CN106215028A - One is used for treating albuminuretic Chinese medicine preparation - Google Patents
One is used for treating albuminuretic Chinese medicine preparation Download PDFInfo
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- CN106215028A CN106215028A CN201610209634.7A CN201610209634A CN106215028A CN 106215028 A CN106215028 A CN 106215028A CN 201610209634 A CN201610209634 A CN 201610209634A CN 106215028 A CN106215028 A CN 106215028A
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- 229940079593 drug Drugs 0.000 claims abstract description 25
- 241000756943 Codonopsis Species 0.000 claims abstract description 8
- 239000009636 Huang Qi Substances 0.000 claims abstract description 8
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Abstract
One is used for treating albuminuretic Chinese medicine preparation, it is characterized in that, be made up of the crude drug of following weight: Radix Puerariae 14 16g, the Radix Astragali 9 11g, Periostracum Cicadae 4 6g, Herba Hedyotidis Diffusae 7 9g, Semen Coicis 14 16g, Semen Euryales 11 13g, Rhizoma dioscoreae 11 13g, Radix Codonopsis 9 11g, Radix Rehmanniae Preparata 14 16g, Cortex Sclerotii Poriae 11 13g, Semen Cuscutae 11 13g, Fructus Psoraleae 11 13g, Cortex Mori 14 16g, Radix Achyranthis Bidentatae 8 10g, Semen Plantaginis 14 16g, Ramulus Cinnamomi 8 10g, Pericarpium Citri Reticulatae 11 13g, Pericarpium Arecae 14 16g.The present invention combines clinical practice for many years on the basis of Traditional Chinese Medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and develops, and has that determined curative effect, instant effect, cure rate be high and the feature such as have no side effect.
Description
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of for treating albuminuretic Chinese medicine preparation.
Background technology
Due to filtration and the Reabsorption of renal tubules of glomerular filtration membrane, in healthy human urine, protein (refers to more
The protein of molecular weight) content seldom (every daily output is less than 150mg), during protein qualitative examination, be negative anti-
Should.When protein content increases in urine, and common routine urianlysis can be measured, claim albuminuria.If urine protein content >=3.5g/
24h, the most referred to as High-grade Proteinuria.Albuminuria is the cardinal symptom of chronic kidney disease, is also the major reason of nephropathy progress.
The albuminuretic method of Current therapeutic has the most several:
1. hormone therapy or hormons immunosuppressant treatment；
2. use RAS to block (including ACEI and ARB) treatment；
3. use NSAIDs Drug therapy；
The hormone therapy using first method may cause infecting, and blood glucose raises, metabolism disorder of blood lipid, protein catabolism
Increase, electrolyte disturbance, osteoporosis, digestive tract hemorrhage, a large amount of side effect such as psychological problem.Combined immunization inhibitor adds
Bone marrow transplantation, liver function injury, alopecia, reproductive dysfunction, the side effect such as tumor generation.
The RAS blocker using second method reduces blood pressure, and may cause acute injury of kidney, blood potassium may be caused to raise,
ACEI may cause cough to occur.
Use the NSAIDs Drug therapy of the third method, renal blood flow may be reduced, increase the weight of renal interstitial infringement, cause kidney merit
Energy exhaustion, causes digestive tract hemorrhage.
Theory of Chinese medical science is thought, albuminuretic leakage is deficiency of YIN-essence, and cloudy smart sealing up for safekeeping and metaplasia, predominantly kidney spleen is led, spleen
Deficiency of the kidney void is this.In lysis, produced water poison wet, evil, blood stasis etc. are mark.Pathologic feature is deficiency in origin and excess in superficiality, and deficiency and excess is pressed from both sides
Miscellaneous.Chinese traditional treatment albuminuria is from entirety, therefore how to hold back essence spermatogenesis with supplementing the kidney to control the nocturnal replenishing essence, spleen invigorating clinically and effect a permanent cure, in order to
Water, toxic removing, blood stasis dispelling take stopgap measures as base therapy rule.Rationally apply Chinese medicine, help elimination albuminuria and delay renal hypofunction.
Summary of the invention
The technical problem to be solved is to provide a kind of effective, and safe and reliable being used for treats albumen
The Chinese medicine preparation of urine.
