CN106213302A - 一种李子超微粉咀嚼片及其制备方法 - Google Patents
一种李子超微粉咀嚼片及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种李子超微粉咀嚼片，是由下述重量份的原料制成：李子30‑40份、广枣10‑15份、竹节参8‑12份、玫瑰花8‑12份、紫草6‑8份、桑叶6‑8份、荷叶4‑6份、淡竹叶4‑6份、凌霄花2‑4份、低聚木糖10‑15份、甘露醇5‑10份、乙醇5‑10份、硬脂酸镁1‑3份。本发明的李子超微粉咀嚼片具有降低血脂、保肝护肝的作用，对高血脂等疾病具有显著的预防和治疗作用，经临床试验证明，总其有效率达97.5％。
Description
技术领域
本发明涉及一种李子超微粉咀嚼片及其制备方法，属于食品加工领域。
背景技术
李子中含有多种营养成分，有养颜美容、润滑肌肤的作用。李子能促进胃酸和胃消化酶的分泌，并能促进胃肠蠕动，因而有改善食欲，促进消化的作用，尤其对胃酸缺乏、食后饱胀、大便秘结者有效。新鲜李子肉中的丝氨酸、甘氨酸、脯氨酸、谷酰胺等氨基酸，有利尿消肿的作用，对肝硬化有辅助治疗效果。但李子不耐贮存，基本以鲜食为主，加工量很少，当大量李子上市时，往往由于保鲜、天气、交通等影响，造成大量果子腐烂，损失很大。因此，利用现代生物技术开发李子的深加工产品，对于提高李子的产品附加值具有十分重要的意义。
超微粉碎一般是指将物料颗粒粉碎至10-25μm或更小的过程，因此物料具有良好的溶解性、分散性、吸附性、流动性、化学活性等多方面的性能及一些新的特性。经超微粉碎的原料加工成的食品具有更好的口感、营养吸收利用度显著提高、完美保持原料原有的生物活性等优点。
咀嚼片是指通过咀嚼或者吮服使片溶化后吞服的片制剂。与普通片剂相比具有分散状态好、崩解时间短、营养溶出迅速，吸收好、利用度高、服用方便等优势。但目前尚未有以李子为主要原料制备成超微粉咀嚼片的报道。
发明内容
本发明的目的是提供一种李子超微粉咀嚼片，将李子、广枣、竹节参、玫瑰花、紫草、桑叶、荷叶、淡竹叶、凌霄花等原料制成超微粉，保持了物料原有的生物活性和营养成分，具有降脂保肝的功效，特别适合高血脂人群食用。
本发明的另一目的是提供该李子超微粉咀嚼片的制备方法。
为实现上述目的，本发明采用下述技术方案：
一种李子超微粉咀嚼片，是由下述重量份的原料制成的：
李子30-40份、广枣10-15份、竹节参8-12份、玫瑰花8-12份、紫草6-8份、桑叶6-8份、荷叶4-6份、淡竹叶4-6份、凌霄花2-4份、低聚木糖10-15份、甘露醇5-10份、乙醇5-10份、硬脂酸镁1-3份。
优选的，所述李子超微粉咀嚼片是由下述重量份的原料制成的：
李子35份、广枣12份、竹节参10份、玫瑰花10份、紫草7份、桑叶7份、荷叶5份、淡竹叶5份、凌霄花3份、低聚木糖12份、甘露醇7份、乙醇6份、硬脂酸镁2份。
上述李子超微粉咀嚼片是通过以下方法制备得到的，步骤如下：
(1)超微粉制备：将李子去核，80-90℃干燥3-5h，粉碎，过300目筛，得李子超微粉；将广枣、竹节参、玫瑰花、紫草、桑叶、荷叶、淡竹叶和凌霄花干燥，粉碎，过300目筛，与李子超微粉混合，得混合超微粉；
(2)制粒：向步骤(1)制得的混合超微粉中加入甘露醇和低聚木糖，用乙醇作为粘合剂，制软材，过筛制得颗粒；
(3)压片：将步骤(2)的颗粒干燥，加入硬脂酸镁压片，灭菌，即得。
优选的，步骤(2)中，所述乙醇的体积分数为95％。
优选的，步骤(2)中，软材过40目筛，制得颗粒。
优选的，步骤(3)中，将步骤(2)的颗粒于60℃烘干1-2h，加硬脂酸镁压片，灭菌，即得李子超微粉咀嚼片。
本发明的组方中，李子能够消食去脂，广枣能行气活血，养心安神，荷叶能利尿通便，竹节参补虚强壮，玫瑰花行气解郁，紫草、桑叶、淡竹叶清热凉血，清肺润燥，各原料互为补充、协同促进，使得本发明超微粉咀嚼片具有降脂保肝之功效。
