-22 | 2016-07-13 | 郑州师范学院 | Caulis dendrobii medlar cordyceps polysaccharide compound, and preparation method and application thereof |
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2016
- 2016-07-17 CN CN201610583446.0A patent/CN106265560B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266367A (en) * | 2011-07-19 | 2011-12-07 | 三峡大学 | Medicinal composition for treating alcoholic liver injury |
| CN102715390A (en) * | 2012-05-03 | 2012-10-10 | 湖北炎帝农业科技股份有限公司 | Liver-protecting functional food and preparation method thereof |
| CN104739896A (en) * | 2015-03-06 | 2015-07-01 | 吉林省现代中药工程研究中心有限公司 | Composite fungal intercellular polysaccharide composition with liver protecting function and preparation method |
| CN105747203A (en) * | 2016-02-22 | 2016-07-13 | 郑州师范学院 | Caulis dendrobii medlar cordyceps polysaccharide compound, and preparation method and application thereof |
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