CN106232120B - 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 - Google Patents

制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 Download PDF

Info

Publication number
CN106232120B
CN106232120B CN201580020246.8A CN201580020246A CN106232120B CN 106232120 B CN106232120 B CN 106232120B CN 201580020246 A CN201580020246 A CN 201580020246A CN 106232120 B CN106232120 B CN 106232120B
Authority
CN
China
Prior art keywords
phenyl
group
butyl
methyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201580020246.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN106232120A (zh
Inventor
迪诺·阿尔贝里克
克雷格·狄克逊
鲍里斯·戈林
扬·欧登尼斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aerpio Therapeutics LLC
Original Assignee
Aerpio Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerpio Therapeutics LLC filed Critical Aerpio Therapeutics LLC
Publication of CN106232120A publication Critical patent/CN106232120A/zh
Application granted granted Critical
Publication of CN106232120B publication Critical patent/CN106232120B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580020246.8A 2014-02-19 2015-02-18 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 Expired - Fee Related CN106232120B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461941540P 2014-02-19 2014-02-19
US61/941,540 2014-02-19
PCT/US2015/016243 WO2015126860A1 (en) 2014-02-19 2015-02-18 Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones

Publications (2)

Publication Number Publication Date
CN106232120A CN106232120A (zh) 2016-12-14
CN106232120B true CN106232120B (zh) 2021-01-08

Family

ID=53797499

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580020246.8A Expired - Fee Related CN106232120B (zh) 2014-02-19 2015-02-18 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法

Country Status (7)

Country Link
US (1) US9388135B2 (https=)
EP (1) EP3107542B1 (https=)
JP (1) JP6549140B2 (https=)
CN (1) CN106232120B (https=)
ES (1) ES2739625T3 (https=)
SG (1) SG11201606862VA (https=)
WO (1) WO2015126860A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
MY160399A (en) 2009-07-06 2017-03-15 Aerpio Therapeutics Inc Compounds, compositions, and methods for preventing metastasis of cancer cells
EP3698794A1 (en) 2009-11-06 2020-08-26 Aerpio Therapeutics, Inc. Compositions and methods for treating colitis
AU2012323856B2 (en) 2011-10-13 2017-05-25 EyePoint, Inc. Methods for treating Vascular Leak Syndrome and cancer
AU2014233363B2 (en) 2013-03-15 2017-06-29 EyePoint, Inc. Compositions, formulations and methods for treating ocular diseases
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
WO2016022813A1 (en) 2014-08-07 2016-02-11 Aerpio Therapeutics, Inc. Combination of immunotherapies with activators of tie-2

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
CN102595896A (zh) * 2009-11-06 2012-07-18 阿尔皮奥治疗学股份有限公司 提高低氧诱导因子-1α的稳定性的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7507568B2 (en) 2002-09-25 2009-03-24 The Proctor & Gamble Company Three dimensional coordinates of HPTPbeta
US7226755B1 (en) 2002-09-25 2007-06-05 The Procter & Gamble Company HPTPbeta as a target in treatment of angiogenesis mediated disorders
US6946479B2 (en) 2002-11-09 2005-09-20 The Procter & Gamble Company N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
US6930117B2 (en) 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
AU2007237096C1 (en) 2006-04-07 2012-12-13 EyePoint, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
JO2934B1 (en) * 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
BRPI0713350B1 (pt) 2006-06-26 2022-04-12 Akebia Therapeutics Inc Composto, e, composição
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US8846685B2 (en) 2006-06-27 2014-09-30 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US20130023542A1 (en) 2006-06-27 2013-01-24 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US7795444B2 (en) 2006-06-27 2010-09-14 Warner Chilcott Company Human protein tyrosine phosphatase inhibitors and methods of use
US7589212B2 (en) 2006-06-27 2009-09-15 Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US9096555B2 (en) 2009-01-12 2015-08-04 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome
SG10201702247SA (en) 2009-01-12 2017-04-27 Aerpio Therapeutics Inc Methods for treating vascular leak syndrome
MY160399A (en) 2009-07-06 2017-03-15 Aerpio Therapeutics Inc Compounds, compositions, and methods for preventing metastasis of cancer cells
US8883832B2 (en) 2009-07-06 2014-11-11 Aerpio Therapeutics Inc. Compounds, compositions, and methods for preventing metastasis of cancer cells
US20120129847A1 (en) 2010-10-07 2012-05-24 Kevin Gene Peters Compositions and methods for treating ocular edema, neovascularization and related diseases
EP3501536B1 (en) 2011-10-13 2025-12-24 EyePoint Pharmaceuticals, Inc. Treatment of ocular disease
AU2012323856B2 (en) 2011-10-13 2017-05-25 EyePoint, Inc. Methods for treating Vascular Leak Syndrome and cancer
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
AU2014233363B2 (en) 2013-03-15 2017-06-29 EyePoint, Inc. Compositions, formulations and methods for treating ocular diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
CN102595896A (zh) * 2009-11-06 2012-07-18 阿尔皮奥治疗学股份有限公司 提高低氧诱导因子-1α的稳定性的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
碘化钾;暖心;《中文百科在线》;20110729;1-6 *

