CN106176876A - A kind of Chinese medicine oil for promoting wound to heal proposes agent and preparation method thereof - Google Patents
A kind of Chinese medicine oil for promoting wound to heal proposes agent and preparation method thereof Download PDFInfo
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- CN106176876A CN106176876A CN201610745796.2A CN201610745796A CN106176876A CN 106176876 A CN106176876 A CN 106176876A CN 201610745796 A CN201610745796 A CN 201610745796A CN 106176876 A CN106176876 A CN 106176876A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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Abstract
The invention discloses a kind of Chinese medicine oil for promoting wound to heal and propose agent, be to be prepared by the following material according to quality volume percentage: Herba Hyperici perforati oil extract 2.5% 8%, vitamin E 0.5% 5%, remaining is olive oil；And provide its preparation method.The invention have the benefit that (1) is easy to use, easily absorb, oiliness liniment has good breathability and the effect prevented water penetration, and is also equipped with suppression or kills the effect of the fraction of pathogens bacterium causing infection, it is possible to play prevention infection, anti-infective effect；(2) there is effect of hemostatic analgesia, be also equipped with activating cell, the effect of reparation damaged cell, promote tissue, the reparation of cell and regeneration, promote wound healing, be not likely to produce spot, have the good compatibility with skin；(3) without the synergism stimulating class, anesthesia class and hormonal substance, green safety, and three kinds of contained materials can play quickening wound healing, the treatment to wound can play the hugest effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine oil for promoting wound to heal carry agent and
Its preparation method.
Background technology
Skin is an outmost Rotating fields of human body, is an organ of human body maximum, refers to that body surface wraps in muscle
The tissue of outside.Mainly carry protection health, perspire, feel the cold and hot and function of pressure.Skin covers whole body, and it makes internal
Various tissues and organ are from the invasion and attack of physical property, mechanicalness, chemical and pathogenic microorganism.People and the skin of higher mammal
By epidermis, corium, subcutaneous tissue up of three layers.Skin is neural sensory receptor, is again effector, hot and cold, pain, feelings
Thread changes etc. mechanically and chemically stimulate can cause to reflexive vasoconstriction and diastole, arrectores pilorum contraction, sweat gland secretion, skin
The change of capillary permeability.The 5%～15% of skin total weight percentage of liveweight, the gross area is 1.5～2 square metres, and thickness is because of people
Or position and different, be 0.5 millimeter～4 millimeters.Skin covers whole body, and it makes internal various tissue and organ from physical property, machine
The invasion and attack of tool, chemical and pathogenic microorganism.Skin has the barrier action of two aspects: on the one hand prevent internal water
Part, electrolyte, other materials are lost；On the other hand the intrusion of extraneous harmful substance is stoped.Skin remains human internal environment's
Stable, skin also assists in the metabolic process of human body simultaneously.Skin has several color (white, yellow, red, brown, black etc.), mainly because of people
Kind, age and position different and different.Skin is made up of epidermis, corium and subcutaneous tissue, and containing accessory organ (sweat gland, sebum
Gland, fingernail, toenail) and blood vessel, lymphatic vessel, N&M etc..
As can be seen here, skin is one of vitals of human body, it is necessary to well protect.But owing to it is in human body
Outer layer, so daily life can be baited, extruded, rubbed, be fallen that the situation such as to touch be to be difficult to avoid.Would generally occur incised wound,
Scratch, blood stasis, injure by a crashing object, squeeze wound, scratch, laceration, stab, the traumatic condition such as mosquito is bitten, burn and scald, the most also ロ etc. is hindered in operation
Wound, after there are these traumatic conditions, it is necessary to process in time, otherwise can also can due to the intrusion generation pyogenic infection of pathogenetic bacteria
Cause local that red, swollen, hot, pain and dysfunction occur, time serious, toxenia can be caused owing to antibacterial and toxin enter blood circulation
The diseases such as disease, septicemia and tetanus, can cause extremely serious consequence.
Wound healing is a height evolutionary process, and first degree wound is only limitted to skin epidermis, can by epithelium again
Raw healing.Slightly severe one has skin and subcutaneous tissue fracture, and wound occurs；Serious wound can have muscle, flesh key, neural breaking
Split and fracture.Skin appendages (hair follicle, sweat gland and sebaceous gland) as destroyed completely, then can not completely regenerate, and cicatrix occurs
Repair.After tendon rupture, the initial stage is also scar repairing, but constantly reconstructs along with functional exercise, and collagen fiber can be by original flesh
Tendon fiber direction arranges, and reaches to regenerate completely.The replacement of disappearance and damaged tissues can be affected by various factors, and wound can not
Fully healing forms cicatrix or difficult wound healing mouth, has a strong impact on the quality of life of patient.Prevent and treat wound infection, necrosis and formed chronic
The best approach of difficult healing is to accelerate the healing of wound.