其中，李子：能够促进胃肠道消化吸收，增加胃动力，促进食欲，还能有效软化宿便，改善便秘症状。李子的酸度够，可以有效生津止渴、清热解毒。同时李子还可以清肝利胆，对治疗肝硬化腹水大有益处。
广枣：甘、酸，平。行气活血，养心，安神。用于气滞血瘀，胸痹作痛，心悸气短，心神不安。
竹节参：甘、微苦，温。归肝、脾、肺经。散瘀止血，消肿止痛，祛痰止咳，补虚强壮。用于痨嗽咯血，跌扑损伤，咳嗽痰多，病后虚弱。
玫瑰花：甘、微苦，温。归肝、脾经。行气解郁，和血，止痛。用于肝胃气痛，食少呕恶，月经不凋，跌扑伤痛。
紫草：甘、咸，寒。归心、肝经。清热凉血，活血解毒，透疹消斑。用于血热毒盛，斑疹紫黑，麻疹不透，疮疡，湿疹，水火烫伤。
桑叶：甘、苦，寒。归肺、肝经。疏散风热，清肺润燥，清肝明目。用于风热感冒，肺热燥咳，头晕头痛，目赤昏花。
荷叶：苦，平。归肝、脾、胃经。清暑化湿，升发清阳，凉血止血。用于暑热烦渴，暑湿泄泻，脾虚泄泻，血热吐衄，便血崩漏。
淡竹叶：甘、淡，寒。归心、胃、小肠经。清热泻火，除烦止渴，利尿通淋。用于热病烦渴，小便短赤涩痛，口舌生疮。
凌霄花：甘、酸，寒。归肝、心包经。活血通经，凉血祛风。用于月经不调，经闭癥瘕，产后乳肿，风疹发红，皮肤瘙痒，痤疮。
本发明的李子超微粉咀嚼片配方科学，以具有降血脂功效的李子为有效成分，辅以广枣、竹节参、玫瑰花、紫草、桑叶、荷叶、淡竹叶和凌霄花等成分，将其制成超微粉，保持了物料原有的生物活性和营养成分，具有降脂保肝的功效。配方中的各组分符合中药的配伍关系，其中，李子清热生津、泻肝利水，有降血脂之功效，是为本方之君药；广枣行气活血，养心，安神，竹节参消肿止痛，祛痰止咳，补虚强壮，共为本方之臣药；玫瑰花行气解郁，和血，止痛，荷叶味苦、辛、微涩、性凉。归心、肝、脾、经。具有清香开散，健脾升阳、利湿散瘀止血之功效，淡竹叶清热泻火，除烦止渴，利尿通淋，与玫瑰花、荷叶同为本方之佐药。各组分协同作用，能够清肝火、散郁结，起到降血脂的作用。因此，本发明的李子超微粉咀嚼片配方中，各原料组分是一个有机的整体，缺一不可。发明人在研发过程中发现，减少上述配方中的任何一种原料组分，或以具有相似性质的其他原料组分对本发明配方中的原料组分进行替换，则配方整体的作用效果显著降低；在本发明配方的基础上再增加其他的原料组分，配方的整体效果并未有明显的改善，甚至有效果降低的情况出现。
本发明的有益效果：
(1)本发明的超微粉咀嚼片所采用的原料粉均为超微粉，制成的咀嚼片具有口感好、天然性、营养高、易于吸收等特点。
(2)本发明的李子超微粉咀嚼片具有降低血脂、保肝护肝的作用，对高血脂等疾病具有显著的预防和治疗作用，经临床试验证明，总其有效率达97.5％。
具体实施方式
下面通过具体实例对本发明进行进一步的阐述，应该说明的是，下述说明仅是为了解释本发明，并不对其内容进行限定。
实施例1：一种李子超微粉咀嚼片
【配方】
李子35克、广枣12克、竹节参10克、玫瑰花10克、紫草7克、桑叶7克、荷叶5克、淡竹叶5克、凌霄花3克、低聚木糖12克、甘露醇7克、乙醇6克、硬脂酸镁2克。
【制法】
(1)按照上述重量配比，称取原料；
将李子去核，85℃干燥4h，粉碎，过300目筛，得李子超微粉；将广枣、竹节参、玫瑰花、紫草、桑叶、荷叶、淡竹叶和凌霄花干燥，粉碎，过300目筛，与李子超微粉混合，得混合超微粉；
(2)制粒：向步骤(1)制得的混合超微粉中加入甘露醇和低聚木糖，用体积分数为95％的乙醇作为粘合剂，制软材，软材过40目筛，制得颗粒；
(3)压片：将步骤(2)的颗粒于60℃烘干2h，加硬脂酸镁压片，灭菌，即得李子超微粉咀嚼片。
实施例2：一种李子超微粉咀嚼片
【配方】李子30克、广枣15克、竹节参8克、玫瑰花12克、紫草6克、桑叶8克、荷叶4克、淡竹叶6克、凌霄花2克、低聚木糖15克、甘露醇5克、乙醇10克、硬脂酸镁1克。
制备方法同实施例1。
实施例3：一种李子超微粉咀嚼片
