CN106232120B - 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 - Google Patents

制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 Download PDF

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Publication number
CN106232120B
CN106232120B CN201580020246.8A CN201580020246A CN106232120B CN 106232120 B CN106232120 B CN 106232120B CN 201580020246 A CN201580020246 A CN 201580020246A CN 106232120 B CN106232120 B CN 106232120B
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China
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phenyl
group
butyl
methyl
hydroxy
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English (en)
Chinese (zh)
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CN106232120A (zh
Inventor
迪诺·阿尔贝里克
克雷格·狄克逊
鲍里斯·戈林
扬·欧登尼斯
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Aerpio Therapeutics LLC
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Aerpio Therapeutics LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201580020246.8A 2014-02-19 2015-02-18 制备n-苄基-3-羟基-4-取代的-吡啶-2-(1h)-酮的方法 Expired - Fee Related CN106232120B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461941540P 2014-02-19 2014-02-19
US61/941,540 2014-02-19
PCT/US2015/016243 WO2015126860A1 (en) 2014-02-19 2015-02-18 Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones

Publications (2)

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CN106232120A CN106232120A (zh) 2016-12-14
CN106232120B true CN106232120B (zh) 2021-01-08

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US (1) US9388135B2 (enExample)
EP (1) EP3107542B1 (enExample)
JP (1) JP6549140B2 (enExample)
CN (1) CN106232120B (enExample)
ES (1) ES2739625T3 (enExample)
SG (1) SG11201606862VA (enExample)
WO (1) WO2015126860A1 (enExample)

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US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
MY160399A (en) 2009-07-06 2017-03-15 Aerpio Therapeutics Inc Compounds, compositions, and methods for preventing metastasis of cancer cells
CN102638983B (zh) 2009-11-06 2014-11-26 阿尔皮奥治疗学股份有限公司 用于治疗结肠炎的组合物和方法
US20130095065A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for Treating Vascular Leak Syndrome and Cancer
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
GB2516561B (en) 2013-03-15 2016-03-09 Aerpio Therapeutics Inc Compositions, formulations and methods for treating ocular diseases
US9539245B2 (en) 2014-08-07 2017-01-10 Aerpio Therapeutics, Inc. Combination of immunotherapies with activators of Tie-2

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US6930117B2 (en) 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
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ES2643469T3 (es) 2006-04-07 2017-11-23 Aerpio Therapeutics, Inc. Anticuerpos que se unen a la proteína tirosina fosfatasa beta humana (HPTP-beta) y usos de los mismos
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US7589212B2 (en) 2006-06-27 2009-09-15 Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US20130023542A1 (en) 2006-06-27 2013-01-24 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US8846685B2 (en) 2006-06-27 2014-09-30 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US7795444B2 (en) 2006-06-27 2010-09-14 Warner Chilcott Company Human protein tyrosine phosphatase inhibitors and methods of use
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US8883832B2 (en) 2009-07-06 2014-11-11 Aerpio Therapeutics Inc. Compounds, compositions, and methods for preventing metastasis of cancer cells
MY160399A (en) 2009-07-06 2017-03-15 Aerpio Therapeutics Inc Compounds, compositions, and methods for preventing metastasis of cancer cells
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ES2774972T3 (es) 2011-10-13 2020-07-23 Aerpio Therapeutics Inc Tratamiento de enfermedades oculares
US20130095065A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for Treating Vascular Leak Syndrome and Cancer
GB2516561B (en) 2013-03-15 2016-03-09 Aerpio Therapeutics Inc Compositions, formulations and methods for treating ocular diseases
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
CN102595896A (zh) * 2009-11-06 2012-07-18 阿尔皮奥治疗学股份有限公司 提高低氧诱导因子-1α的稳定性的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
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Also Published As

Publication number Publication date
US20150232425A1 (en) 2015-08-20
US9388135B2 (en) 2016-07-12
WO2015126860A1 (en) 2015-08-27
CN106232120A (zh) 2016-12-14
JP2017509608A (ja) 2017-04-06
EP3107542A4 (en) 2017-08-23
ES2739625T3 (es) 2020-02-03
SG11201606862VA (en) 2016-09-29
EP3107542A1 (en) 2016-12-28
JP6549140B2 (ja) 2019-07-24
EP3107542B1 (en) 2019-05-01

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