The technical problem to be solved realizes by the following technical solutions:
One is used for treating albuminuretic Chinese medicine preparation, is made up of the crude drug of following weight: Radix Puerariae 14-16g, Radix Astragali 9-
11g, Periostracum Cicadae 4-6g, Herba Hedyotidis Diffusae 7-9g, Semen Coicis 14-16g, Semen Euryales 11-13g, Rhizoma dioscoreae 11-13g, Radix Codonopsis 9-11g, Radix Rehmanniae Preparata
14-16g, Cortex Sclerotii Poriae 11-13g, Semen Cuscutae 11-13g, Fructus Psoraleae 11-13g, Cortex Mori 14-16g, Radix Achyranthis Bidentatae 8-10g, Semen Plantaginis
14-16g, Ramulus Cinnamomi 8-10g, Pericarpium Citri Reticulatae 11-13g, Pericarpium Arecae 14-16g；
Preferred weight part of each crude drug is: Radix Puerariae 15g, Radix Astragali 10g, Periostracum Cicadae 5g, Herba Hedyotidis Diffusae 8g, Semen Coicis 15g, Gorgon euryale
Real 12g, Rhizoma dioscoreae 12g, Radix Codonopsis 10g, Radix Rehmanniae Preparata 15g, Cortex Sclerotii Poriae 12g, Semen Cuscutae 12g, Fructus Psoraleae 12g, Cortex Mori 15g, Huaihe River cattle
Knee joint 9g, Semen Plantaginis 15g, Ramulus Cinnamomi 9g, Pericarpium Citri Reticulatae 12g, Pericarpium Arecae 15g；
Crude drug used in the present invention can be commercially available from common Chinese shop, and its specification meets country's Chinese crude drug standard i.e.
Can.
It is a further object to provide a kind of method preparing Chinese medicine preparation of the present invention, comprise the steps,
(1) each crude drug is weighed by following parts by weight；
(2) above-mentioned each taste material medicine is mixed be placed on marmite in added water no powder, after soaking 30 minutes,
With slow fire boiling, renew after boiling pan-fried 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction.
It is a further object to provide a kind of method preparing Chinese medicine preparation of the present invention, comprise the steps,
(1) weight as described in prescription weighs each taste crude drug；
(2) by above-mentioned each taste crude drug pulverization, capsule is loaded.
1, medicine of the present invention coordinates effect: have invigorating the spleen and benefiting QI, tonifying the kidney to consolidate the essence, blood circulation promoting and blood stasis dispelling, diuretic damp eliminating.
2, usage and consumption:
The dosage of medicine of the present invention depends on the factors such as concrete dosage form, and the age of patient, body weight, health status.
The dosage of medicine of the present invention depends on the factors such as concrete dosage form, and the age of patient, body weight, health status.
Instruction: decoction: 180-200ml, one day 2 times, sub-service sooner or later, 7 days is a course for the treatment of, general 4 the course for the treatment of effect notable.
3, the present composition has carried out substantial amounts of animal acute toxicity test, long-term toxicity test for animals and treatment disease
Sick a large amount of clinical trials, put into the use link for the treatment of disease and provide science and objective foundation this medicine.
Its test method and result of the test are as follows:
(1) decoction preparing the present invention carries out animal acute toxicity test:
Medicine: the crude drug used in the present invention is commercially available from common Chinese shop, its specification meets country's Chinese crude drug mark
Accurate.
Experimental animal: white mice, body weight randomly chooses in about 50g, male and female, market buys.
Method and result: take white mice 10, hungry about 20 hours, fill for 5 times by every every natural gift and feed 50ml, feed continuously
One week, observing 10 days, mice is movable normal, non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical application agent
Amount safety.
(2) decoction preparing the present invention carries out long-term toxicity test for animals:
Experimental animal: rat, body weight randomly chooses in 120-130g, male and female, market buys.
Method and result: take rat 20, be divided into 2 groups, often group 10, and wherein the 1st group as administration group, every by every
Filling for they 2 times and feed, each 5-10ml, the 2nd group of diet as a control group, once a day, fills continuously and feeds 90 days, survey body
Weight, is administered latter 24 hours sacrificed by decapitation in last, surveys blood, routine urinalysis, liver function, renal function, cores, the internal organs such as kidney, sees
Examining the change of tissue morphology, observe the effect of dosage, observe diet, movable change, experiment proves administration group and matched group ratio
Relatively without notable change, equal non-toxic reaction, it is a kind of safe drugs.
4, clinical diagnosis:
(1) patient's totally 100 example, wherein male 45 example, women 55 example, M-F 0.8:1,33 years old mean age are accepted for medical treatment.
Twenty-four-hour urine protein quantification is grown up more than 150mg/24h clinically, and child, more than 300mg/24h, can be diagnosed as albuminuria.
(2) in order to verify clinical efficacy, this prescription is tried out in Quan Yang town, Jieshou City township center hospital.
