CN106177004A - 一种治疗骨折的中药膏剂 - Google Patents

一种治疗骨折的中药膏剂 Download PDF

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CN106177004A
CN106177004A CN201610769123.0A CN201610769123A CN106177004A CN 106177004 A CN106177004 A CN 106177004A CN 201610769123 A CN201610769123 A CN 201610769123A CN 106177004 A CN106177004 A CN 106177004A
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杨振东
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Abstract

本发明涉及一种治疗骨折的中药膏剂，它包含下列重量份的物质：骨碎补8‑12份、生川乌3‑8份、生草乌3‑8份、羌活3‑8份、五加皮5‑10份、防风3‑8份、威灵仙3‑8份、土鳖虫8‑12份、苍术3‑8份、蛇床子5‑10份、槐枝3‑8份、桑枝3‑8份、肉桂5‑10份、丁香3‑8份、冰片3‑8份、三七3‑8份、乳香5‑10份、没药5‑12份、木香3‑8份、红花3‑10份、伸筋草3‑8份、鸡血藤3‑8份、透骨草5‑12份、川芎3‑8份和独活3‑8份。

Description

一种治疗骨折的中药膏剂
技术领域
本发明涉及医药领域，具体来说涉及一种治疗骨折的中药膏剂。
背景技术
骨折是指由于外伤或病理等原因致使骨质部分或完全断裂的一种疾病。其主要临床表现为：骨折部有局限性疼痛和压痛，局部肿胀和出现瘀斑，肢体功能部分或完全丧失，完全性骨质尚可出现肢体畸形及异常活动。骨折时，骨髓、骨膜及周围组织血管破裂出血，在骨折处形成血肿，以及软组织损伤所致水肿，使患肢严重肿胀，甚至出现张力性水疱和皮下瘀斑，由于血红蛋白的分解，可呈紫色、青色或黄色。骨折局部出现剧烈疼痛，特别是移动患肢时加剧，局部肿胀和疼痛使患肢活动受限，如为完全性骨折，可使受伤肢体活动功能完全丧失。
发明内容
本发明的目的是提供一种治疗骨折的中药膏剂。
为了实现本发明的目的，本发明提供一种治疗骨折的中药膏剂，它包含下列重量份的物质：骨碎补8-12份、生川乌3-8份、生草乌3-8份、羌活3-8份、五加皮5-10份、防风3-8份、威灵仙3-8份、土鳖虫8-12份、苍术3-8份、蛇床子5-10份、槐枝3-8份、桑枝3-8份、肉桂5-10份、丁香3-8份、冰片3-8份、三七3-8份、乳香5-10份、没药5-12份、木香3-8份、红花3-10份、伸筋草3-8份、鸡血藤3-8份、透骨草5-12份、川芎3-8份和独活3-8份。
优选地，本发明所述的治疗骨折的中药膏剂包含下列重量份的物质：骨碎补10份、生川乌5份、生草乌5份、羌活5份、五加皮8份、防风5份、威灵仙5份、土鳖虫10份、苍术5份、蛇床子8份、槐枝5份、桑枝5份、肉桂8份、丁香5份、冰片5份、三七5份、乳香8份、没药9份、木香5份、红花6份、伸筋草5份、鸡血藤5份、透骨草9份、川芎5份和独活5份。
更优选地，本发明所述的治疗骨折的中药膏剂还包含下列重量份的物质：0.1份的具有下列结构式的物质：
本发明还提供具有下列结构式的物质在制备治疗骨折的药物中的用途：
优选地，所述药物制成膏剂。
本发明的药物材料易得，制备方法简单，治疗效果好，价格低，见效快，疗效可靠，无明显不良反应和副作用。
具体实施方式
下面通过实施例进一步说明本发明。应该理解的是，本发明的实施例是用于说明本发明而不是对本发明的限制。根据本发明的实质对本发明进行的简单改进都属于本发明要求保护的范围。除非另有说明，否则本发明中的百分数是重量百分数。
实施例1
称取骨碎补10克、生川乌5克、生草乌5克、羌活5克、五加皮8克、防风5克、威灵仙5克、土鳖虫10克、苍术5克、蛇床子8克、槐枝5克、桑枝5克、肉桂8克、丁香5克、冰片5克、三七5克、乳香8克、没药9克、木香5克、红花6克、伸筋草5克、鸡血藤5克、透骨草9克、川芎5克和独活5克，粉碎，过100目筛，即得。
实施例2
化合物具有下列结构式：
试验例
骨折后治疗过程中，IL-4水平是一个非常关键的指标。IL-4水平低则说明炎症少痊愈情况良好。
模型和给药
将清洁级(SPF)雄性Wistar大鼠(鼠龄5-6月，体质量170.0±20.5)分成6组：正常对照组(Normal control group，NC)、模型对照组(Model control group，MC)、氨基葡萄糖对照组(Glucosamine control group，GS)、给药组1、给药组2、给药组3。每组10只。除正常对照组外，向其余各组大鼠的右膝关节注射4重量％木瓜蛋白酶水溶液10μL和0.03mol/L的L-半胱氨酸水溶液，并且分别于第3、7天加强，造成模型。造模后第14天开始给药，各组给药量如下：正常组与模型组，给予生理盐水灌胃1mL/100g体重；氨基葡萄糖组，氨基葡萄糖1g加100mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组1，实施例1的粉末10g加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组2，0.02g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重；给药组3，实施例1的粉末5g和0.01g的化合物加1000mL生理盐水配制成混悬液，给予灌胃1mL/100g体重。1次/日，连续给药30d，造模后第49天取材。
ELISA法检测IL-4
在第49天将动物处死后，行腹主动脉采血，将所采血液3000r/min离心5min，取血清，置-80℃冰箱保存待测。具体操作步骤按试剂盒(IL-4ELISA试剂盒购自上海酶联生物科技有限公司)说明书进行。结果见下表。
组别 IL-4(pg·mL-1)
正常组 172.3±12.6
模型组 29.6±1.9*
氨基葡萄糖组 70.6±6.5*△
给药组1 90.3±8.5*△
给药组2 72.1±6.7*△
给药组3 86.7±7.3*△
和正常对照组比较，*P＜0.05，表明造模成功；和模型组比较，△P＜0.05，说明本发明药物均具有药效。

