CN106265560B - A kind of Sobering-up buccal tablet and preparation method thereof - Google Patents
A kind of Sobering-up buccal tablet and preparation method thereof Download PDFInfo
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- CN106265560B CN106265560B CN201610583446.0A CN201610583446A CN106265560B CN 106265560 B CN106265560 B CN 106265560B CN 201610583446 A CN201610583446 A CN 201610583446A CN 106265560 B CN106265560 B CN 106265560B
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- 239000006189 buccal tablet Substances 0.000 title claims abstract description 49
- 229940046011 buccal tablet Drugs 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 241000196324 Embryophyta Species 0.000 claims abstract description 81
- 150000004676 glycans Chemical class 0.000 claims abstract description 51
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 51
- 239000005017 polysaccharide Substances 0.000 claims abstract description 51
- 239000000284 extract Substances 0.000 claims abstract description 48
- 239000000843 powder Substances 0.000 claims abstract description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 239000000126 substance Substances 0.000 claims abstract description 31
- 238000000605 extraction Methods 0.000 claims abstract description 30
- 239000002994 raw material Substances 0.000 claims abstract description 30
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 25
- 235000012907 honey Nutrition 0.000 claims abstract description 25
- 239000000741 silica gel Substances 0.000 claims abstract description 25
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 25
- 235000013351 cheese Nutrition 0.000 claims abstract description 24
- 239000000853 adhesive Substances 0.000 claims abstract description 20
- 230000001070 adhesive effect Effects 0.000 claims abstract description 20
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 13
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 13
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 13
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 13
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims abstract description 13
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 13
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 13
- 235000008434 ginseng Nutrition 0.000 claims abstract description 13
- 241000234435 Lilium Species 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims description 23
- 230000001954 sterilising effect Effects 0.000 claims description 20
- 238000004659 sterilization and disinfection Methods 0.000 claims description 20
- 239000006228 supernatant Substances 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 14
- 241000208340 Araliaceae Species 0.000 claims description 12
- 239000011812 mixed powder Substances 0.000 claims description 12
- 239000013049 sediment Substances 0.000 claims description 12
- 229920002774 Maltodextrin Polymers 0.000 claims description 11
- 239000005913 Maltodextrin Substances 0.000 claims description 11
- 229940035034 maltodextrin Drugs 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000005516 engineering process Methods 0.000 claims description 9
- 238000007796 conventional method Methods 0.000 claims description 8
- 239000012153 distilled water Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 6
- 238000007908 dry granulation Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims 1
- 210000004185 liver Anatomy 0.000 abstract description 21
- 230000000694 effects Effects 0.000 abstract description 13
- 230000006378 damage Effects 0.000 abstract description 11
- 230000035622 drinking Effects 0.000 abstract description 5
- 230000008520 organization Effects 0.000 abstract description 5
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 description 26
- 241000700159 Rattus Species 0.000 description 18
- 238000003304 gavage Methods 0.000 description 7
- 238000003305 oral gavage Methods 0.000 description 7
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 6
- 230000037396 body weight Effects 0.000 description 6
- 235000020097 white wine Nutrition 0.000 description 6
- 230000004048 modification Effects 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000009467 reduction Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000002504 physiological saline solution Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 150000003254 radicals Chemical class 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000002311 liver mitochondria Anatomy 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010016825 Flushing Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 230000010224 hepatic metabolism Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- OQUKIQWCVTZJAF-UHFFFAOYSA-N phenol;sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=CC=C1 OQUKIQWCVTZJAF-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of Sobering-up buccal tablet, raw material is made of the component of following parts by weight：55-60 parts of plant polyose extract, 10-15 parts of honey, 5-10 parts of cheese, 5-10 parts of adhesive, 1-2 parts of superfine silica gel powder；The plant polyose extract is after being mixed by 1: 1: 1 mass ratio by cordyceps sinensis ginseng, Chinese yam and lily, what the active polysaccharide substance in extraction mixture was prepared.The Sobering-up buccal tablet of the present invention, it is without side-effects to human body for, to the protection of liver, reducing damage of the alcohol to liver organization after drinking, have and is convenient for carrying, is suitable for people of all ages.In addition, the invention also discloses a kind of preparation methods of Sobering-up buccal tablet.
