CN106177012A - A kind of capsule preventing and treating Alzheimer - Google Patents

A kind of capsule preventing and treating Alzheimer Download PDF

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CN106177012A
CN106177012A CN201610527664.2A CN201610527664A CN106177012A CN 106177012 A CN106177012 A CN 106177012A CN 201610527664 A CN201610527664 A CN 201610527664A CN 106177012 A CN106177012 A CN 106177012A
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radix
capsule
hirudo
angelicae sinensis
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雷大鹏
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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Abstract

A kind of capsule preventing and treating Alzheimer, being a kind of Chinese patent medicine that can effectively prevent and treat Alzheimer, method is: take capsule after the Radix Astragali, Hirudo, Flos Carthami, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Polygoni Multiflori, Semen Ziziphi Spinosae, Fructus Mori, Radix Kansui, Rhizoma Coptidis, the effective ingredient of Fructus Jujubae and mineral resources fulvic acid, egg albumen powder mixing.As long as taking this capsule the most according to quantity, just can prevent and treat Alzheimer, making patient lose memory, aphasia, agnosia, the dysfunction such as execution alleviate to recovery.

Description

A kind of capsule preventing and treating Alzheimer
Technical field
The present invention relates to a kind of capsule preventing and treating Alzheimer, belong to the Chinese patent medicine of preventing and treating Alzheimer.
Background technology
Alzheimer is exactly " alzheimer disease ", and preventing and treating Alzheimer (AD) the most in the world does not also have specially good effect Medicine.Conventional antianxiety drugs the most fugitive Benzodiazepines medicine, but this poison of drug side effect is relatively big, unsuitable prolonged application.After taking The side effect such as excess sedation to be watched out for, drowsiness, slurred speech, ataxia and instability of gait, might as well increase activity on daytime ratio Taking medicine can be more effectively.Take this medicine and also can induce or aggravate patient anxiety and insomnia, increase infection, wound, urine retention, constipation Chance.If using antidepressants to treat patient AD, such as, use nortriptyline and desipramine side effect lighter, it is possible to Select doxepin (doxepin) and maprotiline.China has introduced some novel antidepressants in recent years, as 5-hydroxy tryptamine is taken the photograph again Take inhibitor (SSRI) paroxetine (seroxat), fluoxetine (excellent gram, prozac), Sertraline (Zoloft), be administered orally.This kind of medicine Anticholinergic and cardiovascular side effects typically all lighter than tricyclic antidepressants.But fluoxetine long half time, old people is preferably cautious use of.Anti-spirit Sick medicine can help the control conduct disorder of patient, intense, aggressivity and hallucination and vain hope.But low dose should be used, and stop in time , in case there is toxicity in medicine.It is contemplated that low dose of perphenazine is administered orally.The orthostatic hypotension of thioridazine and extrapyramidal system pair are made Light with relatively chlorpromazine, to the common anxiety of elderly patients, intense helpful, it is one of psychosis of commonly using of old people, but Easily cause ECG change, the most often monitor ECG.Haloperidol is relatively light to calmness and orthostatic hypotension effect, and shortcoming is to hold Easily cause the extrapyramidal symptoms.In recent years clinical more conventional atypical antipsychotic agents such as risperidone, olanzapine etc., cardiovascular and The side effect of extrapyramidal system is less, is suitable for elderly patients' short-term and takes, and once symptom takes a turn for the better and to withdraw at once.Above Western medicine all has Some side effect, show no sign of benefit to slow down aging, simply symptomatic treatment of taking medicine, be all cure the symptoms, not the disease helpless it Lift.
Though people's pathogenesis etiology difference that Alzheimer is different, there is a common disease, and this disease is Blood supply insufficiency of brain is formed, as long as improving brain blood supply, just can improve the symptom of Alzheimer patient, to treating this disease Disease plays a positive role.
Summary of the invention
The present invention discloses a kind of capsule preventing and treating Alzheimer, it is therefore an objective to controls and treats Alzheimer, subtracting The misery of few Alzheimer patient, recover their health and ability.
