CN106177425A - A kind of preparation technology of woman's treasured granule - Google Patents
A kind of preparation technology of woman's treasured granule Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses the preparation technology of a kind of woman's treasured granule, in terms of parts by weight: include 80 100 portions of Radix Rehmanniae, 80 100 portions of Caulis Loniceraes, 40 60 portions of prepared RADIX DIPSACI with salt solution, 90 120 portions of salt Cortex Eucommiae (processed) leaves, 40 60 portions of Radix Ophiopogonis, 40 60 portions of Fructus Toosendan (parched), 40 80 portions of Radix Paeoniae Alba, 60 80 portions of vinegar Rhizoma Corydalis, 10 20 portions of Radix Glycyrrhizaes, 60 80 portions of stir-frys Cacumen Platycladi, 60 80 portions of charred Receptaculum Nelumbinis, 60 80 portions of Caulis Sargentodoxae.By raw material is carried out, selects, decocts, concentrates, mixes, obtains soft material, primary dcreening operation, dry, fine screen packaging.The symptoms such as the present invention has good kidney tonifying and blood, effect of regulating QI to relieve pain, and can be used for suffering from a deficiency of the kidney folder waist soreness caused by the stasis of blood, lower abdominal distention pain, leucorrhea amount are many.
Description
Technical field
The present invention relates to Chinese patent drug technique field, more specifically, it relates to the preparation technology of a kind of woman's treasured granule.
Background technology
Along with constantly accelerating and the continuous increase of operating pressure, chronic pelvic inflammatory disease, chronic adnexitis, son of rhythm of life
The gynaecopathia such as Endometrium inflammation, cervicitis become commonly encountered diseases and the frequently-occurring disease of women, if treating not in time, easily cause cervical cancer, ovum
The cancerations such as nest malignant tumor, carcinoma of endometrium, threaten to women life.Generally, antibiotics Western medicine is used quickly to control
Inflammation processed, but Western medicine is easily generated drug resistance, and thorough not to gynopathic treatment, make gynaecopathia recurrent exerbation, perplex women
Orthobiosis.Treat gynopathic Chinese patent medicine, owing to Chinese patent medicine composition therein is not likely to produce drug resistance, there is controlling of gentleness
Treatment effect, has no side effect, and uses by the course for the treatment of, can thoroughly be cured by gynaecopathia, and be applicable to the women in all ages and classes stage
Patient.
The Chinese patent that application publication number is CN104096068A, Shen Qing Publication day is on October 15th, 2014 discloses one
The processing method planting Fubao capsule, its formula is the medical materials such as Radix Codonopsis, Radix Morindae Officinalis, Herba Cistanches;With dispelling, slag concentrates preparation method, and the Radix Rehmanniae is the most public
Jin is joined 2.5 kilograms of old wine and is calculated, and adds the boiled slag of dispelling of a little vinegar, and juice is standby;Use after pulverizing with Herba Plantaginis, Rhizoma Coptidis, Chinese medicine honeysuckle
The boiled slag of dispelling of clear water, juice is standby;Being soaked in water half an hour with Herba monochoriae vaginalis, Flos Chrysanthemi, Cortex Moutan medical material, boiled slag of dispelling, juice is standby;Three kinds
Standby juice mixes, and dries with the stirring of mixed juice with medical material unused in formula, is ground into end altogether, by 180 mesh sieve mistakes
After sieve, make capsule.
The Radix Rehmanniae is concentrated and makes medicine juice by prior art;Herba Plantaginis, Rhizoma Coptidis, Chinese medicine honeysuckle are concentrated and make medicine juice;By duck
SHECAO, Flos Chrysanthemi, Cortex Moutan medical material also concentrate makes medicine juice.Again by three kinds of medicine juice mixing, and by medicines such as Radix Codonopsis, Radix Morindae Officinalis, Herba Cistanches
Material stirring is dried, and is ground into and last makes capsule, more convenient the when of eating, will not be excessively bitter.After capsule enters in human body, glue
Capsule is dissolved by gastric acid, and the internal medical material in powder contacts with stomach and digested in stomach, but, due to Radix Codonopsis, Radix Morindae Officinalis, meat
Containing more fiber in the medical materials such as Herba Cistanches, after being ground into powder, it is difficult to by human consumption, wherein corresponding effective ingredient
It is difficult to be absorbed by human body, therefore, causes drug effect to reduce.