(3) Therapeutic Method: take capsule of the present invention, take the most in three times, one time 6, take continuously 1 month.
(4) efficacy determination:
Complete incidence graph: subjective symptoms, sign disappear, normal renal function, urine erythrocyte, albumen continued depletion；
Basic alleviation: subjective symptoms, sign disappear, and normal renal function, urine erythrocyte, albumen persistently reduce >=50%；
Take a turn for the better: symptom, sign take a turn for the better, and renal function is normal, and urine erythrocyte, albumen persistently reduce >=25%；
Invalid: symptom, sign are without taking a turn for the better, and renal function, urine examination is the most unchanged or increases the weight of.
Concrete therapeutic outcome sees table 1；
Table 1
5, points for attention:
1. diet is the lightest, gives up alcohol and pungent, raw and cold, greasy food.
2. child, women breast-feeding their children, elderly and infirm should take under doctor instructs.
3. driver, work high above the ground person are cautious use of.
The most strictly take by usage and dosage.
5. pair this medicine and alcohol intolerance person disabling, allergic constitution person be cautious use of.
6. this property of drug prohibits the use of when changing.
The most please this medicine is placed on the place that child can not contact.
The most such as it is currently in use other medicines, please Ref Dr or pharmacist before using this medicine.
The invention has the beneficial effects as follows: medicine of the present invention has invigorating the spleen and benefiting QI, tonifying the kidney to consolidate the essence, blood circulation promoting and blood stasis dispelling, diuretic damp eliminating
Etc. effect and evident in efficacy, toxic and side effects is little, and taking convenience is cheap.
Detailed description of the invention
For the technological means making the present invention realize, creation characteristic, reach purpose and be easy to understand with effect, below knot
Close specific embodiment, the present invention is expanded on further.
Embodiment 1
One is used for treating albuminuretic Chinese medicine preparation, is made up of the crude drug of following weight: Radix Puerariae 14g, Radix Astragali 9g, Cicadae
Slough off 4g, Herba Hedyotidis Diffusae 7g, Semen Coicis 14g, Semen Euryales 11g, Rhizoma dioscoreae 11g, Radix Codonopsis 9g, Radix Rehmanniae Preparata 14g, Cortex Sclerotii Poriae 11g, Semen Cuscutae
11g, Fructus Psoraleae 11g, Cortex Mori 14g, Radix Achyranthis Bidentatae 8g, Semen Plantaginis 14g, Ramulus Cinnamomi 8g, Pericarpium Citri Reticulatae 11g, Pericarpium Arecae 14g；
Preparation method is as follows:
(1) weight as described in prescription weighs each taste crude drug；
(2) by above-mentioned each taste crude drug pulverization, capsule is loaded.
Embodiment 2
One is used for treating albuminuretic Chinese medicine preparation, is made up of the crude drug of following weight: Radix Puerariae 16g, Radix Astragali 11g,
Periostracum Cicadae 6g, Herba Hedyotidis Diffusae 9g, Semen Coicis 16g, Semen Euryales 13g, Rhizoma dioscoreae 13g, Radix Codonopsis 11g, Radix Rehmanniae Preparata 16g, Cortex Sclerotii Poriae 13g, Herba cuscutae
Sub-13g, Fructus Psoraleae 13g, Cortex Mori 16g, Radix Achyranthis Bidentatae 10g, Semen Plantaginis 16g, Ramulus Cinnamomi 10g, Pericarpium Citri Reticulatae 13g, Pericarpium Arecae 16g；
Preparation method is as follows:
(1) each crude drug is weighed by following parts by weight；
(2) above-mentioned each taste material medicine is mixed be placed on marmite in added water no powder, after soaking 30 minutes,
With slow fire boiling, renew after boiling pan-fried 30 minutes, decoct three times altogether, merge three decocting liquids and filter, obtain decoction.
Embodiment 3
One is used for treating albuminuretic Chinese medicine preparation, is made up of the crude drug of following weight: Radix Puerariae 15g, Radix Astragali 10g,
Periostracum Cicadae 5g, Herba Hedyotidis Diffusae 8g, Semen Coicis 15g, Semen Euryales 12g, Rhizoma dioscoreae 12g, Radix Codonopsis 10g, Radix Rehmanniae Preparata 15g, Cortex Sclerotii Poriae 12g, Herba cuscutae
Sub-12g, Fructus Psoraleae 12g, Cortex Mori 15g, Radix Achyranthis Bidentatae 9g, Semen Plantaginis 15g, Ramulus Cinnamomi 9g, Pericarpium Citri Reticulatae 12g, Pericarpium Arecae 15g；
Preparation method is as follows:
(1) weight as described in prescription weighs each taste crude drug；
(2) by above-mentioned each taste crude drug pulverization, capsule is loaded.