Method is: extract the Radix Astragali, Hirudo, Flos Carthami, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Polygoni Multiflori, Semen Ziziphi Spinosae, Fructus Mori, Radix Kansui, Rhizoma Coptidis, the having of Fructus Jujubae Imitate capsule after composition and mineral resources fulvic acid, egg albumen powder mixing.As long as taking this capsule the most according to quantity, Alzheimer just can be prevented and treated Disease, makes patient lose memory, aphasia, agnosia, the dysfunction such as execution alleviate to recovery.
What the present invention was claimed is mainly technically characterized ny: formula is: the Radix Astragali 12 deal, Hirudo (clear water) 3 deal, Flos Carthami 4 deals, Rhizoma Chuanxiong 4 deal, Radix Angelicae Sinensis (returning head) 6 deal, the Radix Polygoni Multiflori 3 deal, Semen Ziziphi Spinosae 3 deal, Fructus Mori 3 deal, the Radix Euphorbiae Pekinensis 1 deal, Radix Kansui 1 Deal, Rhizoma Coptidis 0.5 deal, Fructus Jujubae 16 deal, mineral resources fulvic acid 0.1 deal, egg albumen powder 2.6 deal.
What the present invention was claimed secondary technology is characterized in that manufacture method is: by Hirudo, Flos Carthami, Radix Angelicae Sinensis, the fried medicine of Rhizoma Chuanxiong The cryodesiccated solids of liquid concentrates drying with the Radix Astragali, the Radix Polygoni Multiflori, Semen Ziziphi Spinosae, Fructus Mori, Radix Kansui, Rhizoma Coptidis, the fried medicine liquid heating of Fructus Jujubae Solids co-grinding is finely ground, and mineral resources fulvic acid, egg albumen powder mixing and stirring, makes 0.5g (500mg) capsule.
According to tcm theory, in side, the drug effect of each taste Chinese medicine is:
The Radix Astragali: belong to QI invigorating the first Chinese medicine, have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering The most antibacterial, antivirus action, and physical ability can be increased.
Hirudo: there is removing blood stasis and stimulate the menstrual flow, effect of removing blood stasis eliminating mass.For blood stasis amenorrhea, addiction abdominal mass mass in the abdomen, apoplectic hemiplegia, fall and flutter Damage.Modern Chinese medicine research finds that cerebral ischemia-reperfusion cell Hirudo " shield ", and (grass kingfisher is beautiful, and " Chinese traditional medicine leech is to ischemia/reperfusion The Anti-G value of brain cell after note " Hebei Medical University's journal 2000；21(4)；193).
Flos Carthami: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Controlling amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis have a pain, carbuncle Swollen, injury from falling down.Tang Materia Medica: control trismus and inability to speak, blood agglomeration, puerperal all diseases.
Rhizoma Chuanxiong: being usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, the pungent temperature of Rhizoma Chuanxiong is fragrant dry.Blood circulation promoting and blood stasis dispelling effect is extensive, and suitable blood stasis hinders Stagnant various disease；Wind-expelling pain-stopping, effectiveness is favourable, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.
Radix Angelicae Sinensis: be the efficacy of a drug Chinese medicine that is only second to Radix Ginseng, can enrich blood, can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active, can protect Liver is detoxified, and antiinflammatory is anticancer, eliminates free radical, anti-ageing anti-old.Modern Chinese medicine research find Radix Angelicae Sinensis and extract sodium ferulate thereof and Radix Angelicae Sinensis polysaccharide has obvious stimulation to monocytes/macrophages system, and the body of immunologic hypofunction is also had immune regulation And restitution.Radix Angelicae Sinensis also has facilitation to the lymphocyte transformation of Healthy People.Senile dementia can be treated.
The Radix Polygoni Multiflori: nourishing the blood and yin；Loosening bowel to relieve constipation.Compendium of Material Medica: kidney master closes Tibetan, liver controlling conveyance and dispersion, this thing temperature bitter and puckery flavor, hardship The kidney invigorating, temperature compensation liver, vital essence can be restrained, so the liver benefiting that can nourish blood, controlling nocturnal emission with astringent drugs kidney tonifying, muscle reinforcing and bone strengthening, black hair, for tonic medicine, do not tremble with fear not Dry.The modern medicine study Radix Polygoni Multiflori has the effect to nervus centralis, anti-aging effects.
Semen Ziziphi Spinosae: have mind tranquilizing and the heart calming；Nourishing the liver；Effect of arresting sweating, cures mainly restlessness of asrhenia type and insomnia；Palpitation with fear palpitation with a distress feeling；Body void spontaneous perspiration, night sweat. " book on Chinese herbal medicine is the newest ": suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, benefit will surely breathe out, hearing-improing and eyesight improving.Modern Chinese medicine is studied Find that Semen Ziziphi Spinosae has hypermnesis, anti-forgetful effect.