Summary of the invention
The deficiency existed for prior art, it is an object of the invention to provide the preparation technology of a kind of woman's treasured granule, its
Solving after medical material is directly ground into powder, effective ingredient therein is difficult to be fully absorbed by human body, causes drug effect relatively low
Problem, has and makes the effective ingredient in medical material fully be absorbed by the body, reach the effect of preferable drug effect.
For achieving the above object, the technical scheme is that
The preparation technology of a kind of woman's treasured granule, comprises the steps:
S1, selects cleaning raw material: select and weigh in terms of parts by weight: 80-100 part Radix Rehmanniae, 80-100 part Caulis Lonicerae, 40-60
Part prepared RADIX DIPSACI with salt solution, 90-120 part salt Cortex Eucommiae (processed) leaf, 40-60 part Radix Ophiopogonis, 40-60 part Fructus Toosendan (parched), 40-80 part Radix Paeoniae Alba, 60-80 part
Vinegar Rhizoma Corydalis, 10-20 part Radix Glycyrrhizae, 60-80 part fry Cacumen Platycladi, 60-80 part charred Receptaculum Nelumbinis, 60-80 part Caulis Sargentodoxae, are carried out, dry
Dry;
S2, decocts: the raw material after cleaning is inserted in water and fully decocted, and filters, it is thus achieved that decoction liquor;
S3, concentrates: decoction liquor concentrated, it is thus achieved that clear paste, and clear paste volume is more than or equal to 0.027: 1,60 with the ratio of decoction liquor volume
Under conditions of DEG C, the relative density of clear paste is 1.08-1.18;In the clear paste obtained, add ethanol, stir and stand
48h, takes supernatant, reclaims ethanol, filters, and concentrated filtrate obtains thick paste 153-187kg, under conditions of 60 DEG C, the phase of thick paste
It is 1.33-1.45 to density;In thick paste, add pure water, stir, stand 24h, take supernatant concentration, it is thus achieved that concentrate thick
Cream 126-160kg, under conditions of 60 DEG C, the relative density concentrating thick paste is 1.36-1.41;
S4, mixing: pulverize sweeting agent, form sweet taste powder, count by weight, weigh 2-3 part sweet taste powder, 0.5-0.8 part dextrin
With the concentration thick paste obtained in S3, after being sufficiently mixed, form original material;
S5, obtains soft material: add ethanol water in the original material that will obtain in S4, be sufficiently mixed, it is thus achieved that soft material;
S6, primary dcreening operation: by the soft material that obtains in S5 through 12 mesh sieves, make wet grain;
S7, is dried: is dried by the wet grain obtained in S6 to water content less than 2.0%, makes dry granule;
S8, fine screen is packed: is screened through 10-30 mesh sieve by the dry granule obtained in S7, it is thus achieved that coarse granule, is mixed by coarse granule
10-20min, prepares finished product, airtight in being placed in clean container, packs, and specification is 10g/ bag;
Radix Rehmanniae in described S1 is Radix Rehmanniae;In ethanol water in described S5, ethanol is 5-6 with the volume ratio of pure water:
1, described ethanol water is 0.3-0.5: 1 with the volume ratio of original material.
