CN106177206A - A kind of Chinese medicine preparation treating insomnia - Google Patents
A kind of Chinese medicine preparation treating insomnia Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine preparation treating insomnia, belong to technical field of Chinese medicines, mainly prepared material medicine active component by Radix Eriobotryae, FLOS MUME, Semen Oroxyli, Herba lathyri davidii, Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, Fructus Ilicis Purpureae, feathering banyan, land for building wind, mountain centipede, Semen pegani harmalae, ganoderma tenue, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae, Zhong Huacao and the ethanol extraction that Semen Nelumbinis heart channel water carries and/or volumetric concentration is 70 80%, add pharmaceutically acceptable carrier, be processed into according to the preparation method of conventional Chinese medicine preparation.Chinese medicine preparation of the present invention is according to the pathogenesis of insomnia, selected raw material medicine and proportioning, effective ingredient therein interacts, Synergistic, it is total to the effects such as long memorial liver and qi, strengthening spleen, tonifying kidney, clearing heart fire, promoting QI circulation for relieving depression, mind tranquilizing and the heart calming, is used for treating insomnia effect significantly, instant effect, short treating period, cure rate is high, and efficacy consolidation controls difficulty in relapse after healing；And the property of medicine is gentle, no dependence, have no side effect, safe and reliable.
Description
[technical field]
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation treating insomnia.
[background technology]
Insomnia refers to fall asleep and maybe cannot keep sleep state, and causes not having enough sleep.Modern lives busy, economical
Pressure and stress are the biggest, and the people perplexed by insomnia gets more and more.Insomnia mainly shows as difficulty falling asleep, or sleep and not
Intoxicated, sometimes sleeping and sometimes waking, or wake up after can not sleep again；Heavy then be insomnia all night.Its pathogenesis have body illness, physiology, psychology, spirit because of
Element, also has the insomnia caused because of drug administration and other materials.Chronic insomnia can cause headache, dizziness, palpitation and short breath, anxiety
The symptoms such as suspicious, health is weak, anorexia, energy difficulty concentration, hypomnesis, it is also possible to cause heart disease, neurasthenia
Etc. chronic disease.Though insomnia is not critical illness, but chronic insomnia can have a strong impact on the normal day's activities of people, causes life
Quality Down, brings huge misery to patient.
The medicine of at present treatment insomnia is a lot, conventional such as stable, chlordiazepoxide, methaqualone, barbiturate etc., these
Medicine can only temporarily symptom management, relief of symptoms, long-term taking can injure cranial nerve, and side effect is big, is easily generated dependency, right
Heart, kidney, liver all can cause damage.And existing other drug and therapy there is also slow, the length course for the treatment of and treat thorough of taking effect
The defect at the end.
[summary of the invention]
In view of problem above, the invention provides a kind of Chinese medicine preparation treating insomnia, this formula of Chinese materia medica preparation science is closed
Reason, has the effects such as depressed liver-energy dispersing and QI regulating, strengthening spleen, tonifying kidney, clearing heart fire, promoting QI circulation for relieving depression, mind tranquilizing and the heart calming, is used for treating insomnia effect and shows
Write, short treating period, thorough treatment, control difficulty in relapse after healing；And mild in medicine property and, safe and reliable, no dependence, make without any poison is secondary
With.
The traditional Chinese medical science is thought, labor is pondered over one's mistakes many, eating and drinking without temperance, and easy damaged taste make the transportation capabilities of taste weaken, and it is turbid to lead to expectorant,
Accumulateing long fire-transformation, phlegm-fire is tied mutually, inside disturbs mind feelings will, pathogenic fire derived from stagnation of liver-QI, disturbs, hyperactivity of fire caused by deficiency of YIN in expectorant heat, and deficiency of both the heart and spleen etc. is caused, therefore controls
Treat insomnia preferably with dispersing the stagnated live-QI to relieve the stagnation of QI, clearing heart fire as principle.According to above theoretical, for the pathogeny of insomnia, the present invention
Providing a kind of Chinese medicine preparation treating insomnia, its concrete technical scheme is as follows:
A kind of Chinese medicine preparation treating insomnia, is mainly made up of the material medicine of following weight portion: Radix Eriobotryae 10-15 part,
FLOS MUME 5-10 part, Semen Oroxyli 3-7 part, Herba lathyri davidii 6-14 part, Radix clerodendri bungei 12-18 part, Aleuritopteris farinsa (Forsk.) Fee 15-20 part, bud Flos Rosae Multiflorae
Root 13-17 part, Fructus Ilicis Purpureae 6-12 part, feathering banyan 10-15 part, land for building wind 12-16 part, mountain centipede 3-9 part, Semen pegani harmalae 2-6 part,
Ganoderma tenue 5-10 part, lip Rhizoma et radix valerianae 12-16 part, Herba Polygalae Japonicae 9-15 part, campanilla grass 6-15 part, Plumula Nelumbinis 2-5 part.
