CN106232603B - 作为toll-样受体7激动剂的化合物和组合物 - Google Patents

作为toll-样受体7激动剂的化合物和组合物 Download PDF

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CN106232603B
CN106232603B CN201580021618.9A CN201580021618A CN106232603B CN 106232603 B CN106232603 B CN 106232603B CN 201580021618 A CN201580021618 A CN 201580021618A CN 106232603 B CN106232603 B CN 106232603B
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amino
formula
pyrrolo
base
methyl
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CN106232603A (zh
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Y·李
T·莫
P·瓦
T·Y-H·吴
X·张
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Virology (AREA)
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  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201580021618.9A 2014-05-01 2015-04-29 作为toll-样受体7激动剂的化合物和组合物 Active CN106232603B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461987321P 2014-05-01 2014-05-01
US61/987,321 2014-05-01
PCT/US2015/028264 WO2015168269A1 (en) 2014-05-01 2015-04-29 Compounds and compositions as toll-like receptor 7 agonists

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CN106232603A CN106232603A (zh) 2016-12-14
CN106232603B true CN106232603B (zh) 2019-07-05

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EP (1) EP3137470B1 (enExample)
JP (1) JP6484253B2 (enExample)
KR (1) KR102139847B1 (enExample)
CN (1) CN106232603B (enExample)
AP (1) AP2016009485A0 (enExample)
AR (1) AR100244A1 (enExample)
AU (1) AU2015253215B2 (enExample)
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