In the application, using the mode decocted, each effective ingredient in each raw material is substantially dissolved in water;And use decoct
Boiling solvent is water, it is to avoid the operation on the later stage produces impact, and is difficult to affect health.Luteolin-7-in Caulis Lonicerae
The compositions such as scillabiose, luteolin, tannin, alkaloid;The compositions such as alkaloid in prepared RADIX DIPSACI with salt solution, volatile oil;Radix Dipsaci
Radix Dipsaci alkali in root and volatile oil component;The compositions such as volatile oil in Cacumen Platycladi, Flavonoid substances, tannin, resin, vitamin C,
Wherein, containing the composition such as thujene, absinthol, fenchone, pinene, caryophyllene in volatile oil, in flavonoid containing aromadendrin,
The compositions such as Quercetin, myricetin, hinokiflavone, amentoflavone;Protein in Receptaculum Nelumbinis ash, fat, carbon aquation
The compositions such as thing, crude fibre, ash, carotene, thiamine, riboflavin, nicotinic acid, ascorbic acid, nelumbine, at decoction process
In be sufficiently mixed, after substep concentrates, gradually form more uniformly and concentration thick paste that relative density is higher.By ethanol water
Be sufficiently mixed with original material, and the volume ratio of ethanol and pure water be 5-6: 1, by similar compatibility principle, it is simple to Radix Glycyrrhizae with
Volatile oil in ethanol water, with original material merges, and promotes the intestines and stomach absorption to the application, accelerates gynaecopathia
Treatment, may additionally facilitate the ulcer healing in the intestines and stomach;And ethanol forms complex role with the effective ingredient in original material, makes
Each component in original material has preferable stability, reduces original material and rotten probability occurs, agitated uniformly, shape
Become the soft material that nutritional labeling is more rich.Wet grain is dried, remove wherein large quantity of moisture and the ethanol of residual, make being dried of acquisition
Granule becomes pure, and is difficult to corruption, can extend the shelf life.Screen through 10-30 mesh sieve after, make the application of acquisition have all
Even profile, and packing specification is 10g/ bag, it is simple to store, also allow for patient and carry out brewing taking according to institute's expense.
Wherein, Radix Rehmanniae is cool in nature, has the effect of clearing away heat and cooling blood;Caulis Lonicerae has heat clearing away, removing toxic substances, and effect of dredging collateral can
The symptoms such as treatment epidemic febrile disease is generated heat, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain, but be not suitable for the trouble of Deficiency and coldness of spleen and stomach
Person uses;Prepared RADIX DIPSACI with salt solution has invigorating the liver and kidney, reuniting the fractured tendons and bones, the function of blood circulation regulating;Cacumen Platycladi has removing heat from blood, hemostasis, wind-damp dispelling, dissipates and swell
Poison, control the effect of haematemesis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia;Receptaculum Nelumbinis ash has repercussive, the effect stopped blooding, dry;Caulis Sargentodoxae has
Nourish blood repercussive, regulating QI to expel dampness, podomere ache, the effect of heart peratodynia, but be not suitable for the weak patient of blood deficiency gas and use.Radix Rehmanniae,
Caulis Lonicerae, prepared RADIX DIPSACI with salt solution, salt Cortex Eucommiae (processed) leaf, Radix Ophiopogonis, Fructus Toosendan (parched), Radix Paeoniae Alba, vinegar Rhizoma Corydalis, Radix Glycyrrhizae, stir-fry Cacumen Platycladi, charred Receptaculum Nelumbinis,
The Caulis Sargentodoxae effect of cooperating, makes the application have kidney tonifying and blood, effect of regulating QI to relieve pain, can be used for folder waist caused by the stasis of blood of suffering from a deficiency of the kidney
The acid symptoms such as lower limb is soft, lower abdominal distention pain, leucorrhea amount are many.
More preferably: in described S2 decoction liquor the most fully soaked by each raw material, supersound process, the most pan-fried
Boil, it is thus achieved that the preliminary extracting solution of corresponding raw material, more fully decoct acquisition after being sufficiently mixed by each preliminary extracting solution.
In the application, fully being soaked by each raw material respectively, supersound process, fully decoct, every kind of raw material is respectively formed one
Plant corresponding preliminary extracting solution, the corresponding active component in each raw material can be fully extracted out, reduce in the application respectively to become
Divide the loss of drug effect;After each preliminary extracting solution is mixed, then decoct, make each effective ingredient the most abundant.
