SG11201606862VA - Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones - Google Patents

Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones

Info

Publication number
SG11201606862VA
SG11201606862VA SG11201606862VA SG11201606862VA SG11201606862VA SG 11201606862V A SG11201606862V A SG 11201606862VA SG 11201606862V A SG11201606862V A SG 11201606862VA SG 11201606862V A SG11201606862V A SG 11201606862VA SG 11201606862V A SG11201606862V A SG 11201606862VA
Authority
SG
Singapore
Prior art keywords
pyridin
benzyl
hydroxy
ones
substituted
Prior art date
Application number
SG11201606862VA
Other languages
English (en)
Inventor
Dino Alberico
Craig Dixon
Boris Gorin
Jan Oudenes
Original Assignee
Aerpio Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerpio Therapeutics Inc filed Critical Aerpio Therapeutics Inc
Publication of SG11201606862VA publication Critical patent/SG11201606862VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201606862VA 2014-02-19 2015-02-18 Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones SG11201606862VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461941540P 2014-02-19 2014-02-19
PCT/US2015/016243 WO2015126860A1 (en) 2014-02-19 2015-02-18 Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones

Publications (1)

Publication Number Publication Date
SG11201606862VA true SG11201606862VA (en) 2016-09-29

Family

ID=53797499

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201606862VA SG11201606862VA (en) 2014-02-19 2015-02-18 Process for preparing n-benzyl-3-hydroxy-4-substituted-pyridin-2-(1h)-ones

Country Status (7)

Country Link
US (1) US9388135B2 (enExample)
EP (1) EP3107542B1 (enExample)
JP (1) JP6549140B2 (enExample)
CN (1) CN106232120B (enExample)
ES (1) ES2739625T3 (enExample)
SG (1) SG11201606862VA (enExample)
WO (1) WO2015126860A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
CN105412094A (zh) 2009-07-06 2016-03-23 爱尔皮奥治疗有限公司 用于防止癌细胞转移的化合物、组合物和方法
ES2424122T3 (es) 2009-11-06 2013-09-27 Aerpio Therapeutics Inc. Inhibidores de la prolilhidroxilasa
US20130095065A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for Treating Vascular Leak Syndrome and Cancer
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases
HK1206558A1 (en) 2013-03-15 2016-01-15 Aerpio Therapeutics Inc Compositions, formulations and methods for treating ocular diseases
WO2016022813A1 (en) 2014-08-07 2016-02-11 Aerpio Therapeutics, Inc. Combination of immunotherapies with activators of tie-2

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US7226755B1 (en) 2002-09-25 2007-06-05 The Procter & Gamble Company HPTPbeta as a target in treatment of angiogenesis mediated disorders
US7507568B2 (en) 2002-09-25 2009-03-24 The Proctor & Gamble Company Three dimensional coordinates of HPTPbeta
US6946479B2 (en) 2002-11-09 2005-09-20 The Procter & Gamble Company N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
US6930117B2 (en) 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
AU2007237096C1 (en) 2006-04-07 2012-12-13 EyePoint Pharmaceuticals, Inc. Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof
TWI394747B (zh) * 2006-06-23 2013-05-01 Smithkline Beecham Corp 脯胺醯基羥化酶抑制劑
EP2044005B8 (en) * 2006-06-26 2012-12-05 Warner Chilcott Company, LLC Prolyl hydroxylase inhibitors and methods of use
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US7589212B2 (en) 2006-06-27 2009-09-15 Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US20130023542A1 (en) 2006-06-27 2013-01-24 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US8846685B2 (en) 2006-06-27 2014-09-30 Aerpio Therapeutics Inc. Human protein tyrosine phosphatase inhibitors and methods of use
US7795444B2 (en) 2006-06-27 2010-09-14 Warner Chilcott Company Human protein tyrosine phosphatase inhibitors and methods of use
SG172312A1 (en) 2009-01-12 2011-07-28 Akebia Therapeutics Inc Methods for treating vascular leak syndrome
US9096555B2 (en) 2009-01-12 2015-08-04 Aerpio Therapeutics, Inc. Methods for treating vascular leak syndrome
CN105412094A (zh) 2009-07-06 2016-03-23 爱尔皮奥治疗有限公司 用于防止癌细胞转移的化合物、组合物和方法
US8883832B2 (en) 2009-07-06 2014-11-11 Aerpio Therapeutics Inc. Compounds, compositions, and methods for preventing metastasis of cancer cells
ES2424122T3 (es) 2009-11-06 2013-09-27 Aerpio Therapeutics Inc. Inhibidores de la prolilhidroxilasa
NZ610230A (en) 2010-10-07 2015-07-31 Aerpio Therapeutics Inc Compositions and methods for treating ocular edema, neovascularization and related diseases
CN107080843A (zh) 2011-10-13 2017-08-22 爱尔皮奥治疗有限公司 眼病的治疗
US20130095065A1 (en) 2011-10-13 2013-04-18 Aerpio Therapeutics, Inc. Methods for Treating Vascular Leak Syndrome and Cancer
HK1206558A1 (en) 2013-03-15 2016-01-15 Aerpio Therapeutics Inc Compositions, formulations and methods for treating ocular diseases
US20150050277A1 (en) 2013-03-15 2015-02-19 Aerpio Therapeutics Inc. Compositions and methods for treating ocular diseases

Also Published As

Publication number Publication date
US20150232425A1 (en) 2015-08-20
EP3107542A4 (en) 2017-08-23
CN106232120B (zh) 2021-01-08
WO2015126860A1 (en) 2015-08-27
JP2017509608A (ja) 2017-04-06
EP3107542B1 (en) 2019-05-01
EP3107542A1 (en) 2016-12-28
ES2739625T3 (es) 2020-02-03
US9388135B2 (en) 2016-07-12
CN106232120A (zh) 2016-12-14
JP6549140B2 (ja) 2019-07-24

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