Description
Technical field
The invention belongs to health product technology fields, and in particular to a kind of Sobering-up buccal tablet, the invention further relates to the Sobering-up buccal tablets
Specific preparation method.
Background technology
With the change of social pressures and living habit, more and more people hit the bottle in recent years, and excessive consumption of alcohol causes
Body aging degree is aggravated, and liver metabolism pressure increases, a large amount of free radicals and negative oxygen ion attack cells film generated in metabolism,
Cause the damage of liver cell.Secondly the noxious material generated, such as acetaldehyde cause the activity of protein to reduce, the work of antioxidase
Power declines.Therefore, it drinks and causes major injury, chronic alcoholism that will form alcoholic liver, hepatitis hepatic tissue, liver group that What is more
Meeting fibrosis is knitted, and then is converted into liver cancer, hepatopathy caused by drinking has seriously threatened the health of the mankind.
Plant polyose is as most important active material in medicine-food two-purpose plant, with good oxidation resistance,
It can inhibit increasing for free radical, improve immunity of organisms, antibiont mutation, while can be formed and be effectively protected on liver film surface layer
Layer, damage of the hindered alcohol to liver organization.Existing Activities of Some Plants polyoses extract is protected as functional product in food at present
Strong field is applied, but the application in alcohol-neutralize healthy product not yet, therefore, it is necessary to develop a kind of more containing plant
The Sobering-up buccal tablet of sugar extract, for reducing damage of the alcohol to liver organization.
Invention content
A kind of Sobering-up buccal tablet provided by the invention, for reducing damage of the alcohol to liver organization.
The first purpose of the invention is to provide a kind of Sobering-up buccal tablet, raw material is made of the component of following parts by weight：It plants
55-60 parts of object polyoses extract, 10-15 parts of honey, 5-10 parts of cheese, 5-10 parts of adhesive, 1-2 parts of superfine silica gel powder；The plant
Object polyoses extract is after being mixed by 1: 1: 1 mass ratio by cordyceps sinensis ginseng, Chinese yam and lily, and the polysaccharide in extraction mixture is lived
Property substance is prepared；
Wherein, the method for the active polysaccharide substance in extraction mixture, specifically includes following steps：
By mixture at 55-60 DEG C freeze-day with constant temperature 12h, then crush, and cross 40-50 mesh sieve, obtain plant mixed powder
End；
Distilled water is added in the plant mixed-powder for weighing certain mass, and 20 liters of steamings are added in every kilogram of plant mixed-powder
Distilled water, mixing, 900W Microwave Extractions 4-5min, obtains polysaccharide extraction liquid in micro-wave oven；
Polysaccharide extraction liquid standing is cooled to room temperature, and is centrifuged 5min in 600r/min, room temperature, is collected supernatant；
According to supernatant: absolute ethyl alcohol=1: absolute ethyl alcohol is added into supernatant for 4 volume ratio, and in 4 DEG C of standings
18-24h, after in 5000r/min, room temperature centrifuge 10-15min, collect sediment, the sediment is active polysaccharide substance；
By active polysaccharide substance in 60 DEG C of dryings, plant polyose extract is obtained.
Preferably, Sobering-up buccal tablet provided by the invention, raw material are made of the component of following parts by weight：Plant polyose extracts
55 parts of object, 13 parts of honey, 7 parts of cheese, 8 parts of adhesive, 1 part of superfine silica gel powder.
Preferably, Sobering-up buccal tablet provided by the invention, raw material are made of the component of following parts by weight：Plant polyose extracts
60 parts of object, 15 parts of honey, 5 parts of cheese, 6 parts of adhesive, 2 parts of superfine silica gel powder.
Preferably, Sobering-up buccal tablet provided by the invention, raw material are made of the component of following parts by weight：Plant polyose extracts
58 parts of object, 10 parts of honey, 5 parts of cheese, 10 parts of adhesive, 1 part of superfine silica gel powder.
