CN106164296A - 用于预测对抗血管生成药的应答和癌症预后的分子诊断测试 - Google Patents

用于预测对抗血管生成药的应答和癌症预后的分子诊断测试 Download PDF

Info

Publication number
CN106164296A
CN106164296A CN201580016568.5A CN201580016568A CN106164296A CN 106164296 A CN106164296 A CN 106164296A CN 201580016568 A CN201580016568 A CN 201580016568A CN 106164296 A CN106164296 A CN 106164296A
Authority
CN
China
Prior art keywords
sample
biomarkers
expression
biomarker
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201580016568.5A
Other languages
English (en)
Chinese (zh)
Inventor
D·P·哈金
R·肯尼迪
K·E·基廷
A·麦卡维干
L·A·希尔
S·德哈罗
T·达维森
F·帕特森
S·多尼干
G·耶乐玛
C·古尔利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almac Diagnostics Ltd
Original Assignee
Almac Diagnostics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almac Diagnostics Ltd filed Critical Almac Diagnostics Ltd
Publication of CN106164296A publication Critical patent/CN106164296A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201580016568.5A 2014-02-07 2015-02-09 用于预测对抗血管生成药的应答和癌症预后的分子诊断测试 Pending CN106164296A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461937224P 2014-02-07 2014-02-07
US61/937,224 2014-02-07
GBGB1409479.1A GB201409479D0 (en) 2014-05-28 2014-05-28 Molecular diagnostic test for cancer
GB1409479.1 2014-05-28
PCT/GB2015/050352 WO2015118353A1 (en) 2014-02-07 2015-02-09 Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer

Publications (1)

Publication Number Publication Date
CN106164296A true CN106164296A (zh) 2016-11-23

Family

ID=51177582

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201580016568.5A Pending CN106164296A (zh) 2014-02-07 2015-02-09 用于预测对抗血管生成药的应答和癌症预后的分子诊断测试

Country Status (10)

Country Link
US (1) US10280468B2 (https=)
EP (1) EP3102700A1 (https=)
JP (1) JP2017506506A (https=)
KR (1) KR20160117606A (https=)
CN (1) CN106164296A (https=)
AU (1) AU2015213844A1 (https=)
BR (1) BR112016018044A2 (https=)
CA (1) CA2938807A1 (https=)
GB (1) GB201409479D0 (https=)
WO (1) WO2015118353A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107301328A (zh) * 2017-05-19 2017-10-27 浙江工业大学 基于数据流聚类的癌症亚型精准发现与演化分析方法
CN110880356A (zh) * 2018-09-05 2020-03-13 南京格致基因生物科技有限公司 对卵巢癌进行筛查、诊断或风险分级的方法和装置
CN112164474A (zh) * 2020-07-14 2021-01-01 中国矿业大学 一种基于自表达模型的药物敏感性预测方法
CN113667752A (zh) * 2021-09-09 2021-11-19 菲思特(上海)生物科技有限公司 一种用于柔红霉素代谢标志物的检测试剂盒及其检测方法和应用

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11568982B1 (en) 2014-02-17 2023-01-31 Health at Scale Corporation System to improve the logistics of clinical care by selectively matching patients to providers
US10650325B2 (en) * 2015-07-31 2020-05-12 Microsoft Technology Licensing, Llc Deterministic message distribution
US10496691B1 (en) 2015-09-08 2019-12-03 Google Llc Clustering search results
WO2018062862A1 (ko) * 2016-09-28 2018-04-05 가톨릭대학교 산학협력단 신장암 환자의 예후 진단 및 치료 전략 결정용 성별 특이적 마커
JP6899848B2 (ja) * 2016-12-28 2021-07-07 公益財団法人がん研究会 抗ｖｅｇｆｒ−２抗体医薬品の治療効果を予測するバイオマーカー、検査方法、及び検査キット
EP3879535B1 (en) * 2017-06-13 2024-12-11 BostonGene Corporation Systems and methods for identifying cancer treatments from normalized biomarker scores
JP6977965B2 (ja) * 2017-10-26 2021-12-08 公立大学法人福島県立医科大学 卵巣癌組織型鑑別方法
WO2020092808A1 (en) * 2018-10-31 2020-05-07 Regents Of The University Of Minnesota Methods for predicting a response to bevacizumab or platinum-based chemotherapy or both in patients with ovarian cancer
US11610679B1 (en) 2020-04-20 2023-03-21 Health at Scale Corporation Prediction and prevention of medical events using machine-learning algorithms
US12094582B1 (en) 2020-08-11 2024-09-17 Health at Scale Corporation Intelligent healthcare data fabric system
US12080428B1 (en) 2020-09-10 2024-09-03 Health at Scale Corporation Machine intelligence-based prioritization of non-emergent procedures and visits
US20240344138A1 (en) * 2021-03-25 2024-10-17 Feng Biosciences, Inc Targeted therapies in cancer
US20240115699A1 (en) * 2021-06-04 2024-04-11 Cedars-Sinai Medical Center Use of cancer cell expression of cadherin 12 and cadherin 18 to treat muscle invasive and metastatic bladder cancers

