CN106174580A - Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet - Google Patents
Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet Download PDFInfo
- Publication number
- CN106174580A CN106174580A CN201610741062.7A CN201610741062A CN106174580A CN 106174580 A CN106174580 A CN 106174580A CN 201610741062 A CN201610741062 A CN 201610741062A CN 106174580 A CN106174580 A CN 106174580A
- Authority
- CN
- China
- Prior art keywords
- blood
- extract
- fat
- lycium ruthenicum
- ruthenicum murr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004369 blood Anatomy 0.000 title claims abstract description 64
- 239000008280 blood Substances 0.000 title claims abstract description 64
- 241000169546 Lycium ruthenicum Species 0.000 title claims abstract description 38
- 235000000346 sugar Nutrition 0.000 title claims abstract description 31
- 239000000284 extract Substances 0.000 claims abstract description 42
- 241000121220 Tricholoma matsutake Species 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 229940044115 phlorhizin Drugs 0.000 claims abstract description 17
- IOUVKUPGCMBWBT-UHFFFAOYSA-N phloridzosid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-UHFFFAOYSA-N 0.000 claims abstract description 17
- IOUVKUPGCMBWBT-QNDFHXLGSA-N phlorizin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-QNDFHXLGSA-N 0.000 claims abstract description 17
- 235000019139 phlorizin Nutrition 0.000 claims abstract description 17
- 238000005516 engineering process Methods 0.000 claims abstract description 5
- 230000021615 conjugation Effects 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 51
- 235000019197 fats Nutrition 0.000 abstract description 37
- 229940108924 conjugated linoleic acid Drugs 0.000 abstract description 34
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 30
- 230000036039 immunity Effects 0.000 abstract description 18
- 230000002708 enhancing effect Effects 0.000 abstract description 14
- 210000002784 stomach Anatomy 0.000 abstract description 14
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 13
- 230000036772 blood pressure Effects 0.000 abstract description 12
- 206010003210 Arteriosclerosis Diseases 0.000 abstract description 11
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract description 11
- 210000003734 kidney Anatomy 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 9
- 230000008569 process Effects 0.000 abstract description 9
- 230000032683 aging Effects 0.000 abstract description 7
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 6
- 206010010774 Constipation Diseases 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 6
- 210000000952 spleen Anatomy 0.000 abstract description 6
- 235000013402 health food Nutrition 0.000 abstract description 5
- 230000017531 blood circulation Effects 0.000 abstract description 4
- 230000001105 regulatory effect Effects 0.000 abstract description 4
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 3
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 3
- 230000002443 hepatoprotective effect Effects 0.000 abstract description 3
- 230000001954 sterilising effect Effects 0.000 abstract description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 42
- 239000003925 fat Substances 0.000 description 36
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 35
- JBYXPOFIGCOSSB-GOJKSUSPSA-N 9-cis,11-trans-octadecadienoic acid Chemical compound CCCCCC\C=C\C=C/CCCCCCCC(O)=O JBYXPOFIGCOSSB-GOJKSUSPSA-N 0.000 description 32
- 238000011160 research Methods 0.000 description 24
- 102000004877 Insulin Human genes 0.000 description 22
- 108090001061 Insulin Proteins 0.000 description 22
- 229940125396 insulin Drugs 0.000 description 22
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 18
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 17
- 239000008103 glucose Substances 0.000 description 17
- 210000004185 liver Anatomy 0.000 description 16
- 230000006870 function Effects 0.000 description 14
- 241000700159 Rattus Species 0.000 description 13
- 150000004676 glycans Chemical class 0.000 description 12
- 241000699666 Mus <mouse, genus> Species 0.000 description 11
- 230000001629 suppression Effects 0.000 description 11
- 206010028980 Neoplasm Diseases 0.000 description 10
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 10
- 230000015572 biosynthetic process Effects 0.000 description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 229920001282 polysaccharide Polymers 0.000 description 10
- 239000005017 polysaccharide Substances 0.000 description 10
- 229920002414 procyanidin Polymers 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 9
- 241000699670 Mus sp. Species 0.000 description 9
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 9
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 9
- 230000009471 action Effects 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 8
- -1 lipid peroxide Chemical class 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 150000003254 radicals Chemical class 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000001093 anti-cancer Effects 0.000 description 6
- 235000012000 cholesterol Nutrition 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 230000000144 pharmacologic effect Effects 0.000 description 6
- 230000000291 postprandial effect Effects 0.000 description 6
- 230000002633 protecting effect Effects 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 206010020772 Hypertension Diseases 0.000 description 5
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 230000000242 pagocytic effect Effects 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 208000002249 Diabetes Complications Diseases 0.000 description 4
- 108010007622 LDL Lipoproteins Proteins 0.000 description 4
- 102000007330 LDL Lipoproteins Human genes 0.000 description 4
- 208000008589 Obesity Diseases 0.000 description 4
- 208000007107 Stomach Ulcer Diseases 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 201000005917 gastric ulcer Diseases 0.000 description 4
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 230000003859 lipid peroxidation Effects 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 235000020824 obesity Nutrition 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- VGEREEWJJVICBM-UHFFFAOYSA-N phloretin Chemical compound C1=CC(O)=CC=C1CCC(=O)C1=C(O)C=C(O)C=C1O VGEREEWJJVICBM-UHFFFAOYSA-N 0.000 description 4
- 210000002381 plasma Anatomy 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 206010012655 Diabetic complications Diseases 0.000 description 3
- 206010012689 Diabetic retinopathy Diseases 0.000 description 3
- 208000004930 Fatty Liver Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010019708 Hepatic steatosis Diseases 0.000 description 3
- 206010022489 Insulin Resistance Diseases 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 210000001789 adipocyte Anatomy 0.000 description 3
- 210000000577 adipose tissue Anatomy 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 206010009887 colitis Diseases 0.000 description 3
- 238000002485 combustion reaction Methods 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 235000013325 dietary fiber Nutrition 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 208000010706 fatty liver disease Diseases 0.000 description 3
- 230000004153 glucose metabolism Effects 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 3
- 210000003494 hepatocyte Anatomy 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 210000004153 islets of langerhan Anatomy 0.000 description 3
- 235000020778 linoleic acid Nutrition 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 239000011573 trace mineral Substances 0.000 description 3
- 235000013619 trace mineral Nutrition 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- ZWTDXYUDJYDHJR-UHFFFAOYSA-N (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one Natural products OC1=CC(O)=CC=C1C=CC(=O)C1=CC=C(O)C=C1O ZWTDXYUDJYDHJR-UHFFFAOYSA-N 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 208000000501 Lipidoses Diseases 0.000 description 2
- 206010024585 Lipidosis Diseases 0.000 description 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- YQHMWTPYORBCMF-UHFFFAOYSA-N Naringenin chalcone Natural products C1=CC(O)=CC=C1C=CC(=O)C1=C(O)C=C(O)C=C1O YQHMWTPYORBCMF-UHFFFAOYSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 208000022873 Ocular disease Diseases 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 201000005702 Pertussis Diseases 0.000 description 2