Summary of the invention
The purpose of the present invention is aiming at above-mentioned defect of the prior art, it is provided that a kind of for promoting what wound healed
Chinese medicine oil proposes agent and preparation method thereof, can quickly process wound, and can cicatrize a wound again progress faster and do not stay spot.
To achieve these goals, the technical scheme that the present invention provides is: a kind of Chinese medicine oil for promoting wound to heal
Propose agent, be to be prepared by the following material according to quality volume percentage: Herba Hyperici perforati oil extract 2.5%-8%, dimension are raw
Element E 0.5%-5%, remaining is olive oil.
Further, above-mentioned a kind of Chinese medicine oil for promoting wound to heal proposes agent, is by according to quality volume basis
Prepare than the following material of meter: Herba Hyperici perforati oil extract 3%-6%, vitamin E 1%-4%, remaining is olive oil.
Further, above-mentioned a kind of Chinese medicine oil for promoting wound to heal proposes agent, is by according to quality volume basis
Prepare than the following material of meter: Herba Hyperici perforati oil extract 5%, vitamin E 2.5%, remaining is olive oil.
Further, above-mentioned a kind of Chinese medicine oil for promoting wound to heal proposes agent, described Herba Hyperici perforati oil extract
Preparation method is: Herba Hyperici perforati crude drug, micronizing, 200 mesh sieve, takes 50 grams, adds olive oil and is prepared as 5.33% pass through
Leaf Fructus Forsythiae olive oil solution, takes CO after stirring and evenly mixing2Supercritical extraction method carries out being obtained by extraction Herba Hyperici perforati oil extract, extraction
Pressure power is 25MPa, and extraction temperature is 35 DEG C, and extraction time is 6h.
Further, above-mentioned a kind of Chinese medicine oil for promoting wound to heal proposes agent, and it is external that described Chinese medicine oil proposes agent
Oiliness liniment.
Second object of the present invention there is provided above-mentioned a kind of Chinese medicine oil for promoting wound to heal and proposes the preparation of agent
Method, comprises the following steps:
1) weigh Herba Hyperici perforati crude drug, micronizing, 200 mesh sieve according to proportioning, take 50 grams of addition olive oil and be prepared as
The Herba Hyperici perforati olive oil solution of 5.33%, takes CO after stirring and evenly mixing2Supercritical extraction method carries out Herba Hyperici perforati is obtained by extraction
Oil extract, extracting pressure is 25MPa, and extraction temperature is 35 DEG C, and extraction time is 6h；
2) add vitamin E solution according to proportioning in a reservoir, be slowly added to olive oil and stir, vitamin E: the matter of olive oil
Amount ratio is 2:5, and after stirring 5 minutes, vitamin E mixes completely, adds the Herba Hyperici perforati oil extract that step 1) obtains, stirs under room temperature
Mix to mixing, add olive oil constant volume, be prepared as, containing vitamin E2 .5% and the mixed liquor of Herba Hyperici perforati 5%, being for promoting
The Chinese medicine oil entering wound healing proposes agent.
Further, above-mentioned a kind of Chinese medicine oil for promoting wound to heal puies forward the preparation method of agent, described step 2)
The mixed liquor obtained is placed in brown bottle, builds after bottle cap through cobalt-60 irradiation-sterilize 10 seconds, i.e. can get external oiliness and smear
Agent.
Compared with prior art, a kind of Chinese medicine oil for promoting wound to heal that the present invention provides carries agent and preparation side thereof
Method has the advantages that
(1) use is the most convenient, and oil medium is easily absorbed by skin trauma face, and oiliness liniment spreads upon shape after wound wound face
Become one layer of oiliness film, there is good breathability and the effect prevented water penetration, do not hinder wound face secreting liquid, be also equipped with suppression
Or kill the effect of the pathogen such as staphylococcus aureus, streptococcus, bacillus pyocyaneus and escherichia coli causing infecting, it is possible to play
Prevention is infected, anti-infective effect；
(2) there is hemostatic analgesia effect, be also equipped with activating cell simultaneously, repair the effect of damaged cell, promote tissue, cell
Repair and regeneration, promote wound healing, be not likely to produce spot, have the good compatibility with skin；
(3) without stimulating class, anesthesia class and hormonal substance, Product Green safety, and three kinds of contained materials can play quickening
The synergism of wound healing, the treatment to wound can play the hugest function.
