CN106139088A - A kind of Chinese medicine composition treating tinea pedis and preparation method thereof and purposes - Google Patents
A kind of Chinese medicine composition treating tinea pedis and preparation method thereof and purposes Download PDFInfo
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine composition treating tinea pedis and preparation method thereof and purposes.The crude drug of this Chinese medicine composition includes: Alumen 5～25 weight portion, Flos Carthami 2～18 weight portion, Rhizoma Zingiberis Recens 5～25 weight portion, Folium Camelliae sinensis 8～32 weight portion, Pulvis Talci 2～18 weight portion, Herba Taraxaci 2～18 weight portion, Radix Sophorae Flavescentis 8～32 weight portion, Cortex Dictamni 8～32 weight portion, Semen Plantaginis 5～25 weight portion, Cortex Phellodendri 5～25 weight portion, Rhizoma Atractylodis 2～18 weight portion, Mentholum 2～8 weight portion, Bulbus Allii 8～32 weight portion.The present invention take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine proportioning each other, make each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", jointly act on, thus play the therapeutical effect to tinea pedis；This Chinese medicine composition, each crude drug is the most relatively conventional, easily obtain, and composition is simple, cost is relatively low.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition treating tinea pedis and preparation method thereof with
On the way.
Background technology
Tinea pedis is the foot dermatosis caused by fungal infection, is common between toe abdomen and toe.The skin lesion of tinea pedis is often
First occurring from one side, several weeks or several months just develop into offside, and its form of expression mostly is blister, also there will be erosion or skin increases
The symptoms such as thick, coarse, cracking.At present, the medicine of clinical treatment tinea pedis mostly is antimycotic medicine, its not only thorn to skin
Sharp property is relatively big, and life-time service is easily generated drug resistance.
Chinese patent literature CN105412650A discloses: a kind of medicine for treating tinea pedis, it is according to weight portion bag
Include following component: Flos Lonicerae 15-30 part, Folium Artemisiae Argyi 10-20 part, Spica Prunellae 10-15 part, Flos Carthami 8-15 part, Herba Portulacae 12-20 part,
Fructus Forsythiae 5-10 part, Fructus Aurantii 10-15 part, Ramulus Uncariae Cum Uncis 5-10 part, Radix Glycyrrhizae 5-8 part, Rhizoma Coptidis 7-10 part, Cortex Acanthopancis 10-18 part, Fructus Atriplicis Sibiricae 5-
10 parts, Radix Puerariae 10-20 part, Rhizoma Imperatae 8-16 part, Alumen 7-9 part, Herba Pogostemonis 5-10 part, Radix Saposhnikoviae 2-7 part, Pericarpium Zanthoxyli 10-20 part, Pu Gong
English 9-15 part, Herba Houttuyniae 5-8 part, Radix Angelicae Sinensis 2-6 part, Radix Astragali 10-15 part, Rhizoma Atractylodis 10-30 part, Cortex Phellodendri 10-30 part, Flos Chrysanthemi Indici 15-
30 parts, Fructus Lycii 5-15 part, Radix Notoginseng 3-8 part, Radix Aucklandiae 5-9 part, vinegar 5-8 part, Radix Angelicae Dahuricae 4-9 part, salt 3-5 part, Radix Sophorae Flavescentis 3-8 part, thin
Lotus 6-9 part, Fructus Cnidii 7-12 part, Borneolum Syntheticum 2-5 part, Folium Ginkgo 5-15 part, Ramulus Mori 8-11 part, Cortex Albiziae 3-9 part, Rhizoma Dioscoreae 5-11
Part, Herba Andrographis 2-7 part, Olibanum 3-7 part, Radix Et Rhizoma Rhei 5-9 part；Said medicine is made as decoction be used for soaking affected part.But, above-mentioned
Compositions exists and forms the shortcomings such as complicated, relatively costly, thus limits its application.
Therefore, study that novel therapeutic effect is good, toxic and side effects is little, it is simple to form, the medicine of lower-cost treatment tinea pedis
Thing is significant.
Summary of the invention
Therefore, the present invention provide one to treat therapeutic effect is good, toxic and side effects is little, it is simple to form, lower-cost treatment
The Chinese medicine composition of tinea pedis, and then its preparation method and purposes are provided.
For solving above-mentioned technical problem, the present invention is achieved through the following technical solutions:
The present invention provides a kind of Chinese medicine composition treating tinea pedis, and its crude drug includes: Alumen 5～25 weight portion, Flos Carthami 2
～18 weight portions, Rhizoma Zingiberis Recens 5～25 weight portion, Folium Camelliae sinensis 8～32 weight portion, Pulvis Talci 2～18 weight portion, Herba Taraxaci 2～18 weight
Part, Radix Sophorae Flavescentis 8～32 weight portion, Cortex Dictamni 8～32 weight portion, Semen Plantaginis 5～25 weight portion, Cortex Phellodendri 5～25 weight portion, Rhizoma Atractylodis 2
～18 weight portions, Mentholum 2～8 weight portion, Bulbus Allii 8～32 weight portion.
