CN106214847A - 一种可增强免疫力的口服液及其制备方法 - Google Patents
一种可增强免疫力的口服液及其制备方法 Download PDFInfo
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- CN106214847A CN106214847A CN201610796175.7A CN201610796175A CN106214847A CN 106214847 A CN106214847 A CN 106214847A CN 201610796175 A CN201610796175 A CN 201610796175A CN 106214847 A CN106214847 A CN 106214847A
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- ganoderma
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- purified water
- oral liquid
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Abstract
本发明公开了一种可增强免疫力的口服液，包含以下组份：肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七、木糖醇、甜菊糖苷、呈味核苷酸二钠、纯化水。本发明的有益效果为，在现有中医理论的基础上筛选出的具有增强免疫力功能的组方，通过科学配伍，发挥其相互协同作用，制成口服液，起到增强人体免疫力的功效。
Description
技术领域
本发明涉及一种可增强免疫力的口服液及其制备方法。
背景技术
近年来，伴随着每一次病毒性疾病如“非典”、禽流感、甲型流感的大规模流行，都带动广大消费者对抗病毒药物，尤其是抗病毒中药的抢购潮。中医的“毒”与西医的“病毒”概念不同，从西医的角度看，流行性感冒、“非典”、禽流感都是由病毒致病，具有较强的传染性；而从中医的角度来看，这些病都是以“热毒”为主要特点的，属于温病范畴，按中医温病学原则，治疗的办法主要是清热解毒，比如服用板蓝根。中医认为，无论是流行性感冒还是“非典”，发病初期表症未除内热已炽，属卫气同病，在疏散外邪的同时重用清热解毒之品，可收卫气同治、表里双解之功。中西医对感染性疾病的治疗侧重点不同，西医针对的是病原微生物，中医则重在提高人体免疫力。健康的人体对细菌和病毒都有天然的抵抗力，只有在人体器官出现功能失调的情况下，细菌或病毒才能入侵而导致发病。因此，试图单纯通过用一种生物药或化学药就永久杀灭病原体的想法不现实，只要机体的免疫力仍然低下，就不断有病原体侵袭。中医调整身体的整体机能状态，提高机体免疫力，驱除外邪。
发明内容
本发明所要解决的技术问题是：提出一种可增强免疫力的口服液及其制备方法。
本发明采用的技术方案如下：一种可增强免疫力的口服液，包含以下组份：肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七、木糖醇、甜菊糖苷、呈味核苷酸二钠、纯化水。
优选的，按重量份计，各组份比例如下：
肉灵芝20份；灵芝20份；人参10份；黄芪20份；枸杞子20份；大枣20份；三七10份；木糖醇5份；甜菊糖苷0.7份；呈味核苷酸二钠0.2份；纯化水1000份。
所述口服液的制备方法，包括以下步骤：
一、按比例提取肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七，投入纯化水中；
二、投料在纯化水中提取三次，每次1.5小时；
三、将三次的提取液合并，并在-0.05Mpa，70℃的条件下减压浓缩；
四、将浓缩液进行过滤，再与木糖醇、甜菊糖苷、呈味核苷酸二钠、纯化水搅拌溶解后得到的溶液进行混合，静置10分钟；
五、将混合液经过检验后进行灌封，灌入若干100ml的口服液瓶中；
六、在115℃的高温下对口服液瓶进行灭菌，历时40分钟；
七、对口服液瓶进行清洗、灯检；
八、对口服液瓶进行贴标和外包装；
九、成品入库。
本发明的有益效果为，在现有中医理论的基础上筛选出的具有增强免疫力功能的组方，通过科学配伍，发挥其相互协同作用，制成口服液，起到增强人体免疫力的功效。
具体实施方式
一种可增强免疫力的口服液，包含以下组份：肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七、木糖醇、甜菊糖苷、呈味核苷酸二钠、纯化水。
按重量份计，各组份比例如下：
肉灵芝20g；灵芝20g；人参10g；黄芪20g；枸杞子20g；大枣20g；三七10g；木糖醇5g；甜菊糖苷0.7g；呈味核苷酸二钠0.2g；纯化水1000ml。