Typical case:
Ten thousand so-and-so, man, 43 years old age, Quan Yang people from town, Jieshou City, Anhui Province.Because finding urine protein +++, existing three months, warp
Multi-treatment is examined later without being clearly better, light red tongue time medical, white and thin fur, moderate pulse, have a blood test fat and renal function all normal, patient takes
With after two courses for the treatment of of Chinese medicine of the present invention, check urine protein is turned out cloudy, complete incidence graph.
Cypress so-and-so, female, 28 years old age, Gu people from market town, Jieshou City, Anhui Province.Cause albuminuria 2 years repeatedly, though through multi-treatment,
All can not take a turn for the better, have urine examined when examining albumen +++, blood fat is normal, and when examining, face and whole body are without edema, light red tongue, white and thin fur, arteries and veins
Slow.After patient takes two courses for the treatment of of Chinese medicine of the present invention, during check, routine urinalysis is normal, complete incidence graph.
Chen, man, 33 years old age, Guang Wu people from town, Jieshou City, Anhui Province.Urine protein time medical +++, color ultrasound shows: left kidney
94 × 39mm, right kidney 100 × 41mm, and essence Echoenhance, it is diagnosed as chronic nephritis, patient takes the treatment of two, Chinese medicine of the present invention
Cheng Hou, renal function is normal, takes a turn for the better.
The ultimate principle of the present invention and principal character and advantages of the present invention have more than been shown and described.The technology of the industry
Personnel, it should be appreciated that the present invention is not restricted to the described embodiments, simply illustrating this described in above-described embodiment and description
The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these become
Change and improvement both falls within scope of the claimed invention.Claimed scope by appending claims and
Its equivalent defines.
Claims (2)
1. one kind is used for treating albuminuretic Chinese medicine preparation, it is characterised in that be made up of the crude drug of following weight: Radix Puerariae 14-
16g, Radix Astragali 9-11g, Periostracum Cicadae 4-6g, Herba Hedyotidis Diffusae 7-9g, Semen Coicis 14-16g, Semen Euryales 11-13g, Rhizoma dioscoreae 11-13g, Radix Codonopsis
9-11g, Radix Rehmanniae Preparata 14-16g, Cortex Sclerotii Poriae 11-13g, Semen Cuscutae 11-13g, Fructus Psoraleae 11-13g, Cortex Mori 14-16g, Radix Achyranthis Bidentatae 8-
10g, Semen Plantaginis 14-16g, Ramulus Cinnamomi 8-10g, Pericarpium Citri Reticulatae 11-13g, Pericarpium Arecae 14-16g.
One the most according to claim 1 is used for treating albuminuretic Chinese medicine preparation, it is characterised in that by following weight
Crude drug is made: Radix Puerariae 15g, Radix Astragali 10g, Periostracum Cicadae 5g, Herba Hedyotidis Diffusae 8g, Semen Coicis 15g, Semen Euryales 12g, Rhizoma dioscoreae 12g, Radix Codonopsis
10g, Radix Rehmanniae Preparata 15g, Cortex Sclerotii Poriae 12g, Semen Cuscutae 12g, Fructus Psoraleae 12g, Cortex Mori 15g, Radix Achyranthis Bidentatae 9g, Semen Plantaginis 15g, Ramulus Cinnamomi
9g, Pericarpium Citri Reticulatae 12g, Pericarpium Arecae 15g.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757540A (en) * | 2009-10-31 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating nephrotic syndrome and preparation method thereof |
| CN103169894A (en) * | 2013-04-19 | 2013-06-26 | 李其梅 | Traditional Chinese medicine composition for treating proteinuria |
| CN104288594A (en) * | 2014-09-11 | 2015-01-21 | 湖北省中医院 | Traditional Chinese medicine preparation for treating qi-yin deficiency syndrome of chronic kidney disease and preparation method of traditional Chinese medicine preparation |
-
2016
- 2016-04-01 CN CN201610209634.7A patent/CN106215028A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757540A (en) * | 2009-10-31 | 2010-06-30 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating nephrotic syndrome and preparation method thereof |
| CN103169894A (en) * | 2013-04-19 | 2013-06-26 | 李其梅 | Traditional Chinese medicine composition for treating proteinuria |
| CN104288594A (en) * | 2014-09-11 | 2015-01-21 | 湖北省中医院 | Traditional Chinese medicine preparation for treating qi-yin deficiency syndrome of chronic kidney disease and preparation method of traditional Chinese medicine preparation |
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