Preferably, the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, its crude drug includes: Alumen 10～20 weight portion,
Flos Carthami 6～14 weight portion, Rhizoma Zingiberis Recens 10～20 weight portion, Folium Camelliae sinensis 14～26 weight portion, Pulvis Talci 6～14 weight portion, Herba Taraxaci 6～
14 weight portions, Radix Sophorae Flavescentis 14～26 weight portion, Cortex Dictamni 14～26 weight portion, Semen Plantaginis 10～20 weight portion, Cortex Phellodendri 10～20 weight
Amount part, Rhizoma Atractylodis 6～14 weight portion, Mentholum 3.5～6.5 weight portion, Bulbus Allii 14～26 weight portion.
It is further preferred that the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, its crude drug includes: Alumen 15 weight
Part, Flos Carthami 10 weight portion, Rhizoma Zingiberis Recens 15 weight portion, Folium Camelliae sinensis 20 weight portion, Pulvis Talci 10 weight portion, Herba Taraxaci 10 weight portion, Radix Sophorae Flavescentis
20 weight portions, Cortex Dictamni 20 weight portion, Semen Plantaginis 15 weight portion, Cortex Phellodendri 15 weight portion, Rhizoma Atractylodis 10 weight portion, Mentholum 5 weight
Part, Bulbus Allii 20 weight portion；Or
Alumen 10 weight portion, Flos Carthami 14 weight portion, Rhizoma Zingiberis Recens 10 weight portion, Folium Camelliae sinensis 26 weight portion, Pulvis Talci 6 weight portion, Pu
Herba Taraxaci 14 weight portion, Radix Sophorae Flavescentis 14 weight portion, Cortex Dictamni 26 weight portion, Semen Plantaginis 10 weight portion, Cortex Phellodendri 20 weight portion, Rhizoma Atractylodis 6 weight
Amount part, Mentholum 6.5 weight portion, Bulbus Allii 14 weight portion；Or
Alumen 20 weight portion, Flos Carthami 6 weight portion, Rhizoma Zingiberis Recens 20 weight portion, Folium Camelliae sinensis 14 weight portion, Pulvis Talci 14 weight portion, Pu
Herba Taraxaci 6 weight portion, Radix Sophorae Flavescentis 26 weight portion, Cortex Dictamni 14 weight portion, Semen Plantaginis 20 weight portion, Cortex Phellodendri 10 weight portion, Rhizoma Atractylodis 14 weight
Amount part, Mentholum 3.5 weight portion, Bulbus Allii 26 weight portion；Or
Alumen 13 weight portion, Flos Carthami 9 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Folium Camelliae sinensis 21 weight portion, Pulvis Talci 10 weight portion, Pu
Herba Taraxaci 8 weight portion, Radix Sophorae Flavescentis 19 weight portion, Cortex Dictamni 23 weight portion, Semen Plantaginis 13 weight portion, Cortex Phellodendri 18 weight portion, Rhizoma Atractylodis 12 weight
Amount part, Mentholum 5.4 weight portion, Bulbus Allii 20 weight portion.
It is further preferred that the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, its crude drug also includes: vinegar 65～
135 parts by volume, Spirit 65～135 parts by volume, Sal 14～26 weight portion, described weight portion is g/ with the relation of parts by volume
mL。
It is further preferred that the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, described vinegar is 100 parts by volume, described
Spirit is 100 parts by volume, and described Sal is 20 weight portions.
It is further preferred that the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, described vinegar is white vinegar, described Spirit
For China white wine, the number of degrees of described Spirit are 35～45 °.
It is further preferred that the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, described Spirit is 40 ° of China white wines.
The present invention also provides for the preparation method of the Chinese medicine composition of a kind of above-mentioned treatment tinea pedis, comprises the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing, make 50～150 mesh powder after grinding, dries at 100～200 DEG C
Roasting at least 5min, to obtain final product；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction at least 1 time, add the water extraction at least 0.5 of at least 1 weight times amount every time
Hour, filtering, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.05-1.30, to obtain final product.