Fructus Mori: sweet in flavor and cold in property, has the effects such as the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, black hair improving eyesight.Modern Chinese medicine research finds Mulberry Mulberry is embodied in the weight that can strengthen immune organ, can strengthen nonspecific immunity function, humoral immunization is had increasing action, thin to T The immunologic function of born of the same parents' mediation has significant facilitation, and cell mutation is had preventive effect.
Rhizoma Coptidis: there is antibacterial and antifungal, antivirus action, also antiinflammatory, anti-diarrhea effect.Human body is mainly had clear The effect of thermal detoxification, also blood sugar lowering, blood fat reducing, vessel softening effect, also antioxidation, antiulcer effect.
The Radix Euphorbiae Pekinensis: have antibacterial, diuresis, effect of analgesia, for edema distension, phlegm retention accumulation, carbuncle furunculosis, two the most not Logical.The modern medicine study Radix Euphorbiae Pekinensis has nerve growth factor promoting to enter effect: nerve growth factor promoting enters agent and may be used for treating spinal cord Damage, the disease such as peripheral nerve injury and amyotrophic lateral sclerosis (spinal cord) lateral sclerosis.Isolated from euphorbia The compounds such as KansuininA, Triacetyl2ingenol and Jolkinolide have nerve growth factor promoting and enter effect. (" progress of Euphorbia medicinal plants " Li Wei, Cai Xia, Hu Zhenghai, Wang Yongjian " Chinese Wild plant resources " the 5th phase 2008 October in year).
Radix Kansui: removing water retention by purgation by swollen, dispersing swelling and dissipating binds.Modern medicine study proves, the diterpene-kind compound obtained from Radix Kansui lures The lymphopoiesis led has significant potentiation.In Radix Kansui, the special kansuinineA contained is that the NGF induction having now been found that is lived Compound that property is the strongest (research [D] of abietane diterpene in chemical constitution study 2. Euphorbia fischeriana S teud． of Pan Qin .1. Radix Kansui. Shenyang Pharmaceutical university, 2006.).The Radix Euphorbiae Pekinensis, Radix Kansui drug side effect greatly, but as long as rationally concocting and compatibility, just can reduce side effect.
Fructus Jujubae: be medicine-food two-purpose product.Fructus Jujubae sweet in the mouth, warm in nature, can invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, be used for treating " insufficiency of the spleen weak, Anorexia and loose stool, deficiency of qi and blood " etc. disease.Often food Fructus Jujubae can treat physical weakness, neurasthenia, anemia are become thin, nourishing the liver anti-cancer merit Can be especially prominent.Its low side effect can drop in Fructus Jujubae and the Radix Euphorbiae Pekinensis, Radix Kansui compatibility.
Mineral resources fulvic acid: fulvic acid (Fulvic Acid is called for short FA) is humic acids (Humic Acid is called for short HA) class thing A component in matter, is a kind of baroque natural organic-compound matter.The basic structure aromatic ring of humic acids macromole and Alicyclic ring, ring is connected with the functional groups such as carboxyl, hydroxyl, carbonyl, quinonyl, methoxyl group, is the uncertain unsaturated organic acid of a kind of structure. Humic acid substance integrates multiple therapeutical effect, including antiinflammatory, antiviral, regulation immune system, antibacterial, antiulcer, anti- Toxin, free radical resisting, treatment rheumatism etc..Treating disease as far back as beginning in non-year in the Northern Song Dynasty, Ming Dynasty's Compendium of Material Medica, " card controls standard Rope surgeon " the most on the books.Mineral resources fulvic acid main pharmacodynamics composition as medicine in this capsule is directly treated, Stabilizer, synergist and slow releasing agent simultaneously as effective ingredient.This product mineral resources fulvic acid is to carry in Changji coal A kind of high-purity humic acid taken.
Theoretical according to doctor trained in Western medicine, the capsule primary efficacy that the present invention makes with above-mentioned Chinese medicine is:
1, CO2 laser weld function: nerve system of human body can be repaired.
2, immunosuppressive action: suppression lymphocyte is formed, reduces oxygen consumption, reduces energy expenditure.
3, suppression cytometaplasia: the present invention can be formed by mutation inhibiting cell effectively, prevents own cells variation from causing The generation of disease.
