CN106177675A - 一种治疗椎管狭窄及骨折的中药膏贴 - Google Patents

一种治疗椎管狭窄及骨折的中药膏贴 Download PDF

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CN106177675A
CN106177675A CN201610769232.2A CN201610769232A CN106177675A CN 106177675 A CN106177675 A CN 106177675A CN 201610769232 A CN201610769232 A CN 201610769232A CN 106177675 A CN106177675 A CN 106177675A
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parts
radix
rhizoma
herba
cortex
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栾军
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

本发明涉及一种治疗椎管狭窄及骨折的中药膏贴，它包含下列重量份的物质：龙骨、丹参、红花、桃仁、骨碎补、三七、荆芥、自然铜、延胡索、鸡血藤、王不留行、路路通、土鳖虫、丹皮、赤芍、川芎、刘寄奴、三棱、苏木、牛膝、琥珀、大黄、栀子、葛根、黄柏、白花蛇舌草、钩藤、川楝子、乌药、炒香附、枳实、桂枝、制草乌、制川乌、防风、茯苓、羌活、独活、海风藤、桑枝、厚朴、全虫、乌梢蛇、地龙、蜈蚣、伸筋草、透骨草、威灵仙、千年健、木瓜、天麻、海桐皮、秦艽、细辛12‑18份、白芍、僵蚕、补骨脂、地骨皮、何首乌、海螵蛸、白术、菟丝子、杜仲、熟地、当归、黄芪、山药、续断和桑寄生。