Preferably, the preparation method of the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, comprise the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing, make 80～120 mesh powder after grinding, dries at 130～170 DEG C
Roasting 10～30min, to obtain final product；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 1～5 times, each water extraction 1 adding 1～5 weight times amount～3 hours,
Filtering, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
It is further preferred that the preparation method of the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, comprise the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing, make 100 mesh powder after grinding, toasts 20min, i.e. at 150 DEG C
?；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 3 times, the water extraction of addition 3 weight times amount 2 hours, filter every time, merge
Filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The present invention also provides for the preparation method of the Chinese medicine composition of a kind of above-mentioned treatment tinea pedis, comprises the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into the vinegar of selected parts by volume, the Spirit of selected parts by volume and selected weight
The Sal of amount part, airtight immersion 7～10 days under room temperature, filter, to obtain final product；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into the vinegar of selected parts by volume, the Spirit of selected parts by volume and selected weight
The Sal of amount part, airtight dipping 1～3 times at 40～50 DEG C, every time dipping 1～5 day, cooling, filter, merge impregnation liquid, i.e.
?.
Preferably, the preparation method of the Chinese medicine composition of the present invention above-mentioned treatment tinea pedis, comprise the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into the vinegar of selected parts by volume, the Spirit of selected parts by volume and selected weight
The Sal of amount part, airtight immersion 8 days under room temperature, filter, to obtain final product；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into the vinegar of selected parts by volume, the Spirit of selected parts by volume and selected weight
The Sal of amount part, airtight dipping 2 times at 45 DEG C, every time dipping 3 days, cooling, filter, merge impregnation liquid, to obtain final product.
The present invention also provides for including the preparation of the Chinese medicine composition of above-mentioned treatment tinea pedis or including above-mentioned preparation method system
The preparation of the Chinese medicine composition of the standby treatment tinea pedis obtained,
Described Chinese medicine composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule
Agent, powder, mixture, pill, granule, solution, syrup, soft extract or patch.
Described customary adjuvant is: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, anticorrosion
Agent, substrate etc..Filler includes: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.；Collapse
Solution agent includes: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low replacement hydroxyl
Third cellulose, cross-linked carboxymethyl cellulose are received；Lubricant includes: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, dioxy
SiClx etc.；Suspending agent includes: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl methyl cellulose etc.；Bonding
Agent includes, starch slurry, polyvinylpyrrolidone, hydroxypropyl methyl cellulose etc.；Sweeting agent includes: saccharin sodium, Aspartane, sugarcane
Sugar, cyclamate, enoxolone etc.；Correctives includes: sweeting agent and various essence；Preservative includes: parabens, benzoic acid,
Sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the eucalyptus oil of acetic acid chloroethene etc.；Substrate includes: PEG6000,
PEG4000, insect wax etc..The present invention also provides for above-mentioned Chinese medicine composition, above-mentioned preparation method prepares Chinese medicine composition or
The application in the medicine of preparation treatment tinea pedis of the preparation of above-mentioned Chinese medicine composition.
Compared with prior art, technical scheme has the advantage that
[Alumen] is cold in nature, sour in the mouth, puckery, returns lung, spleen, liver, large intestine channel, and external has removing toxic substances parasite killing, effect of dampness removing to stop itchin,
Interior with having hemostasis antidiarrheal, the effect of the expectorant that dispels the wind.
[Flos Carthami] is warm in nature, acrid in the mouth, GUIXIN, Liver Channel, has effect of promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
[Rhizoma Zingiberis Recens] slightly warm in nature, acrid in the mouth, return spleen, lung, stomach warp, there is effect of relieving exterior syndrome and dispelling cold, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.
[Folium Camelliae sinensis] cold nature, sweet in the mouth, hardship, GUIXIN, lung, stomach warp, have heat clearing away, help digestion, diuresis, convergence, dysentery relieving, removing toxic substances
Effect.
[Pulvis Talci] is cold in nature, sweet in the mouth, light, return bladder, lung, stomach warp, has inducing diuresis for treating stranguria syndrome, clearing away summer-heat, damp eliminating sore
Effect.
[Herba Taraxaci] is cold in nature, bitter in the mouth, sweet, returns liver, stomach warp, has effect of clearing away summer-heat, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.
[Radix Sophorae Flavescentis] is cold in nature, bitter in the mouth, GUIXIN, liver, stomach, large intestine, bladder warp, has effect of heat clearing and damp drying, parasite killing, diuresis.
[Cortex Dictamni] is cold in nature, bitter in the mouth, salty, returns spleen, stomach warp, have dispel the wind, dampness, heat clearing away, effect of removing toxic substances.
[Semen Plantaginis] is cold in nature, sweet in the mouth, returns kidney, liver, lung meridian, has relieving stranguria by diuresis, dampness removing antidiarrheal, liver heat removing and eyesight improving, lung heat clearing
Effect of expectorant.
[Cortex Phellodendri] is cold in nature, bitter in the mouth, returns kidney, bladder warp, has heat clearing and damp drying, pathogenic fire purging except steaming, effect of detoxification sore treatment.
[Rhizoma Atractylodis] are warm in nature, acrid in the mouth, hardship, return spleen, stomach, Liver Channel, have drying damp and strengthening spleen, dispel the wind, dispel the heat, effect of improving eyesight.