Further, described Chinese medicine preparation is mainly made up of the material medicine of following weight portion: Radix Eriobotryae 12-14 part, green
Calyx prunus mume (sieb.) sieb.et zucc. 7-9 part, Semen Oroxyli 4-6 part, Herba lathyri davidii 8-12 part, Radix clerodendri bungei 14-16 part, Aleuritopteris farinsa (Forsk.) Fee 16-18 part, Radix Rosae Bracteatae
14-16 part, Fructus Ilicis Purpureae 8-10 part, feathering banyan 12-14 part, land for building wind 13-15 part, mountain centipede 5-7 part, Semen pegani harmalae 3-5 part, close
Stricture of vagina thin sesame 7-9 part, lip Rhizoma et radix valerianae 13-15 part, Herba Polygalae Japonicae 11-13 part, campanilla grass 9-12 part, Plumula Nelumbinis 3-4 part.
Further, described Chinese medicine preparation is mainly made up of the material medicine of following weight portion: Radix Eriobotryae 13 parts, FLOS MUME
8 parts, Semen Oroxyli 5 parts, Herba lathyri davidii 10 parts, Radix clerodendri bungei 15 parts, Aleuritopteris farinsa (Forsk.) Fee 17 parts, Radix Rosae Bracteatae 15 parts, Fructus Ilicis Purpureae 9 part, clump
Hair banyan 13 parts, land for building wind 14 parts, mountain centipede 6 parts, Semen pegani harmalae 4 parts, ganoderma tenue 8 parts, lip Rhizoma et radix valerianae 14 parts, Herba Polygalae Japonicae 12 parts,
Campanilla grass 10 parts, Plumula Nelumbinis 4 parts.
Further, described Chinese medicine preparation is that the active component by described material medicine is joined with pharmaceutically acceptable carrier
Close, make required dosage form, such as powder, granule, tablet, pill and capsule etc. according to the preparation method of conventional Chinese medicine preparation.
Further, the active component of described material medicine is that employing water carries and/or volumetric concentration is the ethanol of 70-80%
Extract and prepare.Concrete preparation method is as follows:
Scheme one: pick described material medicine by described weight portion；By Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering
The disconnected length that is broken to is less than 2cm respectively, then with Radix Eriobotryae, green calyx for banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and campanilla grass
Prunus mume (sieb.) sieb.et zucc., Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae, ganoderma tenue, Plumula Nelumbinis mixing, extracting in water three times, add water every time
Amount is 6-8 times of material medicine gross weight, and extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues then enter
Row extracts next time；After extraction terminates, merging three times and extract gained extracting solution, filter, filtrate is condensed into thick paste, obtains described former
The active component of material medicine.
Scheme two: pick described material medicine by described weight portion, by Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering
Banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and the campanilla grass disconnected length that is broken to respectively less than 2cm, then with Radix Eriobotryae, green calyx
Prunus mume (sieb.) sieb.et zucc., Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae, ganoderma tenue, Plumula Nelumbinis mixing, be then 70-by volumetric concentration
The alcohol reflux of 80% three times, each ethanol consumption is 4-6 times of material medicine gross weight, and extraction time is 1-2h, often
Secondary extraction terminates, and filters, takes extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three times and extract gained extraction
Liquid, filters, and filtrate is condensed into thick paste, obtains the active component of described material medicine.
