CN106265530B - A kind of Mercaptamine pre-mixing agent and preparation method thereof - Google Patents
A kind of Mercaptamine pre-mixing agent and preparation method thereof Download PDFInfo
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- CN106265530B CN106265530B CN201610694724.XA CN201610694724A CN106265530B CN 106265530 B CN106265530 B CN 106265530B CN 201610694724 A CN201610694724 A CN 201610694724A CN 106265530 B CN106265530 B CN 106265530B
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- mercaptamine
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- slow
- mixing agent
- releasing granules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
Abstract
The present invention provides a kind of Mercaptamine pre-mixing agents, are grouped as by following parts by weight group：30 ~ 60 parts of Mercaptamine slow-releasing granules, 3 ~ 5 parts of hygroscopic agents, 8 ~ 15 parts of polyethylene glycol, 1 ~ 3 part of honey element and 40 ~ 55 parts of montmorillonites；The Mercaptamine slow-releasing granules preparation method is as follows：Chitosan and sodium cellulose glycolate are dissolved in obtained solution A in 3wt% aqueous acetic acids, Mercaptamine is added in solution A, after being uniformly mixed, spray-dried obtained Mercaptamine slow-releasing granules.Chitosan and sodium cellulose glycolate are coated on Mercaptamine surface by the present invention using the method for spray drying; form one layer of sustained release protective film; Mercaptamine moisture absorption oxidation probability is effectively reduced, and makes it have sustained release effect, reducing Mercaptamine stimulates animal intestines and stomach.
Description
Technical field
The present invention relates to a kind of veterinary drug pre-mixing agents more particularly to a kind of Mercaptamine pre-mixing agent and preparation method thereof.
Background technology
Cysteamine, also known as Mercamine Cysteamine, white crystalline powder, 99~100 DEG C of fusing point, slightly stink are soluble easily in water
And alcohol, it is in alkaline reaction.It easily deliquesces, aqueous solution is contacted with metal ion becomes dark-coloured, has sulfydryl in cysteamine molecule, in sky
It is oxidizable in gas to become disulphide, usually use its hydrochloride as its substitute.Mercaptamine chemical property is stablized,
It is solid under room temperature, hygroscopicity is strong, is easy oxidation at high temperature, and fusing point is 70.2~70.7 DEG C.Cysteamine can be exhausted in vivo
Growth hormone release inhibiting hormone since, numerous studies confirm that cysteamine and its hydrochloride are that have that reduce body growth chalone horizontal, promote
Body digestion and metabolism promotes the ideal substance of growth of animal.It can be used as a kind of growth accelerator and is applied to Production of Livestock and Poultry,
According to《Science and Technology Daily》The report on June 28th, 2004, the ruminant milk production developed centered on cysteamine and growth promotion are novel
Feed addictive have many advantages, such as it is safe efficient, pollution-free, improve butterfat percnetage 4%, content of milk protein 3%, the output of milk 18%,
It is therefore widely used in animal feed additive.
The easily oxidation moisture absorption is to influence the using effect of product during processing and storing for cysteamine, simultaneously because half
Cystamine hydrochloride is easily oxidized to disulphide in air, can stimulate stomach wall under one's belt, influences the functions of intestines and stomach of animal.
Invention content
For the disadvantages mentioned above of Mercaptamine, the present invention provides a kind of Mercaptamine pre-mixing agents, can be effective
It reduces Mercaptamine and aoxidizes the moisture absorption, and there is slow-release function, reducing it stimulates animal intestines and stomach.
The technical proposal for solving the technical problem of the invention is：
A kind of Mercaptamine pre-mixing agent is grouped as by following parts by weight group：30~60 parts of Mercaptamines are slow
Release particle, 3~5 parts of hygroscopic agents, 8~15 parts of polyethylene glycol, 1~3 part of honey element and 40~55 parts of montmorillonites；
The Mercaptamine slow-releasing granules preparation method is as follows：
Chitosan and sodium cellulose glycolate are dissolved in obtained solution A in 3wt% aqueous acetic acids, by Mercaptamine
It is added in solution A, after being uniformly mixed, spray-dried obtained Mercaptamine slow-releasing granules, chitosan and methylol
It is spray-dried to form one layer of sustained release film on Mercaptamine surface after cellulose is dissolved in 3wt% aqueous acetic acids, from
And play the role of sustained release and the moisture absorption, reduce the probability of Mercaptamine oxidation moisture absorption.Hygroscopic agent in pre-mixing agent can be further
Moisture in moisture absorption air reduces Mercaptamine and deliquesces oxidation probability.Montmorillonite is to Escherichia coli, comma bacillus, jejunum
Campylobacter spp, staphylococcus aureus and rotavirus and cholate have preferable suction-operated, are known as fixed work to bacterial poison
With being a kind of good gastric mucosa protective agent of animal, while the mobility of pre-mixing agent can be improved, it made to be dispersed in feed
In.
Preferably, the mass ratio of the chitosan, sodium cellulose glycolate and aqueous acetic acid is 10~15：4~6：
100。
Preferably, the Mercaptamine and the mass ratio of solution A are 0.2~0.4：1.