More preferably: the sweeting agent in described S4 is sucrose or steviosin, described sweet taste powder is through 180-200 mesh sieve
Screen.
Sucrose and steviosin are respectively provided with sweet taste, improve the mouthfeel of the application, make patient more be easily accepted by the application.And steviosin
There is preferable sweet taste, and heat is low, also have thermostability, the application uses steviosin, replace sugar product to improve mouthfeel, and subtract
Few impact on the patient suffering from diabetes and gynaecopathia simultaneously, makes diabetics treat gynaecopathia by the application;
And steviosin is soluble in water or ethanol, can be sufficiently mixed with dextrin, concentration thick paste, and be uniformly distributed in original material, make system
The application obtained has sweet taste.
More preferably: being dried in described S7 and use HighefficientFluidbeddrier, inlet temperature is 50-95 DEG C, goes out pathogenic wind-warm
Degree is for 50-80 DEG C, and drying time is 30-50min.
In the application, the wet grain obtained after 12 mesh sieves carry out primary dcreening operation, its particle diameter is about 1.5-1.6mm, and makes air intake temperature
Degree forms temperature difference with leaving air temp, and wet grain can be dried by HighefficientFluidbeddrier quickly through high velocity air, and is dried
The most uniform.
More preferably: in described S8 through 10-30 mesh sieve sieve fall for fine grained, collect, repeat S5-S8 and make
Make.
When wet grain after drying, due to internal moisture and the ethanol evaporation of residual, the particle diameter of wet grain reduces, and particle diameter is little
Fine grained in mesh size is difficult to screened, after collecting and remanufacturing, makes the granule in the application have unified grain
Footpath, more preferably controls weight when packing, make the application in every bag of packaging have identical drug effect, make the state of an illness of patient obtain
Control and stable treatment.
In sum, the method have the advantages that
1. raw material is cleaned, select, decoct, concentrate, mix, obtain soft material, primary dcreening operation, be dried, fine screen packaging obtains after the application, tool
There are good kidney tonifying and blood, effect of regulating QI to relieve pain, can be used for suffer from a deficiency of the kidney folder waist soreness caused by the stasis of blood, lower abdominal distention pain, leucorrhea amount
The symptoms such as many;
2. the volatile oil in Radix Glycyrrhizae and ethanol water, with original material merges, and promotes the intestines and stomach absorption to the application, adds
The fast treatment to gynaecopathia, may additionally facilitate the ulcer healing in the intestines and stomach;
3. ethanol water forms complex role with the effective ingredient in original material, makes each component have preferable stability,
Reduce original material and rotten probability occurs, thus extend the shelf life.
Detailed description of the invention
This specific embodiment is only explanation of the invention, and it is not limitation of the present invention, people in the art
The present embodiment can be made after reading this specification by member as required does not has the amendment of creative contribution, but as long as at this
All protected by Patent Law in the right of invention.
