CN106215079A - A kind of Chinese medicine composition treating hyperosteogeny - Google Patents

A kind of Chinese medicine composition treating hyperosteogeny Download PDF

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Publication number
CN106215079A
CN106215079A CN201610562294.6A CN201610562294A CN106215079A CN 106215079 A CN106215079 A CN 106215079A CN 201610562294 A CN201610562294 A CN 201610562294A CN 106215079 A CN106215079 A CN 106215079A
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parts
radix
ramulus
chinese medicine
marsili
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王恩禄
王芳
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
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Abstract

The present invention relates to a kind of Chinese medicine composition treating hyperosteogeny, it comprises the material of following weight portion: external preparation: red 20 parts of old monarch, cartilage Ramulus et Folium Mussaendae Pubescentis 25 parts, Radix seu Caulis Kadsurae Heteroclitae 15 parts, Olibanum 10 parts, blood phoenix grass 15 parts, Myrrha 10 parts, viscous fragrant skin 10 parts, Herba Lycopodii 15 parts, Firmiana platanifolia (Linn. f.) Marsili 10 parts, Ramulus et folium taxi cuspidatae 20 parts, pale reddish brown Firmiana platanifolia (Linn. f.) Marsili 10 parts and Radix Arnebiae (Radix Lithospermi) 10 parts；Oral preparations: Caulis seu Radix Schisandrae Henryi 25 parts, Radix Angelicae Sinensis 25 parts, Lignum Sappan 10 parts, Ramulus Uncariae Cum Uncis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Paridis 10 parts, Radix Dipsaci 10 parts, red 10 parts of old monarch, Rhizoma Corydalis 10 parts, 10 parts of Semen Persicae, Ramulus et Folium Mussaendae Pubescentis 10 parts, 6 parts of Radix Glycyrrhizae and Radix Achyranthis Bidentatae 10 parts.