Scheme three: pick described material medicine by described weight portion；By Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering
The disconnected length that is broken to is less than 2cm respectively, then with Radix Eriobotryae, green calyx for banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and campanilla grass
Prunus mume (sieb.) sieb.et zucc., Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae, ganoderma tenue, Plumula Nelumbinis mixing, extracting in water three times, add water every time
Amount is 6-8 times of material medicine gross weight, and extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues then enter
Row extracts next time；After extraction terminates, merging three water extraction gained extracting solution, obtain aqueous extract, remaining medicinal residues retain；Water carries
Remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 70-80% twice after taking, and each ethanol consumption is that material medicine is total
4-6 times of weight, extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues extract the most next time；Carry
After taking end, merge twice alcohol extraction gained extracting solution, obtain alcohol extract；Merge aqueous extract and alcohol extract, filter, filtrate
It is condensed into thick paste, obtains the active component of described material medicine.
Using method: for oral administration, each takes the Chinese medicine preparation of the present invention of effective dose 1-2g, three times a day, early, middle and late meal
Half an hour after warm water takes, and within 2 weeks, is a course for the treatment of, avoids tobacco and wine, pungent, raw and cold, greasy food during medication, it is to avoid feelings will is stung
Swashing, life is regular.
The present invention is according to the pathogenesis of insomnia, it then follows the prescriptions principle of the traditional Chinese medical science, carries out dialectical composition of prescription, choosing
Take Radix Eriobotryae, FLOS MUME, Semen Oroxyli, Herba lathyri davidii, Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, Fructus Ilicis Purpureae, feathering banyan, land for building
Wind, mountain centipede, Semen pegani harmalae, ganoderma tenue, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae, Zhong Huacao and Plumula Nelumbinis are material medicine.Wherein, Folium Eriobotryae
Core, bitter in the mouth, property is put down, is had effect of preventing phlegm from forming and stopping coughing, depressed liver-energy dispersing and QI regulating；FLOS MUME, sour in the mouth, puckery, property is put down, and enters liver, lung two warp, has
Effect that dispersing the stagnated live-QI to relieve the stagnation of QI, stomach function regulating reduce phlegm；Semen Oroxyli, bitter in the mouth, cold in nature, there is effect of lung heat clearing sound producing, depressed liver-energy dispersing and QI regulating；Mountain black
Bean, acrid in the mouth, warm in nature, enter Liver Channel, there is effect of depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving；Radix clerodendri bungei, acrid in the mouth is bitter, warm in nature, has circulation of qi promoting
Spleen invigorating, the suppressing the hyperactive liver that dispels the wind, effect of subduing swelling and detoxicating；Aleuritopteris farinsa (Forsk.) Fee, lightly seasoned, micro-puckery, warm in nature, enter lung, spleen, Liver Channel, have expelling phlegm for arresting cough,
Invigorating spleen to remove dampness, effect of promoting blood circulation and hemostasis；Radix Rosae Bracteatae, sweet in the mouth, hardship, puckery, warm in nature, enter spleen, kidney channel, there is strengthening the spleen the kidney invigorating, astringe the lung
Astringing intestine to stop diarrhea, promoting blood flow to regulate menstruation, expelling wind and removing dampness, effect of powder detoxifcation；Fructus Ilicis Purpureae, sweet in the mouth, hardship, cool in nature, enter liver, kidney channel, there is tonifying liver
Kidney tonifying, strengthen the muscle and bone, effect of expelling wind and removing dampness, arresting bleeding and healing up ulcer；Feathering banyan, sweet in the mouth, micro-pungent, warm in nature, there is circulation of qi promoting of dispeling the wind, spleen invigorating
Effect of dampness removing；Land for building wind, mildly bitter flavor, puckery, property is put down, and has effect of heat clearing and blood circulation promoting, promoting the circulation of QI to relieve pain；Mountain centipede, acrid in the mouth, sweet,
Property flat, there is expelling phlegm for arresting cough, resolving depression dissipating blood stasis, effect of Shugan Zhitong；Semen pegani harmalae, bitter in the mouth, warm in nature, enter lung, Liver Channel, only have
Cloperastine is breathed heavily, effect of wind-damp dispelling, resolving depression；Ganoderma tenue, mildly bitter flavor, warm in nature, there is mind tranquilizing and the heart calming, effect protected the liver of detoxifying；Lip
Rhizoma et radix valerianae, taste oil is pungent, cool in nature, has mind tranquilizing and the heart calming, effect of diuretic heat clearing away；Herba Polygalae Japonicae, acrid in the mouth is bitter, and property is put down, have promoting blood circulation to remove blood stasis,
Dehumidifying stomach invigorating, eliminating phlegm and relieving cough, removing toxic substances pain relieving, effect of calming the nerves；Zhong Huacao, bitter in the mouth, micro-pungent, cool in nature, have clearing away heart-fire, invigorate blood circulation logical
Effect of network；Plumula Nelumbinis, bitter in the mouth, cold in nature, enter the heart, kidney channel, there is effect of clearing away heart-fire for tranquillization, restoring normal coordination between the heart and kidney, unsmoothing the sperm and stopping bleeding.This
Bright selected raw material compound ratio, above all medicine compatibilities, wherein effective ingredient interacts, is complementary to one another, Synergistic, altogether
The effects such as long memorial liver and qi, strengthening spleen, tonifying kidney, clearing heart fire, promoting QI circulation for relieving depression, mind tranquilizing and the heart calming, can machine to insomniac on the whole
Body is adjusted, and then fundamentally cures insomnia.