Embodiment 1: the preparation technology of a kind of woman's treasured granule, each component and parts by weight thereof are as shown in table 1, and include as follows
Step:
S1, selects cleaning raw material: select and weigh the Radix Rehmanniae of corresponding parts by weight, Caulis Lonicerae, prepared RADIX DIPSACI with salt solution, salt Cortex Eucommiae (processed) leaf,
Radix Ophiopogonis, Fructus Toosendan (parched), Radix Paeoniae Alba, vinegar Rhizoma Corydalis, Radix Glycyrrhizae, stir-fry Cacumen Platycladi, charred Receptaculum Nelumbinis, Caulis Sargentodoxae, be carried out, and is dried;
S2, decocts: the raw material after cleaning is inserted in water and fully decocted, and filters, it is thus achieved that decoction liquor;
S3, concentrates: decoction liquor concentrated, it is thus achieved that clear paste, and clear paste volume is more than or equal to 0.027: 1,60 with the ratio of decoction liquor volume
Under conditions of DEG C, the relative density of clear paste is 1.08-1.18;In the clear paste obtained, add ethanol, stir and stand
48h, takes supernatant, reclaims ethanol, filters, and concentrated filtrate obtains thick paste 153-187kg, under conditions of 60 DEG C, the phase of thick paste
It is 1.33-1.45 to density;In thick paste, add pure water, stir, stand 24h, take supernatant concentration, it is thus achieved that concentrate thick
Cream 126-160kg, under conditions of 60 DEG C, the relative density concentrating thick paste is 1.36-1.41;
S4, mixing: use Universalpulverizer to pulverize sucrose, form cane sugar powder, count by weight, weigh corresponding parts by weight
The concentration thick paste obtained in cane sugar powder, dextrin and S3, after being sufficiently mixed by trough type mixing machine, forms original material;
S5, obtains soft material: adding ethanol water 3.5L in the original material that will obtain in S4, ethanol with the volume ratio of pure water is
5-6: 1, and the volume ratio of ethanol water and original material is 0.3-0.5: 1, is sufficiently mixed, it is thus achieved that soft material;
S6, primary dcreening operation: by the soft material that obtains in S5 through 12 mesh sieves, after being shaken by oscillating granulator, make wet grain;
S7, is dried: being dried through HighefficientFluidbeddrier by the wet grain obtained in S6, inlet temperature is 50-95 DEG C, and leaving air temp is
50-80 DEG C, drying time is 30-50min, and the water content being dried to wet grain less than 2.0%, makes dry granule;
S8, fine screen is packed: screened through 10-30 mesh sieve by the dry granule obtained in S7, it is thus achieved that coarse granule, by coarse granule by two
Dimension movement mixer mixing 10-20min, prepares finished product, airtight in being placed in clean container, packs, and specification is 10g/ bag;
S9, the fine grained that will fall through 10-30 mesh sieve sieve in S8, collect, repeat S5-S8 and manufacture.
Embodiment 2: the preparation technology of a kind of woman's treasured granule, with being distinguished as of embodiment 1: the sucrose in S4 replaces to Flos Chrysanthemi
Element, the preparation technology of the woman's treasured granule in other step reference examples 1.
Embodiment 3: the preparation technology of a kind of woman's treasured granule, with being distinguished as of embodiment 1: the sucrose in S4 is polished,
Screen through 180-200 mesh sieve again, and the volume ratio of ethanol and pure water is 6: 1, and ethanol water and original material
Volume ratio be 0.5: 1, the preparation technology of the woman's treasured granule in other step reference examples 1.
Embodiment 4: the preparation technology of a kind of woman's treasured granule, with being distinguished as of embodiment 1: the sucrose in S4 is polished,
Screen through 180-200 mesh sieve again, and the volume ratio of ethanol and pure water is 5.5: 1, and ethanol water and initial material
The volume ratio of material is 0.3: 1, the preparation technology of the woman's treasured granule in other step reference examples 1.
Embodiment 5: the preparation technology of a kind of woman's treasured granule, and being distinguished as of embodiment 1:
S2, each raw material the most fully soaks, supersound process, fully decoct, it is thus achieved that the preliminary extracting solution of corresponding raw material, then will
Each preliminary extracting solution the most fully decocts after being sufficiently mixed, it is thus achieved that cooking liquor.
The preparation technology of the woman's treasured granule in other step reference examples 1.
Comparative example 1-4: the preparation technology of a kind of woman's treasured granule, and being distinguished as of embodiment 3: its each component and corresponding weigh
Amount number is as shown in table 2.The preparation technology of preparation technology reference example 3.
Comparative example 5-7: the preparation technology of a kind of woman's treasured granule, and being distinguished as of embodiment 5: its each component and corresponding weigh
Amount number is as shown in table 2.The preparation technology of preparation technology reference example 5.
