CN106265121A - 盖菜多肽在制备美白修复化妆品中的应用 - Google Patents
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Abstract
本发明提供了一种盖菜多肽在制备美白修复化妆品中的应用。盖菜多肽分子量小,容易为肌肤所吸收,用于化妆品的制备,可针对皮损修复过程中造成的色素沉着问题,促进加快皮肤的损伤修复过程,加快皮肤细胞的生长分化,缩短修复时间,保护皮肤,从而改善皮肤因保护反应性而造成的色素沉着。
Description
技术领域
本发明涉及化妆品领域,特别涉及盖菜多肽在制备美白修复化妆品中的应用。
背景技术
皮损即皮肤损伤,常见的皮肤损伤有烧伤、碰伤、咬伤、日晒伤、冻伤以及皮炎所造成的皮肤损伤,皮肤遭受到损伤后会有一个自我修复的过程,在这个修复过程中皮肤出于自我保护往往会在损伤处形成色素沉着,需要长时间才能康复消退。在皮肤自我修复过程中不能使用祛斑类美白产品以及对皮肤有刺激性的产品,避免造成皮肤的再次损伤而加重色素沉着。
中国专利CN103860645A公开了一种防止和修复皮肤损伤的化妆产品,所述组合物含有重量比为1:1-10的经蜜炙加工的所述槐花提取物和/或蜜炙加工的所述丹参提取物作为活性成分,还含有化妆品用辅料,为增稠剂、表面活性剂、皮肤调理剂、溶剂、防腐剂、香精、润滑剂、崩解剂、湿润剂、粘合剂和填充剂中的一种或多种。
中国专利CN105534848A公开了一种化妆品或药物组合物及其用途,所述组合物每10ml中含有如下组分:间充质干细胞5×106-5×107个、透明质酸0.01-0.1g、人白蛋白0.05-0.2ml、余量水。
皮肤损伤是极为常见的现象,但较少的化妆品是针对皮损可用的,对于皮损造成的色素沉着使用一般的美白祛斑类产品却可能会刺激皮肤而造成对皮肤的二次损害,因此,找到一种能用于改善消除由于皮损造成的色素沉着但又不会刺激或再次损伤皮肤的化妆品尤为重要。
发明内容
为了解决现有技术存在的上述问题,本发明提供了可用于改善皮损修复过程中造成的色素沉着的盖菜多肽其在制备美白修复化妆品中的应用,盖菜多肽对于皮肤损伤有良好的促进修复的作用,同时还可改善消除因皮肤损伤而造成的皮肤色素沉着。
本发明可以通过以下技术方案来实现:
盖菜多肽在制备改善皮损修复过程中造成的色素沉着的化妆品中的应用,其在化妆品中的添加量为0.5%-1.5%。
进一步地,所述化妆品为美白修复霜。
本发明提供了一种美白修复霜,由下述重量百分比的组分组成:
盖菜多肽:0.5%-1.5%,
丁二醇:6%-8%,
丙二醇:3%-6%,
辛酸/癸酸甘油三酯:3%-4%,
环五聚二甲基硅氧烷/环己硅氧烷:3%-5%,
鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷:2%-2.5%,
牛油果树果脂:1.8%-2.5%,
氢化霍霍巴油:1.5%-2.5%,
鲸蜡硬脂醇:0.8%-1.2%,
角鲨烷:0.8%-1.2%,
甘油硬脂酸酯/PEG-100硬脂酸酯:0.6%-0.8%,
丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物/聚山梨醇酯-80/异十六烷:0.6%-0.8%,
丙二醇/双(羟甲基)咪唑烷基脲/碘丙炔醇丁基氨甲酸酯:0.002%-0.003%,
生育酚:0.15%-0.22%,
羟苯甲酯:0.12%-0.16%,
羟苯丙酯:0.08%-0.1%,
黄原胶:0.08%-0.1%,
透明质酸钠:0.03%-0.04%,
去离子水:余量。
盖菜富含蛋白质,但由于其大分子量和空间结构,难以为人体皮肤所吸收,将盖菜蛋白制备成小分子多肽,使其能够通过皮肤表层的孔隙吸收进细胞,大大地提高了人体皮肤对其的吸收。经本发明试验证明,盖菜多肽可用于化妆品的制备,且对皮肤因碰伤、咬伤、日晒伤、皮炎等所造成的损伤具有促进修复作用,促使皮肤角质层加快剥落,去除老旧坏死的细胞,促进新细胞的增殖分化,从而缩短皮肤的修复时间,对于因皮损而造成的色素沉着有良好的改善效果。