Preferably, adhesive described in above-mentioned Sobering-up buccal tablet is maltodextrin.
The present invention also provides a kind of preparation methods of Sobering-up buccal tablet, are specifically implemented according to the following steps：
Step 1, cordyceps sinensis ginseng, Chinese yam and lily are weighed by 1: 1: 1 mass ratio, and mixes resulting mixture；
Step 2, the active polysaccharide substance in extraction mixture, and active polysaccharide substance is dried, it obtains plant polyose and carries
Take object；
Step 3, each component is weighed respectively by following parts by weight：55-60 parts of plant polyose extract, 10-15 parts of honey, milk
5-10 parts of junket, 5-10 parts of adhesive, 1-2 parts of superfine silica gel powder；
Step 4, by after the plant polyose extract microwave sterilization weighed processing, with honey, the cheese weighed, adhesive is mixed
It closes, and routinely dry granulation technology prepares raw material powder；
Step 5, raw material powder microwave sterilization according to a conventional method；
Step 6, be added the superfine silica gel powder weighed into the raw material powder after microwave sterilization, mixing, after in tabletting machine
Forming, obtains Sobering-up buccal tablet.
Preferably, in the preparation method of above-mentioned Sobering-up buccal tablet, the condition of the microwave sterilization is to make under 900W, 2450MHZ
Use 2-3min.
The Sobering-up buccal tablet of the present invention, it by oxidation of ethanol is acetaldehyde that can prevent alcohol, and ethyl alcohol is prevented to be produced in metabolic process
Raw a large amount of free radical and negative oxygen ion, secondly shield acetaldehyde and blood or it is histiocytic contact, for after drinking to liver
Dirty protection reduces damage of the alcohol to liver organization, without side-effects to human body, has and is convenient for carrying, is suitable for people of all ages；Addition
Cheese and honey can wrap up ethanol molecule, it is made not absorbed by cell, and body is directly excluded by body while protecting stomach lining
Outside.
Specific implementation mode
With reference to specific embodiment, the present invention is described in detail, but should not be construed as the limitation of the present invention.
A kind of Sobering-up buccal tablet of the present invention, is made of the component of following parts by weight：55-60 parts of plant polyose extract, honey
10-15 parts, 5-10 parts of cheese, 5-10 parts of adhesive, 1-2 parts of superfine silica gel powder, wherein adhesive be maltodextrin；The plant is more
Sugar extract is the active polysaccharide object in extraction mixture after being mixed by 1: 1: 1 mass ratio by cordyceps sinensis ginseng, Chinese yam and lily
What matter was prepared.
The present invention also provides a kind of application method of Sobering-up buccal tablet, Sobering-up buccal tablet 0.5-1h before drinking takes or drinks
It takes immediately after drinking, and each taking 0.6-0.8g, the adjacent interval time 4-6h taken twice.
Meanwhile be based on same inventive concept, the present invention also provides a kind of preparation methods of Sobering-up buccal tablet, specifically according to
Following steps are implemented：
Step 1, cordyceps sinensis ginseng, Chinese yam and lily are weighed by 1: 1: 1 mass ratio, and mixes resulting mixture.
Step 2, the active polysaccharide substance in extraction mixture, and active polysaccharide substance is dried, it obtains plant polyose and carries
Take object, wherein the method for the active polysaccharide substance in extraction mixture specifically includes following steps：
Step 2.1, by mixture at 55-60 DEG C freeze-day with constant temperature 12h, then crush, and cross 40-50 mesh sieve, planted
Object mixed-powder.
Step 2.2, distilled water is added in the plant mixed-powder for weighing certain mass, and every kilogram of plant mixed-powder adds
Enter 20 liters of distilled water, mixing, 900W Microwave Extractions 4-5min, obtains polysaccharide extraction liquid in micro-wave oven.
Step 2.3, polysaccharide extraction liquid standing is cooled to room temperature, and is centrifuged 5min in 600r/min, room temperature, is collected supernatant.