- 241000018646 Pinus brutia Species 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- 241000282894 Sus scrofa domesticus Species 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 206010000496 acne Diseases 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 229930014669 anthocyanidin Natural products 0.000 description 2
- 150000001452 anthocyanidin derivatives Chemical class 0.000 description 2
- 235000008758 anthocyanidins Nutrition 0.000 description 2
- 210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 150000001746 carotenes Chemical class 0.000 description 2
- 235000005473 carotenes Nutrition 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 239000002532 enzyme inhibitor Substances 0.000 description 2
- 229940125532 enzyme inhibitor Drugs 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 201000005577 familial hyperlipidemia Diseases 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 150000002212 flavone derivatives Chemical class 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000007661 gastrointestinal function Effects 0.000 description 2
- 238000007446 glucose tolerance test Methods 0.000 description 2
- 230000002641 glycemic effect Effects 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 150000002338 glycosides Chemical class 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 231100000753 hepatic injury Toxicity 0.000 description 2
- 201000001421 hyperglycemia Diseases 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 229940049918 linoleate Drugs 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000008518 lycium barbarum polysaccharide Substances 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003387 muscular Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- VSMOENVRRABVKN-UHFFFAOYSA-N oct-1-en-3-ol Chemical compound CCCCCC(O)C=C VSMOENVRRABVKN-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 230000004792 oxidative damage Effects 0.000 description 2
- 210000003024 peritoneal macrophage Anatomy 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 201000009104 prediabetes syndrome Diseases 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000004223 radioprotective effect Effects 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 229910001415 sodium ion Inorganic materials 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 102000005606 Activins Human genes 0.000 description 1
- 108010059616 Activins Proteins 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 description 1
- 244000024893 Amaranthus tricolor Species 0.000 description 1
- 235000014748 Amaranthus tricolor Nutrition 0.000 description 1
- 241000216654 Armillaria Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 244000178993 Brassica juncea Species 0.000 description 1
- 235000011332 Brassica juncea Nutrition 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000219357 Cactaceae Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 102000018711 Facilitative Glucose Transport Proteins Human genes 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 208000002705 Glucose Intolerance Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 108091052347 Glucose transporter family Proteins 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 108010006464 Hemolysin Proteins Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 235000005206 Hibiscus Nutrition 0.000 description 1
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 description 1
- 244000048199 Hibiscus mutabilis Species 0.000 description 1
- 235000003973 Hibiscus mutabilis Nutrition 0.000 description 1
- 244000284380 Hibiscus rosa sinensis Species 0.000 description 1
- 241000167880 Hirundinidae Species 0.000 description 1
- 101000852815 Homo sapiens Insulin receptor Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102100036721 Insulin receptor Human genes 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 244000228367 Lewisia rediviva Species 0.000 description 1
- 235000007279 Lewisia rediviva Nutrition 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 102000052812 Ornithine decarboxylases Human genes 0.000 description 1
- 108700005126 Ornithine decarboxylases Proteins 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 102000023984 PPAR alpha Human genes 0.000 description 1
- 108010028924 PPAR alpha Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- WXTPOHDTGNYFSB-UHFFFAOYSA-N Phlorin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(O)=C1 WXTPOHDTGNYFSB-UHFFFAOYSA-N 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 108010047620 Phytohemagglutinins Proteins 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 241000219295 Portulaca Species 0.000 description 1
- 208000001280 Prediabetic State Diseases 0.000 description 1
- 208000033240 Progressive symmetric erythrokeratodermia Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- 206010057430 Retinal injury Diseases 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 244000181025 Rosa gallica Species 0.000 description 1
- 235000000533 Rosa gallica Nutrition 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 102000013275 Somatomedins Human genes 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 240000000851 Vaccinium corymbosum Species 0.000 description 1
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 1
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010048222 Xerosis Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000488 activin Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical class CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 235000021014 blueberries Nutrition 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 230000005907 cancer growth Effects 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 210000000695 crystalline len Anatomy 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000003511 endothelial effect Effects 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 230000009229 glucose formation Effects 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 235000021384 green leafy vegetables Nutrition 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- XMHIUKTWLZUKEX-UHFFFAOYSA-N hexacosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O XMHIUKTWLZUKEX-UHFFFAOYSA-N 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 108091008039 hormone receptors Proteins 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000003832 immune regulation Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- VNYSSYRCGWBHLG-AMOLWHMGSA-N leukotriene B4 Chemical compound CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O VNYSSYRCGWBHLG-AMOLWHMGSA-N 0.000 description 1
- 208000013433 lightheadedness Diseases 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000009854 mucosal lesion Effects 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000001885 phytohemagglutinin Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 201000001514 prostate carcinoma Diseases 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 229940064064 purslane extract Drugs 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 201000008261 skin carcinoma Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001694 thigh bone Anatomy 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet belongs to high-end health food.Especially with raw materials such as Qinghai-Tibet Platean natural pollution-free green high quality Lycium ruthenicum Murr. extract, Tricholoma matsutake (lto et lmai) Singer extract, Herba Portulacae extract, Radix et Caulis Opuntiae Dillenii extract, phlorhizin, conjugated linoleic acids, the health food that modern advanced technologies processes is taked.This product has the kidney invigorating and essence nourishing, benefiting QI and nourishing blood, YIN nourishing hepatoprotective, invigorating the spleen and regulating the stomach, invigorates blood circulation, it is adapted to blood sugar lowering, prevent and treat the various complication of diabetes, blood fat reducing, blood pressure lowering, fat-reducing, anti-inflammation and sterilization, prevent and treat arteriosclerosis and cardiovascular and cerebrovascular disease, enhancing immunity, antioxidation, improve the effect such as constipation, slow down aging.
Description
One, technical field: the invention belongs to high-end health food, especially with the natural black Chinese holly of pollution-free green high quality in Qinghai-Tibet Platean
The raw materials such as Qi extract, Tricholoma matsutake (lto et lmai) Singer extract, Herba Portulacae extract, Radix et Caulis Opuntiae Dillenii extract, phlorhizin, conjugated linoleic acid, take existing
The health food processed for advanced technologies.