The invention provides a kind of Chinese medicine preparation treating insomnia, relative to prior art, the invention have the benefit that
Chinese medicine preparation of the present invention is used for treating insomnia effect significantly, instant effect, short treating period, and cure rate is high, and thorough treatment is difficult to after healing
Recurrence；And Chinese medicine preparation of the present invention use pure natural material medicine be prepared from, mild in medicine property and, the intestines and stomach will not be caused stimulation
Generation untoward reaction and side effect, no dependence, safe and reliable.
[detailed description of the invention]
The following examples can help those skilled in the art that the present invention is more fully understood, but cannot be with any
Mode limits the present invention.
Embodiment 1
A kind of Chinese medicine preparation treating insomnia, concrete manufacture method comprises the following steps:
1) material medicine of following weight portion is weighed: Radix Eriobotryae 10 parts, FLOS MUME 5 parts, Semen Oroxyli 3 parts, Herba lathyri davidii 6
Part, Radix clerodendri bungei 12 parts, Aleuritopteris farinsa (Forsk.) Fee 15 parts, Radix Rosae Bracteatae 13 parts, Fructus Ilicis Purpureae 6 parts, feathering banyan 10 parts, land for building wind 12 parts, mountain hundred
3 parts of foot, Semen pegani harmalae 2 parts, ganoderma tenue 5 parts, lip Rhizoma et radix valerianae 12 parts, Herba Polygalae Japonicae 9 parts, campanilla grass 6 parts, Plumula Nelumbinis 2 parts；
2) by Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and campanilla
The grass disconnected length that is broken to respectively less than 2cm, then with Radix Eriobotryae, FLOS MUME, Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae,
Ganoderma tenue, Plumula Nelumbinis mix, extracting in water three times, and each amount of water is 6-8 times of material medicine gross weight, and extraction time is
1-2h, extracts every time and terminates, filter, take extracting solution, and medicinal residues extract the most next time；
3) combining step 2) extract gained extracting solution for three times, to filter, filtrate is condensed into thick paste, obtains the activity one-tenth of material medicine
Point；
4) to step 3) active component of gained material medicine adds pharmaceutically acceptable carrier combination, according to routine
The preparation method of Chinese medicine preparation makes required dosage form, and get product Chinese medicine preparation.
