CN106075347A - One treats cervical and lumbar diseases and arthritic external application Chinese medicine unguentum - Google Patents
One treats cervical and lumbar diseases and arthritic external application Chinese medicine unguentum Download PDFInfo
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- CN106075347A CN106075347A CN201610562292.7A CN201610562292A CN106075347A CN 106075347 A CN106075347 A CN 106075347A CN 201610562292 A CN201610562292 A CN 201610562292A CN 106075347 A CN106075347 A CN 106075347A
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Abstract
nullThe present invention relates to one and treat cervical and lumbar diseases and arthritic external application Chinese medicine unguentum，It comprises the material of following weight portion: Semen Strychni 30 50 parts、Rhizoma Arisaematis 30 50 parts、Rhizoma Pinelliae 30 50 parts、Radix Aconiti 30 50 parts、Radix Aconiti Kusnezoffii 30 50 parts、Cortex Cinnamomi 5 10 parts、Rhizoma Zingiberis 5 10 parts、The Radix Angelicae Dahuricae 5 10 parts、Radix Clematidis 10 30 parts、Rhizoma Kaempferiae 5 10 parts、Rhizoma Chuanxiong 5 10 parts、Fructus Evodiae 10 30 parts、Herba Asari 10 30 parts、10 30 parts of Herba Ephedrae、Semen Sinapis Albae 30 50 parts、Herba speranskiae tuberculatae 50 100 parts、Radix Angelicae Sinensis 10 30 parts、5 10 parts of Flos Carthami、Eupolyphaga 5 10 parts、Fructus Gleditsia 5 10 parts、Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 5 10 parts、Rhizoma Et Radix Notopterygii 5 10 parts、Pollen Tyjphae 30 50 parts、Olibanum 5 10 parts、Myrrha 5 10 parts、Camphora 35 parts、Borneolum Syntheticum 35 parts、0.3 1 parts of Moschus and Sanguis Draxonis 35 parts.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to one and treat cervical and lumbar diseases and arthritic Chinese medicine lotion for external use
Agent.
Background technology
Cervical and lumbar diseases is the commonly encountered diseases of middle-aged and elderly people, high morbidity.Doctor trained in Western medicine thinks that this disease is due to human body undue force or negative
Carry overweight and strain, cause annulus fibrosus disci intervertebralis to rupture and Nucleus pulposus；Or the asthenia because person in middle and old age suffer from a deficiency of the kidney, intervertebral disc is elastic
Reduce, degenerate and bulging.Prominent or the portion extrusion spinal cord dural sac of bulging or nerve root and produce stimulation, make blood flow occur
Obstacle, causes tissue ischemia, anoxia, metabolism alluvial swelling and fall ill.This disease can cause lumbago or cervicodynia, numb limbs and tense tendons, aching and tired,
The symptoms such as walking disorder.As long as therefore ensureing inflammation and the nerve root relaxing muscles and tendons to promote blood circulation of edema, diminishing inflammation, can pain relieving health
Multiple.At present, doctor trained in Western medicine generally uses hot packing, draws, beats the methods such as anesthesia needle and treat this disease, but these means can only alleviate or
Postpone slight illness, it is impossible to efficient solution removes swelling and the pain in affected part, and therapeutic effect is inconspicuous.Above-mentioned invalid patient is typically adopted
Treat with operation method, although instant effect, but exist risk greatly, costly, that patient is subjected to bigger operation is painful.
The traditional Chinese medical science thinks that primary disease belongs to " lumbago ", " rheumatism involving the bone ", the category of " arthromyodynia ", and it is pathogenic inherent bar that vim and vigour battalion defends interior-deficiency
Part, the damp and hot outer extrinsic factor being to cause numbness of attacking of wind and cold, the retardance of meridians vim and vigour is then the main pathogenesis of arthromyodynia；It addition, painstaking excessive,
Kidney qi loss, the condensation of wind-cold damp pathogen, blood stasis, numbness resistance meridians etc. also can cause hyperosteogeny.Therefore, treatment should follow conditioning
QI and blood meridian, temperature dissipate the rules such as blood stasis dispelling, reducing swelling and alleviating pain, activating blood and removing stasis, softening eliminating stagnation, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, respectively manage with it；Make through being so incensed that
With smooth and easy, QI and blood is in harmonious proportion its pain from only.