Also Published As

Publication number Publication date
US20150232425A1 (en) 2015-08-20
WO2015126860A1 (en) 2015-08-27
SG11201606862VA (en) 2016-09-29
EP3107542A4 (en) 2017-08-23
JP2017509608A (ja) 2017-04-06
EP3107542B1 (en) 2019-05-01
ES2739625T3 (es) 2020-02-03
JP6549140B2 (ja) 2019-07-24
CN106232120A (zh) 2016-12-14
US9388135B2 (en) 2016-07-12
EP3107542A1 (en) 2016-12-28

Similar Documents

Publication Publication Date Title
CN106232120B (zh) 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法
US20140371465A1 (en) 1,2,3-Triazole Based Metal-Organic Framework as Photo-Active Materials
KR20130132617A (ko) 수성 매질에서 이환형 구아니딘 염의 제조
CN103467388A (zh) 一种芳基或杂芳基取代喹唑啉化合物的合成方法
Mathapati et al. Zinc Sulfamate Catalyzed Efficient Selective Synthesis of Benzimidazole Derivatives under Ambient Conditions
Ibrahim et al. A facile, practical and metal-free microwave-assisted protocol for mono-and bis-[1, 2, 4] triazolo [1, 5-a] pyridines synthesis utilizing 1-amino-2-imino-pyridine derivatives as versatile precursors
Kale et al. Conventional and microwave-assisted multicomponent reaction of alkyne, halide and sodium azide catalyzed by copper apatite as heterogeneous base and catalyst in water
US9096551B2 (en) Method for producing 2-(triazinylcarbonyl) sulfonanilides
Salaheldin et al. Studies with enaminonitriles: Synthesis and chemical reactivity of 2‐phenyl‐3‐piperidin‐1‐yl acrylonitrile under microwave heating
JP5964320B2 (ja) ２−（トリアジニルカルボニル）スルホンアニリド類の製造方法
CN112500366A (zh) 一种石墨烯共价嫁接噻唑盐催化剂及其应用
Kalhor et al. Facile synthesis of 2-arylbenzimidazoles by nano-CuY zeolite as an efficient and eco-friendly nanocatalyst
CN102471292A (zh) 取代的3-氨基-5-氧代-4,5-二氢-[1,2,4]三氮烯的方法
DE69912936T2 (de) Herstellung von n-arylsulfonamidverbindungen
Wu et al. One-pot synthesis of polysubstituted imidazoles from arylaldehydes in water catalyzed by NHC using microwave irradiation
EP0253396A2 (en) Process for preparing 5,6-substituted-2,4-quinazolinediamines and intermediates
Chornous et al. Polyfunctional imidazoles: II. Synthesis and reactions with nucleophilic reagents of 1-substituted 2, 4-dichloro-1 H-imidazole-5-carbaldehydes
Myznikov et al. Tetrazoles: LVI. Synthesis of 5-substituted tetrazoles under microwave activation in the presence of heterogeneous catalyst (zinc oxide).
IL23932A (en) Alkyl derivatives of 2-nitroimidazole and improved process for the preparation of 2-nitro imidazoles
CN1068882C (zh) 5－(烷氧基甲基)－2,3－吡啶二甲酰亚胺化合物的制备方法
RU2241710C1 (ru) Способ получения замещенных пиридо[1,2-а][1,3]бензимидазолов
CN110857299B (zh) 3-硫氰基咪唑并[1,5-a]喹啉化合物的合成方法
JP6941155B2 (ja) 芳香族フッ素化の方法
CN118679153A (zh) 用于制备3-溴-1-(3-氯吡啶-2-基)-4,5-二氢-1h-吡唑-5-甲酸乙酯的方法
Kuznetsov et al. Heteroadamantanes and their derivatives. 13. Synthesis of 1-azaadamantane and some derivatives of it

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20210108