Accompanying drawing explanation
Fig. 1 is test rat blood serum 5-HT changing trend diagram.
Fig. 2 is test rat blood serum changing trend diagram.
Fig. 3 is test rat blood serum histamine changing trend diagram.
Detailed description of the invention
Embodiment 1-5:
The present invention provide for promoting that the Chinese medicine oil that wound heals proposes the preparation of agent:
Chinese medicine oil carries agent prescription composition as shown in table 1, and in table 1, data are quality percent by volume.
Table 1
Preparation method:
(1) Herba Hyperici perforati crude drug, micronizing, add olive oil, stirring and evenly mixing, take CO subsequently2Supercritical extraction method, extraction
Pressure power 25MPa, extraction temperature is 35 DEG C, and extraction time is 6h；
(2) adding vitamin E oil solution in a reservoir, be slowly added to olive oil and stir, after stirring 5 minutes, vitamin E is complete
Mixing, adds the Herba Hyperici perforati oil extract of step (1), and under room temperature, stirring is to mixing, adds olive oil constant volume, obtains mixed liquor and be
Chinese medicine oil for wound healing proposes agent.
The described Chinese medicine oil for wound healing puies forward the preparation method of agent, wherein step (2) described mixed liquor is contained in palm fibre
In color bottle, good and sound bottle cap, through cobalt-60 irradiation-sterilize, obtain external oiliness liniment.
Comparative example:
Prescription forms: vitamin E 2.5%, remaining is olive oil.
Preparation method: add vitamin E oil solution in a reservoir, be slowly added to olive oil and stir, stirring under room temperature
Mixing extremely mixing in 5 minutes, vitamin E mixes completely, adds olive oil constant volume, obtains miscible oil.
Embodiment 6:
The Chinese medicine oily experimental study carrying agent promotion perianal abscess postoperative rat model wound healing of rush wound healing of the present invention:
Cleaning grade SPF Wistar rat 160, male and female half and half, body weight 160 ± 20g, with 3% pentobarbital sodium (40mg/kg) abdomen
Chamber injecting anesthetic.Electricity pushes away rejecting rat back hypomere hair to both sides midaxillary line, iodophor disinfection.Keep right district in rat spine caudal
Diameter 1cm circular incision is done in territory, and otch is deep to muscle layer.Stool supernatant 0.5mL (adult normal's feces is dripped in wound surface after hemostasis
Add normal saline mixing, centrifugal, take supernatant, now with the current), control rats dropping normal saline 0.5mL.All rats
Postoperative oil yarn covers, and adhesive tape is fixed, and after 48h, wound surface occurs that purulent secretion oozes out for modeling success.
Rat model is divided into matched group, tests 1 group, test 2 groups, test 3 groups, often 40 rats of group.Each group rat is adopted
Clean a wound with normal saline, iodophor disinfection, wrap up dressing.Test group is changed dressings every day, changes dressings first 30 minutes with stool supernatant
Dropping wound surface, the fecal pollution of simulation perianal abscess patient's defecation every day；Matched group is changed dressings every day, and dropping in first 30 minutes of changing dressings is raw
Reason saline, all changes dressings to wound healing for two groups.
Wherein, matched group, according to penicillin sodium 140,000 units/kg body weight intraperitoneal injection, divides in morning, noon and afternoon every day simultaneously
Do not clean a wound with normal saline.Test 1 group, test 2 groups except according to penicillin sodium 140,000 units/kg body weight intraperitoneal injection
Outward, the Chinese medicine rush wound healing oil using embodiment 1,3 preparation the most respectively proposes agent treatment, and morning, noon and afternoon every day are each the most once.Test 3
Group, in addition to by penicillin sodium 140,000 units/kg body weight intraperitoneal injection, uses miscible oil prepared by comparative example simultaneously
Treatment, morning, noon and afternoon every day are each once.
After modeling the 3rd, 7,10,14d, points 4 batches (every batches often group randomly select 10 rats) put to death rat, aseptic condition
Under carry out collection of specimens, cut 0.5cm × 0.5cm granulation tissue at edge of wound, put into 4% formalin and fix, conventional dehydration, stone
Serial section after wax embedding, slice thickness 3 μm, conventional H E dyes, and uses capillary in SABC CD34 method detection granulation tissue
Blood vessel number, SABC 36kDa method detection fibroblast number, all fix through 4% paraformaldehyde, take 5 visuals field, 400 times of light microscopics
Lower observation counts.Inflammatory mediator detects: use ELISA method to detect rat blood serum, 3,7,10,14d randomly selects
Before 10 rats are put to death, taking inguinal artery blood, conventional centrifugal is deposited, and uses rat 5-HT, PGE2, histamine detection kit inspection
Survey.4 groups of rats are all changed dressings to wound healing, to the time used by wound healing after record modeling.