Description

一种治疗椎管狭窄及骨折的中药膏贴
技术领域
本发明涉及医药领域，具体来说涉及一种治疗椎管狭窄及骨折的中药膏贴。
背景技术
目前，在治疗骨伤骨折方面，医疗单位多数采用石膏固定，或手术治疗的方法，患者靠自身生长愈合，身体强壮者尚可，往往隐患和后遗症不计其数，临床上没有有效的药物，能够促进骨伤骨折愈合，医者亦是无奈，给患者带来终生痛苦。
发明内容
本发明的目的是提供一种治疗椎管狭窄及骨折的中药膏贴。
为了实现本发明的目的，本发明提供一种治疗椎管狭窄及骨折的中药膏贴，它包含下列重量份的物质：龙骨18-25份、丹参18-25份、红花18-25份、桃仁18-25份、骨碎补18-25份、三七18-25份、荆芥18-25份、自然铜18-25份、延胡索18-25份、鸡血藤18-25份、王不留行18-25份、路路通18-25份、土鳖虫18-25份、丹皮18-25份、赤芍18-25份、川芎18-25份、刘寄奴18-25份、三棱18-25份、苏木18-25份、牛膝18-25份、琥珀18-25份、大黄18-25份、栀子18-25份、葛根18-25份、黄柏18-25份、白花蛇舌草18-25份、钩藤18-25份、川楝子18-25份、乌药18-25份、炒香附18-25份、枳实18-25份、桂枝18-25份、制草乌18-25份、制川乌18-25份、防风18-25份、茯苓18-25份、羌活18-25份、独活18-25份、海风藤18-25份、桑枝18-25份、厚朴18-25份、全虫18-25份、乌梢蛇18-25份、地龙18-25份、蜈蚣18-25份、伸筋草18-25份、透骨草18-25份、威灵仙18-25份、千年健18-25份、木瓜18-25份、天麻18-25份、海桐皮18-25份、秦艽18-25份、细辛12-18份、白芍18-25份、僵蚕18-25份、补骨脂18-25份、地骨皮18-25份、何首乌18-25份、海螵蛸18-25份、白术18-25份、菟丝子18-25份、杜仲18-25份、熟地18-25份、当归18-25份、黄芪18-25份、山药18-25份、续断18-25份和桑寄生18-25份。
优选地，本发明所述的治疗椎管狭窄及骨折的中药膏贴包含下列重量份的物质：龙骨22份、丹参22份、红花22份、桃仁22份、骨碎补22份、三七22份、荆芥22份、自然铜22份、延胡索22份、鸡血藤22份、王不留行22份、路路通22份、土鳖虫22份、丹皮22份、赤芍22份、川芎22份、刘寄奴22份、三棱22份、苏木22份、牛膝22份、琥珀22份、大黄22份、栀子22份、葛根22份、黄柏22份、白花蛇舌草22份、钩藤22份、川楝子22份、乌药22份、炒香附22份、枳实22份、桂枝22份、制草乌22份、制川乌22份、防风22份、茯苓22份、羌活22份、独活22份、海风藤22份、桑枝22份、厚朴22份、全虫22份、乌梢蛇22份、地龙22份、蜈蚣22份、伸筋草22份、透骨草22份、威灵仙22份、千年健22份、木瓜22份、天麻22份、海桐皮22份、秦艽22份、细辛12-18份、白芍22份、僵蚕22份、补骨脂22份、地骨皮22份、何首乌22份、海螵蛸22份、白术22份、菟丝子22份、杜仲22份、熟地22份、当归22份、黄芪22份、山药22份、续断22份和桑寄生22份。
更优选地，本发明所述的治疗椎管狭窄及骨折的中药膏贴还包含下列重量份的物质：0.1份的具有下列结构式的物质：
本发明还提供具有下列结构式的物质在制备治疗椎管狭窄及骨折的药物中的用途：
优选地，所述药物制成膏贴。
本发明的药物材料易得，制备方法简单，治疗效果好，价格低，见效快，疗效可靠，无明显不良反应和副作用。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例1
称取龙骨22克、丹参22克、红花22克、桃仁22克、骨碎补22克、三七22克、荆芥22克、自然铜22克、延胡索22克、鸡血藤22克、王不留行22克、路路通22克、土鳖虫22克、丹皮22克、赤芍22克、川芎22克、刘寄奴22克、三棱22克、苏木22克、牛膝22克、琥珀22克、大黄22克、栀子22克、葛根22克、黄柏22克、白花蛇舌草22克、钩藤22克、川楝子22克、乌药22克、炒香附22克、枳实22克、桂枝22克、制草乌22克、制川乌22克、防风22克、茯苓22克、羌活22克、独活22克、海风藤22克、桑枝22克、厚朴22克、全虫22克、乌梢蛇22克、地龙22克、蜈蚣22克、伸筋草22克、透骨草22克、威灵仙22克、千年健22克、木瓜22克、天麻22克、海桐皮22克、秦艽22克、细辛12-18克、白芍22克、僵蚕22克、补骨脂22克、地骨皮22克、何首乌22克、海螵蛸22克、自术22克、菟丝子22克、杜仲22克、熟地22克、当归22克、黄芪22克、山药22克、续断22克和桑寄生22克，粉碎，过100目筛，即得。
实施例2
化合物具有下列结构式：
试验例
椎管狭窄及骨折后治疗过程中，IL-4水平是一个非常关键的指标。IL-4水平低则说明炎症少痊愈情况良好。
模型和给药
将清洁级(SPF)雄性Wistar大鼠(鼠龄5-6月，体质量170.0±20.5)分成6组：正常对照组(Normal control group，NC)、模型对照组(Model control group，MC)、氨基葡萄糖对照组(Glucosamine control group，GS)、给药组1、给药组2、给药组3。每组10只。除正常对照组外，向其余各组大鼠的右膝关节注射4重量％木瓜蛋白酶水溶液10μL和0.03mol/L的L-半胱氨酸水溶液，并且分别于第3、7天加强，造成模型。造模后第14天开始给药，各组给药量如下：正常组与模型组，给予生理盐水灌胃1mL/100g体重；氨基葡萄糖组，氨基葡萄糖1g加100mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组1，实施例1的粉末10g加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组2，0.02g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组3，实施例1的粉末5g和0.01g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重。1次/日，连续给药30d，造模后第49天取材。
ELISA法检测IL-4
在第49天将动物处死后，行腹主动脉采血，将所采血液3000r/min离心5min，取血清，置-80℃冰箱保存待测。具体操作步骤按试剂盒(IL-4ELISA试剂盒购自上海酶联生物科技有限公司)说明书进行。结果见下表。
组别 IL-4(pg·mL-1)
正常组 179.6±9.9
模型组 33.2±2.1*
氨基葡萄糖组 60.5±4.2*△
给药组1 83.5±5.9*△
给药组2 65.8±5.2*△
给药组3 77.2±5.6*△
和正常对照组比较，*P＜0.05，表明造模成功；和模型组比较，△P＜0.05，说明本发明药物均具有药效。

