CN106177561A - 一种治疗肺结核的中药组合物 - Google Patents

一种治疗肺结核的中药组合物 Download PDF

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CN106177561A
CN106177561A CN201610701311.XA CN201610701311A CN106177561A CN 106177561 A CN106177561 A CN 106177561A CN 201610701311 A CN201610701311 A CN 201610701311A CN 106177561 A CN106177561 A CN 106177561A
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孙晓程
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Abstract

本发明涉及一种治疗肺结核的中药组合物，其中药原料及重量份配比为：黄芪10‑30份、党参5‑25份、芦笋5‑25份、青果5‑20份、树茭瓜5‑25份、紫金牛5‑25份、毛蜂子5‑25份、燕窝5‑20份、紫菀5‑25份、鳖甲5‑25份、人参5‑20份、龙骨莲5‑25份、穿心莲5‑25份、鸭皂树根5‑25份、木耳5‑20份、石苇5‑25份、木槿根5‑25份、葎草5‑20份、地榆5‑25份、南瓜藤5‑25份、杏仁5‑20份、太子参5‑25份、麦冬5‑25份、多花沿阶草5‑25份、甘草5‑15份。本发明的中药组合物具有润肺生津、滋阴清热、补气养血、化痰止咳、敛疮止血的功效，其治疗肺结核疗效显著，作用可靠。

