CN106265530A - A kind of Mercaptamine pre-mixing agent and preparation method thereof - Google Patents
A kind of Mercaptamine pre-mixing agent and preparation method thereof Download PDFInfo
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- CN106265530A CN106265530A CN201610694724.XA CN201610694724A CN106265530A CN 106265530 A CN106265530 A CN 106265530A CN 201610694724 A CN201610694724 A CN 201610694724A CN 106265530 A CN106265530 A CN 106265530A
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- mercaptamine
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- releasing granules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a kind of Mercaptamine pre-mixing agent, be made up of following parts by weight component: 30 ~ 60 parts of Mercaptamine slow-releasing granules, 3 ~ 5 parts of hygroscopic agents, 8 ~ 15 parts of Polyethylene Glycol, 1 ~ 3 part of cyclamate and 40 ~ 55 parts of montmorillonites；Described Mercaptamine slow-releasing granules preparation method is as follows: chitosan and Carboxymethyl cellulose sodium are dissolved in obtained solution A in 3wt% aqueous acetic acid, Mercaptamine is added in solution A, after being uniformly mixed, spray-dried prepared Mercaptamine slow-releasing granules.Chitosan and Carboxymethyl cellulose sodium are used the method being spray-dried to be coated on Mercaptamine surface by the present invention; form one layer of slow release protecting film; effectively reducing Mercaptamine moisture absorption oxidation probability, and make it have slow release effect, reducing Mercaptamine stimulates animal intestines and stomach.
Description
Technical field
The present invention relates to a kind of veterinary drug pre-mixing agent, particularly relate to a kind of Mercaptamine pre-mixing agent and preparation method thereof.
Background technology
Cysteamine, also known as Mercamine Cysteamine, white crystalline powder, fusing point 99～100 DEG C, slightly stink, soluble in water
And alcohol, in alkaline reaction.Easily deliquescence, its aqueous solution contacts i.e. dimmed color, has sulfydryl, at sky in cysteamine molecule with metal ion
Oxidizable in gas become disulphide, generally with its hydrochlorate as its succedaneum.Mercaptamine stable chemical nature,
Being solid under room temperature, hygroscopicity is strong, the most easily aoxidizes, and fusing point is 70.2～70.7 DEG C.Cysteamine can be exhausted internal
Somatostatin since, numerous studies confirm cysteamine and hydrochlorate thereof be have reduction body growth chalone level, promote
Body digestion and metabolism, promotes the ideal material of growth of animal.It can be applied to Production of Livestock and Poultry as a kind of growth promoter,
According to " Science and Technology Daily " on June 28th, 2004, the ruminant developed centered by cysteamine gives milk and growth promotion is novel
Feed additive has advantages such as safe efficient, pollution-free, improves butterfat percnetage 4%, content of milk protein 3%, milk yield 18%,
Therefore it is widely used in animal feed additive.
Cysteamine easily aoxidizes the moisture absorption during processing and storage thus affects the using effect of product, simultaneously because half
Cystamine hydrochlorate is the most easily oxidized to disulphide, can stimulate coat of the stomach under one's belt, affect the gastrointestinal function of animal.
Summary of the invention
For the disadvantages mentioned above of Mercaptamine, the invention provides a kind of Mercaptamine pre-mixing agent, can be effective
Reducing the Mercaptamine oxidation moisture absorption, and have slow-release function, reducing it stimulates animal intestines and stomach.