Embodiment 2
A kind of Chinese medicine preparation treating insomnia, concrete manufacture method comprises the following steps:
1) material medicine of following weight portion is weighed: Radix Eriobotryae 12 parts, FLOS MUME 7 parts, Semen Oroxyli 4 parts, Herba lathyri davidii 8
Part, Radix clerodendri bungei 14 parts, Aleuritopteris farinsa (Forsk.) Fee 16 parts, Radix Rosae Bracteatae 14 parts, Fructus Ilicis Purpureae 8 parts, feathering banyan 12 parts, land for building wind 13 parts, mountain hundred
5 parts of foot, Semen pegani harmalae 3 parts, ganoderma tenue 7 parts, lip Rhizoma et radix valerianae 13 parts, Herba Polygalae Japonicae 11 parts, campanilla grass 9 parts, Plumula Nelumbinis 3 parts；
2) by Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and campanilla
The grass disconnected length that is broken to respectively less than 2cm, then with Radix Eriobotryae, FLOS MUME, Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae, close
The thin sesame of stricture of vagina, Plumula Nelumbinis mixing, then with the alcohol reflux that volumetric concentration is 70-80% three times, each ethanol consumption is former
4-6 times of material medicine gross weight, extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues then carry out next
Secondary extraction；
3) combining step 2) extract gained extracting solution for three times, to filter, filtrate is condensed into thick paste, obtains the activity one-tenth of material medicine
Point；
4) to step 3) active component of gained material medicine adds pharmaceutically acceptable carrier combination, according to routine
The preparation method of Chinese medicine preparation makes required dosage form, and get product Chinese medicine preparation.
Embodiment 3
A kind of Chinese medicine preparation treating insomnia, concrete manufacture method comprises the following steps:
1) material medicine of following weight portion is weighed: Radix Eriobotryae 13 parts, FLOS MUME 8 parts, Semen Oroxyli 5 parts, Herba lathyri davidii 10
Part, Radix clerodendri bungei 15 parts, Aleuritopteris farinsa (Forsk.) Fee 17 parts, Radix Rosae Bracteatae 15 parts, Fructus Ilicis Purpureae 9 parts, feathering banyan 13 parts, land for building wind 14 parts, mountain hundred
6 parts of foot, Semen pegani harmalae 4 parts, ganoderma tenue 8 parts, lip Rhizoma et radix valerianae 14 parts, Herba Polygalae Japonicae 12 parts, campanilla grass 10 parts, Plumula Nelumbinis 4 parts；
2) by Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and campanilla
The grass disconnected length that is broken to respectively less than 2cm, then with Radix Eriobotryae, FLOS MUME, Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae,
Ganoderma tenue, Plumula Nelumbinis mix, extracting in water three times, and each amount of water is 6-8 times of material medicine gross weight, and extraction time is
1-2h, extracts every time and terminates, filter, take extracting solution, and medicinal residues extract the most next time；Merge three water extraction gained to extract
Liquid, obtains aqueous extract, and remaining medicinal residues retain；
3) after water extraction, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 70-80% twice, and each ethanol is used
Amount is 4-6 times of material medicine gross weight, and extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues then enter
Row extracts next time；Merge twice alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains former
The active component of material medicine；
5) to step 4) active component of gained material medicine adds pharmaceutically acceptable carrier combination, according to routine
The preparation method of Chinese medicine preparation makes required dosage form, and get product Chinese medicine preparation.
Embodiment 4
A kind of Chinese medicine preparation treating insomnia, concrete manufacture method is:
Weigh the material medicine of following weight portion: Radix Eriobotryae 14 parts, FLOS MUME 9 parts, Semen Oroxyli 6 parts, Herba lathyri davidii 12 parts,
Radix clerodendri bungei 16 parts, Aleuritopteris farinsa (Forsk.) Fee 18 parts, Radix Rosae Bracteatae 16 parts, Fructus Ilicis Purpureae 10 parts, feathering banyan 14 parts, land for building wind 15 parts, mountain centipede 7
Part, Semen pegani harmalae 5 parts, ganoderma tenue 9 parts, lip Rhizoma et radix valerianae 15 parts, Herba Polygalae Japonicae 13 parts, campanilla grass 12 parts, Plumula Nelumbinis 4 parts；Next
Manufacture method with the step 2 of embodiment 1) to step 4).
Embodiment 5
A kind of Chinese medicine preparation treating insomnia, concrete manufacture method is:
Weigh the material medicine of following weight portion: Radix Eriobotryae 15 parts, FLOS MUME 10 parts, Semen Oroxyli 7 parts, Herba lathyri davidii 14
Part, Radix clerodendri bungei 18 parts, Aleuritopteris farinsa (Forsk.) Fee 20 parts, Radix Rosae Bracteatae 17 parts, Fructus Ilicis Purpureae 12 parts, feathering banyan 15 parts, land for building wind 16 parts, mountain hundred
9 parts of foot, Semen pegani harmalae 6 parts, ganoderma tenue 10 parts, lip Rhizoma et radix valerianae 16 parts, Herba Polygalae Japonicae 15 parts, campanilla grass 15 parts, Plumula Nelumbinis 5 parts；Connect
The manufacture method got off is with the step 2 of embodiment 3) to step 5).