Two, background technology: this invention is with Lycium ruthenicum Murr. extract, Tricholoma matsutake (lto et lmai) Singer extract, Herba Portulacae extract, Radix et Caulis Opuntiae Dillenii extraction
The health food that the raw materials such as thing, phlorhizin, conjugated linoleic acid are made.This product has the kidney invigorating and essence nourishing, benefiting QI and nourishing blood, YIN nourishing are protected
Liver, invigorating the spleen and regulating the stomach, invigorate blood circulation, be adapted to blood sugar lowering, prevent and treat the various complication of diabetes, blood fat reducing, blood pressure lowering, fat-reducing, antiinflammatory
Sterilize, prevent and treat arteriosclerosis and cardiovascular and cerebrovascular disease, enhancing immunity, antioxidation, improve the effect such as constipation, slow down aging.Mesh
On front market, the most this product does not occurs, it can be to provide a kind of to diabetes and diabetic complication patient that this product is researched and developed in innovation
New product, this product is hard capsule or tablet, belongs to pure natural, has no side effect, and taking convenience, effect is obvious.
Three, summary of the invention: diabetes are a kind of to decline with Instreptozotocin Induced Progressive symmetric erythrokeratodermia, blood glucose persistently raises be characterized slow
Property PD.Due to the interaction result of the factors such as gene genetic, nutrition and environment, endocrine metabolism is caused to be lacked of proper care,
Cause a series of metabolism disorders such as protein, fat, water and electrolyte, make the absolute and relative hyposecretion of insulin, and target
Organize and insulin sensitivity is reduced, insulin resistant occurs.Along with the development of the state of an illness, may occur in which multiple chronic complicating diseases, and
Cause multisystem and multiple organ damage, have a strong impact on people physically and mentally healthy, bring the financial burden of load-bearing to family and society.According to
National authority department statistics shows, there are more than 93,000 10,000 type bran urine patients, pre-diabetes 1.5 hundred million in current China；Have every year
More than 400 ten thousand people die from diabetes, more than 100 ten thousand people's amputation because of diabetic complication；And diabetes number is still with annual 3%
Speed increase.Therefore, innovation research and development prevent and treat the new product of diabetes and complication, have important change significance of times.
Four, composition of raw materials: Lycium ruthenicum Murr. extract 30-60 kilogram, Tricholoma matsutake (lto et lmai) Singer extract 20-50 kilogram, Herba Portulacae extract 50-
80 kilograms, Radix et Caulis Opuntiae Dillenii extract 40-90 kilogram, phlorhizin 5-30 kilogram, conjugated linoleic acid 10-50 kilogram be raw material.
Five, technical scheme:
(1) Lycium ruthenicum Murr. extract: (Lyciam barbarnm extraat), Lycium ruthenicum Murr. is to be grown in Qinghai-Tibet Platean green
Ecological environment, pure natural treasure medicine food dual purpose plant Lycium ruthenicum Murr. dry fruit.Lycium ruthenicum Murr. is that the ecosystem of a kind of rare preciousness is high
End tonic.Lycium ruthenicum Murr. is matrimony vine of solanaceae plant mature fruit.Property flat, sweet in the mouth.Return liver, kidney channel.There is nourishing the liver and kidney, benefit shrewdness
Mesh, effect of lung moistening.Quench one's thirst for asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat, blood deficiency and yellow complexion, raising vision, blurred vision
Fail to understand.Modern medicine study is thought, Lycium ruthenicum Murr. has enhancing immunity, resisting fatigue, lowering blood pressure and blood fat, blood sugar lowering, protection
Liver, fat-reducing, defying age, the function such as anticancer.
Chemical composition: Lycium ruthenicum Murr. is many containing polysaccharide, aminoacid, glycine betaine, carotene, vitamin B, vitamin C, nicotinic acid etc.
Plant the trace element such as vitamin and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalt.And also have abundant natural procyanidins, wherein
Procyanidin content is the several times of blue berry content, is to find the wild plant that procyanidin content is the highest up to now.
Pharmacological action: 1, enhancing immunity: mouse gavaging water extract or intramuscular injection alcohol extraction thing all can be obviously enhanced its net
The shape endothelial system phagocytic activity to india ink.Water extract or lycium barbarum polysaccharide all can promote that Turnover of Mouse Peritoneal Macrophages swallows
Lysozyme activity in function and serum.Give normal or Aged Mice gavage or abdomen lycium barbarum polysaccharide, can be obviously enhanced abdominal cavity huge bite thin
Born of the same parents c3The acceptor number of b and Fc and vigor, can make Aged Mice suppressor T lymphocyte regulation antibody function return to the water of adult mice
Flat.Lycium ruthenicum Murr. polysaccharide sterling has more significant effect of immune response than crude product, and every immune indexes (includes nonspecific immunity
Immune organ quality, macrophage phagocytic effect, the serum hemolysin of specific humoral immunity, in specific cellular immunity
Move back hair style allergy, lymhocyte transformation rate, E red rose pigment etc.) all there is significant difference.
2, the liver protecting, anti-fatty liver: the liver protecting and anti-fatty liver tool are had certain effect by Lycium ruthenicum Murr. extract.Existing
Finding for medical research, containing a kind of effective ingredient-glycine betaine in Lycium ruthenicum Murr., it is the most effective to treatment hepatic disease.Experiment table
Bright, glycine betaine has suppression fat to deposit in hepatocyte, promotes the effect of liver cell regeneration.It addition, the middle glycine betaine of Lycium ruthenicum Murr.
Excess fat storage in liver can be prevented, have the effect of anti-fatty liver, it was reported that feed water extract or sweet through rat for a long time
Dish alkali feedstuff is to ccl4The protected effect of hepatic injury caused, can substantially reduce the change of lipid in transaminase and liver, can suppress
In liver, lipidosis and promotion hepatocyte are newborn, and hepatic lipid peroxidation damage is had significant protective effect.
3, blood fat reducing, arteriosclerosis is prevented and treated: Lycium ruthenicum Murr. extract animal and clinical experiment are respectively provided with good blood fat reducing and make
With.Polysaccharide has significantly effect to the blood fat of hyperlipidemia rabbit, can substantially reduce the content of serum cholesterol and triacylglycerol.Black
Fructus Lycii also can reduce rat serum cholesterol, and substantially suppression fills the rabbit anteserum cholesterol rising feeding cholesterol and Adeps Sus domestica, also has
There is the effect of arteriosclerosis.