The present invention solves the technical scheme that technical problem used:
A kind of Mercaptamine pre-mixing agent, is made up of following parts by weight component: 30～60 parts of Mercaptamines delay
Release granule, 3～5 parts of hygroscopic agents, 8～15 parts of Polyethylene Glycol, 1～3 part of cyclamate and 40～55 parts of montmorillonites；
Described Mercaptamine slow-releasing granules preparation method is as follows:
Chitosan and Carboxymethyl cellulose sodium are dissolved in obtained solution A in 3wt% aqueous acetic acid, by Mercaptamine
Add in solution A, after being uniformly mixed, spray-dried prepared Mercaptamine slow-releasing granules, chitosan and methylol
After cellulose is dissolved in 3wt% aqueous acetic acid, spray-dried Mercaptamine surface formed one layer of sustained release film, from
And play slow release and moisture absorption effect, reduce the probability of Mercaptamine oxidation moisture absorption.Hygroscopic agent in pre-mixing agent can be further
Moisture in moisture absorption air, reduces Mercaptamine deliquescence oxidation probability.Montmorillonite is to escherichia coli, vibrio cholera, jejunum
Campylobacter spp, staphylococcus aureus and rotavirus and cholate have preferable adsorption, and bacterial poison have fixing work
With, it is a kind of good gastric mucosa protective agent of animal, the mobility of pre-mixing agent can be improved so that it is be dispersed in feedstuff simultaneously
In.
As preferably, the mass ratio of described chitosan, Carboxymethyl cellulose sodium and aqueous acetic acid is 10～15:4～6:
100。
As preferably, the mass ratio of described Mercaptamine and solution A is 0.2～0.4:1.
As preferably, described hygroscopic agent is calcium hydrogen phosphate or calcium phosphate.
As preferably, described Mercaptamine pre-mixing agent is made up of following parts by weight component: 34 parts of cysteamine hydrochloric acid
Salt slow-releasing granules, 4 parts of hygroscopic agents, 10 parts of Polyethylene Glycol, 2 parts of cyclamates and 50 parts of montmorillonites.
As preferably, described preparation method comprises the steps:
(1) by Mercaptamine slow-releasing granules, hygroscopic agent, Polyethylene Glycol, cyclamate, montmorillonite and 30wt% ethanol water
After solution mix homogeneously, extruded machine extruding pelletization；
(2) the wet grain of step (1) gained is dried employing 20 mesh, 80 mesh classifying screen sub-sieves, and obtaining granularity is 20-80 purpose half Guang
Amine hydrochlorate pre-mixing agent, is less than granularity 20 mesh and returns to again pelletize in step (1) more than the granule of 80 mesh.
As preferably, quality is pre-mixing agent gross mass 0.3～0.4 times of ethanol water described in step (1).
The invention have the benefit that
1, the method being spray-dried is used to be coated on Mercaptamine surface, shape chitosan and Carboxymethyl cellulose sodium
Become one layer of slow release protecting film, effectively reduce Mercaptamine moisture absorption oxidation probability, and make it have slow release effect, reduce by half Guang
Animal intestines and stomach is stimulated by amine hydrochlorate.
2, hygroscopic agent absorbs moisture in air further, reduces Mercaptamine moisture absorption probability.
3, use montmorillonite to improve the mobility of pre-mixing agent, there is antibiotic effect simultaneously.
Detailed description of the invention
Below in conjunction with specific experiment embodiment, the present invention is described in further detail.
Embodiment 1
(1) 12g chitosan and 5g Carboxymethyl cellulose sodium are added 100g 3wt% aqueous acetic acid, after mix homogeneously,
It is added thereto to 35g Mercaptamine, spray-dried prepared 50.8g Mercaptamine slow-releasing granules again.
(2) by 50g Mercaptamine slow-releasing granules, 5g hygroscopic agent, 12g Polyethylene Glycol, 3g cyclamate, 30g montmorillonite
After 30g 30wt% ethanol water mix homogeneously, extruded machine extruding pelletization；
(3) the wet grain of step (2) gained is dried employing 20 mesh, 80 mesh classifying screen sub-sieves, and obtaining granularity is 20-80 purpose half Guang
Amine hydrochlorate pre-mixing agent, is less than granularity 20 mesh and returns to again pelletize in step (2) more than the granule of 80 mesh.
Embodiment 2
(1) 10g chitosan and 6g Carboxymethyl cellulose sodium are added 100g 3wt% aqueous acetic acid, after mix homogeneously,
It is added thereto to 46.4g Mercaptamine, spray-dried prepared 61g Mercaptamine slow-releasing granules again.