Step 2.4, according to supernatant: absolute ethyl alcohol=1: absolute ethyl alcohol is added into supernatant for 4 volume ratio, and
In 4 DEG C stand 18-24h, after in 5000r/min, room temperature centrifuge 10-15min, collect sediment, the sediment is polysaccharide
Active material.
Step 2.5, active polysaccharide substance is obtained into plant polyose extract in 60 DEG C of dryings.
Step 3, each component is weighed respectively by following parts by weight：55-60 parts of plant polyose extract, 10-15 parts of honey, milk
5-10 parts of junket, 5-10 parts of adhesive, 1-2 parts of superfine silica gel powder；
Step 4, by after the plant polyose extract microwave sterilization weighed processing, with honey, the cheese weighed, adhesive is mixed
It closes, and routinely dry granulation technology prepares raw material powder；
Step 5, raw material powder microwave sterilization according to a conventional method；
Step 6, be added the superfine silica gel powder weighed into the raw material powder after microwave sterilization, mixing, after in tabletting machine
Forming, obtains Sobering-up buccal tablet.
Preferably, a kind of Sobering-up buccal tablet of the present invention, including following embodiment：
Embodiment 1
The Sobering-up buccal tablet of embodiment 1, raw material are made of the component of following parts by weight：55 parts of plant polyose extract, bee
13 parts of honey, 7 parts of cheese, 8 parts of adhesive, 1 part of superfine silica gel powder, the plant polyose extract are by cordyceps sinensis ginseng, Chinese yam and lily
After 1: 1: 1 mass ratio mixing, what the active polysaccharide substance in extraction mixture was prepared, specifically according to the following steps
Implement：
Step 1, cordyceps sinensis ginseng, Chinese yam and lily are weighed by 1: 1: 1 mass ratio, and mixes resulting mixture.
Step 2, the active polysaccharide substance in extraction mixture, and active polysaccharide substance is dried, it obtains plant polyose and carries
Take object, wherein the extracting method of active polysaccharide substance in mixture specifically includes following steps：
Step 2.1, by mixture at 55 DEG C freeze-day with constant temperature 12h, then crush, and cross 40 mesh sieve, obtain plant mixing
Powder.
Step 2.2,2 kilograms of plant mixed-powder is weighed, 40 liters of distilled water are added, mixing, 900W is micro- in micro-wave oven
Wave extracts 4min, obtains polysaccharide extraction liquid.
Step 2.3, polysaccharide extraction liquid standing is cooled to room temperature, and is centrifuged 5min in 600r/min, room temperature, is collected supernatant.
Step 2.4, according to supernatant: absolute ethyl alcohol=1: absolute ethyl alcohol is added into supernatant for 4 volume ratio, and
For 24 hours in 4 DEG C of standings, 10min is centrifuged in 5000r/min, room temperature after, collects sediment, the sediment is active polysaccharide object
Matter.
Step 2.5, active polysaccharide substance is obtained into plant polyose extract in 60 DEG C of dryings.
Step 3, each component is weighed respectively by following parts by weight：55 parts of plant polyose extract, 13 parts of honey, 7 parts of cheese,
8 parts of maltodextrin, 1 part of superfine silica gel powder；
Step 4, after the plant polyose extract microwave sterilization weighed being handled, with honey, the cheese weighed, maltodextrin
Mixing, and routinely dry granulation technology prepares raw material powder；
Step 5, raw material powder microwave sterilization according to a conventional method；
Step 6, be added the superfine silica gel powder weighed into the raw material powder after microwave sterilization, mixing, after in tabletting machine
Forming, obtains Sobering-up buccal tablet.
Embodiment 2
The Sobering-up buccal tablet of embodiment 1, raw material are made of the component of following parts by weight：60 parts of plant polyose extract, bee
Sweet 15 parts, 5 parts of cheese, 6 parts of maltodextrin, 2 parts of superfine silica gel powder, the plant polyose extract are by cordyceps sinensis ginseng, Chinese yam and hundred
After closing the mass ratio mixing by 1: 1: 1, what the active polysaccharide substance in extraction mixture was prepared, specifically according to following step
It is rapid to implement：
Step 1, cordyceps sinensis ginseng, Chinese yam and lily are weighed by 1: 1: 1 mass ratio, and mixes resulting mixture.