皮肤损伤后在其自我修复的过程中,容易出现干痒的感觉,此时更需要对皮肤进行保湿,配方中的丁二醇、丙二醇、牛油果树果脂、氢化霍霍巴油、角鲨烷、透明质酸钠等都具有良好的保湿效果,与盖菜多肽配合使用可降低新生表皮神经的敏感度,减轻伤口处皮肤的干痒感,给皮肤提供充足的水分并协助皮肤形成天然皮脂膜,在保湿的同时还可阻隔细菌污染受损皮肤,有利于皮肤的修复。
进一步地,所述美白修复霜由下述重量百分比的组分组成:
盖菜多肽:0.9%,
丁二醇:8%,
丙二醇:5%,
辛酸/癸酸甘油三酯:4%,
环五聚二甲基硅氧烷/环己硅氧烷:4%,
鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷:2.5%,
牛油果树果脂:2%,
氢化霍霍巴油:2%,
鲸蜡硬脂醇:1%,
角鲨烷:1%,
甘油硬脂酸酯/PEG-100硬脂酸酯:0.8%,
丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物/聚山梨醇酯-80/异十六烷:0.8%,
丙二醇/双(羟甲基)咪唑烷基脲/碘丙炔醇丁基氨甲酸酯:0.003%,
生育酚:0.2%,
羟苯甲酯:0.15%,
羟苯丙酯:0.1%,
黄原胶:0.1%,
透明质酸钠:0.04%,
去离子水:余量。
盖菜多肽的制备方法:盖菜低温干燥至恒重,粉碎至30目,加入10倍量的50%乙醇溶液,45℃下超声波提取30min,4000r/min离心分离取上清液,等电点沉淀蛋白质,取沉淀,用蒸馏水洗涤沉淀3次,加入适量中性磷酸盐缓冲溶液完全溶解沉淀,加入5%的中性蛋白酶,于45℃下酶解8h,70℃灭酶5min,反相高效液相色谱分离纯化得到盖菜多肽。
本发明的有益效果为:盖菜多肽分子量小,容易为肌肤所吸收,用于化妆品的制备,可针对皮损修复过程中造成的色素沉着问题。盖菜多肽配合配方中的其他保湿护肤成分,给细胞的更新提供充足的营养,促进皮肤的损伤修复过程,加快皮肤细胞的生长分化,缩短修复时间,保护皮肤,从而改善皮肤因自我保护反应而造成的色素沉着。
文中出现的以下成分名称均为INCI(International Nomenclature CosmeticIngredient,即国际化妆品原料命名)所规定的名称:辛酸/癸酸甘油三酯、环五聚二甲基硅氧烷/环己硅氧烷、鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷、甘油硬脂酸酯/PEG-100硬脂酸酯、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物/聚山梨醇酯-80/异十六烷、丙二醇/双(羟甲基)咪唑烷基脲/碘丙炔醇丁基氨甲酸酯。
具体实施方式
为了使本技术领域的人员更好地理解本发明的技术方案,下面结合实施例对本发明的技术方案作进一步详细的说明。
实施例1-5
表1美白修复霜配方各组成及其重量百分比
制备方法:将A相原料投入到油相锅中,B相原料也投入到水箱锅中,A、B两相分别加热至85℃,B相抽入到乳化锅中,将A抽入乳化锅中,45r/min搅拌,均质7min(均质时搅拌速度控制在30r/min,均质完后搅拌速度控制在45r/min),保温30min抽真空,乳化锅冷却至60℃加入C相均质3min,降温到38℃加入D相,35r/min搅拌至均匀,加入E相,35r/min搅拌5min,出料。
实施例6功效评价试验
对实施例1-5制得的美白修复霜进行功效评价试验,选取350名25-40岁皮肤伤口结痂掉落的志愿者进行试验,分为7组,每组男女各25名,实验组1-5分别使用实施例1-5制得的美白修复霜,对照组1使用对比例1制得的霜,对照组2使用空白对照组制得的霜。使用方法:受试者每日早晚洁面后将试验品涂抹于伤口黑印处,轻轻按摩至其吸收,留下一半的伤口不涂抹任何东西,连续使用两个月后观察受试者的伤口处情况并统计改善情况,结果见表2。
表2美白修复霜功效评价试验
从表2的结果可知,本发明制得的含盖菜多肽的美白修复霜具有良好的保湿性能,有效加速伤口处的角质层剥落,促进皮肤细胞的新生,同时可改善伤口处的色素沉着,淡化黑印。比较实施例3、对比例1以及空白对照组的结果可知,盖菜多肽与本发明配方中的丁二醇、丙二醇、氢化霍霍巴油、透明质酸钠等保湿护肤的原料配合使用,能够使配方整体发挥更大的效用,显著提高美白修复霜的保湿、促进细胞新生、淡化黑印的效果。