(2) by 20g Mercaptamine slow-releasing granules, 3g hygroscopic agent, 15g Polyethylene Glycol, 2g cyclamate, 60g montmorillonite
After 35g 30wt% ethanol water mix homogeneously, extruded machine extruding pelletization；
(3) the wet grain of step (2) gained is dried employing 20 mesh, 80 mesh classifying screen sub-sieves, and obtaining granularity is 20-80 purpose half Guang
Amine hydrochlorate pre-mixing agent, is less than granularity 20 mesh and returns to again pelletize in step (2) more than the granule of 80 mesh.
Embodiment 3
(1) 15g chitosan and 4g Carboxymethyl cellulose sodium are added 100g 3wt% aqueous acetic acid, after mix homogeneously,
It is added thereto to 23.8g Mercaptamine, spray-dried prepared 40g Mercaptamine slow-releasing granules again.
(2) by 40g Mercaptamine slow-releasing granules, 4g hygroscopic agent, 8g Polyethylene Glycol, 1g cyclamate, 47g montmorillonite and
After 40g 30wt% ethanol water mix homogeneously, extruded machine extruding pelletization；
(3) the wet grain of step (2) gained is dried employing 20 mesh, 80 mesh classifying screen sub-sieves, and obtaining granularity is 20-80 purpose half Guang
Amine hydrochlorate pre-mixing agent, is less than granularity 20 mesh and returns to again pelletize in step (2) more than the granule of 80 mesh.
Embodiment 4 antioxidation is tested
Mercaptamine pre-mixing agent embodiment 1-3 prepared is placed in air storage two months, and detects pre-mixing agent
The initial content of middle Mercaptamine and store Mercaptamine content after two months, the results are shown in Table 1:
Table 1:
By table 1 it can be seen that the Mercaptamine pre-mixing agent prepared by the present invention is through storing after two months, effectively become
Code insurance allowance is still more than 97%.
Embodiment 5 animal experiment
Select the DLY tri-crossbreeding that 160 body conditions are good, average weight is 60kg, be randomly divided into four groups, often group
Four repetitions, 10 pigs of each repetition (male and female half and half).Mix all with feedstuff according to 0.5wt% (in terms of Mercaptamine)
Even, in feedstuff, add the Mercaptamine pre-mixing agent prepared by embodiment 1-4 respectively.To only eat normal feedstuff day simultaneously
Grain, without the swinery of any medicine as blank group.Test pig group feeding powder, free choice feeding and drinking-water, carry out routine
Immune programme for children, feeding and management is carried out routinely.Before Shi Yan, pig house is carried out disinfection.5 days preliminary trial periods, just trying the phase 40 days.Experimental period
Between every day entry feed consumption.After off-test, weigh after stopping raising 24h, calculate the lean meat percentage (%) of test group, the thickness of backfat
And eye muscle area (CM (CM)2), the results are shown in Table 2:
Table 2:
| Numbering | Daily gain (g) | Lean meat percentage (%) | The thickness of backfat (CM) | Eye muscle area (CM2) |
| Blank group | 658.6 | 60.23 | 3 | 48.3 |
| Embodiment 1 | 805.3 | 69.54 | 2.7 | 52.2 |
| Embodiment 2 | 812.2 | 70.21 | 2.8 | 53.4 |
| Embodiment 3 | 810.6 | 67.39 | 2.7 | 51.8 |
By table 2 it can be seen that the cysteamine pre-mixing agent prepared by the present invention can significantly improve Daily gain and lean meat percentage.
Above example is only in order to illustrate technical scheme and unrestricted, although preferred by referring to the present invention
Invention has been described for embodiment, it should be appreciated by those of ordinary skill in the art that can in form and carefully
On Jie, it is made various change, the protection domain limited without departing from claims of the present invention.