Step 2, the active polysaccharide substance in extraction mixture, and active polysaccharide substance is dried, it obtains plant polyose and carries
Take object, wherein the extracting method of active polysaccharide substance in mixture specifically includes following steps：
Step 2.1, by mixture at 58 DEG C freeze-day with constant temperature 12h, then crush, and cross 45 mesh sieve, obtain plant mixing
Powder.
Step 2.2,1 kilogram of plant mixed-powder is weighed, 20 liters of distilled water are added, mixing, 900W is micro- in micro-wave oven
Wave extracts 5min, obtains polysaccharide extraction liquid.
Step 2.3, polysaccharide extraction liquid standing is cooled to room temperature, and is centrifuged 5min in 600r/min, room temperature, is collected supernatant.
Step 2.4, according to supernatant: absolute ethyl alcohol=1: absolute ethyl alcohol is added into supernatant for 4 volume ratio, and
In 4 DEG C stand 20h, after in 5000r/min, room temperature centrifuge 10min, collect sediment, the sediment is active polysaccharide object
Matter.
Step 2.5, active polysaccharide substance is obtained into plant polyose extract in 60 DEG C of dryings.
Step 3, each component is weighed respectively by following parts by weight：60 parts of plant polyose extract, 15 parts of honey, 5 parts of cheese,
6 parts of maltodextrin, 2 parts of superfine silica gel powder；
Step 4, after the plant polyose extract microwave sterilization weighed being handled, with honey, the cheese weighed, maltodextrin
Mixing, and routinely dry granulation technology prepares raw material powder；
Step 5, raw material powder microwave sterilization according to a conventional method；
Step 6, be added the superfine silica gel powder weighed into the raw material powder after microwave sterilization, mixing, after in tabletting machine
Forming, obtains Sobering-up buccal tablet.
Embodiment 3
The Sobering-up buccal tablet of embodiment 1, raw material are made of the component of following parts by weight：58 parts of plant polyose extract, bee
10 parts of honey, 5 parts of cheese, 10 parts of maltodextrin, 1 part of superfine silica gel powder, the plant polyose extract are by cordyceps sinensis ginseng, Chinese yam and hundred
After closing the mass ratio mixing by 1: 1: 1, what the active polysaccharide substance in extraction mixture was prepared, specifically according to following step
It is rapid to implement：
Step 1, cordyceps sinensis ginseng, Chinese yam and lily are weighed by 1: 1: 1 mass ratio, and mixes resulting mixture.
Step 2, the active polysaccharide substance in extraction mixture, and active polysaccharide substance is dried, it obtains plant polyose and carries
Take object, wherein the extracting method of active polysaccharide substance in mixture specifically includes following steps：
Step 2.1, by mixture at 60 DEG C freeze-day with constant temperature 12h, then crush, and cross 50 mesh sieve, obtain plant mixing
Powder.
Step 2.2,5 kilograms of plant mixed-powder is weighed, 100 liters of distilled water are added, mixing, 900W is micro- in micro-wave oven
Wave extracts 4min, obtains polysaccharide extraction liquid.
Step 2.3, polysaccharide extraction liquid standing is cooled to room temperature, and is centrifuged 5min in 600r/min, room temperature, is collected supernatant.
Step 2.4, according to supernatant: absolute ethyl alcohol=1: absolute ethyl alcohol is added into supernatant for 4 volume ratio, and
In 4 DEG C stand 18h, after in 5000r/min, room temperature centrifuge 12min, collect sediment, the sediment is active polysaccharide object
Matter.
Step 2.5, active polysaccharide substance is obtained into plant polyose extract in 60 DEG C of dryings.