4, blood pressure lowering and protection cardiovascular and cerebrovascular vessel: the elastic fiber in blood vessel gradually aoxidizes hardening, are the masters causing hypertension
Want reason.Procyanidin contained by Lycium ruthenicum Murr., can reduce blood pressure by improving blood vessel elasticity.It is demonstrated experimentally that Lycium ruthenicum Murr. extraction
Thing can reduce Blood Cholesterol level, reduces cholesterol deposits and suppression angiotonase activity in blood vessel wall and reduces blood
Pressure.Separately there is research, rat feed adds Lycium ruthenicum Murr. extract, chromium, zinc composition, and experimental group blood pressure is significantly lower than comparison
Group, its mechanism is the formation that Lycium ruthenicum Murr. extract reduces free radical, improves the sensitivity of insulin.
5, antioxidation: Lycium ruthenicum Murr. has good antioxidation.Lycium ruthenicum Murr. contains abundant procyanidin, can suppress blood
Lipid peroxidation free radical nucleus formation in slurry, can block again lipid peroxidation.At protection DNA, protein and film knot
Structure exempts from oxidative damage and plays an important role, it is known that the superoxide dismutase activity in human crystalline lens, cornea and vitreous body
Low, old people's blood plasma and tissue, this is that a kind of support mechanism weakens, it may be possible to old people's plasma lipid peroxide content increase with
And it is susceptible to suffer from one of major reasons of disease such as cataract, and the procyanidin in Lycium ruthenicum Murr., there is powerful antioxidation, permissible
Reverse this process.According to another report, the procyanidin in Lycium ruthenicum Murr., owing to there being hydroxyl (phenolic group) portion of electronics in molecular structure
Point, it is the donor of the hydrogen by excellent or neutron, has the strongest oxidation resistance.It is about 50 times of vitamin E in vivo, for dimension
20 times of raw element C.Test report according to the French Academy, it is believed that procyanidin be found up to now the strongest, most effective
One of the clear agent of free radical, activity, is that other antioxidants are incomparable the most in vivo.
6, blood sugar lowering: preventing and treating secondary diabetes: Lycium ruthenicum Murr. extract has significant blood sugar lowering and prevents and treats diabetes
Function.Research shows, Lycium ruthenicum Murr. polysaccharide on the blood glucose of normal mouse and the impact of carbohydrate tolerance and causes hyperglycemia to alloxan
The protective effect of mice shows, fills to normal mouse respectively and feeds a certain amount of Lycium ruthenicum Murr. polysaccharide, and its result makes blood glucose substantially reduce.
Carbohydrate tolerance experiment shows, a certain amount of Lycium ruthenicum Murr. polysaccharide can substantially resist normal mouse and give the blood glucose that a certain amount of glucose causes
Raise.Substantially, Lycium ruthenicum Murr. polysaccharide all has hypoglycemic activity to normal and diabetic animal models in research.Another it was found that Lycium ruthenicum Murr.
Can effectively control post-prandial glycemia, hence it is evident that reduce Postprandial peak glucose, thus form the demand of glycemic peaks phase insulin, alleviate
The load of insulin cell excreting insulin, thus reach to protect the effect of insulin cell.Long-term taking can also reduce on an empty stomach
The effect of blood glucose.Experiment shows, no matter to normal person, or can reduce post-prandial glycaemic peaks after taking carbohydrate tolerance reduction person
Value and reduction level of postprandial blood sugar, prevent secondary diabetes.Also having been reported that, results of animal shows, the former cyanine of Lycium ruthenicum Murr.
Have the blood glucose helping reduce diabetics.Animal pancreatic cell insulin production can be made to increase by 50%.Michigan, United States is big
Disciplinary study personnel represent, edible fruits contains procyanidin and becomes branch to produce great to human body and insulin level with other
Impact.
7, preventing and treating diabetic retinopathy: diabetic retinopathy is retinal microvascular disease, and it shows as, sugar
Urine glucose fluctuates to causing the respective change such as blood pressure, blood vessel, causes the chain reactions such as optical fundus blood vessel is hemorrhage, has influence on and regard
The function of nethike embrane.Research shows, the anthocyanidin in Lycium ruthenicum Murr. has powerful anti-oxidation efficacy, protected diabetes rat view
The effect of film oxidative damage.Clinical studies show, Lycium ruthenicum Murr. anthocyanidin can reduce LPO in diabetic retina patients serum and contain
Amount, raises Vitamin C content and SOD activity, has the effect significantly preventing and treating diabetic retinopathy.Defend according to US National
Raw academy studies confirmation, and the ocular disease that treatment diabetes and hypertension are caused by the procyanidin in Lycium ruthenicum Murr. is effective, especially
It contributes to preventing and treating ocular angiogenesis infringement that diabetes and hypertension etc. causes and causes retinal damage.It addition, Lycium ruthenicum Murr. flower
The ocular disease such as age-related degeneration of macula, cataract are had certain effect by blue or green element.
(2), Tricholoma matsutake (lto et lmai) Singer extract (Tricholoma matsutake extract), have another name called armillaria Matsutake etc., for smooth daughter bacteria, mouth
The sporophore of mushroom section plant pine oak, warm in nature, sweet in the mouth, returns kidney, stomach warp.Have kidney invigorating and YANG supporting, keep fit, benefit the intestines and stomach, activating QI to eliminate phlegm, drive
The effects such as worm.For soreness of the waist and knees, Light-headedness, the coughing of damp-phlegm, the disease such as nausea and vomiting, limbs are sleepy.Research now shows, pine
Fine and soft enhancing immunity, treatment diabetes and treatment cardiovascular disease, the liver protecting, looks improving and the skin nourishing, promotion gastrointestinal function, anti-spoke
Penetrate, mutation, cancer-resisting etc. act on.
Chemical composition: Tricholoma matsutake (lto et lmai) Singer is containing blazei polysaccharide, Tricholoma matsutake (lto et lmai) Singer polypeptide, matsutakealcohol, 18 kinds of aminoacid, unsaturated fatty acid, sugar eggs
In vain, various active enzyme, abundant dietary fiber, multivitamin and various trace elements and bioactive substance, be referred to as sky
So nutrition treasure-house.