Clinical observation is added up:
1, the object of observation:
Select insomniac 150 example made a definite diagnosis to carry out clinical observation, be randomly divided into treatment group and matched group two groups, treatment group
75 examples, wherein male 35 example, women 40 example, age 18-60 year, 41.5 years old mean age, the shortest person of the course of disease 2 months, elder 5
Year；Matched group 75 example, wherein male 36 example, women 39 example, age 18-60 year, 41.6 years old mean age, the shortest person of the course of disease 2
Month, elder 5 years.Treatment group and the course of disease of two groups of cases of matched group, degrees of symptoms are basically identical, without significant difference, tool
There is comparability.
2, medication and observational technique:
Treatment group: for oral administration, each takes the Chinese medicine preparation of the present invention of effective dose 1-2g, three times a day, early, middle and late after meal
Half an hour, warm water took, and within 2 weeks, was a course for the treatment of, avoided tobacco and wine, pungent, raw and cold, greasy food, it is to avoid emotional stimulation during medication,
Life is regular.Observing time is six courses for the treatment of；During observation, patient recovers, and discontinues medication, and other patients of not healing then continue
Continuous medication treatment is observed.
Matched group: take the endo-medicine of commercially available treatment insomnia, take according to taking explanation, avoid tobacco and wine, pungent during treatment
Peppery, raw and cold, greasy food, it is to avoid emotional stimulation, life is regular.Adopt with treatment group and observe system the most simultaneously
Meter.
3, treatment standard:
With reference to " disease of tcm Standardization of diagnosis and curative effect " (State Administration of Traditional Chinese Medicine's promulgation), " new Chinese medicine clinical research refers to
Lead principle " in the diagnostic criteria of insomnia:
Recovery from illness: the length of one's sleep is normal, total sleep time more than 6 hours, few dream, time for falling asleep is less than half an hour, to sleep
Quality is satisfied, without other Somatic discomfort senses after waking up；
Effective: sleep is clearly better, total sleep time increases by more than 3 hours, and relatively satisfactory to sleep, daytime, taediumvitae disappeared
Losing, other malaise symptoms are clearly better；
Effective: sleep takes a turn for the better, total sleep time increases by more than 2 hours, and other malaise symptoms make moderate progress；
Invalid: insomnia is without improving or counter increasing the weight of, and other Somatic discomfort symptoms are without improving or increasing the weight of.
4, observed result and analysis
Respectively treatment group and matched group case being carried out clinical observation, acquired results is as shown in table 1 below:
Table 1 clinical observation result
| Cure | Effective | Effectively | Invalid | Total effective rate | |
| Treatment group | 29 examples | 23 examples | 18 examples | 5 examples | 93.3% |
| Matched group | 25 examples | 19 examples | 14 examples | 17 examples | 77% |
By upper table 1 it can be seen that 75 example insomniacs for the treatment of group, Chinese medicine preparation of the present invention is used to treat, wherein,
Cure 29 examples, account for total number of persons 38.7%；Effective 23 examples, account for total number of persons 30.6%；Effective 18 examples, account for total number of persons 24%；Invalid 5
Example, accounts for total number of persons 6.7%；Total effective rate reaches 93.3%.And matched group 75 example insomniac, use the medicine of commercially available treatment insomnia
Treat, cure 25 examples, account for total number of persons 33.3%；Effective 19 examples, account for total number of persons 25.3%；Effective 14 examples, account for total number of persons
18.7%；Invalid 17 examples, account for total number of persons 22.7%；Total effective rate is 77.3%.Two groups of contrasts understand, and use Chinese medicine system of the present invention
Agent treatment insomnia has significantly more curative effect, and cure rate is high, short treating period.