Step 3, each component is weighed respectively by following parts by weight：58 parts of plant polyose extract, 10 parts of honey, 5 parts of cheese,
10 parts of maltodextrin, 1 part of superfine silica gel powder；
Step 4, after the plant polyose extract microwave sterilization weighed being handled, with honey, the cheese weighed, maltodextrin
Mixing, and routinely dry granulation technology prepares raw material powder；
Step 5, raw material powder microwave sterilization according to a conventional method；
Step 6, be added the superfine silica gel powder weighed into the raw material powder after microwave sterilization, mixing, after in tabletting machine
Forming, obtains Sobering-up buccal tablet.
The dispelling effects of alcohol of Sobering-up buccal tablet of the present invention is further described below, it should be noted that the present invention is relieved the effect of alcohol
The formula of lozenge and embodiment 1-3 can reach effect, since the effect between each formula is similar, be relieved the effect of alcohol below with embodiment 1
It is described in detail for the formula and preparation method of lozenge.
The content of plant polyose in polysaccharide extraction liquid in order to detect the multistage microwave amplifier of Sobering-up buccal tablet of the present invention, below profit
The plant polyose content in embodiment 1 is measured with phend-sulphuric acid.
According to data creating glucose standard curve shown in table 1, which is y=15.620x-
0.0032, wherein R2=0.9987, within the allowable range, normal equation can use error.
Plant polyose extract is configured to 1mg/mL solution by being extracted in embodiment 1,15 times is then diluted, takes 2mL
Dilution is separately added into 1mL 6% (v/v) phenol solution, the 5mL concentrated sulfuric acids, is placed at room temperature for 20min, after at 490nm survey extinction
Value is 0.936, and according to the reduction formula of glucose standard curve equation and total reducing sugar, the plant for calculating to extract in embodiment 1 is more
Total sugar content is 79.17% in sugar extract.
Wherein, the reduction formula of total reducing sugar is as follows：
Total sugar content=glucose content × sample extension rate × 0.9 × 100% in sample
Wherein, 0.9 be monosaccharide and plant polyose extract conversion factor.
1 Phenol sulfuric acid procedure of table surveys total sugar content Specification Curve of Increasing
In order to further verify the dispelling effects of alcohol of plant polyose in Sobering-up buccal tablet of the present invention, following zoopery is carried out：
60 healthy rats are randomly divided into 5 groups, respectively control group, alcohol model group, plant polyose low content group, plant
Content groups and plant polyose high-content group in object polysaccharide.After adaptability raising, control group gavage physiological saline, other groups press every thousand
The ratio of gram weight rat oral gavage 8ml gives rat oral gavage white wine (56%vol), and 30min before gavage white wine, plant polyose are low
Content groups and plant polyose high content component An not be per kg body weight rat oral gavage 100mg, 200mg in content groups, plant polyose
With the ratio of 500mg to the polysaccharide extraction liquid of the above-mentioned multistage microwave amplifier of rat oral gavage.Containing raising rat 21d according to a conventional method,
22d extracts eyeball and takes blood, and whole livers are taken after execution, measures the variation of liver performance figure, and above-mentioned each parameter takes in every group
The average value of all big white mouse, the results are shown in Table 2.
As can be seen from Table 2, after gavage white wine 21d, compared with the control group, the body of big white mouse in 4 groups of gavage white wine
Weight has reduction, but in 3 groups of gavage plant polyose, rat body weight reduces less, illustrates that the use of plant polyose can be with
The phenomenon that rat body weight caused by slowing down alcohol reduces.
Compared with alcohol model group, the liver weight of content groups and plant polyose high-content group big white mouse is aobvious in plant polyose
Higher, P < 0.05 are write, illustrate that plant polyose has the function of certain anti-oxidative damage in Sobering-up buccal tablet of the present invention, has
Conducive to damage of the alcohol to liver is reduced, damage of the alcohol to body can be improved, and plant polyose usage amount it is higher when act on
It is with obvious effects.
The measurement result of 2 rat body weight of table, liver weight and liver organ coefficient
Note：The P < 0.05 of ▲ expression compared with the control group；* the P < 0.05 compared with alcohol model group are indicated.