4, inducing neural somatomedin formation effect: the present invention is formed with uniqueness to the nerve growth factor in neurocyte Inducing action, be the native compound that the nerve growth factor induced activity having now been found that is the strongest, be that human body is indispensable, nothing The native compound that method replicates.
5, aid digestion, increasing absorbs: can accelerate the metabolism of patient body, make patient accelerate to get well.
The invention has the beneficial effects as follows:
The most effectively prevent and treat Alzheimer, reduce the misery of Alzheimer patient, recover the sum of their health Ability.
2. the Chinese medicine that the present invention uses is preparation, has enhancing human body brain QI and blood function, has nervous system well Ground repair.
3. can suppress the variation of patient's human body cell.
4. can accelerate the metabolism in patient's body, effectively carry out toxin expelling.
5. tradition is boiled the process of Chinese medicine and is carried out by factory by the present invention, for patients, has that treatment is simple, the side of taking Just, bitterness is minimum when taking medicine, the dosage control series of advantages such as accurately.
Detailed description of the invention
The present invention uses: Radix Astragali 12kg, Hirudo (clear water) 3kg, Flos Carthami 4kg, Rhizoma Chuanxiong 4kg, Radix Angelicae Sinensis (returning head) 6kg, the Radix Polygoni Multiflori 3kg, Semen Ziziphi Spinosae 3kg, Fructus Mori 3kg, Radix Euphorbiae Pekinensis 1kg, Radix Kansui 1kg, Rhizoma Coptidis 0.5kg, Fructus Jujubae 16kg, mineral resources fulvic acid 0.1kg, egg albumen powder 2.6kg。
Concrete manufacture method is:
First Hirudo, Flos Carthami, Radix Angelicae Sinensis, the Radix Euphorbiae Pekinensis, this seven tastes Chinese medicine of Rhizoma Chuanxiong are soaked 3 hours with water purification respectively, boil immediately 30 minutes, being leached by medicinal liquid standby, medicinal residues add equivalent water purification and soak half an hour, boil 15 minutes, then are filtered by secondary medicinal liquid Go out and dregs pressing is taken liquid, after second time medicinal liquid is mixed with first time medicinal liquid and pressed liquor, being sent into freezer dryer-40 DEG C it is dried to the low temperature environment of-55 DEG C, and dried solids is pulverized finely ground.
The Radix Astragali, the Radix Polygoni Multiflori, Semen Ziziphi Spinosae, Fructus Mori, Radix Kansui, Rhizoma Coptidis, that this Six-element Chinese medicine of yam and red dates soaks 5 with water purification respectively is little Time, boiling immediately 1 hour, medicinal liquid is leached standby, medicinal residues add equivalent water purification and soak, and boil half an hour, then by secondary medicine Liquid leaches and by dregs pressing, second time medicinal liquid with after medicinal liquid and pressed liquor mix for the first time (remain solids need not, only make With liquid), carry out heating and concentrate, the moisture of medicinal liquid is evaporated dry in the case of heating, and by after the drying of remaining solids Pulverize finely ground.
Above two powder is sufficiently mixed with egg albumen powder, stirs, be divided into 10000 equal portions, make capsule weight 0.5g (500mg), the essential ingredient 240mg of Chinese medicine, egg albumen powder 260mg are comprised.
In capsule, powder is golden yellow or brown ceramic powder or granule.Gas is fragrant, bitter in the mouth.
Usage and dosage:
Prevention phase dose is: a twice-daily, one time 2.
Treatment phase dose is: three times on the one, one time 2.
Taboo: anemia of pregnant woman disables.Age of sucking disables.Forbid during taking this product to drink, smoking.
Points for attention during taking medicine:
1, take during dining simultaneously, forbid auf nuechternen Magen einnehmen.
2, this product has and speeds gastrointestinal peristalsis, accelerates the effect of human metabolism；During taking this product, should drink in a large number Water；Three meals in a day, the most enough, eat enough protein foods every day.
3, this product composition is soluble in ethanol, drink can cause medicine concentration release and uncomfortable, therefore take medicine during should keep away Exempt to drink.
4, smoking can reduce the oxygen-supplying amount of brain, and the harmful substance such as nicotine is to cerebral lesion simultaneously, forbids during treatment Smoking and suction second hand smoking.
5, the quantity of motion that every day is enough；Keep in high spirits.
6, note striking a proper balance between work and rest, it is to avoid excessively tired.
Storage: low temperature 3～7 DEG C are deposited, lucifuge, sealing can preserve more than 24 months.