Description

A kind of Chinese medicine composition treating hyperosteogeny
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Chinese medicine composition treating hyperosteogeny.
Background technology
Hyperosteogeny is also known as Hypertrophic osteoarthritis, and including constitutional and Secondary cases, the most idiopathic Basic disease cause is, The most aging and degeneration after people's body maturation, the performance in terms of osteoarthrosis；Secondary cases refers to because of certain known reason, such as Wound, operation or other obvious factors and the cartilage destruction that causes, or articulation structure changes.Due to articular surface friction or pressure not The factors such as balance, cause the degeneration of articular surface.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating hyperosteogeny.
In order to realize the purpose of the present invention, the present invention provides a kind of Chinese medicine composition treating hyperosteogeny, under it comprises The material of row weight portion:
External preparation: red 20 parts of old monarch, cartilage Ramulus et Folium Mussaendae Pubescentis 25 parts, Radix seu Caulis Kadsurae Heteroclitae 15 parts, Olibanum 10 parts, blood phoenix grass 15 parts, do not have Medicine 10 parts, viscous fragrant skin 10 parts, Herba Lycopodii 15 parts, Firmiana platanifolia (Linn. f.) Marsili 10 parts, Ramulus et folium taxi cuspidatae 20 parts, pale reddish brown Firmiana platanifolia (Linn. f.) Marsili 10 parts and Radix Arnebiae (Radix Lithospermi) 10 parts；
Oral preparations: Caulis seu Radix Schisandrae Henryi 25 parts, Radix Angelicae Sinensis 25 parts, Lignum Sappan 10 parts, Ramulus Uncariae Cum Uncis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Paridis 10 parts, Radix Dipsaci 10 Part, red 10 parts of old monarch, Rhizoma Corydalis 10 parts, 10 parts of Semen Persicae, Ramulus et Folium Mussaendae Pubescentis 10 parts, 6 parts of Radix Glycyrrhizae and Radix Achyranthis Bidentatae 10 parts.
Preferably, the Chinese medicine composition for the treatment of hyperosteogeny of the present invention comprises the material of following weight portion: 0.2 part The material with following structural:
The present invention also provide for the material with following structural preparation treatment hyperosteogeny medicine in purposes:
Medicine of the present invention has liver-kidney tonifying, promoting blood circulation and stopping pain, effect of the solid bone of strong muscle, can effectively treat hyperosteogeny.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention Claimed scope.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment 1
External preparation: red 20 grams of old monarch, cartilage Ramulus et Folium Mussaendae Pubescentis 25 grams, Radix seu Caulis Kadsurae Heteroclitae 15 grams, Olibanum 10 grams, blood phoenix grass 15 grams, do not have Medicine 10 grams, viscous fragrant skin 10 grams, Herba Lycopodii 15 grams, Firmiana platanifolia (Linn. f.) Marsili 10 grams, Ramulus et folium taxi cuspidatae 20 grams, pale reddish brown Firmiana platanifolia (Linn. f.) Marsili 10 grams and Radix Arnebiae (Radix Lithospermi) 10 grams, pulverize, Crossing 100 mesh sieves, mix homogeneously obtains powder.
Oral preparations: Caulis seu Radix Schisandrae Henryi 25 grams, Radix Angelicae Sinensis 25 grams, Lignum Sappan 10 grams, Ramulus Uncariae Cum Uncis 10 grams, Radix Salviae Miltiorrhizae 10 grams, Rhizoma Paridis 10 grams, Radix Dipsaci 10 Gram, red 10 grams of old monarch, Rhizoma Corydalis 10 grams, 10 grams of Semen Persicae, Ramulus et Folium Mussaendae Pubescentis 10 grams, 6 grams of Radix Glycyrrhizae and Radix Achyranthis Bidentatae 10 grams, pulverize, cross 100 mesh sieves, Mix homogeneously obtains powder.
Embodiment 2
Compound has a following structural:
Experimental example
Age in August SPF level Healthy female SD rat 40, body weight (350 ± 10) g.II Collagen Type VI, complete Freund's adjuvant are (beautiful Sigma company of state produces)；Rat IL-1 β enzyme-linked immunologic detecting kit (production of R&D company of the U.S.).
It is divided into blank group 10, model group 10, embodiment 2 compound group 10 and methotrexate group 10.Take II type Collagen protein is dissolved in 0.1mol/L acetic acid, is made into the solution that concentration is 2mg/mL, and 4 DEG C overnight.Next day helps with complete Freund Agent makes emulsion with 1: 1 volume mixture.Repeatedly aspirate with syringe, until mixture is complete, fully emulsified, drip with emulsion Entering in water the loosest, one-tenth drop-wise floats on water and is that emulsifying is complete.Take the collagen-induced property rheumatoid arthritis model after emulsifying (CIA) modeling agent, in addition to blank group, after carrying out disinfection rat root of the tail portion, back, right metapedes toes portion with 75% ethanol, presses 0.4mL/, only in upper 3 intradermal injections, sees circular skin mound and is swollen with, for injecting successfully.After modeling the 7th day with same method 3 point Booster injection 1 time.After booster injection, rat foot claw serious swelling, articulatio talocruralis diameter increasing degree >=12mm, rear solid end volume increase Amplitude >=0.80mL is modeling success.
Within after modeling the 14th day, rise and start to be administered.Model group: give normal saline gavage 1mL/1000g body weight；Embodiment 2 is changed The compound of compound group: 0.05g adds 1000mL normal saline and becomes suspension, gives gavage 1mL/1000g body weight；Positive drug The methotrexate of methotrexate group: 0.05g adds 1000mL normal saline and becomes suspension, gives gavage 1mL/1000g body weight. Equal every day 1 time, successive administration 21d above.
By rat after intraperitoneal anesthesia, femoral artery takes blood about 4mL, is centrifuged 20min with 3000r/min, draws serum standby With, by rat blood serum IL-1 β.It is measured according to the method for the requirement of detection kit.
Using SPSS15.0 statistical package that every detection data carry out variance analysis, all analytical data results are all adopted By mean ± standard deviationRepresenting, P ＜ 0.05, for there are differences, has statistical significance.
Each group of rat blood serum IL-1 β is affected change compare (ng/L,) see table
Compare with blank group, * P ＜ 0.05；Compare with model group, #P ＜ 0.05；Compare with positive drug group, Δ P ＜ 0.05.
Originally test result indicate that, medicine of the present invention can effectively alleviate the swelling degree in RA joint, hence it is evident that reduces IL-1 β's Content, thus block inflammatory reaction, improve function of joint, delay the process of RA, alleviate the destruction of RA.Medicine of the present invention is described Thing has obvious therapeutic action to RA.