Each component and parts by weight thereof in table 1 embodiment 1-5
Each component and parts by weight thereof in table 2 comparative example 1-7
1 | 2 | 3 | 4 | 5 | 6 | 7 | |
Radix Rehmanniae | 100 | 100 | 100 | 100 | 90 | 30 | 30 |
Caulis Lonicerae | 80 | 80 | 80 | 80 | 0 | 80 | 20 |
Prepared RADIX DIPSACI with salt solution | 0 | 0 | 10 | 20 | 0 | 40 | 10 |
Salt Cortex Eucommiae (processed) leaf | 95 | 95 | 95 | 95 | 100 | 30 | 50 |
Radix Ophiopogonis | 50 | 50 | 50 | 50 | 45 | 20 | 20 |
Fructus Toosendan (parched) | 60 | 60 | 60 | 60 | 50 | 10 | 15 |
Radix Paeoniae Alba | 40 | 40 | 40 | 40 | 70 | 30 | 10 |
Vinegar Rhizoma Corydalis | 60 | 60 | 60 | 60 | 75 | 50 | 25 |
Radix Glycyrrhizae | 0 | 5 | 8 | 10 | 0 | 10 | 5 |
Fry Cacumen Platycladi | 0 | 20 | 0 | 30 | 0 | 60 | 25 |
Charred Receptaculum Nelumbinis | 65 | 65 | 65 | 65 | 70 | 15 | 30 |
Caulis Sargentodoxae | 70 | 70 | 70 | 70 | 80 | 80 | 25 |
Controlled trial 1: absorption test
Test specimen: use the sample that embodiment 1-5 prepares as test sample 1-5, use comparative example 1-4 to prepare
Sample is as control sample 1-4.
Test method: areal extract same hospital admission, suffer from the chronic pelvic inflammatory disease of similar degree, adnexitis,
The female subjects of endometritis totally 300, and 300 experimenters are in the age bracket in 29-39 year.Experimenter is average
It is divided into 10 groups, numbering 1-10 group respectively, often organize 30 people.Using the 1st group as blank, 2-10 group experimenter is respectively adopted examination
Test sample 1-5 and control sample 1-4 is treated, take after mixing it with water according to the every day of boiled water half an hour after meal, each 20g, after treating 3 months, enters
Row symptom, the inspection of sign situation, be analyzed.
Result of the test: 2-6 group experimenter, after each taking sample 1min, can feel that the obvious of pain is alleviated;7-10
Experimenter is after taking sample about 10min for group, experiences pain and slightly alleviates.After the treatment of 3 months, the 1st group, during fashion
Bad, even some people sb.'s illness took a turn for the worse;2nd group, there is the uterine activity of 28 experimenters that limited and tenderness phenomenon no longer occurs, little
Abdomen no longer distending pain, leucorrhea reduces, recovery from illness;3rd group and the 4th group has 25 and 27 experimenter's recoveries from illness respectively;5th group and the 6th group has
26 and 28 experimenter's recoveries from illness;In 7th group, only 5 experimenter's recoveries from illness, also 18 experimenter's still sensation uterine activities are subject to
Limiting and tenderness phenomenon occur, leucorrhea is the most a lot, and lower abdomen has distending pain sense;In 8th group and the 9th group, 8 experimenters are had to fully recover from an illness respectively
More;In 10th group, having 12 experimenter's recoveries from illness, still sensation uterine activity is limited and goes out with tenderness phenomenon for 10 experimenters
Existing, leucorrhea amount somewhat reduces.
It follows that prepared RADIX DIPSACI with salt solution, Radix Glycyrrhizae, the use compounding with ethanol water of stir-fry Cacumen Platycladi, the intestines and stomach can be accelerated to the application
Assimilation effect;And raw material is cleaned, select, decoct, concentrate, mix, obtain soft material, primary dcreening operation, dry, this Shen of fine screen packaging acquisition
After please, there is good kidney tonifying and blood, effect of regulating QI to relieve pain, can be used for suffering from a deficiency of the kidney folder waist soreness caused by the stasis of blood, lower abdominal distention pain,
The symptoms such as leucorrhea amount is many.