Description

一种治疗肺结核的中药组合物
技术领域
本发明涉及一种传统草药的未确定结构的医药配制品，尤其是一种治疗肺结核的中药组合物。
背景技术
肺结核是由结核分枝杆菌引发的肺部感染性疾病，结核分枝杆菌的传染源主要是 排菌的肺结核患者，通过呼吸道传播。健康人感染结核菌并不一定发病，只有在机体免疫力下降时才发病。世界卫生组织(WHO)统计表明，全世界每年发生结核病800-1000万，每年约 有300万人死于结核病，是造成死亡人数最多的单一传染病。肺结核的临床表现有：低热、盗汗乏力、食欲减退、体重减轻、失眠、恶病质面容、肺性肥大、钙化灶、咳嗽、咳痰、咯血、胸痛、呼吸困难等症状，肺结核还可能引起气胸、支气管扩张、脓胸、慢性肺源性心脏病等并发症， 严重威胁人类健康。目前治疗肺结核大多采用以抗菌素为主的西药，采用西药治疗存在效果快，但副作用极大，并且会对胃、肝造成不同程度伤害的不足。
祖国医学认为肺结核属中医学“肺痨”范畴。多因体质虚弱、气血不足、阴精耗损、痨虫侵肺所致。
根据中医理论，针对肺结核的发病机理，采用润肺生津、滋阴清热、补气养血、化痰止咳、敛疮止血的治法，进行辩证配伍组方，以达到标本兼治的目的。
发明内容
为了克服现有技术中以抗菌素治疗肺结核存在副作用大的不足，本发明提供一种配制简便、成本低、疗效显著、无副作用的治疗肺结核的中药组合物。
本发明解决其技术问题所采用的技术方案是：一种治疗肺结核的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪10-30份、党参5-25份、芦笋5-25份、青果5-20份、树茭瓜5-25份、紫金牛5-25份、毛蜂子5-25份、燕窝5-20份、紫菀5-25份、鳖甲5-25份、人参5-20份、龙骨莲5-25份、穿心莲5-25份、鸭皂树根5-25份、木耳5-20份、石苇5-25份、木槿根5-25份、葎草5-20份、地榆5-25份、南瓜藤5-25份、杏仁5-20份、太子参5-25份、麦冬5-25份、多花沿阶草5-25份、甘草5-15份。
本发明的优选技术方案是：一种治疗肺结核的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪20份、党参15份、芦笋15份、青果10份、树茭瓜15份、紫金牛15份、毛蜂子15份、燕窝10份、紫菀15份、鳖甲15份、人参10份、龙骨莲15份、穿心莲15份、鸭皂树根15份、木耳10份、石苇15份、木槿根15份、葎草10份、地榆15份、南瓜藤15份、杏仁10份、太子参15份、麦冬15份、多花沿阶草15份、甘草10份。
本发明中药组合物是在传统中医理论和临床经验指导下，精选药物组方。本发明中药组合物中：黄芪具有益气固表、敛汗固脱、托疮生肌、利水消肿的功效；党参具有补中益气、健脾益肺的功效；芦笋具有清热生津、利水通淋的功效；青果具有清肺利咽、生津止渴、解毒的功效；树茭瓜具有清热润肺、化痰止咳、散瘀止血的功效；紫金牛具有止咳化痰、祛风解毒、活血止痛的功效；毛蜂子具有滋阴润燥、补虚益损的功效；燕窝具有养阴润燥、益气补中、化痰止咳的功效；紫菀具有润肺下气、化痰止咳的功效；鳖甲具有滋阴潜阳、软坚散结、退热除蒸的功效；人参具有大补元气、复脉固脱、补脾益肺的功效；龙骨莲具有滋阴清热的功效；穿心莲具有清热解毒、凉血消肿的功效；鸭皂树根具有清热解毒、消痈排脓、祛风除湿。的功效；木耳具有补气养血、润肺止咳的功效；石苇具有利水通淋，清肺泄热的功效；木槿根具有清热解毒、消痈肿的功效；葎草具有清热解毒、利尿消肿的功效；地榆具有凉血止血、清热解毒、消肿敛疮的功效；南瓜藤具有平肝和胃、通经络、利血脉、滋肾水的功效；杏仁具有祛痰止咳、平喘润肠、下气开痹的功效；太子参具有益气健脾、生津润肺的功效；麦冬具有养阴生津、润肺清心的功效；多花沿阶草具有润肺生津、止咳化痰的功效；甘草具有补脾益气、清热解毒、祛痰止咳、调和诸药的功效。本发明精选药物组方，其药物组分经辩证配伍，在作用上相互佐助，共奏润肺生津、滋阴清热、补气养血、化痰止咳、敛疮止血的功效，对肺结核的治疗达到标本兼治。
本发明组合物的组分均采用天然的中药原料，其配制简便、药源广、成本低。本发明遵循中医的处方用药原则，各种组分药物采用水煎服用。经临床应用验证和中药品不良反应（ADR）安全性评价，其疗效显著，安全可靠，药性平和，未出现毒副作用，有效率达96%，治愈率74%。
具体实施方式
下面结合实施例对本发明作进一步说明。
实施例1
一种治疗肺结核的中药组合物，其中药原料及重量配比为：黄芪20g、党参15g、芦笋15g、青果10g、树茭瓜15g、紫金牛15g、毛蜂子15g、燕窝10g、紫菀15g、鳖甲15g、人参10g、龙骨莲15g、穿心莲15g、鸭皂树根15g、木耳10g、石苇15g、木槿根15g、葎草10g、地榆15g、南瓜藤15g、杏仁10g、太子参15g、麦冬15g、多花沿阶草15g、甘草10g。
实施例2
一种治疗肺结核的中药组合物，其中药原料及重量配比为：黄芪15g、党参25g、芦笋10g、青果20g、树茭瓜5g、紫金牛25g、毛蜂子10g、燕窝20g、紫菀5g、鳖甲25g、人参12g、龙骨莲20g、穿心莲5g、鸭皂树根25g、木耳12g、石苇20g、木槿根5g、葎草15g、地榆10g、南瓜藤20g、杏仁5g、太子参25g、麦冬10g、多花沿阶草20g、甘草5g。