Pharmacological action: 1, treatment diabetes: research shows, diabetes are had significant therapeutic effect by table Tricholoma matsutake (lto et lmai) Singer.Tricholoma matsutake (lto et lmai) Singer energy
Improve the content of insulin, particularly to insulin-dependent diabetics, can effectively reduce blood glucose, improve internal insulin
Usefulness, promote glucose metabolism.Its mechanism of action is: 1. improve insulin content；Tricholoma matsutake (lto et lmai) Singer can stimulate islet cells to divide
Secrete insulin, protect and repair beta Cell of islet, increase internal insulin content；2. reducing blood sugar content after meal, Tricholoma matsutake (lto et lmai) Singer contains rich
Rich α-heteroside enzyme inhibitor, and alpha-glucosidase inhibitor is a kind of novel hypoglycemic medicine, it is demonstrated experimentally that in Tricholoma matsutake (lto et lmai) Singer
α-heteroside the enzyme inhibitor (G1) extracted can significantly reduce diabetics post-prandial glycemia；3. blood glucose can be directly reduced:
Research display, Tricholoma matsutake (lto et lmai) Singer can improve insulin resistant, accelerates liver glucose metabolism, has hypoglycemic effect of directly dropping.
2, treatment cardiovascular disease: Tricholoma matsutake (lto et lmai) Singer has the effect for the treatment of cardiovascular diseases.Research shows, containing abundant in Tricholoma matsutake (lto et lmai) Singer
The compositions such as unsaturated fatty acid, can effectively eliminate the rubbish in blood of human body, reduce blood viscosity and cholesterol and glycerol three
Ester, prevents and treats hypertension, hyperlipidemia, arteriosclerosis and cardio-cerebrovascular diseases.
3, the liver protecting: Tricholoma matsutake (lto et lmai) Singer has the strongest free radical scavenging effect, it is possible to suppress and block free radical to cause lipid mistake
Oxidation reaction, strengthens superoxide dismutase, CAT, GSH-P activity, improves antioxidant ability of organism, have the work of hepatoprotective
With.
4, enhancing immunity: Tricholoma matsutake (lto et lmai) Singer contains the various nutritional labelings of tens kinds of needed by human body, has guarantor and closes enhancing immunity
Effect, particularly in Tricholoma matsutake (lto et lmai) Singer rich in double-strand blazei polysaccharide, can the T cell of human activin, to nonspecific immunity and special
Property immunity has significant potentiation, quickly improves physical weakness, crowd in postoperative puerperal immunity and has significant effect.
It addition, Tricholoma matsutake (lto et lmai) Singer also has looks improving and the skin nourishing, defying age, improves gastrointestinal function, radioprotective, mutation, cancer-resisting etc.
Effect.
(3) Herba Portulacae extract (Purslane extract), has another name called Amaranthus mangostanus L., longevity greens/mustard green etc..For portulacaceous plant horse
The herb of bitterroot.Cold in nature, sour in the mouth, return spleen, liver, large intestine channel.There is the effect such as heat-clearing and toxic substances removing, cooling blood for hemostasis.For acute and chronic gastritis
Enteritis, bacillary dysentery, diarrhoea, tuberculosis, noxious dampness, pertussis, erysipelas, dermatitis band are inferior, and pharmacological research shows in recent years, Dens Equi
Herba Amaranthi tricoloris has blood fat reducing, blood sugar lowering, arteriosclerosis, anti-inflammation and sterilization, antioxidation, the liver protecting, defying age, enhancing immunity, resists
Tumors etc. act on.
Chemical composition: Herba Portulacae contains norepinephrine, protein, aminoacid, fat, dopamine, malic acid, α-Asia
The compositions such as fiber crops acid, Quercetin, carotene, VitAVitE, vitamin C, several mineral materials and trace element.
Pharmacological action: 1, blood sugar lowering: severe diabetes mellitus animal caused by carbon tetrachloride pyrimidine is had bright by Herba portulacae extract
Aobvious blood sugar reducing function.Its blood sugar reducing function is relevant containing functional factors such as alkaloid, flavone and abundant alpha-linolenic acids with it.It addition,
According to foreign study, the chronic colitis that obesity causes can cause insulin resistant, thus causes diabetes.Research display,
Various inflammation and cytokine are had the strongest inhibitory action, particularly Herba Portulacae to have chronic colitis by Herba portulacae extract
Obvious therapeutic action.Can substantially repair insulin function, promote the β cells secrete insulin in islets of langerhans, improve receptor to islets of langerhans
The sensitivity of element, long-term taking can recover islet function.
2, blood fat reducing, arteriosclerosis: research shows, linoleic acid, flavonoid isoreactivity composition that Herba Portulacae contains have
Well blood fat reducing, the effect of arteriosclerosis, prevention and cure of cardiovascular disease.Herba Portulacae can substantially reduce Experimental Hyperlipemia disease man
Rabbit whole blood undercut apparent viscosity and blood plasma are cut apparent viscosity, and serum total cholesterol, high density lipoprotein increasing can also be reduced
Cholesterol, significantly reduces blood fat.
3, anti-inflammation: will Hayes, Song's Hayes, this Buddhist Shigella flexneri are all had suppression to make by Herba Portulacae ethanol extraction
With, Bacillus typhi, escherichia coli, Staphylococcus aureus also there are is certain inhibitory action, some pathogenic fungus is also had not
With the inhibitory action of degree, the laudatory title of intrinsic " natural antibiotics ".It addition, Herba Portulacae and have significant antiinflammation, in clinic
Can be used for treating chronic colitis.
4, the liver protecting: Herba Portulacae has stronger antioxidation and eliminates the effect of free radical, can protect super oxygen cloudy from
Erythrocyte Damage caused by sub-free radical, reduces in liver MDA content and strengthens SOD in Mice and GSH-PX vigor, causing little to ethanol
Hepar Mus damage has protective effect.Experiment shows, Herba Portulacae has certain preventive and therapeutic effect to alcohol induced hepatic injury, this with
It is relevant that Herba Portulacae contains abundant nutrient substance antioxidant.
5, slow down aging: research finds, Portulaca water extract can protect the blood ability of aging year model mice, promotes
The antioxidant activity of SOD and CAT, is reduced or eliminated free radical and the damage to body of the lipid peroxidation degree, contributes to slow down aging.
It addition, Herba Portulacae also has and prevents and treats chloasma, enhancing immunity, promotion ulcer healing, prevents and treats pertussis, acute breast
Gland class, metrorrhagia, herpes zoster, the effect such as anticancer.