Claims (5)

1.一种治疗骨折的中药膏剂，其特征在于，它包含下列重量份的物质：骨碎补8-12份、生川乌3-8份、生草乌3-8份、羌活3-8份、五加皮5-10份、防风3-8份、威灵仙3-8份、土鳖虫8-12份、苍术3-8份、蛇床子5-10份、槐枝3-8份、桑枝3-8份、肉桂5-10份、丁香3-8份、冰片3-8份、三七3-8份、乳香5-10份、没药5-12份、木香3-8份、红花3-10份、伸筋草3-8份、鸡血藤3-8份、透骨草5-12份、川芎3-8份和独活3-8份。
2.根据权利要求1所述的治疗骨折的中药膏剂，其特征在于，它包含下列重量份的物质：骨碎补10份、生川乌5份、生草乌5份、羌活5份、五加皮8份、防风5份、威灵仙5份、土鳖虫10份、苍术5份、蛇床子8份、槐枝5份、桑枝5份、肉桂8份、丁香5份、冰片5份、三七5份、乳香8份、没药9份、木香5份、红花6份、伸筋草5份、鸡血藤5份、透骨草9份、川芎5份和独活5份。
3.根据权利要求1所述的治疗骨折的中药膏剂，其特征在于，它还包含下列重量份的物质：0.1份的具有下列结构式的物质：
4.具有下列结构式的物质在制备治疗骨折的药物中的用途：
5.根据权利要求4所述的用途，其特征在于，所述药物制成膏剂。
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