Model case
Case 1: Huang, man, 25 years old, student, insomniac 3 wheat harvesting periods, cardinal symptom shows: difficulty falling asleep, dreaminess,
Often awakening, minimum 3 hours an of length of one's sleep, most 5 hours, attend class daytime out of spirits, energy is not concentrated.Arrived many once
Family's hospitalize, DeGrain.Take Chinese medicine preparation of the present invention afterwards to treat, after the course for the treatment of, when fall asleep in the evening
Between shorten, the phenomenon such as dreaminess, Yi Xing alleviate, every night total sleep time increase；Continuing to take two courses for the treatment of, insomnia disappears completely
Losing, sleep every day more than 6 hours, insomnia obtains healing.
Case 2: leaf so-and-so, female, 38 years old, company clerk, within insomniac 1 year, have a surplus, cardinal symptom show: difficulty falling asleep,
Dreaminess at night, easily wakes up with a start, and difficult sleep after waking up, with cardiopalmus, vexed, anxiety irritability.Used various ways treatment, effect once
Fruit is the best.Taking Chinese medicine preparation of the present invention afterwards to treat, after taking a course for the treatment of, above symptom is obviously improved；Continue
Taking three courses for the treatment of, insomnia is wholly absent, and sleep recovers normal；Follow up a case by regular visits to have no recurrence half a year.
Although, the present invention is described in detail the most with a general description of the specific embodiments, but
On the basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (8)
1. the Chinese medicine preparation treating insomnia, it is characterised in that described Chinese medicine preparation is mainly by the crude drug of following weight portion
Thing is made: Radix Eriobotryae 10-15 part, FLOS MUME 5-10 part, Semen Oroxyli 3-7 part, Herba lathyri davidii 6-14 part, Radix clerodendri bungei 12-18 part,
Aleuritopteris farinsa (Forsk.) Fee 15-20 part, Radix Rosae Bracteatae 13-17 part, Fructus Ilicis Purpureae 6-12 part, feathering banyan 10-15 part, land for building wind 12-16 part, mountain centipede
3-9 part, Semen pegani harmalae 2-6 part, ganoderma tenue 5-10 part, lip Rhizoma et radix valerianae 12-16 part, Herba Polygalae Japonicae 9-15 part, campanilla grass 6-15 part, lotus
Sub-heart 2-5 part.
2. the Chinese medicine preparation for the treatment of insomnia as claimed in claim 1, it is characterised in that described Chinese medicine preparation is mainly by following heavy
The material medicine of amount part is made: Radix Eriobotryae 12-14 part, FLOS MUME 7-9 part, Semen Oroxyli 4-6 part, Herba lathyri davidii 8-12 part, smelly male
DANGEN 14-16 part, Aleuritopteris farinsa (Forsk.) Fee 16-18 part, Radix Rosae Bracteatae 14-16 part, Fructus Ilicis Purpureae 8-10 part, feathering banyan 12-14 part, land for building wind
13-15 part, mountain centipede 5-7 part, Semen pegani harmalae 3-5 part, ganoderma tenue 7-9 part, lip Rhizoma et radix valerianae 13-15 part, Herba Polygalae Japonicae 11-13 part,
Campanilla grass 9-12 part, Plumula Nelumbinis 3-4 part.
3. the Chinese medicine preparation for the treatment of insomnia as claimed in claim 2, it is characterised in that described Chinese medicine preparation is mainly by following heavy
Amount part material medicine make: Radix Eriobotryae 13 parts, FLOS MUME 8 parts, Semen Oroxyli 5 parts, Herba lathyri davidii 10 parts, Radix clerodendri bungei 15 parts,
Aleuritopteris farinsa (Forsk.) Fee 17 parts, Radix Rosae Bracteatae 15 parts, Fructus Ilicis Purpureae 9 parts, feathering banyan 13 parts, land for building wind 14 parts, mountain centipede 6 parts, Semen pegani harmalae 4
Part, ganoderma tenue 8 parts, lip Rhizoma et radix valerianae 14 parts, Herba Polygalae Japonicae 12 parts, campanilla grass 10 parts, Plumula Nelumbinis 4 parts.
4. the Chinese medicine preparation of the treatment insomnia as described in claim 1-3 is arbitrary, it is characterised in that described Chinese medicine preparation is by institute
State the active component of material medicine and pharmaceutically acceptable carrier combination, according to the preparation method processing system of conventional Chinese medicine preparation
Become.