以上所述的仅是本发明的优选实施方式,应当指出,对于本领域的普通技术人员来说,在不脱离本发明创造构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。
Claims (6)
1.盖菜多肽在制备美白修复化妆品中的应用。
2.根据权利要求1所述的盖菜多肽在制备美白修复化妆品中的应用,其特征在于,盖菜多肽在制备改善皮损修复过程中造成的色素沉着的化妆品中的应用。
3.根据权利要求1所述的盖菜多肽在制备美白修复化妆品中的应用,其特征在于,所述盖菜多肽在美白修复化妆品中的添加量为0.5%-1.5%。
4.根据权利要求3所述的美白修复化妆品,其特征在于,所述美白修复化妆品为美白修复霜。
5.一种美白修复霜,其特征在于,由下述重量百分比的组分组成:
盖菜多肽:0.5%-1.5%,
丁二醇:6%-8%,
丙二醇:3%-6%,
辛酸/癸酸甘油三酯:3%-4%,
环五聚二甲基硅氧烷/环己硅氧烷:3%-5%,
鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷:2%-2.5%,
牛油果树果脂:1.8%-2.5%,
氢化霍霍巴油:1.5%-2.5%,
鲸蜡硬脂醇:0.8%-1.2%,
角鲨烷:0.8%-1.2%,
甘油硬脂酸酯/PEG-100硬脂酸酯:0.6%-0.8%,
丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物/聚山梨醇酯-80/异十六烷:0.6%-0.8%,
丙二醇/双(羟甲基)咪唑烷基脲/碘丙炔醇丁基氨甲酸酯:0.002%-0.003%,
生育酚:0.15%-0.22%,
羟苯甲酯:0.12%-0.16%,
羟苯丙酯:0.08%-0.1%,
黄原胶:0.08%-0.1%,
透明质酸钠:0.03%-0.04%,
去离子水:余量。
6.根据权利要求5所述的一种美白修复霜,其特征在于,由下述重量百分比的组分组成:
盖菜多肽:0.9%,
丁二醇:8%,
丙二醇:5%,
辛酸/癸酸甘油三酯:4%,
环五聚二甲基硅氧烷/环己硅氧烷:4%,
鲸蜡硬脂醇/鲸蜡硬脂基葡糖苷:2.5%,
牛油果树果脂:2%,
氢化霍霍巴油:2%,
鲸蜡硬脂醇:1%,
角鲨烷:1%,
甘油硬脂酸酯/PEG-100硬脂酸酯:0.8%,
丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物/聚山梨醇酯-80/异十六烷:0.8%,
丙二醇/双(羟甲基)咪唑烷基脲/碘丙炔醇丁基氨甲酸酯:0.003%,
生育酚:0.2%,
羟苯甲酯:0.15%,
羟苯丙酯:0.1%,
黄原胶:0.1%,
透明质酸钠:0.04%,
去离子水:余量。
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CN108524344A (zh) * | 2017-03-01 | 2018-09-14 | 广州佰盛利和化妆品有限公司 | 一种含有柠檬的净化通透霜配方及其制备工艺 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN106727017A (zh) * | 2017-01-06 | 2017-05-31 | 广州市聚吉科绿色化学共性技术研究院有限公司 | 一种含紫菜头多糖的天然面霜 |
CN108524344A (zh) * | 2017-03-01 | 2018-09-14 | 广州佰盛利和化妆品有限公司 | 一种含有柠檬的净化通透霜配方及其制备工艺 |
CN107242982A (zh) * | 2017-06-07 | 2017-10-13 | 广州科玛生物科技股份有限公司 | 一种皙透亮白乳液及其制备方法 |
CN107320419A (zh) * | 2017-08-08 | 2017-11-07 | 广州蜜妆生物科技有限公司 | 一种温和修复尿素霜 |
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