CN106232107B - 用于抗孕激素的阴道递送的制剂和方法 - Google Patents

用于抗孕激素的阴道递送的制剂和方法 Download PDF

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Publication number
CN106232107B
CN106232107B CN201580022706.0A CN201580022706A CN106232107B CN 106232107 B CN106232107 B CN 106232107B CN 201580022706 A CN201580022706 A CN 201580022706A CN 106232107 B CN106232107 B CN 106232107B
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CN
China
Prior art keywords
pharmaceutical formulation
cdb
amount
present
pullulan
Prior art date
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Expired - Fee Related
Application number
CN201580022706.0A
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English (en)
Chinese (zh)
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CN106232107A (zh
Inventor
J.S.波多尔斯基
K.苏
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elastagen Pty Ltd
Original Assignee
Elastagen Pty Ltd
Repros Therapeutics Inc
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Application filed by Elastagen Pty Ltd, Repros Therapeutics Inc filed Critical Elastagen Pty Ltd
Priority to CN202010411810.1A priority Critical patent/CN111840246A/zh
Publication of CN106232107A publication Critical patent/CN106232107A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201580022706.0A 2014-05-05 2015-04-22 用于抗孕激素的阴道递送的制剂和方法 Expired - Fee Related CN106232107B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010411810.1A CN111840246A (zh) 2014-05-05 2015-04-22 用于抗孕激素的阴道递送的制剂和方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461988766P 2014-05-05 2014-05-05
US61/988766 2014-05-05
PCT/US2015/027122 WO2015171319A1 (en) 2014-05-05 2015-04-22 Formulations and methods for vaginal delivery of antiprogestins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202010411810.1A Division CN111840246A (zh) 2014-05-05 2015-04-22 用于抗孕激素的阴道递送的制剂和方法

Publications (2)

Publication Number Publication Date
CN106232107A CN106232107A (zh) 2016-12-14
CN106232107B true CN106232107B (zh) 2020-06-05

Family

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Family Applications (2)

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CN202010411810.1A Pending CN111840246A (zh) 2014-05-05 2015-04-22 用于抗孕激素的阴道递送的制剂和方法
CN201580022706.0A Expired - Fee Related CN106232107B (zh) 2014-05-05 2015-04-22 用于抗孕激素的阴道递送的制剂和方法

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CN202010411810.1A Pending CN111840246A (zh) 2014-05-05 2015-04-22 用于抗孕激素的阴道递送的制剂和方法

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Country Link
US (3) US10064815B2 (enExample)
EP (1) EP3139908A4 (enExample)
JP (2) JP6591447B2 (enExample)
CN (2) CN111840246A (enExample)
AU (1) AU2015256473B2 (enExample)
CA (1) CA2948287A1 (enExample)
IL (1) IL248621B (enExample)
MX (2) MX384159B (enExample)
WO (1) WO2015171319A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020516653A (ja) * 2017-04-14 2020-06-11 カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップＣａｐｓｕｇｅｌ Ｂｅｌｇｉｕｍ ＮＶ プルランカプセル
US10857151B1 (en) 2020-02-21 2020-12-08 Villya LLC Treatment of female genital schistosomiasis
US20220047506A1 (en) 2020-08-12 2022-02-17 Villya LLC Praziquantel Formulations
WO2024158694A1 (en) 2023-01-23 2024-08-02 Villya LLC Compositions and methods for improving the solubility of erectile dysfunction therapeutics
EP4417192A1 (en) 2023-02-17 2024-08-21 meliodys medical UG Medical device, kit, method, and anti-inflammatory substance

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013181449A1 (en) * 2012-05-31 2013-12-05 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070516A1 (en) * 1997-10-28 2005-03-31 Vivus Inc. As-needed administration of an androgenic agent to enhance female desire and responsiveness
AU2002329842B2 (en) * 2001-08-29 2006-09-14 Umd, Inc. Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy
US7417013B2 (en) * 2002-05-01 2008-08-26 Mcneil-Ppc, Inc. Warming and nonirritating lubricant compositions and method of comparing irritation
EP1593376A1 (en) * 2004-05-04 2005-11-09 Warner-Lambert Company LLC Improved pullulan capsules
WO2007103510A2 (en) * 2006-03-08 2007-09-13 Danco Laboratories Llc Methods, dosing regimens & medications using anti-progestational agents for the treatment of disorders
CA2682752C (en) * 2007-04-05 2015-07-07 University Of Kansas Rapidly dissolving pharmaceutical compositions comprising pullulan
MX2010004789A (es) * 2007-11-02 2010-07-05 Acrux Dds Pty Ltd Sistema de liberacion transdermica para hormonas y esteroides.
PH12012501812A1 (en) * 2010-03-22 2012-12-10 Allergan Pharmaceuticals Int Ltd Compositions and methods for non-toxic delivery of antiprogestins
UA113283C2 (xx) * 2010-12-23 2017-01-10 19-норстероїди і їх застосування для лікування прогестеронзалежних станів
RS62297B1 (sr) * 2011-11-23 2021-09-30 Therapeuticsmd Inc Prirodne kombinovane hormonske supstitucione formulacije i terapije

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013181449A1 (en) * 2012-05-31 2013-12-05 Repros Therapeutics Inc. Formulations and methods for vaginal delivery of antiprogestins

Also Published As

Publication number Publication date
IL248621A0 (en) 2017-01-31
EP3139908A4 (en) 2018-05-16
HK1232125A1 (zh) 2018-01-05
WO2015171319A1 (en) 2015-11-12
US10064815B2 (en) 2018-09-04
CA2948287A1 (en) 2015-11-12
US20200222315A1 (en) 2020-07-16
AU2015256473B2 (en) 2018-07-12
JP2017514851A (ja) 2017-06-08
MX2020005921A (es) 2020-08-20
JP6591447B2 (ja) 2019-10-16
EP3139908A1 (en) 2017-03-15
CN106232107A (zh) 2016-12-14
MX384159B (es) 2025-03-14
JP2019194271A (ja) 2019-11-07
AU2015256473A1 (en) 2016-11-17
IL248621B (en) 2020-09-30
CN111840246A (zh) 2020-10-30
US20180325810A1 (en) 2018-11-15
US20170181965A1 (en) 2017-06-29
US10555900B2 (en) 2020-02-11
MX2016014256A (es) 2017-02-06
JP6796693B2 (ja) 2020-12-09

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