(4) Radix et Caulis Opuntiae Dillenii extract (Cactus extract), has another name called angle's palm etc..For Cactaeous plants Radix et Caulis Opuntiae Dillenii
Root and stem, cool in nature, mildly bitter flavor, GUIXIN, lung, stomach warp.There is promoting flow of QI and blood, heat-clearing and toxic substances removing, relaxing muscles and tendons and activating QI and blood in the collateral, detumescence dissipating blood stasis, solve intestinal
Poison, cooling blood and relieving pain, stomach invigorating, diuresis of calming the nerves, town are eaten, nourishing function, intestine moistening hemostasis.For duodenal ulcer, hemorrhoid, urgency
Property dysentery, cough etc..Research in recent years shows, Radix et Caulis Opuntiae Dillenii has blood sugar lowering, blood fat reducing, fat-reducing, blood pressure lowering, antiinflammatory, reduction
Cholesterol, relieving constipation, treatment diabetes, obesity, arteriosclerosis etc. achieve good effect.
Chemical composition: Radix et Caulis Opuntiae Dillenii is containing protein, 18 kinds of aminoacid, polysaccharide, flavone, linoleic acid, triterpene, malic acid, beautiful cottonrose hibiscus
Rong, succinic acid, dietary fiber, SOD, multiple micro-element and mineral matter and other components.
Pharmacological action: 1, blood sugar lowering: the diabetes that normal mouse blood sugar carbon tetrachloride pyrimidine is induced by Radix et Caulis Opuntiae Dillenii extract
Mouse blood sugar has obvious reduction effect.
2, enhancing human body immunity function: the phagocytic function of Turnover of Mouse Peritoneal Macrophages is had significantly by Radix et Caulis Opuntiae Dillenii aqueous extract
Facilitation, can make its phagocytic rate and phagocytic index be remarkably reinforced.
3, antiinflammatory: Radix et Caulis Opuntiae Dillenii decocting liquid can substantially suppress dimethylbenzene induced mice auricle edema, swells to the rat agar foot sole of the foot
Swollen and ice cerinic acid induction mice exudative inflammation, cotton balls induction mice granulation tissue hyperplasia also have obvious inhibitory action.
4, relieving constipation: Radix et Caulis Opuntiae Dillenii contains abundant dietary fiber, can increase the storage capacity of intestinal moisture, can promote that intestinal is compacted
Dynamic, reduce stool consistency, make feces soften and be conducive to discharging, be used for treating constipation.
5, blood fat reducing: give 2.7-5.4g/kg mixed fodder feeding animals every day with Radix et Caulis Opuntiae Dillenii extract, feed 21 continuously
My god, Experimental Hyperlipemia disease rat T-CHOL, low density lipoprotein, LDL and triglyceride are decreased obviously, have and significantly drop blood
The effect of fat.
6, protection gastric mucosa: Radix et Caulis Opuntiae Dillenii can improve coat of the stomach blood circulation, improves coat of the stomach PGE2Content, has mucosal lesion
Significant protective effect, simultaneously to stress gastric ulcer, indometacin type gastric ulcer, acetic acid gastric ulcer and ligation stomach pylorus type stomach
Ulcer all has obvious protective function.
It addition, Radix et Caulis Opuntiae Dillenii also has fat-reducing, blood pressure lowering, toxin expelling, antioxidation, radioprotective, treatment urine disease, obesity, tremulous pulse
The effects such as hardening.
(5) phlorhizin (Phlorin Dihydrate), calls phlorhizin, phloretin.Phlorhizin is from Fructus Mali pumilae bark, tree
A kind of polyphenol compound extracted in branch, leaves.Phlorhizin is by the glycosides that phloretin and glycocide are glucose synthesis, has female
Hormone-like effect, has blood sugar lowering, antioxidation, looks improving and the skin nourishing, freckle removing and whitening, elimination acne, improves the works such as note second power, anti-cancer
With.
Pharmacological action: 1, treatment diabetes: diabetes are to be characterized with hyperglycemia.Glucose constantly filtered at kidney and
Re-absorption, the sugar of polarity needs certain carrier to carry out actively and the transport of promotion property through the cell membrane of rich fat, has two class sugar to carry
Body, a class is that sodium ion glucose associates carrier, another kind of for glucose transporter, transports coupling sugar by " descending " of sodium ion
" upward slope " of molecule, is transported through cell membrane, and SGL carries glycan molecule Concentraton gradient and enters intracellular.Research in recent years finds, root bark
Glycosides has the therapeutic effect of uniqueness to diabetes and complication thereof.Phlorhizin suppresses SGL and SGL exclusively, competitively2To Fructus Vitis viniferae
The transport of glycan molecule, it turned out in several animal models, and phlorhizin can promote glucose metabolism, reduce on an empty stomach and blood after the meal
, there is not hypoglycemic side effect in sugar level.Processing diabetes rat with phlorhizin can make its insulin sensitivity recover normal,
Eliminate or alleviate the insulin resistant caused by sugar poison.
2, the absorption of suppression sugar: research finds, the sugar of small intestinal and kidney is absorbed by phlorhizin obvious inhibitory action.Examination
Verifying bright, phlorhizin processes and the insulin sensitivity of diabetic animal can be made to be restored, the insulin action to intact animal
Not impact.Another it is demonstrated that the outer row that phlorhizin can promote glucose secretes, reduce on an empty stomach and post-prandial glycemia.
It addition, phlorhizin also have antioxidation, looks improving and the skin nourishing, functions of removing chloasma, whitening, acne of dispelling, preventing and treating climacteric comprehensive
The effect such as disease, enhancing female libido, raising memory, slow down aging, cancer-resisting.
(6) conjugated linoleic acid (CLA), conjugated linoleic acid is present in ruminant cattle, the butterfat of sheep and meat products one
Plant natural fatty acid.It is multiple position and the general name of geometry foreign body object of the conjugated double bond derivative by fatty acid-linoleic acid, i.e.
It is that the item of linoleic acid 9,12-18: 2 gains interest biology.It contains C9, t11 and the t10 of about equivalent, c12, and two kinds of isomers are demonstrate,proved
In fact there is the strongest physiologically active.Confirming according to external substantial amounts of research, conjugated linoleic acid has a various biological function: fat-reducing,
Blood fat reducing, prevent and treat diabetes, anticancer, strengthen immunologic function, the effect such as antioxidation.
Physiological function: 1, fat-reducing: research shows, conjugated linoleic acid has minimizing lipidosis and increases in adipose cell
The oxidation of fatty acid and decomposition, have the title of " fat combustion agent ".Through domestic and international scientific research institution, substantial amounts of test proves, the sub-oil of conjugation
Acid can significantly reduce the fat content in rat body, does not has any toxic and side effects.Through more than 40 obesities and overweight 2 months by a definite date
Test-meal, the examination body weight of trencherman and body fat substantially reduce, particularly waistline, buttocks and triangular muscle, the subcutaneous fat of omoplate etc.