Test 2: gastric ulcer therapeutic test
Test specimen: identical with the test specimen in test 1.
Test method: 100 experimenters of random choose, every experimenter all suffers from the cervicitis stomach function regulating of same degree and bursts
Infections, and every experimenter is all from areal, diet is the lightest.100 experimenters are equally divided into 10 groups, numbering 1-10,
Often organize 10 people, using the 1st group as blank, 2-10 group experimenter is respectively adopted test sample 1-5 and control sample 1-4 is controlled
Treat, take after mixing it with water according to the every day of boiled water half an hour after meal, each 20g, after treating 6 months, carry out gastroscopy, cervical secretions training
Support, then carry out record, and be analyzed according to record.
Result of the test: gastric ulcer and the cervicitis situation of 1-10 group experimenter are as shown in table 3.
The gastric ulcer of table 3 1-10 group experimenter and cervicitis situation
As shown in Table 3, using the experimenter of test sample 1-5 treatment, its cervical secretions is cultivated normally, cervicitis is described
Substantially it is cured, and gastric ulcer also has and significantly reduces;And using the experimenter that control sample 1-4 treats, its cervical secretions is trained
Support and be still abnormal, and gastric ulcer situation does not improves significantly.Therefore, prepared RADIX DIPSACI with salt solution, Radix Glycyrrhizae, stir-fry Cacumen Platycladi and ethanol are illustrated
Aqueous solution is mutually compounding to be used, and not only can promote the recovery from illness of gynaecopathia, also can reach the effect of good treatment gastric ulcer.
Test 3: stability test
Test specimen: test specimen: use the sample that embodiment 1-5 prepares as test sample 1-5, use comparative example 5-7
The sample prepared is as control sample 5-7.
Test method: by each to packaged test sample 1-5 and control sample 5-7 20 bags, be divided into 1-8 group successively, together with bag
Pack carries out process of weighing, the average data that record is often organized respectively;Afterwards, all opening and being uprightly positioned over temperature is (40 ± 2) DEG C,
Under conditions of relative humidity is (75 ± 5) %, carry out the experimental period of 6 months by a definite date.The 1st, 2,3,6 the end of month of test period is respectively
Weigh once, the average data that record is often organized, and be analyzed.
Result of the test: 1-8 group sample quality situation of change is as shown in table 4.Wherein, 1-5 group sample does not finds deterioration,
And 6-8 group sample, then going mouldy in various degree occurs, the mildew phenomena of the 6th group is the most serious.
Table 4 1-8 group sample quality situation of change
As shown in Table 4, during testing, the mass change of test sample 1-5 is less, and the mass change of control sample 5-7 is relatively
Greatly, especially control sample 5, mass weight gain situation is the most serious.Therefore, ethanol water and the effective ingredient shape in original material
Become complex role, make each component have preferable stability, reduce original material and rotten probability occurs, thus extend and guarantee the quality
Phase.
The above is only the preferred embodiment of the present invention, and protection scope of the present invention is not limited merely to above-mentioned enforcement
Example, all technical schemes belonged under thinking of the present invention belong to protection scope of the present invention.It should be pointed out that, for the art
Those of ordinary skill for, some improvements and modifications without departing from the principles of the present invention, these improvements and modifications are also
Should be regarded as protection scope of the present invention.