Summary of the invention
It is an object of the invention to provide one and treat cervical and lumbar diseases and arthritic external application Chinese medicine unguentum.
In order to realize the purpose of the present invention, the present invention provides one to treat cervical and lumbar diseases and arthritic Chinese medicine lotion for external use
Agent, it comprises the material of following weight portion: Semen Strychni 30-50 part, Rhizoma Arisaematis 30-50 part, Rhizoma Pinelliae 30-50 part, Radix Aconiti
30-50 part, Radix Aconiti Kusnezoffii 30-50 part, Cortex Cinnamomi 5-10 part, Rhizoma Zingiberis 5-10 part, Radix Angelicae Dahuricae 5-10 part, Radix Clematidis 10-30 part, Rhizoma Kaempferiae 5-10
Part, Rhizoma Chuanxiong 5-10 part, Fructus Evodiae 10-30 part, Herba Asari 10-30 part, Herba Ephedrae 10-30 part, Semen Sinapis Albae 30-50 part, Herba speranskiae tuberculatae 50-
100 parts, Radix Angelicae Sinensis 10-30 part, Flos Carthami 5-10 part, eupolyphaga 5-10 part, Fructus Gleditsia 5-10 part, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 5-10 part, Rhizoma Et Radix Notopterygii 5-10 part, raw Pu
Yellow 30-50 part, Olibanum 5-10 part, Myrrha 5-10 part, Camphora 3-5 part, Borneolum Syntheticum 3-5 part, Moschus 0.3-1 part and Sanguis Draxonis 3-5 part.
Preferably, treatment cervical and lumbar diseases of the present invention and arthritic external application Chinese medicine unguentum comprise following weight portion
Material: Semen Strychni 40 parts, Rhizoma Arisaematis 40 parts, Rhizoma Pinelliae 40 parts, Radix Aconiti 40 parts, Radix Aconiti Kusnezoffii 40 parts, Cortex Cinnamomi 8 parts, Rhizoma Zingiberis 8
Part, the Radix Angelicae Dahuricae 8 parts, Radix Clematidis 20 parts, Rhizoma Kaempferiae 8 parts, Rhizoma Chuanxiong 8 parts, Fructus Evodiae 20 parts, Herba Asari 20 parts, 20 parts of Herba Ephedrae, Semen Sinapis Albae 40
Part, Herba speranskiae tuberculatae 80 parts, Radix Angelicae Sinensis 20 parts, 8 parts of Flos Carthami, eupolyphaga 8 parts, Fructus Gleditsia 8 parts, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 8 parts, Rhizoma Et Radix Notopterygii 8 parts, Pollen Tyjphae 40 parts, breast
Fragrant 8 parts, Myrrha 8 parts, Camphora 4 parts, Borneolum Syntheticum 4 parts, 0.5 part of Moschus and Sanguis Draxonis 4 parts.
It is highly preferred that treatment cervical and lumbar diseases of the present invention and arthritic external application Chinese medicine unguentum also comprise: 0.5 part
There is the material of following structural:
The present invention also provides for the material with following structural in preparation treatment cervical and lumbar diseases and arthritic medicine
Purposes:
Preferably, described medicine can be lotion, ointment or powder.
Medicine of the present invention has blood circulation promoting and blood stasis dispelling, expelling wind and cold, promoting the circulation of QI to relieve pain, invigorating the kidney and strengthening the bones, stimulate the menstrual flow only numbness, treating both the principal and secondary aspects of a disease etc.