The computing formula of wound surface CI:
Wound surface CI=(wound surface area/original wound surface area after 1-treatment) × 100%.
Each group wound surface CI comparative result is as shown in table 2.Each specimen observes 5 visuals field, in counting granulation tissue
Newborn capillary number and fibroblast number, and average, fibroblast number and blood capillary in each group wound granulation tissue
The comparative result of number is as shown in table 3.Inflammatory mediator 5-HT, PGE2, histamine testing result as Figure 1-3.Rat Wound Healing
It is as shown in table 4 that time compares (d, MEAN ± SD).
Wound healing is a complex process, the treatment health of almost impact major part surgical diseases in clinic
Multiple.The factor affecting wound healing is the most, and it promotees mainly by granulation tissue growth, new vessels and fibroblastic growth
Entering healing, the wound surface initial stage is inflammatory phase, mainly shows as leukocyte infiltration, phagocytosis, and substantial amounts of breed bacteria is bitten carefully by huge
Endocytosis is bitten, and discharges various active material and assist, and perianal abscess postoperative wound surface is owing to amount of bacteria is big, kind is many, therefore scorching
Time disease phase is longer, now PEG2Also can cause peripheral vasodilation etc. the factor, cause wound site edema.In hypertrophy subsequently
Phase relies primarily on granulation tissue formation, proliferation of fibrous tissue carrys out wound healing, and fibroblast serves important function, its
Provide collagen protein important in agglutination, provide enough tension force for tissue repair；The formation of the raw blood capillary of the heart also promotees
Enter wound surface myocardial revascularization.In the final moulding phase, the collagen protein that fibroblast provides also functions to important function, wound tissue
Gradually forming cicatrix, cell and vascular repair to reduce, the contraction of wound surface relies primarily on fibroblast and collagen protein permutatation
Common effect.
Result of the test according to table 2 and table 3 is it can be seen that test 1,2 groups is compared with model control group, at rat wound surface more
The aspects such as hop index, fibroblast number and capillary vessel number have significant difference (P < 0.05) or pole significant difference (P <
0.01), the Chinese medicine rush wound healing oil of this explanation present invention proposes agent and can improve the content of wound granulation tissue fibroblast cell, from
And effectively rapidly promote wound healing.
Table 2
Table 3
Table 4
Being drawn by above lot of experiment validation, the Chinese medicine rush wound healing oil of the present invention proposes agent and has the advantage that
(1) it is that wound surface provides good healing environment.When Chinese medicine promote wound healing oil carry agent spread upon wound surface time, wound is had
Well affinity.Liquid can be belonged at the protecting film of one layer of oiliness of wound face stroke owing to oil proposes agent, there is certain flowing
Property, and oiliness dosage form has good tack, can not only the wound surface of misalignment be completely covered, moreover it is possible to form one protection
Layer, stops the harmful microorganism such as fungus, antibacterial and booty directly to contact with wound face.Oiliness protecting film has the most ventilative
Property, poisture-penetrability, provide the good environment being suitable for growth for wound face tissue, thus accelerate the healing of wound.
(2) component needed for skin is provided.Vitamin E has antioxidation comprehensive, efficient, can protect cell
Polyunsaturated fatty acid on film, from the attack of free radical, maintains the integrity of cell.Vitamin E can be absorbed by the skin,
Improve Immunosuppressant therapy effect, strengthen anti-infection ability, the healing of wound can be accelerated.
(3) can anti-inflammation, prevent and treat traumatic infection.The oil of the present invention proposes agent to brevibacterium flavum, through yellow Fructus Vitis viniferae ball
Bacterium, bacillus subtilis, bacillus pyocyaneus, Bacillus thuringiensis etc. have the strongest antibacterial and bactericidal action.Clinical common antibiotics is had resistance to
The gram positive bacterial strain of the property of medicine all has stronger antibacterial and bactericidal action.Active component in oil proposes agent and Wound contact
Time, being attached to the pathogen in wound surface and wound will be killed by pressing down, and prevent wound infection.
(4) cell regeneration, maintenance damaging cells, accelerating wound healing are promoted.
(5) there is hemostatic analgesia effect.
(6) skin tissue recovering and healing are promoted.