Claims (5)
1. the preparation technology of woman's treasured granule, it is characterised in that comprise the steps:
S1, selects cleaning raw material: select and weigh in terms of parts by weight: 80-100 part Radix Rehmanniae, 80-100 part Caulis Lonicerae, 40-60
Part prepared RADIX DIPSACI with salt solution, 90-120 part salt Cortex Eucommiae (processed) leaf, 40-60 part Radix Ophiopogonis, 40-60 part Fructus Toosendan (parched), 40-80 part Radix Paeoniae Alba, 60-80 part
Vinegar Rhizoma Corydalis, 10-20 part Radix Glycyrrhizae, 60-80 part fry Cacumen Platycladi, 60-80 part charred Receptaculum Nelumbinis, 60-80 part Caulis Sargentodoxae, are carried out, dry
Dry;
S2, decocts: the raw material after cleaning is inserted in water and fully decocted, and filters, it is thus achieved that decoction liquor;
S3, concentrates: decoction liquor concentrated, it is thus achieved that clear paste, the ratio of clear paste volume and decoction liquor volume more than or equal to 0.027:1,60
Under conditions of DEG C, the relative density of clear paste is 1.08-1.18;In the clear paste obtained, add ethanol, stir and stand
48h, takes supernatant, reclaims ethanol, filters, and concentrated filtrate obtains thick paste 153-187kg, under conditions of 60 DEG C, the phase of thick paste
It is 1.33-1.45 to density;In thick paste, add pure water, stir, stand 24h, take supernatant concentration, it is thus achieved that concentrate thick
Cream 126-160kg, under conditions of 60 DEG C, the relative density concentrating thick paste is 1.36-1.41;
S4, mixing: pulverize sweeting agent, form sweet taste powder, count by weight, weigh 2-3 part sweet taste powder, 0.5-0.8 part dextrin
With the concentration thick paste obtained in S3, after being sufficiently mixed, form original material;
S5, obtains soft material: add ethanol water in the original material that will obtain in S4, be sufficiently mixed, it is thus achieved that soft material;
S6, primary dcreening operation: by the soft material that obtains in S5 through 12 mesh sieves, make wet grain;
S7, is dried: is dried by the wet grain obtained in S6 to water content less than 2.0%, makes dry granule;
S8, fine screen is packed: is screened through 10-30 mesh sieve by the dry granule obtained in S7, it is thus achieved that coarse granule, is mixed by coarse granule
10-20min, prepares finished product, airtight in being placed in clean container, packs, and specification is 10g/ bag;
Radix Rehmanniae in described S1 is Radix Rehmanniae;In ethanol water in described S5, ethanol is 5-6 with the volume ratio of pure water:
1, described ethanol water is 0.3-0.5:1 with the volume ratio of original material.
The preparation technology of a kind of woman's treasured granule the most according to claim 1, it is characterised in that in described S2, decoction liquor is by respectively
Raw material the most fully soaks, supersound process, fully decoct, it is thus achieved that the preliminary extracting solution of corresponding raw material, more tentatively carries each
Take and after liquid is sufficiently mixed, the most fully decoct acquisition.
The preparation technology of a kind of woman's treasured granule the most according to claim 1, it is characterised in that the sweeting agent in described S4 is
Sucrose or steviosin, described sweet taste powder screens through 180-200 mesh sieve.
The preparation technology of a kind of woman's treasured granule the most according to claim 1, it is characterised in that be dried in described S7 and use height
Effect boiling drier, inlet temperature is 50-95 DEG C, and leaving air temp is 50-80 DEG C, and drying time is 30-50min.
The preparation technology of a kind of woman's treasured granule the most according to claim 1, it is characterised in that through 10-30 mesh in described S8
Sieve sieve fall for fine grained, collect, repeat S5-S8 and manufacture.
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CN113855742A (en) * | 2021-11-08 | 2021-12-31 | 陕西省老医协生殖医学医院有限公司 | Traditional Chinese medicine granules for treating gynecological inflammation caused by kidney deficiency and preparation method and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1739731A (en) * | 2005-09-13 | 2006-03-01 | 张力 | Gynecopathy treating medicine prepn and its prepn process |
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Title |
---|
国家药典委员会: "《中华人民共和国药典一部》", 31 December 2010, 中国医药科技出版社 * |
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CN113855742A (en) * | 2021-11-08 | 2021-12-31 | 陕西省老医协生殖医学医院有限公司 | Traditional Chinese medicine granules for treating gynecological inflammation caused by kidney deficiency and preparation method and application thereof |
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