Preferably, the hygroscopic agent is calcium monohydrogen phosphate or calcium phosphate.
Preferably, the Mercaptamine pre-mixing agent is grouped as by following parts by weight group：34 parts of cysteamine hydrochloric acid
Salt slow-releasing granules, 4 parts of hygroscopic agents, 10 parts of polyethylene glycol, 2 parts of honey elements and 50 parts of montmorillonites.
Preferably, the preparation method includes the following steps：
(1) by Mercaptamine slow-releasing granules, hygroscopic agent, polyethylene glycol, honey element, montmorillonite and 30wt% ethanol waters
Solution after mixing, extruded machine extruding pelletization；
(2) wet grain obtained by step (1) is dried, using 20 mesh, 80 mesh classifying screen sub-sieves, it is 20-80 purposes to obtain granularity
Granularity is less than 20 mesh and returns in step (1) and pelletize again more than the particle of 80 mesh by Mercaptamine pre-mixing agent.
Preferably, the quality of ethanol water described in step (1) is 0.3~0.4 times of pre-mixing agent gross mass.
Beneficial effects of the present invention are：
1, chitosan and sodium cellulose glycolate are coated on Mercaptamine surface, shape using the method for spray drying
At one layer of sustained release protective film, Mercaptamine moisture absorption oxidation probability is effectively reduced, and make it have sustained release effect, reduce by half Guang
Amine hydrochlorate stimulates animal intestines and stomach.
2, hygroscopic agent further absorbs moisture in air, reduces Mercaptamine moisture absorption probability.
3, the mobility of pre-mixing agent is improved using montmorillonite, while there is antibiotic effect.
Specific implementation mode
With reference to specific experiment embodiment, the present invention is described in further detail.
Embodiment 1
(1) 100g 3wt% aqueous acetic acids are added in 12g chitosans and 5g sodium cellulose glycolates, after mixing,
35g Mercaptamines, spray-dried obtained 50.8g Mercaptamines slow-releasing granules are added thereto again.
(2) by 50g Mercaptamines slow-releasing granules, 5g hygroscopic agents, 12g polyethylene glycol, 3g honey elements, 30g montmorillonites
After mixing with 30g 30wt% ethanol waters, extruded machine extruding pelletization；
(3) wet grain obtained by step (2) is dried, using 20 mesh, 80 mesh classifying screen sub-sieves, it is 20-80 purposes to obtain granularity
Granularity is less than 20 mesh and returns in step (2) and pelletize again more than the particle of 80 mesh by Mercaptamine pre-mixing agent.
Embodiment 2
(1) 100g 3wt% aqueous acetic acids are added in 10g chitosans and 6g sodium cellulose glycolates, after mixing,
46.4g Mercaptamines, spray-dried obtained 61g Mercaptamines slow-releasing granules are added thereto again.
(2) by 20g Mercaptamines slow-releasing granules, 3g hygroscopic agents, 15g polyethylene glycol, 2g honey elements, 60g montmorillonites
After mixing with 35g 30wt% ethanol waters, extruded machine extruding pelletization；
(3) wet grain obtained by step (2) is dried, using 20 mesh, 80 mesh classifying screen sub-sieves, it is 20-80 purposes to obtain granularity
Granularity is less than 20 mesh and returns in step (2) and pelletize again more than the particle of 80 mesh by Mercaptamine pre-mixing agent.
Embodiment 3
(1) 100g 3wt% aqueous acetic acids are added in 15g chitosans and 4g sodium cellulose glycolates, after mixing,
23.8g Mercaptamines, spray-dried obtained 40g Mercaptamines slow-releasing granules are added thereto again.
(2) by 40g Mercaptamines slow-releasing granules, 4g hygroscopic agents, 8g polyethylene glycol, 1g honey elements, 47g montmorillonites
After mixing with 40g 30wt% ethanol waters, extruded machine extruding pelletization；
(3) wet grain obtained by step (2) is dried, using 20 mesh, 80 mesh classifying screen sub-sieves, it is 20-80 purposes to obtain granularity
Granularity is less than 20 mesh and returns in step (2) and pelletize again more than the particle of 80 mesh by Mercaptamine pre-mixing agent.
4 anti-oxidant experiment of embodiment
Mercaptamine pre-mixing agent prepared by embodiment 1-3 is placed in air and is stored two months, and detects pre-mixing agent
The Mercaptamine content of the initial content and storage of middle Mercaptamine after two months, the results are shown in Table 1：
Table 1：
It can be seen from Table 1 that the present invention prepared by Mercaptamine pre-mixing agent through store after two months, effectively at
Code insurance allowance is still 97% or more.