所述口服液的制备方法，包括以下步骤：
一、按比例提取肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七，投入纯化水中；
二、投料在纯化水中提取三次，每次1.5小时；
三、将三次的提取液合并，并在-0.05Mpa，70℃的条件下减压浓缩；
四、将浓缩液进行过滤，再与木糖醇、甜菊糖苷、呈味核苷酸二钠、纯化水搅拌溶解后得到的溶液进行混合，静置10分钟；
五、将混合液经过检验后进行灌封，灌入若干100ml的口服液瓶中；
六、在115℃的高温下对口服液瓶进行灭菌，历时40分钟；
七、对口服液瓶进行清洗、灯检；
八、对口服液瓶进行贴标和外包装；
九、成品入库。
本品是以肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七为主要原料制成的保健饮品，肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七符合《中华人民共和国药典》一部的规定，是保健食品可用原料。
各组份作用机理如下：
肉灵芝，又称太岁，李时珍《本草纲目》记载有肉灵芝，并把它收入“菜”部“芝”类，可食用、入药，奉为“本经上品”，功效为“久食，轻身不老，延年神仙”。据《神农本草经[3]》记载：“肉灵芝，无毒、补中、益精气、增智慧，治胸中结，久服轻身不老”。《山海经》称之谓“视肉”、“聚肉”、“太岁”、“封”，乃古代帝王养生佳肴。太岁十分稀有，是百药中的上品。有典籍记载，太岁性平，苦，无毒，具有补脾润肺，补肾益肝等价值。科学研究发现，肉灵芝在三方面有重大开发价值：1、由于体内含有高度抗腐化物质，在无公害食品开发、食品添加剂、食品防腐剂领域有重大开发价值。2、肉灵芝的生命力和适应力极强，体内含有丰富的提高免疫力的物质，因此在保健品方面有开发价值。3、肉灵芝通过吸收有机物和腐殖质可以自身复制，其体内含有目前地球上迄今为止发现的最强的生物活性成份物质，具有最全的功能性营养元，从中医上讲是补品中的上品，因此在医药方面有重大的开发价值。
灵芝又称林中灵、琼珍，是多孔菌科真菌灵芝的子实体。具有补气安神、止咳平喘、延年益寿的功效。灵芝主含氨基酸、多肽、蛋白质、真菌溶菌酶，以及糖类(还原糖和多糖)、麦角甾醇、三萜类、香豆精甙、挥发油、硬脂酸、苯甲酸、生物碱、维生素B2及C等；孢子还含甘露醇、海藻糖。灵芝中分离的蛋白多糖腹腔注射可使小鼠腹腔渗出液中的细胞、巨噬细胞、多形核白细胞增加，表明有免疫加强作用，对绵羊红细胞(SRBC)免疫小鼠的脾脏溶血空斑形成细胞数明显增加，此种多糖含半乳糖、葡萄糖和木糖。
人参的别称为黄参、地精、神草、百草之王，是闻名遐迩的“东北三宝”之一。人参的肉质根为著名强壮滋补药，适用于调整血压、恢复心脏功能、神经衰弱及身体虚弱等症，也有祛痰、健胃、利尿、兴奋等功效。
黄芪，又名绵芪。黄芪的药用迄今已有2000多年的历史，其有增强机体免疫功能、保肝、利尿、抗衰老、抗应激、降压和较广泛的抗菌作用。
枸杞子，为茄科植物枸杞的成熟果实。枸杞子富含枸杞多糖，枸杞多糖是一种水溶性多糖，由阿拉伯糖、葡萄糖、半乳糖、甘露糖、木糖、鼠李糖这6种单糖成分组成，具有生理活性，能够增强非特异性免疫功能，提高抗病能力，抑制肿瘤生长和细胞突变。枸杞多糖能显著增加小鼠肌糖原、肝糖原储备量，提高运动前后血液乳酸脱氢酶总活力；降低小鼠剧烈运动后血尿素氮增加量，加快运动后血尿素氮的清除速率。这表明枸杞多糖对消除疲劳具有十分明显的作用。
大枣，又名红枣。特点是维生素含量非常高，有“天然维生素丸”的美誉,具有滋阴补阳，补血之功效。枣能提高人体免疫力，并可抑制癌细胞：药理研究发现，红枣能促进白细胞的生成，降低血清胆固醇，提高血清白蛋白，保护肝脏，红枣中还含有抑制癌细胞，甚至可使癌细胞向正常细胞转化的物质。
三七，中药名。主产于云南文山州，故名文山三七，又名文州三七，为五加科植物三七的干燥根和根茎。具有散瘀止血，消肿定痛的功效，主治用于咯血，吐血，衄血，便血，崩漏，外伤出血，胸腹刺痛，跌扑肿痛。
Claims (3)
1.一种可增强免疫力的口服液，其特征在于，包含以下组份：肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七、木糖醇、甜菊糖苷、呈味核苷酸二钠、纯化水。
2.如权利要求1所述的口服液，其特征在于，按重量份计，各组份比例如下：肉灵芝20份；灵芝20份；人参10份；黄芪20份；枸杞子20份；大枣20份；三七10份；木糖醇5份；甜菊糖苷0.7份；呈味核苷酸二钠0.2份；纯化水1000份。
3.权利要求1所述口服液的制备方法，其特征在于，包括以下步骤：
一、按比例提取肉灵芝、灵芝、人参、黄芪、枸杞子、大枣、三七，投入纯化水中；
二、投料在纯化水中提取三次，每次1.5小时；