5. the Chinese medicine preparation for the treatment of insomnia as claimed in claim 4, it is characterised in that the active component of described material medicine is
The ethanol extraction that water carries and/or volumetric concentration is 70-80% is used to prepare.
6. the Chinese medicine preparation for the treatment of insomnia as claimed in claim 5, it is characterised in that the active component of described material medicine is
Prepare by the following method: pick described material medicine by described weight portion；By Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering
The disconnected length that is broken to is less than 2cm respectively, then with Radix Eriobotryae, green calyx for banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and campanilla grass
Prunus mume (sieb.) sieb.et zucc., Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae, ganoderma tenue, Plumula Nelumbinis mixing, extracting in water three times, add water every time
Amount is 6-8 times of material medicine gross weight, and extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, and medicinal residues then enter
Row extracts next time；After extraction terminates, merging three times and extract gained extracting solution, filter, filtrate is condensed into thick paste, obtains described former
The active component of material medicine.
7. the Chinese medicine preparation for the treatment of insomnia as claimed in claim 5, it is characterised in that the active component of described material medicine is
Prepare by the following method: pick described material medicine by described weight portion, by Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering
Banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and the campanilla grass disconnected length that is broken to respectively less than 2cm, then with Radix Eriobotryae, green calyx
Prunus mume (sieb.) sieb.et zucc., Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae, ganoderma tenue, Plumula Nelumbinis mixing, be then 70-by volumetric concentration
The alcohol reflux of 80% three times, each ethanol consumption is 4-6 times of material medicine gross weight, and extraction time is 1-2h, often
Secondary extraction terminates, and filters, takes extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three times and extract gained extraction
Liquid, filters, and filtrate is condensed into thick paste, obtains the active component of described material medicine.
8. the Chinese medicine preparation for the treatment of insomnia as claimed in claim 5, it is characterised in that the active component of described material medicine is
Prepare by the following method:
1) described material medicine is picked by described weight portion；
2) Radix clerodendri bungei, Aleuritopteris farinsa (Forsk.) Fee, Radix Rosae Bracteatae, feathering banyan, land for building wind, mountain centipede, lip Rhizoma et radix valerianae, Herba Polygalae Japonicae and campanilla grass are divided
Duan not be broken to length and be less than 2cm, then with Radix Eriobotryae, FLOS MUME, Semen Oroxyli, Herba lathyri davidii, Fructus Ilicis Purpureae, Semen pegani harmalae, fine groove
Bao Zhi, Plumula Nelumbinis mix, and extracting in water three times, each amount of water is 6-8 times of material medicine gross weight, and extraction time is 1-
2h, extracts every time and terminates, filter, take extracting solution, and medicinal residues extract the most next time；After extraction terminates, merge three water extraction
Gained extracting solution, obtains aqueous extract, and remaining medicinal residues retain；
3) after water extraction, remaining medicinal residues are again with the alcohol reflux that volumetric concentration is 70-80% twice, and each ethanol consumption is
4-6 times of material medicine gross weight, extraction time is 1-2h, extracts every time and terminates, filters, take extracting solution, under medicinal residues are then carried out
Once extract；After extraction terminates, merge twice alcohol extraction gained extracting solution, obtain alcohol extract；
4) combining step 2) gained aqueous extract and step 3) gained alcohol extract, to filter, filtrate is condensed into thick paste, obtains described
The active component of material medicine.
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| CN105663517A (en) * | 2015-08-04 | 2016-06-15 | 李琳 | Traditional Chinese medicine electuary for treating insomnia and preparation method thereof |
| CN105708990A (en) * | 2015-08-04 | 2016-06-29 | 刘广利 | Traditional Chinese medicinal pills for treating insomnia and preparation method of traditional Chinese medicinal pills |
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| CN105663517A (en) * | 2015-08-04 | 2016-06-15 | 李琳 | Traditional Chinese medicine electuary for treating insomnia and preparation method thereof |
| CN105708990A (en) * | 2015-08-04 | 2016-06-29 | 刘广利 | Traditional Chinese medicinal pills for treating insomnia and preparation method of traditional Chinese medicinal pills |
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Application publication date: 20161207 |