Effect.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustrating
The present invention rather than limitation of the present invention.The simple modifications that the present invention is carried out by the essence according to the present invention broadly falls into the present invention
Claimed scope.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment 1
Weigh Semen Strychni 40 grams, Rhizoma Arisaematis 40 grams, Rhizoma Pinelliae 40 grams, Radix Aconiti 40 grams, Radix Aconiti Kusnezoffii 40 grams, Cortex Cinnamomi 8 grams,
Rhizoma Zingiberis 8 grams, the Radix Angelicae Dahuricae 8 grams, Radix Clematidis 20 grams, Rhizoma Kaempferiae 8 grams, Rhizoma Chuanxiong 8 grams, Fructus Evodiae 20 grams, Herba Asari 20 grams, 20 grams of Herba Ephedrae, Caulis et Folium Sinapis albee
Son 40 grams, Herba speranskiae tuberculatae 80 grams, Radix Angelicae Sinensis 20 grams, 8 grams of Flos Carthami, eupolyphaga 8 grams, Fructus Gleditsia 8 grams, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 8 grams, Rhizoma Et Radix Notopterygii 8 grams, Pollen Tyjphae 40
Gram, Olibanum 8 grams, Myrrha 8 grams, Camphora 4 grams, Borneolum Syntheticum 4 grams, 0.5 gram of Moschus and Sanguis Draxonis 4 grams, pulverize, cross 100 mesh sieves, add Pilus Caprae seu Ovis
200 grams of fat, stirs and i.e. obtains ointment.
Embodiment 2
Compound has a following structural:
Weigh Compound 1 gram, adds lanoline 200 grams, stirs and i.e. obtain ointment.
Experimental example
Age in August SPF level Healthy female SD rat 50, body weight (350 ± 10) g.II Collagen Type VI, complete Freund's adjuvant are (beautiful
Sigma company of state produces)；Rat TNF-α enzyme-linked immunologic detecting kit (production of R&D company of the U.S.).
It is divided into blank group 10, model group 10, embodiment 1 ointment group 10, embodiment 2 ointment group 10 and right
According to medicine methotrexate group 10.Take II collagen type to be dissolved in 0.1mol/L acetic acid, be made into the solution that concentration is 2mg/mL,
4 DEG C overnight.Next day and complete Freund's adjuvant make emulsion with 1: 1 volume mixture.Repeatedly aspirate with syringe, until mixture
Completely, fully emulsified, instill in water the loosest with emulsion, become drop-wise to float on water and be that emulsifying is complete.Take the collagen after emulsifying
Inductivity rheumatoid arthritis model (CIA) modeling agent, in addition to blank group, with 75% ethanol to rat root of the tail portion, back, the right side after
After whole toe carries out disinfection, by 0.4mL/ only in upper 3 intradermal injections, see circular skin mound and be swollen with, for injecting successfully.Modeling
Latter 7th day with 3 booster injection of same method 1 time.After booster injection, rat foot claw serious swelling, articulatio talocruralis diameter increase width
Degree >=12mm, rear solid end volume increasing degree >=0.80mL are modeling success.
Within after modeling the 14th day, rise and start to be administered.Model group: give normal saline gavage 1mL/1000g body weight；Embodiment 1 is soft
Unguentum group: 2 grams of ointment uniform application are at arthroncus；Embodiment 2 ointment group: 2 grams of ointment uniform application are in joint
At swelling；Positive drug methotrexate group: the methotrexate of 0.05g adds 1000mL normal saline and becomes suspension, gives gavage
1mL/1000g body weight.Equal every day 1 time, successive administration 21d above.
By rat after intraperitoneal anesthesia, femoral artery takes blood about 4mL, is centrifuged 20min with 3000r/min, draws serum standby
With, rat blood serum TNF-α is measured according to the method for the requirement of detection kit.
Using SPSS15.0 statistical package that every detection data carry out variance analysis, all analytical data results are all adopted
By mean ± standard deviationRepresenting, P ＜ 0.05, for there are differences, has statistical significance.
Each group of rat blood serum TNF-α is affected change compareSee table
Compare with blank group, * P ＜ 0.05；Compare with model group, #P ＜ 0.05；Compare with positive drug group, Δ P ＜ 0.05.
Originally test result indicate that, medicine of the present invention can effectively alleviate the swelling degree in RA joint, hence it is evident that reduces TNF-α
Content, thus block inflammatory reaction, improve function of joint, delay the process of RA, alleviate the destruction of RA.Medicine of the present invention is described
Thing has obvious therapeutic action to RA, provides the experimentation evidence of science for clinical practice.