5 animal experiment of embodiment
It selects that 160 body conditions are good, average weight is the Ternary Pig tri-crossbreeding of 60kg, is randomly divided into four groups, every group
Four repetitions each repeat 10 pigs (male and female is fifty-fifty).It is mixed with feed according to 0.5wt% (in terms of Mercaptamine)
It is even, the Mercaptamine pre-mixing agent prepared by embodiment 1-4 is added in feed respectively.It will only eat basal feed day simultaneously
Grain does not add the swinery of any drug as blank control group.Test pig group feeding powder, is freely eaten and drinking-water, progress are conventional
Immune programme, feeding management routinely carry out.It carries out disinfection to pig house before experiment.It is 5 days preliminary trial periods, positive to try 40 days phases.Experimental period
Between per day entry feed consumption.After the test, stop to raise and weigh afterwards for 24 hours, calculate lean meat percentage (%), the thickness of backfat of test group
(CM) and eye muscle area (CM2), it the results are shown in Table 2：
Table 2：
| Number | Daily gain (g) | Lean meat percentage (%) | The thickness of backfat (CM) | Eye muscle area (CM2) |
| Blank control group | 658.6 | 60.23 | 3 | 48.3 |
| Embodiment 1 | 805.3 | 69.54 | 2.7 | 52.2 |
| Embodiment 2 | 812.2 | 70.21 | 2.8 | 53.4 |
| Embodiment 3 | 810.6 | 67.39 | 2.7 | 51.8 |
It can be seen from Table 2 that the cysteamine pre-mixing agent prepared by the present invention can significantly improve Daily gain and lean meat percentage.
The above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although by referring to the preferred of the present invention
Invention has been described for embodiment, it should be appreciated by those of ordinary skill in the art that can in form and carefully
Various changes are made to it on section, without departing from protection domain defined by claims of the present invention.
Claims (4)
1. a kind of Mercaptamine pre-mixing agent, which is characterized in that the Mercaptamine pre-mixing agent is by following parts by weight
Group is grouped as：20~50 parts of Mercaptamine slow-releasing granules, 3~5 parts of hygroscopic agents, 8~15 parts of polyethylene glycol, 1~3 part of sweetness
Element and 30~60 parts of montmorillonites, the hygroscopic agent are calcium monohydrogen phosphate or calcium phosphate；
The Mercaptamine slow-releasing granules preparation method is as follows：
Chitosan and sodium cellulose glycolate are dissolved in obtained solution A in 3wt% aqueous acetic acids, Mercaptamine is added
In solution A, after being uniformly mixed, spray-dried obtained Mercaptamine slow-releasing granules, the chitosan, methylol are fine
The mass ratio of the plain sodium of dimension and aqueous acetic acid is 10~15：4~6：100, the mass ratio of the Mercaptamine and solution A is
0.2~0.4：1.
2. Mercaptamine pre-mixing agent as described in claim 1, which is characterized in that the Mercaptamine pre-mixing agent by
Following parts by weight group is grouped as：34 parts of Mercaptamine slow-releasing granules, 4 parts of hygroscopic agents, 10 parts of polyethylene glycol, 2 parts of sweetnesses
Element and 50 parts of montmorillonites.
3. the method for preparing Mercaptamine pre-mixing agent described in claim 1-2 any one, which is characterized in that the preparation
Method includes the following steps：
(1) by Mercaptamine slow-releasing granules, hygroscopic agent, polyethylene glycol, honey element, montmorillonite and 30wt% ethanol waters
After mixing, extruded machine extruding pelletization；
(2) wet grain obtained by step (1) is dried, using 20 mesh, 80 mesh classifying screen sub-sieves, obtains the cysteamine that granularity is 20-80 mesh
Granularity is less than 20 mesh and returns in step (1) and pelletize again more than the particle of 80 mesh by hydrochloride pre-mixing agent.
4. the preparation method of Mercaptamine pre-mixing agent as claimed in claim 3, which is characterized in that described in step (1)
The quality of ethanol water is 0.3~0.4 times of pre-mixing agent gross mass.
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| CN201610694724.XA CN106265530B (en) | 2016-08-19 | 2016-08-19 | A kind of Mercaptamine pre-mixing agent and preparation method thereof |
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| CN201610694724.XA CN106265530B (en) | 2016-08-19 | 2016-08-19 | A kind of Mercaptamine pre-mixing agent and preparation method thereof |
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| CN106265530A CN106265530A (en) | 2017-01-04 |
| CN106265530B true CN106265530B (en) | 2018-11-02 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014102741A2 (en) * | 2012-12-28 | 2014-07-03 | University Of The Witwatersrand, Johannesburg | Pharmaceutical dosage form |
| CN104922074A (en) * | 2015-05-26 | 2015-09-23 | 浙江汇能动物药品有限公司 | Granular quinocetone premix and preparation method thereof |
-
2016
- 2016-08-19 CN CN201610694724.XA patent/CN106265530B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014102741A2 (en) * | 2012-12-28 | 2014-07-03 | University Of The Witwatersrand, Johannesburg | Pharmaceutical dosage form |
| CN104922074A (en) * | 2015-05-26 | 2015-09-23 | 浙江汇能动物药品有限公司 | Granular quinocetone premix and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 壳聚糖与羧甲基纤维素钠的复凝聚及其微囊的制备;邢秀丽;《中国优秀硕士学位论文全文数据库 工程科技I辑》;20131215;第1-8页 * |
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