To verify the effects of dispelling effects of alcohol and protecting liver of Sobering-up buccal tablet of the present invention, 36 healthy rats are randomly divided into 3 groups, respectively pair
According to group, alcohol model group, Sobering-up buccal tablet group.Control group gavage physiological saline, other groups are by per kg body weight rat oral gavage 8ml's
Ratio gives rat oral gavage white wine (56%vol), and 30min before gavage white wine, and Sobering-up buccal tablet group is pressed to be filled per kg body weight rat
The ratio of stomach 200mg gives rat oral gavage Sobering-up buccal tablet.
It is put to death after raising rat 21d according to a conventional method, takes liver, clear up extra connective tissue, with 4 DEG C of physiological saline
It rinses, liver 1.0g is taken after water suction, shred and use 4 DEG C of normal saline flushings again 2-3 times, 4 DEG C of homogenate Jie is added with 1: 10 (w/v)
Matter is homogenized in ice-water bath, abandons precipitation after centrifuging 8-10min with 2 000rpm, supernatant centrifuges 15-20min with 15 000rpm
Afterwards, supernatant is abandoned, precipitation is cleaned 2-3 times with homogenate medium, and homogenate medium mixing is finally added into precipitation and obtains mitochondria
Solution, wherein the Tris-HCl solution for being homogenized medium sucrose containing 0.25mol/L, 0.1mol/L, pH=7.4.
SOD vigor, GSH, Cyt C and MDA contents in rat liver mitochondria are measured, the results are shown in Table 3, with control group
It compares, the content of MDA dramatically increases in alcohol model group, and SOD vigor, GSH and Cyt C contents significantly reduce；It simultaneously will be right
According to group, the data of alcohol model group respectively compared with the data of Sobering-up buccal tablet group, the increasing degree of MDA contents in Sobering-up buccal tablet group
Smaller, the reduction amplitude of SOD vigor and Cyt C contents is smaller, illustrates that the plant polyose ingredient in Sobering-up buccal tablet of the present invention can
To slow down the influence of Alcohol on Rat Liver dirty SOD vigor, Cyt C and MDA contents, be conducive to the damage for slowing down alcohol to liver.
The measurement result of SOD vigor, GSH, Cyt C and MDA contents in 3 rat liver mitochondria of table
Note：The P < 0.05 of ▲ expression compared with the control group；* the P < 0.05 compared with alcohol model group are indicated.
Although the preferred implementation side of the present invention has been described, created once a person skilled in the art knows basic
Property concept, then additional changes and modifications may be made to these embodiments.So it includes excellent that the following claims are intended to be interpreted as
It selects embodiment and falls into all change and modification of the scope of the invention.
Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art
God and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies
Within, then the present invention is also intended to include these modifications and variations.
Claims (7)
1. a kind of Sobering-up buccal tablet, which is characterized in that its raw material is made of the component of following parts by weight：Plant polyose extract 55-
60 parts, 10-15 parts of honey, 5-10 parts of cheese, 5-10 parts of adhesive, 1-2 parts of superfine silica gel powder；The plant polyose extract be by
After cordyceps sinensis ginseng, Chinese yam and lily are by 1: 1: 1 mass ratio mixing, the active polysaccharide substance in extraction mixture is prepared
's；
Wherein, the method for the active polysaccharide substance in extraction mixture, specifically includes following steps：
By mixture at 55-60 DEG C freeze-day with constant temperature 12h, then crush, and cross 40-50 mesh sieve, obtain plant mixed-powder；
Distilled water is added in the plant mixed-powder for weighing certain mass, and 20 liters of distillations are added in every kilogram of plant mixed-powder
Water, mixing, 900W Microwave Extractions 4-5min, obtains polysaccharide extraction liquid in micro-wave oven；
Polysaccharide extraction liquid standing is cooled to room temperature, and is centrifuged 5min in 600r/min, room temperature, is collected supernatant；
According to supernatant: absolute ethyl alcohol=1: absolute ethyl alcohol is added into supernatant, and stands 18- in 4 DEG C for 4 volume ratio
For 24 hours, 10-15min is centrifuged in 5000r/min, room temperature after, collects sediment, the sediment is active polysaccharide substance；
By active polysaccharide substance in 60 DEG C of dryings, plant polyose extract is obtained.