实施例3
一种治疗肺结核的中药组合物，其中药原料及重量配比为：黄芪25g、党参10g、芦笋20g、青果5g、树茭瓜25g、紫金牛10g、毛蜂子20g、燕窝5g、紫菀25g、鳖甲10g、人参20g、龙骨莲5g、穿心莲25g、鸭皂树根10g、木耳20g、石苇5g、木槿根25g、葎草12g、地榆20g、南瓜藤5g、杏仁15g、太子参10g、麦冬20g、多花沿阶草5g、甘草8g。
实施例4
一种治疗肺结核的中药组合物，其中药原料及重量配比为：黄芪10g、党参20g、芦笋5g、青果15g、树茭瓜10g、紫金牛20g、毛蜂子5g、燕窝15g、紫菀10g、鳖甲20g、人参5g、龙骨莲25g、穿心莲10g、鸭皂树根20g、木耳5g、石苇25g、木槿根10g、葎草20g、地榆5g、南瓜藤25g、杏仁12g、太子参20g、麦冬5g、多花沿阶草25g、甘草12g。
实施例5
一种治疗肺结核的中药组合物，其中药原料及重量配比为：黄芪30g、党参5g、芦笋25g、青果12g、树茭瓜20g、紫金牛5g、毛蜂子25g、燕窝2g、紫菀20g、鳖甲5g、人参15g、龙骨莲10g、穿心莲20g、鸭皂树根5g、木耳15g、石苇10g、木槿根20g、葎草5g、地榆25g、南瓜藤10g、杏仁20g、太子参5g、麦冬25g、多花沿阶草10g、甘草15g。
本发明实施例中的中药组合物按常规的水煎法制取药剂。具体方法如下：将组方的中药原料放入容器中，加冷水漫过药面，浸泡15～20分钟，再加水没过药面约6厘米，进行第一次煎煮，未沸前采用武火煎煮，沸后用文火煎煮20～30分钟；第二次煎煮，加水没过药面约4厘米，水沸后煎煮15～20分钟。两次煎煮取汁，合并。
本发明以实施例1所给出的一种治疗肺结核的中药组合物，做临床疗效总结如下：
一、一般性资料：本中药组合物应用于临床观察病例70例，男39例，女31例，年龄15～75岁。
二、诊断依据：
1、初期仅感疲劳乏力，干咳，食欲不振，形体逐渐消瘦，病重者可出现咳（咯）血，潮热，颧红，盗汗，形体明显消瘦等症；
2、常有与肺痨者密切接触史；
3、病灶部位呼吸音减弱，或闻及支气管呼吸音及湿罗音；
4、痰液涂片、浓缩或培养，结核菌多呈阳性；
5、血沉增快；
6、结核菌素皮试呈强阳性；
7、X线摄片示肺部可见结核病灶。必要时可作X线断层摄片。
三、用法用量：临床应用时，一日一剂，水煎两遍取汁约400ml，分早、晚两次空腹温服。五天为一疗程。治疗期间忌生冷辛辣刺激之物。
四、疗效标准：
1、治愈：症状消失，肺部病灶吸收钙化，痰菌检查转阴；
2、有效：症状改善，肺部病灶部分吸收；
3、无效：症状及病灶无变化。
五、治疗效果：该临床观察病例中，服药5-10个疗程，痊愈52例，随访未见复发；有效15例，无效3例。治疗期间对中药品临床引起各类型的过敏反应、疑为药物引起人体各系统、器官、组织的功能和形态方面的异常、疑为药物引起癌症等致突变反应、药物的依赖性以及认为重要或有价值的其他不良反应进行了评价，即中药品不良反应（ADR）评价，未发生不良反应和毒副作用。
六、典型病例：
病例1：
陈某，女，26岁。半个月前出现咳嗽、痰中带血、胸闷气短、夜间盗汗、口干咽燥等症状。经细菌学检查和X线检查诊断为：肺结核。服用本发明中药组合物制备的药剂2个疗程，咳嗽、胸闷气短症状明显减轻，痰中无血丝；继续服用3个疗程，复检痰菌转阴，X 线检查结核病灶吸收钙化，治愈。随访1年未复发。
病例2：
袁某，男，52岁。患肺结核1年，咳嗽、胸痛、咳血、食欲不振、形体消瘦，同时伴有低热、盗汗。曾住院医院治疗，疗效不佳。服用本发明中药组合物制备的药剂3个疗程，咳嗽、胸痛等症状有所好转，食欲增加，低热、盗汗症状消失；继续服用3个疗程，所有症状完全消失，痊愈。

Claims (2)

1.一种治疗肺结核的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪10-30份、党参5-25份、芦笋5-25份、青果5-20份、树茭瓜5-25份、紫金牛5-25份、毛蜂子5-25份、燕窝5-20份、紫菀5-25份、鳖甲5-25份、人参5-20份、龙骨莲5-25份、穿心莲5-25份、鸭皂树根5-25份、木耳5-20份、石苇5-25份、木槿根5-25份、葎草5-20份、地榆5-25份、南瓜藤5-25份、杏仁5-20份、太子参5-25份、麦冬5-25份、多花沿阶草5-25份、甘草5-15份。
2.根据权利要求1所述一种治疗肺结核的中药组合物，其特征在于：其中药原料及重量份配比为：黄芪20份、党参15份、芦笋15份、青果10份、树茭瓜15份、紫金牛15份、毛蜂子15份、燕窝10份、紫菀15份、鳖甲15份、人参10份、龙骨莲15份、穿心莲15份、鸭皂树根15份、木耳10份、石苇15份、木槿根15份、葎草10份、地榆15份、南瓜藤15份、杏仁10份、太子参15份、麦冬15份、多花沿阶草15份、甘草10份。
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