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060127928A1 (en) * 2004-12-10 2006-06-15 Bacus Sarah S Targeted therapy marker panels
CN101910416A (zh) * 2007-11-09 2010-12-08 健泰科生物技术公司 在癌症患者中诊断性使用的方法和组合物
CN102471799A (zh) * 2009-07-06 2012-05-23 Aveo制药公司 Tivozanib应答预测
WO2012092336A2 (en) * 2010-12-28 2012-07-05 Caris Mpi, Inc. Molecular profiling for cancer
WO2012167278A1 (en) * 2011-06-02 2012-12-06 Almac Diagnostics Limited Molecular diagnostic test for cancer
WO2013106765A1 (en) * 2012-01-13 2013-07-18 Genentech, Inc. Biological markers for identifying patients for treatment with vegf antagonists

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
EP0430881A3 (en) 1989-11-29 1991-10-23 Ciba-Geigy Ag Photochromic compounds, process for their preparation and their use
US5288644A (en) 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
ATE173767T1 (de) 1992-04-03 1998-12-15 Perkin Elmer Corp Proben zusammensetzung und verfahren
US5503980A (en) 1992-11-06 1996-04-02 Trustees Of Boston University Positional sequencing by hybridization
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
GB9401833D0 (en) 1994-02-01 1994-03-30 Isis Innovation Method for discovering ligands
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5661028A (en) 1995-09-29 1997-08-26 Lockheed Martin Energy Systems, Inc. Large scale DNA microsequencing device
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
US6998234B2 (en) 2000-11-03 2006-02-14 Oncotech, Inc. Methods for cancer prognosis and diagnosis relating to tumor vascular endothelial cells
MXPA05012723A (es) 2003-05-30 2006-02-08 Genentech Inc Tratamiento con anticuerpos anti-vgf.
WO2004108896A2 (en) 2003-06-03 2004-12-16 The Board Of Trustees Of The University Of Arkansas Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors
CN102321584B (zh) 2003-12-31 2014-01-08 宾夕法尼亚州研究基金会 预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法
US20080113874A1 (en) 2004-01-23 2008-05-15 The Regents Of The University Of Colorado Gefitinib sensitivity-related gene expression and products and methods related thereto
CA2563074C (en) 2004-04-09 2014-05-20 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
EP1756306A2 (en) 2004-05-14 2007-02-28 Ludwig Institute For Cancer Research Identification and characterization of a subset of glioblastomas sensitive to treatment with imatinib
AU2005263972A1 (en) 2004-07-23 2006-01-26 Astrazeneca Ab Method of predicting the responsiveness of a tumor to erbB receptor drugs
EP1815021A2 (en) 2004-11-03 2007-08-08 Almac Diagnostics Limited Transcriptome microarray technology and methods of using the same
EP1937837A2 (en) 2005-07-29 2008-07-02 Siemens Healthcare Diagnostics Inc. Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
US7919261B2 (en) 2005-12-05 2011-04-05 Merck Sharp & Dohme Corp. Methods for predicting treatment response based on the expression profiles of protein and transcription biomarkers
EP2363711A1 (en) 2006-01-27 2011-09-07 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
KR20090071603A (ko) 2006-09-19 2009-07-01 노파르티스 아게 Ｒａｆ 억제제에 대한 표적 조절, 효능, 진단 및/또는 예후의 바이오마커
US20090082218A1 (en) 2007-08-13 2009-03-26 Paul Harkin 3'-Based sequencing approach for microarray manufacture
WO2009149297A1 (en) 2008-06-04 2009-12-10 The Arizona Board Regents, On Behalf Of The University Of Arizona Diffuse large b-cell lymphoma markers and uses therefor
US20110195064A1 (en) 2008-06-06 2011-08-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Survival predictor for diffuse large b cell lymphoma
AU2009270851A1 (en) 2008-07-16 2010-01-21 Dana-Farber Cancer Institute, Inc. Signatures and PCDETERMINANTS associated with prostate cancer and methods of use thereof
JP5606438B2 (ja) 2008-07-23 2014-10-15 エフ．ホフマン−ラ ロシュ アーゲー 抗血管新生療法を受容可能な被験体の同定
EA020764B1 (ru) 2008-12-23 2015-01-30 Мерк Патент Гмбх Биомаркеры для ингибиторов с антиангиогенной активностью
WO2010088688A2 (en) 2009-02-02 2010-08-05 Biotheranostics, Inc. Diagnosis of in situ and invasive breast cancer
SG10201401722XA (en) 2009-05-01 2014-08-28 Genomic Health Inc Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer andresponse to chemotherapy
AU2010297344A1 (en) 2009-09-17 2012-02-23 F. Hoffmann-La Roche Ag Methods and compositions for diagnostics use in cancer patients
CA2811015A1 (en) 2010-09-15 2012-03-22 Almac Diagnostics Limited Molecular diagnostic test for cancer
MX2015006955A (es) * 2012-12-03 2016-01-25 Almac Diagnostics Ltd Prueba de diagnostico molecular para cancer.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060127928A1 (en) * 2004-12-10 2006-06-15 Bacus Sarah S Targeted therapy marker panels
CN101910416A (zh) * 2007-11-09 2010-12-08 健泰科生物技术公司 在癌症患者中诊断性使用的方法和组合物
CN102471799A (zh) * 2009-07-06 2012-05-23 Aveo制药公司 Tivozanib应答预测
WO2012092336A2 (en) * 2010-12-28 2012-07-05 Caris Mpi, Inc. Molecular profiling for cancer
WO2012167278A1 (en) * 2011-06-02 2012-12-06 Almac Diagnostics Limited Molecular diagnostic test for cancer
WO2013106765A1 (en) * 2012-01-13 2013-07-18 Genentech, Inc. Biological markers for identifying patients for treatment with vegf antagonists