Claims (3)

1. the Chinese medicine composition treating hyperosteogeny, it is characterised in that it comprises the material of following weight portion:
External preparation: red 20 parts of old monarch, cartilage Ramulus et Folium Mussaendae Pubescentis 25 parts, Radix seu Caulis Kadsurae Heteroclitae 15 parts, Olibanum 10 parts, blood phoenix grass 15 parts, Myrrha 10 Part, viscous fragrant skin 10 parts, Herba Lycopodii 15 parts, Firmiana platanifolia (Linn. f.) Marsili 10 parts, Ramulus et folium taxi cuspidatae 20 parts, pale reddish brown Firmiana platanifolia (Linn. f.) Marsili 10 parts and Radix Arnebiae (Radix Lithospermi) 10 parts；
Oral preparations: Caulis seu Radix Schisandrae Henryi 25 parts, Radix Angelicae Sinensis 25 parts, Lignum Sappan 10 parts, Ramulus Uncariae Cum Uncis 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Paridis 10 parts, Radix Dipsaci 10 parts, Red 10 parts of old monarch, Rhizoma Corydalis 10 parts, 10 parts of Semen Persicae, Ramulus et Folium Mussaendae Pubescentis 10 parts, 6 parts of Radix Glycyrrhizae and Radix Achyranthis Bidentatae 10 parts.
The Chinese medicine composition for the treatment of hyperosteogeny the most according to claim 1, it is characterised in that it comprises following weight portion Material: the material with following structural of 0.2 part:
3. there is the material of the following structural purposes in the medicine of preparation treatment hyperosteogeny:
CN201610562294.6A 2016-07-18 2016-07-18 A kind of Chinese medicine composition treating hyperosteogeny Pending CN106215079A (en)

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1091649A (en) * 1993-08-04 1994-09-07 付云辉 Stasis reducing liquor
CN1275402A (en) * 1999-11-30 2000-12-06 王福伟 Powder medicine for treating hyperosteogeny
CN1331983A (en) * 2001-03-13 2002-01-23 曲丽萍 Hyperosteogeny treating medicine
CN1459293A (en) * 2002-05-20 2003-12-03 焦青山 Traditional Chinese medicine for treating prolapse of lumbar intervertebral disc and osteoproliferation
CN101185672A (en) * 2007-12-19 2008-05-28 崔月清 Orally-administered traditional Chinese medicine decoction for treating lumbar hyperosteogeny
CN104547034A (en) * 2014-12-30 2015-04-29 曲成明 Traditional Chinese medicinal preparation for treating hyperosteogeny and method for preparing preparation
CN106038562A (en) * 2016-07-18 2016-10-26 郝红娟 Medicine for treating rheumatoid arthritis
CN106038557A (en) * 2016-07-18 2016-10-26 李振芳 Medicine for treating rheumatoid arthritis
CN106075347A (en) * 2016-07-18 2016-11-09 王明亮 One treats cervical and lumbar diseases and arthritic external application Chinese medicine unguentum
CN107158093A (en) * 2017-07-20 2017-09-15 东阳市人民医院 A kind of external application hot compress preparation for treating lumbar vertebrae hyperosteogeny

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1091649A (en) * 1993-08-04 1994-09-07 付云辉 Stasis reducing liquor
CN1275402A (en) * 1999-11-30 2000-12-06 王福伟 Powder medicine for treating hyperosteogeny
CN1331983A (en) * 2001-03-13 2002-01-23 曲丽萍 Hyperosteogeny treating medicine
CN1459293A (en) * 2002-05-20 2003-12-03 焦青山 Traditional Chinese medicine for treating prolapse of lumbar intervertebral disc and osteoproliferation
CN101185672A (en) * 2007-12-19 2008-05-28 崔月清 Orally-administered traditional Chinese medicine decoction for treating lumbar hyperosteogeny
CN104547034A (en) * 2014-12-30 2015-04-29 曲成明 Traditional Chinese medicinal preparation for treating hyperosteogeny and method for preparing preparation
CN106038562A (en) * 2016-07-18 2016-10-26 郝红娟 Medicine for treating rheumatoid arthritis
CN106038557A (en) * 2016-07-18 2016-10-26 李振芳 Medicine for treating rheumatoid arthritis
CN106075347A (en) * 2016-07-18 2016-11-09 王明亮 One treats cervical and lumbar diseases and arthritic external application Chinese medicine unguentum
CN107158093A (en) * 2017-07-20 2017-09-15 东阳市人民医院 A kind of external application hot compress preparation for treating lumbar vertebrae hyperosteogeny

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