Finally it is noted that the foregoing is only the preferred embodiments of the present invention, it is not limited to the present invention,
Although being described in detail the present invention with reference to previous embodiment, for a person skilled in the art, it still may be used
So that the technical scheme described in foregoing embodiments to be modified, or wherein portion of techniques feature is carried out equivalent.
All within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included in the present invention's
Within protection domain.
Claims (7)
1. one kind proposes agent for the Chinese medicine oil promoting wound to heal, it is characterised in that by according to quality volume percentage
Following material prepares: Herba Hyperici perforati oil extract 2.5%-8%, vitamin E 0.5%-5%, and remaining is olive oil.
A kind of Chinese medicine oil for promoting wound to heal the most according to claim 1 proposes agent, it is characterised in that be by according to
The following material of quality volume percentage prepares: Herba Hyperici perforati oil extract 3%-6%, vitamin E 1%-4%, and remaining is
Olive oil.
A kind of Chinese medicine oil for promoting wound to heal the most according to claim 1 proposes agent, it is characterised in that be by according to
The following material of quality volume percentage prepares: Herba Hyperici perforati oil extract 5%, vitamin E 2.5%, and remaining is Fructus Canarii albi
Oil.
4. propose agent according to the arbitrary described a kind of Chinese medicine oil for promoting wound to heal of claim 1-3, it is characterised in that institute
The preparation method stating Herba Hyperici perforati oil extract is: Herba Hyperici perforati crude drug, micronizing, 200 mesh sieve, takes 50 grams, adds olive
Olive oil is prepared as the Herba Hyperici perforati olive oil solution of 5.33%, takes CO after stirring and evenly mixing2Supercritical extraction method carries out extracting
To Herba Hyperici perforati oil extract, extracting pressure is 25MPa, and extraction temperature is 35 DEG C, and extraction time is 6h.
5. propose agent according to the arbitrary described a kind of Chinese medicine oil for promoting wound to heal of claim 1-3, it is characterised in that institute
Stating Chinese medicine oil and proposing agent is external oiliness liniment.
6. the preparation method of agent is put forward according to the arbitrary described a kind of Chinese medicine oil for promoting wound to heal of claim 1-3, its
It is characterised by, comprises the following steps:
1) weigh Herba Hyperici perforati crude drug, micronizing, 200 mesh sieve according to proportioning, take 50 grams of addition olive oil and be prepared as
The Herba Hyperici perforati olive oil solution of 5.33%, takes CO after stirring and evenly mixing2Supercritical extraction method carries out Herba Hyperici perforati is obtained by extraction
Oil extract, extracting pressure is 25MPa, and extraction temperature is 35 DEG C, and extraction time is 6h；
2) add vitamin E solution according to proportioning in a reservoir, be slowly added to olive oil and stir, vitamin E: the matter of olive oil
Amount ratio is 2:5, and after stirring 5 minutes, vitamin E mixes completely, adds the Herba Hyperici perforati oil extract that step 1) obtains, stirs under room temperature
Mix to mixing, add olive oil constant volume, be prepared as, containing vitamin E2 .5% and the mixed liquor of Herba Hyperici perforati 5%, being for promoting
The Chinese medicine oil entering wound healing proposes agent.
A kind of Chinese medicine oil for promoting wound to heal the most according to claim 6 puies forward the preparation method of agent, and its feature exists
In, described step 2) mixed liquor that obtains is placed in brown bottle, builds through cobalt-60 irradiation-sterilize 10 seconds after bottle cap, the most available
External oiliness liniment.
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| CN201610745796.2A CN106176876A (en) | 2016-08-29 | 2016-08-29 | A kind of Chinese medicine oil for promoting wound to heal proposes agent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107308046A (en) * | 2017-06-29 | 2017-11-03 | 湖南大三湘油茶生态产业有限公司 | Toxin-expelling and face nourishing camellia soothing oil of high penetration and preparation method thereof |
-
2016
- 2016-08-29 CN CN201610745796.2A patent/CN106176876A/en active Pending
Non-Patent Citations (3)
| Title |
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| 李玲等: "贯叶连翘的超临界二氧化碳提取工艺研究", 《时珍国医国药》 * |
| 蒋尊成: "贯叶连翘研究进展", 《中成药》 * |
| 马莉: "《维生素保健康全书》", 31 May 2013, 天津科学技术出版社 * |
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| CN107308046A (en) * | 2017-06-29 | 2017-11-03 | 湖南大三湘油茶生态产业有限公司 | Toxin-expelling and face nourishing camellia soothing oil of high penetration and preparation method thereof |
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Application publication date: 20161207 |