Claims (5)
1. a treatment cervical and lumbar diseases and arthritic external application Chinese medicine unguentum, it is characterised in that it comprises the thing of following weight portion
Matter: Semen Strychni 30-50 part, Rhizoma Arisaematis 30-50 part, Rhizoma Pinelliae 30-50 part, Radix Aconiti 30-50 part, Radix Aconiti Kusnezoffii 30-50 part, meat
Osmanthus 5-10 part, Rhizoma Zingiberis 5-10 part, Radix Angelicae Dahuricae 5-10 part, Radix Clematidis 10-30 part, Rhizoma Kaempferiae 5-10 part, Rhizoma Chuanxiong 5-10 part, Fructus Evodiae 10-
30 parts, Herba Asari 10-30 part, Herba Ephedrae 10-30 part, Semen Sinapis Albae 30-50 part, Herba speranskiae tuberculatae 50-100 part, Radix Angelicae Sinensis 10-30 part, Flos Carthami 5-
10 parts, eupolyphaga 5-10 part, Fructus Gleditsia 5-10 part, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 5-10 part, Rhizoma Et Radix Notopterygii 5-10 part, Pollen Tyjphae 30-50 part, Olibanum 5-10 part, do not have
Medicine 5-10 part, Camphora 3-5 part, Borneolum Syntheticum 3-5 part, Moschus 0.3-1 part and Sanguis Draxonis 3-5 part.
Treatment cervical and lumbar diseases the most according to claim 1 and arthritic external application Chinese medicine unguentum, it is characterised in that it comprises
The material of following weight portion: Semen Strychni 40 parts, Rhizoma Arisaematis 40 parts, Rhizoma Pinelliae 40 parts, Radix Aconiti 40 parts, Radix Aconiti Kusnezoffii 40 parts, meat
8 parts of osmanthus, Rhizoma Zingiberis 8 parts, the Radix Angelicae Dahuricae 8 parts, Radix Clematidis 20 parts, Rhizoma Kaempferiae 8 parts, Rhizoma Chuanxiong 8 parts, Fructus Evodiae 20 parts, Herba Asari 20 parts, Herba Ephedrae 20
Part, Semen Sinapis Albae 40 parts, Herba speranskiae tuberculatae 80 parts, Radix Angelicae Sinensis 20 parts, 8 parts of Flos Carthami, eupolyphaga 8 parts, Fructus Gleditsia 8 parts, Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 8 parts, Rhizoma Et Radix Notopterygii 8 parts, life
Pollen Typhae 40 parts, Olibanum 8 parts, Myrrha 8 parts, Camphora 4 parts, Borneolum Syntheticum 4 parts, 0.5 part of Moschus and Sanguis Draxonis 4 parts.
Treatment cervical and lumbar diseases the most according to claim 2 and arthritic external application Chinese medicine unguentum, it is characterised in that it also wraps
Contain: the material with following structural of 0.5 part:
4. the material with following structural is preparing the purposes treated in cervical and lumbar diseases and arthritic medicine:
Purposes the most according to claim 4, it is characterised in that described medicine can be lotion, ointment or powder.
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| CN106215079A (en) * | 2016-07-18 | 2016-12-14 | 王恩禄 | A kind of Chinese medicine composition treating hyperosteogeny |
| CN112618689A (en) * | 2021-01-05 | 2021-04-09 | 顿善淼 | External application medicament for quickly treating cervical vertebra, lumbar vertebra and arthritis |
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| CN101417051A (en) * | 2007-10-26 | 2009-04-29 | 魏先刚 | External collateral dredging bone strengthening looses |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215079A (en) * | 2016-07-18 | 2016-12-14 | 王恩禄 | A kind of Chinese medicine composition treating hyperosteogeny |
| CN112618689A (en) * | 2021-01-05 | 2021-04-09 | 顿善淼 | External application medicament for quickly treating cervical vertebra, lumbar vertebra and arthritis |
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