2. Sobering-up buccal tablet according to claim 1, which is characterized in that its raw material is made of the component of following parts by weight：It plants
55 parts of object polyoses extract, 13 parts of honey, 7 parts of cheese, 8 parts of adhesive, 1 part of superfine silica gel powder.
3. Sobering-up buccal tablet according to claim 1, which is characterized in that its raw material is made of the component of following parts by weight：It plants
60 parts of object polyoses extract, 15 parts of honey, 5 parts of cheese, 6 parts of adhesive, 2 parts of superfine silica gel powder.
4. Sobering-up buccal tablet according to claim 1, which is characterized in that its raw material is made of the component of following parts by weight：It plants
58 parts of object polyoses extract, 10 parts of honey, 5 parts of cheese, 10 parts of adhesive, 1 part of superfine silica gel powder.
5. according to claim 1-4 any one of them Sobering-up buccal tablets, which is characterized in that described adhesive is maltodextrin.
6. the preparation method of Sobering-up buccal tablet according to claim 1, which is characterized in that be specifically implemented according to the following steps：
Step 1, cordyceps sinensis ginseng, Chinese yam and lily are weighed by 1: 1: 1 mass ratio, and mixes resulting mixture；
Step 2, the active polysaccharide substance in extraction mixture, obtains plant polyose extract；
Step 3, each component is weighed respectively by following parts by weight：55-60 parts of plant polyose extract, 10-15 parts of honey, cheese 5-
10 parts, 5-10 parts of adhesive, 1-2 parts of superfine silica gel powder；
Step 4, by after the plant polyose extract microwave sterilization weighed processing, with honey, the cheese weighed, adhesive mixes,
And routinely dry granulation technology prepares raw material powder；
Step 5, raw material powder microwave sterilization according to a conventional method；
Step 6, be added the superfine silica gel powder weighed into the raw material powder after microwave sterilization, mixing, after shaped in tabletting machine,
Obtain Sobering-up buccal tablet.
7. the preparation method of Sobering-up buccal tablet according to claim 6, which is characterized in that the condition of the microwave sterilization is
2-3min is acted under 900W, 2450MHZ.
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|---|---|---|---|---|
| CN102266367A (en) * | 2011-07-19 | 2011-12-07 | 三峡大学 | Medicinal composition for treating alcoholic liver injury |
| CN102715390A (en) * | 2012-05-03 | 2012-10-10 | 湖北炎帝农业科技股份有限公司 | Liver-protecting functional food and preparation method thereof |
| CN104739896A (en) * | 2015-03-06 | 2015-07-01 | 吉林省现代中药工程研究中心有限公司 | Composite fungal intercellular polysaccharide composition with liver protecting function and preparation method |
| CN105747203A (en) * | 2016-02-22 | 2016-07-13 | 郑州师范学院 | Caulis dendrobii medlar cordyceps polysaccharide compound, and preparation method and application thereof |
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2016
- 2016-07-17 CN CN201610583446.0A patent/CN106265560B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266367A (en) * | 2011-07-19 | 2011-12-07 | 三峡大学 | Medicinal composition for treating alcoholic liver injury |
| CN102715390A (en) * | 2012-05-03 | 2012-10-10 | 湖北炎帝农业科技股份有限公司 | Liver-protecting functional food and preparation method thereof |
| CN104739896A (en) * | 2015-03-06 | 2015-07-01 | 吉林省现代中药工程研究中心有限公司 | Composite fungal intercellular polysaccharide composition with liver protecting function and preparation method |
| CN105747203A (en) * | 2016-02-22 | 2016-07-13 | 郑州师范学院 | Caulis dendrobii medlar cordyceps polysaccharide compound, and preparation method and application thereof |
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