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107301328A (zh) * 2017-05-19 2017-10-27 浙江工业大学 基于数据流聚类的癌症亚型精准发现与演化分析方法
CN107301328B (zh) * 2017-05-19 2021-04-06 浙江工业大学 基于数据流聚类的癌症亚型精准发现与演化分析方法
CN110880356A (zh) * 2018-09-05 2020-03-13 南京格致基因生物科技有限公司 对卵巢癌进行筛查、诊断或风险分级的方法和装置
CN112164474A (zh) * 2020-07-14 2021-01-01 中国矿业大学 一种基于自表达模型的药物敏感性预测方法
CN112164474B (zh) * 2020-07-14 2024-05-24 中国矿业大学 一种基于自表达模型的药物敏感性预测方法
CN113667752A (zh) * 2021-09-09 2021-11-19 菲思特(上海)生物科技有限公司 一种用于柔红霉素代谢标志物的检测试剂盒及其检测方法和应用

Also Published As

Publication number Publication date
GB201409479D0 (en) 2014-07-09
WO2015118353A1 (en) 2015-08-13
CA2938807A1 (en) 2015-08-13
EP3102700A1 (en) 2016-12-14
JP2017506506A (ja) 2017-03-09
AU2015213844A1 (en) 2016-09-15
US10280468B2 (en) 2019-05-07
KR20160117606A (ko) 2016-10-10
US20170073761A1 (en) 2017-03-16
BR112016018044A2 (pt) 2018-02-20

Similar Documents

Publication Publication Date Title
JP6067686B2 (ja) 癌の分子的診断検査
US10280468B2 (en) Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer
US11091809B2 (en) Molecular diagnostic test for cancer
US11254986B2 (en) Gene signature for immune therapies in cancer
US10378066B2 (en) Molecular diagnostic test for cancer
AU2012261820A1 (en) Molecular diagnostic test for cancer
AU2014316824A1 (en) Molecular diagnostic test for lung cancer
CN105874080A (zh) 用于食道癌的分子诊断测试

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20161123