【配方】李子40克、广枣10克、竹节参12克、玫瑰花8克、紫草8克、桑叶6克、荷叶6克、淡竹叶4克、凌霄花4克、低聚木糖10克、甘露醇10克、乙醇5克、硬脂酸镁3克。
制备方法同实施例1。
本发明制备的李子超微粉咀嚼片，感官评价结果如下：
表1：
注：感官评定为10人小组评定结果。
效果验证试验：
按照中医诊断标准诊断为胸痹、心悸、头痛、眩晕、消渴等病而出现气滞血瘀症状的患者。高脂血症符合国家中医药管理局《中药新药治疗高脂血症的临床研究指导原则》制定的高脂血症诊断标准，脂肪肝诊断标准符合《最新国内外疾病诊断标准》中脂肪肝诊断标准。从出现上述症状的人群中选择40例作为试食对象，其中男性20例，女性20例。
疗效判定：
1、显效：临床症状、体征基本消失，血脂检测达到以下任一项者,即TC指标下降率≥20％，TG指标下降率≥40％或HDL-C指标≥0.26mmol/L。
2、有效：血脂检测达到以下任一项者,即TC指标下降率≥10％同时＜20％，TG指标下降率≥20％同时＜40％或HDL-C指标≥0.104mmol/L同时＜0.26mmol/L。
3、无效：治疗后症状、体征与血脂检测无明显改善。
试验时，停服其它药物和保健营养品，服用本发明实施例1制备的李子超微粉咀嚼片，每天食用6克，4个月后进行随访，普遍反映口感风味良好，症状明显改善。试食对象的40人中，显效23人，有效16人，无效1人，总有效率97.5％。
Claims (6)
1.一种李子超微粉咀嚼片，其特征在于，是由下述重量份的原料制成：
李子30-40份、广枣10-15份、竹节参8-12份、玫瑰花8-12份、紫草6-8份、桑叶6-8份、荷叶4-6份、淡竹叶4-6份、凌霄花2-4份、低聚木糖10-15份、甘露醇5-10份、乙醇5-10份、硬脂酸镁1-3份。
2.如权利要求1所述的李子超微粉咀嚼片，其特征在于，由下述重量配比的原料制成：李子35份、广枣12份、竹节参10份、玫瑰花10份、紫草7份、桑叶7份、荷叶5份、淡竹叶5份、凌霄花3份、低聚木糖12份、甘露醇7份、乙醇6份、硬脂酸镁2份。
3.权利要求1或2所述的李子超微粉咀嚼片的制备方法，其特征在于，包括以下步骤：
(1)超微粉制备：将李子去核，80-90℃干燥3-5h，粉碎，过300目筛，得李子超微粉；将广枣、竹节参、玫瑰花、紫草、桑叶、荷叶、淡竹叶和凌霄花干燥，粉碎，过300目筛，与李子超微粉混合，得混合超微粉；
(2)制粒：向步骤(1)制得的混合超微粉中加入甘露醇和低聚木糖，用乙醇作为粘合剂，制软材，过筛制得颗粒；
(3)压片：将步骤(2)的颗粒干燥，加入硬脂酸镁压片，灭菌，即得。
4.如权利要求3所述的制备方法，其特征在于，步骤(2)中，所述乙醇的体积分数为95％。
5.如权利要求3所述的制备方法，其特征在于，步骤(2)中，软材过40目筛，制得颗粒。
6.如权利要求3所述的制备方法，其特征在于，步骤(3)中，将步骤(2)的颗粒于60℃烘干1-2h，加硬脂酸镁压片，灭菌，即得李子超微粉咀嚼片。
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| CN110101677A (zh) * | 2019-05-24 | 2019-08-09 | 蚌埠医学院 | 一种竹叶提取物咀嚼片及其制备方法 |
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| CN107455747B (zh) * | 2017-09-12 | 2020-09-08 | 福建省农业科学院农业工程技术研究所 | 一种芙蓉李多酚咀嚼片及其制备方法 |
| CN110101677A (zh) * | 2019-05-24 | 2019-08-09 | 蚌埠医学院 | 一种竹叶提取物咀嚼片及其制备方法 |
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