三、将三次的提取液合并，并在-0.05Mpa，70℃的条件下减压浓缩；
四、将浓缩液进行过滤，再与木糖醇、甜菊糖苷、呈味核苷酸二钠、纯化水搅拌溶解后得到的溶液进行混合，静置10分钟；
五、将混合液经过检验后进行灌封，灌入100ml的口服液瓶中；
六、在115℃的高温下对口服液瓶进行灭菌，历时40分钟；
七、对口服液瓶进行清洗、灯检；
八、对口服液瓶进行贴标和外包装；
九、成品入库。
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108991523A (zh) * | 2018-06-22 | 2018-12-14 | 金少举 | 一种环保型鸟苷酸二钠枸杞口服液的制备方法 |
| CN109105884A (zh) * | 2018-09-11 | 2019-01-01 | 无锡太康生物科技有限公司 | 一种植物酵素饮液及其制备方法 |
| CN111979079A (zh) * | 2020-09-24 | 2020-11-24 | 四川意润达科技有限公司 | 一种肉灵芝保健酒的配方及其制备方法 |
| CN112586735A (zh) * | 2020-12-30 | 2021-04-02 | 北京一解梅生物科技有限公司 | 一种具活血美颜功效的三七复合酵素及其制备方法 |
| CN113244372A (zh) * | 2021-04-22 | 2021-08-13 | 建昌帮药业有限公司 | 一种增强免疫力的组合物及其制备工艺与应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583159A (zh) * | 2003-08-19 | 2005-02-23 | 初真文 | 肉灵芝保健品及其制备方法 |
| CN104127577A (zh) * | 2014-08-12 | 2014-11-05 | 安徽衡济堂灵芝产业开发有限公司 | 一种用于缓解体力疲劳的中药胶囊及其制备方法 |
| KR20150101157A (ko) * | 2014-02-26 | 2015-09-03 | 농업회사법인 자연드림 주식회사 | 인삼잎차 티백 제조방법 |
| CN105125738A (zh) * | 2015-09-16 | 2015-12-09 | 云南清华源生物环境工程有限公司 | 一种中药组合物及其制备方法与用途 |
-
2016
- 2016-08-31 CN CN201610796175.7A patent/CN106214847A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583159A (zh) * | 2003-08-19 | 2005-02-23 | 初真文 | 肉灵芝保健品及其制备方法 |
| KR20150101157A (ko) * | 2014-02-26 | 2015-09-03 | 농업회사법인 자연드림 주식회사 | 인삼잎차 티백 제조방법 |
| CN104127577A (zh) * | 2014-08-12 | 2014-11-05 | 安徽衡济堂灵芝产业开发有限公司 | 一种用于缓解体力疲劳的中药胶囊及其制备方法 |
| CN105125738A (zh) * | 2015-09-16 | 2015-12-09 | 云南清华源生物环境工程有限公司 | 一种中药组合物及其制备方法与用途 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108991523A (zh) * | 2018-06-22 | 2018-12-14 | 金少举 | 一种环保型鸟苷酸二钠枸杞口服液的制备方法 |
| CN109105884A (zh) * | 2018-09-11 | 2019-01-01 | 无锡太康生物科技有限公司 | 一种植物酵素饮液及其制备方法 |
| CN111979079A (zh) * | 2020-09-24 | 2020-11-24 | 四川意润达科技有限公司 | 一种肉灵芝保健酒的配方及其制备方法 |
| CN112586735A (zh) * | 2020-12-30 | 2021-04-02 | 北京一解梅生物科技有限公司 | 一种具活血美颜功效的三七复合酵素及其制备方法 |
| CN113244372A (zh) * | 2021-04-22 | 2021-08-13 | 建昌帮药业有限公司 | 一种增强免疫力的组合物及其制备工艺与应用 |
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Application publication date: 20161214 |