Claims (7)
1. a Mercaptamine pre-mixing agent, it is characterised in that described Mercaptamine pre-mixing agent is by following parts by weight
Component forms: 20 ~ 50 parts of Mercaptamine slow-releasing granules, 3 ~ 5 parts of hygroscopic agents, 8 ~ 15 parts of Polyethylene Glycol, 1 ~ 3 part of cyclamate and
30 ~ 60 parts of montmorillonites；
Described Mercaptamine slow-releasing granules preparation method is as follows:
Chitosan and Carboxymethyl cellulose sodium are dissolved in obtained solution A in 3wt% aqueous acetic acid, Mercaptamine is added
In solution A, after being uniformly mixed, spray-dried prepared Mercaptamine slow-releasing granules.
2. Mercaptamine pre-mixing agent as claimed in claim 1, it is characterised in that described chitosan, hydroxymethyl cellulose
The mass ratio of sodium and aqueous acetic acid is 10 ~ 15:4 ~ 6:100.
3. Mercaptamine pre-mixing agent as claimed in claim 1, it is characterised in that described Mercaptamine and solution A
Mass ratio be 0.2 ~ 0.4:1.
4. Mercaptamine pre-mixing agent as claimed in claim 1, it is characterised in that described hygroscopic agent is calcium hydrogen phosphate or phosphorus
Acid calcium.
5. Mercaptamine pre-mixing agent as claimed in claim 1, it is characterised in that described Mercaptamine pre-mixing agent by
Following parts by weight component forms: 34 parts of Mercaptamine slow-releasing granules, 4 parts of hygroscopic agents, 10 parts of Polyethylene Glycol, 2 parts of sweetnesses
Element and 50 parts of montmorillonites.
6. the method for Mercaptamine pre-mixing agent described in preparation claim 1-5 any one, it is characterised in that described preparation
Method comprises the steps:
(1) by Mercaptamine slow-releasing granules, hygroscopic agent, Polyethylene Glycol, cyclamate, montmorillonite and 30wt% ethanol water
After mix homogeneously, extruded machine extruding pelletization；
(2) the wet grain of step (1) gained is dried employing 20 mesh, 80 mesh classifying screen sub-sieves, and obtaining granularity is 20-80 purpose half Guang
Amine hydrochlorate pre-mixing agent, is less than granularity 20 mesh and returns to again pelletize in step (1) more than the granule of 80 mesh.
7. the preparation method of Mercaptamine pre-mixing agent as claimed in claim 6, it is characterised in that described in step (1)
The quality of ethanol water is 0.3 ~ 0.4 times of pre-mixing agent gross mass.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610694724.XA CN106265530B (en) | 2016-08-19 | 2016-08-19 | A kind of Mercaptamine pre-mixing agent and preparation method thereof |
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| CN201610694724.XA CN106265530B (en) | 2016-08-19 | 2016-08-19 | A kind of Mercaptamine pre-mixing agent and preparation method thereof |
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| CN106265530A true CN106265530A (en) | 2017-01-04 |
| CN106265530B CN106265530B (en) | 2018-11-02 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014102741A2 (en) * | 2012-12-28 | 2014-07-03 | University Of The Witwatersrand, Johannesburg | Pharmaceutical dosage form |
| CN104922074A (en) * | 2015-05-26 | 2015-09-23 | 浙江汇能动物药品有限公司 | Granular quinocetone premix and preparation method thereof |
-
2016
- 2016-08-19 CN CN201610694724.XA patent/CN106265530B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014102741A2 (en) * | 2012-12-28 | 2014-07-03 | University Of The Witwatersrand, Johannesburg | Pharmaceutical dosage form |
| CN104922074A (en) * | 2015-05-26 | 2015-09-23 | 浙江汇能动物药品有限公司 | Granular quinocetone premix and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杨明，等: "《药剂学》", 31 August 2014, 中国医药科技出版社 * |
| 邢秀丽: "壳聚糖与羧甲基纤维素钠的复凝聚及其微囊的制备", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
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