Claims (2)

1. prevent and treat a capsule for Alzheimer, by Hirudo, Flos Carthami, Rhizoma Coptidis, the Radix Astragali, Rhizoma Chuanxiong, Radix Angelicae Sinensis, the Radix Polygoni Multiflori, the Radix Euphorbiae Pekinensis, sweet Then, make after the effective ingredient of yam and red dates and egg albumen powder mixing, it is characterised in that formula is: the Radix Astragali 12 deal, and Hirudo is (clear Water) 3 deals, Flos Carthami 4 deal, Rhizoma Chuanxiong 4 deal, Radix Angelicae Sinensis (returning head) 6 deal, the Radix Polygoni Multiflori 3 deal, Semen Ziziphi Spinosae 3 deal, the Radix Euphorbiae Pekinensis 1 deal, sweet Then 1 deal, Rhizoma Coptidis 0.5 deal, Fructus Jujubae 16 deal, Fructus Mori 3 deal, mineral resources fulvic acid 0.1 deal, egg albumen powder 2.6 deal.
A kind of capsule preventing and treating Alzheimer the most according to claim 1, it is characterised in that manufacture method is: will Hirudo, Flos Carthami, Radix Angelicae Sinensis, the Radix Euphorbiae Pekinensis, the cryodesiccated solids of the fried medicinal liquid of Rhizoma Chuanxiong are decocted with the Radix Polygoni Multiflori, the Radix Astragali, Fructus Jujubae, Radix Kansui, Rhizoma Coptidis The solids co-grinding going out medicine liquid heating concentration drying is finely ground, and mineral resources fulvic acid, egg albumen powder mixing and stirring, makes 0.5g (500mg) capsule.
CN201610527664.2A 2016-07-01 2016-07-01 A kind of capsule preventing and treating Alzheimer Withdrawn CN106177012A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102078460A (en) * 2011-01-14 2011-06-01 中国中医科学院西苑医院 Traditional Chinese medicine for preventing and treating Alzheimer disease and preparation method thereof
CN103417664A (en) * 2013-08-06 2013-12-04 南京弘典医药科技有限公司 Application of fructus ziziphi jujubae in preparing medicine or health-care product for treating Alzheimer disease
CN104069424A (en) * 2014-04-09 2014-10-01 中国人民解放军北京军区总医院 Traditional Chinese medicine for treating alzheimer disease and preparation method thereof
CN105267917A (en) * 2015-10-20 2016-01-27 张宁 Chinese herbal compound extract for preventing and treating Alzheimer disease and application of Chinese herbal compound extract

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CN102078460A (en) * 2011-01-14 2011-06-01 中国中医科学院西苑医院 Traditional Chinese medicine for preventing and treating Alzheimer disease and preparation method thereof
CN102078460B (en) * 2011-01-14 2012-08-22 中国中医科学院西苑医院 Traditional Chinese medicine for preventing and treating Alzheimer disease and preparation method thereof
CN103417664A (en) * 2013-08-06 2013-12-04 南京弘典医药科技有限公司 Application of fructus ziziphi jujubae in preparing medicine or health-care product for treating Alzheimer disease
CN104069424A (en) * 2014-04-09 2014-10-01 中国人民解放军北京军区总医院 Traditional Chinese medicine for treating alzheimer disease and preparation method thereof
CN105267917A (en) * 2015-10-20 2016-01-27 张宁 Chinese herbal compound extract for preventing and treating Alzheimer disease and application of Chinese herbal compound extract

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Application publication date: 20161207