Reducing particularly evident, examination trencherman generally feels that spirit examination trencherman's blood pressure vigorous, hypertension of sleeping, have is reduced to normal model
Enclose.According to expert introduction, conjugated linoleic acid may be by the effect playing minimizing body fat of 5 aspects.(1), cut down one's diet
The absorption storage in human body of the rear fat.(2), adipose cell decomposition rate and the fat combustion speed in mitochondrion are accelerated.
(3) fat division and the propagation of suppression PECTORAL LIMB SKELETON 3t3-L1 and differentiation, are reduced.(4), total fatty somatoblast is reduced.
(5), reduce inflammatory cytokine release, suppression chronic inflammatory disease resistance.Conjugated linoleic acid also can reduce muscle egg
White release, promotes insulin regulation and control glucose and is converted into energy, thus play effect of weight-reducing.
Foreign scholar studies proof, and conjugated linoleic acid has the ability redistributing health composition.Feeding conjugated linoleic acid
Pig lean compared to feeding under Oleum Helianthi Corii Sus domestica, and muscular tissue is more, and this shows, conjugated linoleic acid has regulation fat
The function redistributed with muscular tissue.Substantial amounts of test result indicate that, conjugated linoleic acid can reduce the accumulation of fat.Also have
Foreign scholar supplemented conjugated linoleic acid after 35 days to rat, and peritoneum and the weight of uterine fat pad decrease 13-32%, body
Heavily reducing 15-29%, after mice supplements conjugated linoleic acid, fat reduces 57-60%, and particularly stomach fat reduces the brightest
Aobvious, and the muscle quality of health adds 5-14%, it was demonstrated that feeding conjugated linoleic acid can suppress the oils and fats suction containing fat
Receive.According to another external relevant report, isomerization linoleic acid has the effect of uniqueness to control body weight and fat-reducing, and it is to adipose cell
There is directly effect, can prevent fat from absorbing fat from food, suppress adipocytic cell growth, promote fat combustion metabolism.Fat
Person daily intakes conjugation oleic acid, is not i.e. reducing energy intake, the most no motion of in the case of still throw away the effect of fat-reducing.The most also
Having human test results to show, average weight is the Healthy People of 156 pounds, takes 3.6 grams of conjugated linoleic acids every day, internal after three months
Fat reduces by 20%, and therefore the fat-reducing effect of conjugated linoleic acid is paid close attention to by international community.
2, blood fat reducing: conjugated linoleic acid can reduce the concentration of low density lipoprotein cholesterol in serum and triglyceride is dense
Degree, stops fat and platelet to deposit at arterial wall.Research finds, conjugated linoleic acid increases by combining and activate peroxidase
Raw solid sub-activated receptor alpha (PPAR α) carrys out regulating lipid metabolism, reduces low density lipoprotein, LDL in blood plasma, triglyceride and total gallbladder alcohol
Concentration, thus suppress the generation of arteriosclerosis, there is effect for reducing blood fat.
3, diabetes are prevented and treated: debita spissitudo conjugated linoleic acid can obviously reduce internal glucose, insulin and triglyceride
Level.At the glucose tolerance test of the high sugar feed rat fed containing conjugated linoleic acid 5%, blood glucose response is normal.According to another
Report, conjugated linoleic acid can improve the sensitivity of Insulin receptor INSR in hepatocyte, makes impaired Glucose tolerance test recover normal,
Diabetes are had certain preventive and therapeutic effect.
4, anticancer: conjugated linoleic acid has the swollen growth of cancer cells of suppression, reduces Normocellular canceration physiological action and cancer
Disease is shifted.It can also significantly reduce the sickness rate of the kinds cancers such as gastric cancer, carcinoma of prostate, breast carcinoma, skin carcinoma.Its antitumaous effect
Including: (1) suppression chemical carcinogens and the episomal formation of DNA；(2) generation of cytokines LTB4 and endotoxin etc., is suppressed；
(3) enhancing immunity；(4) cancer cell multiplication of hormone receptor is held in suppression.Separately have been reported that, substantial amounts of animal model and human body cancer
Cell injuring model model experiment finds, conjugated linoleic acid all has inhibitory action in each stage of development.Its suppression cancer includes
The development overall process of incipient stage, development and transition phase, even cancer.And the enzyme such as ornithine decarboxylase and egg kinase c
Activity, and anticancer protein and the formation of nucleic acid.
5, looks improving and the skin nourishing: research shows, conjugate linoleate has the lipotropy of excellence, can prevent Skin Cell lipid mistake
Oxidation and UV-induced radical damage, have and prevent xerosis cutis, and coarse and waiting of pigmented spots acts on.Abroad incite somebody to action
Conjugate linoleate is applied to the cosmetic field of looks improving and the skin nourishing.
6, strengthen immunologic function: research shows: conjugated linoleic acid participates in immune regulation effect, promote lymphocyte
Hypertrophy and macrophage lethality, promote spleen and serum immunoglobulin IgG, the enhancing of IgM, IgA, moreover it is possible to reduces immunity and makes
Become the alienation of skeletal muscle, be not the most that immunity benefit weakens simultaneously, delay human body immunocompetence to fail.Zoopery shows, conjugation
Linoleic acid can strengthen phytohemagglutinin reaction and the phagocytosis of macrophage of rat.Separately have been reported that, conjugated linoleic acid
Rats Spleen lymphopoiesis and (IL-2) of interleukin and the synthesis of antibody can be promoted；Make rat blood serum IgG and
IgM concentration rises.
7, promoting skeleton development and growth: research display, conjugated linoleic acid can increase the aggregate velocity of skeleton, reduces PGE2
Synthesis, forward regulation insulin-like growth factor, to promote formation and the growth of skeleton.Separately have been reported that, at tibia and Thigh bone
Cell culture system adds its PGE of conjugated linoleic acid2Generation is decreased obviously.Someone is confirmed by mouse experiment, the sub-oil of conjugation
Acid can promote division and the regeneration of osseous tissue, promotes the synthesis of cartilaginous tissue cell and mineral deposition in osseous tissue.State
Outer scholar's research finds, conjugated linoleic acid can increase Mouse Bone and form speed, and skeleton grows the effect that tool is certain.Conjugation Asia
The mechanism of oleic acid regulation New bone formation is possibly due to conjugated linoleic acid and causes PGE2Concentration change, and PGE2Excessive concentration can press down
The formation of sclerotin processed, because conjugated linoleic acid can effectively reduce PGE2Concentration, therefore, it can promote the formation of bone and life
Long.