Claims (5)

1.一种治疗椎管狭窄及骨折的中药膏贴，其特征在于，它包含下列重量份的物质：龙骨18-25份、丹参18-25份、红花18-25份、桃仁18-25份、骨碎补18-25份、三七18-25份、荆芥18-25份、自然铜18-25份、延胡索18-25份、鸡血藤18-25份、王不留行18-25份、路路通18-25份、土鳖虫18-25份、丹皮18-25份、赤芍18-25份、川芎18-25份、刘寄奴18-25份、三棱18-25份、苏木18-25份、牛膝18-25份、琥珀18-25份、大黄18-25份、栀子18-25份、葛根18-25份、黄柏18-25份、白花蛇舌草18-25份、钩藤18-25份、川楝子18-25份、乌药18-25份、炒香附18-25份、枳实18-25份、桂枝18-25份、制草乌18-25份、制川乌18-25份、防风18-25份、茯苓18-25份、羌活18-25份、独活18-25份、海风藤18-25份、桑枝18-25份、厚朴18-25份、全虫18-25份、乌梢蛇18-25份、地龙18-25份、蜈蚣18-25份、伸筋草18-25份、透骨草18-25份、威灵仙18-25份、千年健18-25份、木瓜18-25份、天麻18-25份、海桐皮18-25份、秦艽18-25份、细辛12-18份、白芍18-25份、僵蚕18-25份、补骨脂18-25份、地骨皮18-25份、何首乌18-25份、海螵蛸18-25份、白术18-25份、菟丝子18-25份、杜仲18-25份、熟地18-25份、当归18-25份、黄芪18-25份、山药18-25份、续断18-25份和桑寄生18-25份。
2.根据权利要求1所述的治疗椎管狭窄及骨折的中药膏贴，其特征在于，它包含下列重量份的物质：龙骨22份、丹参22份、红花22份、桃仁22份、骨碎补22份、三七22份、荆芥22份、自然铜22份、延胡索22份、鸡血藤22份、王不留行22份、路路通22份、土鳖虫22份、丹皮22份、赤芍22份、川芎22份、刘寄奴22份、三棱22份、苏木22份、牛膝22份、琥珀22份、大黄22份、栀子22份、葛根22份、黄柏22份、白花蛇舌草22份、钩藤22份、川楝子22份、乌药22份、炒香附22份、枳实22份、桂枝22份、制草乌22份、制川乌22份、防风22份、茯苓22份、羌活22份、独活22份、海风藤22份、桑枝22份、厚朴22份、全虫22份、乌梢蛇22份、地龙22份、蜈蚣22份、伸筋草22份、透骨草22份、威灵仙22份、千年健22份、木瓜22份、天麻22份、海桐皮22份、秦艽22份、细辛12-18份、白芍22份、僵蚕22份、补骨脂22份、地骨皮22份、何首乌22份、海螵蛸22份、白术22份、菟丝子22份、杜仲22份、熟地22份、当归22份、黄芪22份、山药22份、续断22份和桑寄生22份。
3.根据权利要求1所述的治疗椎管狭窄及骨折的中药膏贴，其特征在于，它还包含下列重量份的物质：0.1份的具有下列结构式的物质：
4.具有下列结构式的物质在制备治疗椎管狭窄及骨折的药物中的用途：
5.根据权利要求4所述的用途，其特征在于，所述药物制成膏贴。
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