In sum, this product has the kidney invigorating and essence nourishing, benefiting QI and nourishing blood, YIN nourishing hepatoprotective, invigorating the spleen and regulating the stomach, invigorates blood circulation, and is adapted to
Blood sugar lowering, prevents and treats the various complication of diabetes, blood fat reducing, blood pressure lowering, fat-reducing, anti-inflammation and sterilization, prevents and treats arteriosclerosis and heart and brain blood
Pipe disease, enhancing immunity, antioxidation, improve the effect such as constipation, slow down aging.
Six, processing technology:
1, raw material mixing: the raw material in formula is mixed by physical characteristic.
2, stirring: mixed raw material feeding blender is stirred.
3, tabletting: the raw material stirred is sent into tablet machine, is pressed into tablet.
4, test package: the tablet that will be pressed into, it is qualified to check, and is packaged as finished product.
Raw material mixed processes is by the process of all raw materials mixing in component design.Raw material stirring operation is by mixed
The process that raw material stirs.Sheeting process is the process that the raw material stirred is pressed into tablet, test package work
Sequence be by suppress tablet inspection qualified, be packaged as finished product.
Seven, quality standard:
1, physical and chemical index:
2, adaptation population: be applicable to each age group diabetics and diabetic complication patient.
3, instructions of taking: three times a day, each serving consumption 1.5-2.0 gram.
Embodiment: take Fructus Lycii extract 30-60 kilogram, Tricholoma matsutake (lto et lmai) Singer extract 20-50 kilogram, Herba Portulacae extract 50-80 thousand
Gram, Radix et Caulis Opuntiae Dillenii extract 40-90 kilogram, phlorhizin 5-30 kilogram, conjugated linoleic acid 10-50 kilogram be raw material, through will more than
Raw material mixes, and stirs, and sends into tablet machine and raw material is pressed into tablet, and it is qualified to check, and is packaged as finished product.
Claims (1)
1. Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet processing technology, is characterized by: Fructus Lycii extract 30-60 kilogram, Tricholoma matsutake (lto et lmai) Singer extract
20-50 kilogram, Herba Portulacae extract 50-80 kilogram, Radix et Caulis Opuntiae Dillenii extract 40-90 kilogram, phlorhizin 5-30 kilogram, the sub-oil of conjugation
Acid 10-50 kilogram is raw material, through being mixed by above raw material, stirs, and sends into tablet machine and raw material is pressed into tablet,
It is qualified to check, and is packaged as finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610741062.7A CN106174580A (en) | 2016-08-29 | 2016-08-29 | Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610741062.7A CN106174580A (en) | 2016-08-29 | 2016-08-29 | Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106174580A true CN106174580A (en) | 2016-12-07 |
Family
ID=57526957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610741062.7A Pending CN106174580A (en) | 2016-08-29 | 2016-08-29 | Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106174580A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371709A (en) * | 2018-03-29 | 2018-08-07 | 苟春虎 | Lycium ruthenicum tumor recovering gene enzyme |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041828A (en) * | 2014-06-17 | 2014-09-17 | 苟春虎 | Lycium ruthenicum murr tablets with functions of whitening and removing freckles |
| CN104206955A (en) * | 2014-08-17 | 2014-12-17 | 苟春虎 | Lycium ruthenicum tablet for reducing blood fat |
| CN104383123A (en) * | 2014-11-14 | 2015-03-04 | 程金生 | Method for preparing golden camellia lipid-lowering blood sugar-reducing preparation |
-
2016
- 2016-08-29 CN CN201610741062.7A patent/CN106174580A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041828A (en) * | 2014-06-17 | 2014-09-17 | 苟春虎 | Lycium ruthenicum murr tablets with functions of whitening and removing freckles |
| CN104206955A (en) * | 2014-08-17 | 2014-12-17 | 苟春虎 | Lycium ruthenicum tablet for reducing blood fat |
| CN104383123A (en) * | 2014-11-14 | 2015-03-04 | 程金生 | Method for preparing golden camellia lipid-lowering blood sugar-reducing preparation |
Non-Patent Citations (2)
| Title |
|---|
| 董华强等: "多穗柯黄酮根皮苷对糖尿病小鼠的降血糖血脂效果", 《食品科学》 * |
| 谭等: "根皮苷研究进展", 《食品与发酵工业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371709A (en) * | 2018-03-29 | 2018-08-07 | 苟春虎 | Lycium ruthenicum tumor recovering gene enzyme |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101473953B (en) | Fabricated food for cleaning blood and expelling toxin as well as method for processing the same and application | |
| CN103238897B (en) | Composite plant solid drink suitable for diabetic patients | |
| CN106261763A (en) | A kind of grain dietary fiber meal replacement powder and preparation method thereof | |
| CN109123643A (en) | A kind of preparation method of cereal generation meal ball | |
| CN105795468A (en) | Composition having efficacy of losing weight | |
| CN104856003A (en) | Non-full nutritional formula food for patients with diabetes | |
| CN102919330B (en) | Pine pollen fiber biscuit | |
| CN101579120A (en) | Nutritional food with weight-losing function and preparation method thereof | |
| CN105815514A (en) | Weight-losing quinoa milk tea | |
| CN105707707A (en) | Super quinoa nutrition powder for pregnant and lying-in women | |
| CN106107463A (en) | Super Quinoa Antifatigue milk tea processing technology | |
| CN1814167A (en) | Health-care for diabetes | |
| CN102197837B (en) | Sea buckthorn fiber biscuits | |
| CN103431377A (en) | Foodstuff capable of reducing blood pressure and preventing complications | |
| CN101946895B (en) | Functional food taking loach as main material and preparation method thereof | |
| CN113712199A (en) | Weight-losing leaf-eating grass meal-replacing food | |
| CN103285145A (en) | Pure traditional Chinese medicine preparation for prompting rapid growth of pigs as well as preparation method and application method thereof | |
| CN104872638A (en) | Non-total nutrient formula food for constipation patients | |
| CN105613882A (en) | Black barley hypoglycemic tea (milky tea) | |
| CN105707378A (en) | Black-highland barley coffee with effect of slimming | |
| CN108713755A (en) | Quinoa weight reducing nutrition milk shake | |
| CN106174286A (en) | Senior gold Chinese-wolfberry nutritive fruit jam | |
| CN106174580A (en) | Lycium ruthenicum Murr. blood sugar lowering anti-complication sheet | |
| CN115553406A (en) | Weight-reducing composition beverage for inhibiting absorption of fat and sugar substances and preparation method thereof | |
| CN109043555A (en) | A kind of Special food and preparation method thereof that hyperglycemic patients are edible |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20161207 |
|
| RJ01 | Rejection of invention patent application after publication |