[Mentholum] is cool in nature, and acrid in the mouth returns lung meridian, have dispel the wind, effect of heat clearing away.
[Bulbus Allii] is warm in nature, acrid in the mouth, returns spleen, lung, stomach warp, have warming middle-JIAO help digestion, warming the spleen and stomach, removing food stagnancy removing toxic substances, effect of parasite killing.
(1) Chinese medicine composition of the present invention, take into full account each Chinese medicine return through and nature and flavor, and select each Chinese medicine mutually it
Between proportioning, make each Chinese medicine cooperate according to the compatibility relationship of " monarch, minister, help, make ", jointly act on, thus play tinea pedis
Therapeutical effect；
(2) Chinese medicine composition of the present invention, each crude drug is the most relatively conventional, easily obtain, composition is simple, cost relatively
Low.
Detailed description of the invention
Embodiment 1
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 15g, Flos Carthami 10g, Rhizoma Zingiberis Recens 15g, tea
Leaf 20g, Pulvis Talci 10g, Herba Taraxaci 10g, Radix Sophorae Flavescentis 20g, Cortex Dictamni 20g, Semen Plantaginis 15g, Cortex Phellodendri 15g, Rhizoma Atractylodis 10g, Mentholum
5g, Bulbus Allii 20g, white vinegar 100mL, 40 ° of China white wine 100mL, Sal 20g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis,
Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri, Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into selected volume
Vinegar, the Spirit of selected volume and the Sal of selected weight, airtight immersion 8 days under room temperature, filter, to obtain final product；Or
Take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into the white vinegar of selected volume, 40 ° of China white wines of selected volume and selected weight
The Sal of amount, airtight dipping 2 times at 45 DEG C, every time dipping 3 days, cooling, filter, merge impregnation liquid, to obtain final product.
Embodiment 2
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 10g, Flos Carthami 14g, Rhizoma Zingiberis Recens 10g, tea
Leaf 26g, Pulvis Talci 6g, Herba Taraxaci 14g, Radix Sophorae Flavescentis 14g, Cortex Dictamni 26g, Semen Plantaginis 10g, Cortex Phellodendri 20g, Rhizoma Atractylodis 6g, Mentholum
6.5g, Bulbus Allii 14g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis,
Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri, Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 3 times, every time
Adding the water extraction 2 hours of 3 weight times amount, filter, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The Chinese medicine composition of the present embodiment treatment tinea pedis adds customary adjuvant, according to common process, makes capsule.
Embodiment 3
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 20g, Flos Carthami 6g, Rhizoma Zingiberis Recens 20g, tea
Leaf 14g, Pulvis Talci 14g, Herba Taraxaci 6g, Radix Sophorae Flavescentis 26g, Cortex Dictamni 14g, Semen Plantaginis 20g, Cortex Phellodendri 10g, Rhizoma Atractylodis 14g, Mentholum
3.5g, Bulbus Allii 26g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis,
Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri, Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 1 time, every time
Adding the water extraction 1 hour of 5 weight times amount, filter, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The Chinese medicine composition of the present embodiment treatment tinea pedis adds customary adjuvant, according to common process, makes tablet.
Embodiment 4
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 13g, Flos Carthami 9g, Rhizoma Zingiberis Recens 17g, tea
Leaf 21g, Pulvis Talci 10g, Herba Taraxaci 8g, Radix Sophorae Flavescentis 19g, Cortex Dictamni 23g, Semen Plantaginis 13g, Cortex Phellodendri 18g, Rhizoma Atractylodis 12g, Mentholum
5.4g, Bulbus Allii 20g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis,
Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri, Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 5 times, every time
Adding the water extraction 3 hours of 1 weight times amount, filter, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The Chinese medicine composition of the present embodiment treatment tinea pedis adds customary adjuvant, according to common process, makes oral liquid.
Embodiment 5
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 15g, Flos Carthami 10g, Rhizoma Zingiberis Recens 15g, tea
Leaf 20g, Pulvis Talci 10g, Herba Taraxaci 10g, Radix Sophorae Flavescentis 20g, Cortex Dictamni 20g, Semen Plantaginis 15g, Cortex Phellodendri 15g, Rhizoma Atractylodis 10g, Mentholum
5g, Bulbus Allii 20g；
The preparation method of this Chinese medicine composition, comprises the following steps:
Take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Huang
Cypress, Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing, make 100 mesh powder after grinding, toasts 20min, i.e. at 150 DEG C
?.
Embodiment 6
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 13g, Flos Carthami 9g, Rhizoma Zingiberis Recens 17g, tea
Leaf 21g, Pulvis Talci 10g, Herba Taraxaci 8g, Radix Sophorae Flavescentis 19g, Cortex Dictamni 23g, Semen Plantaginis 13g, Cortex Phellodendri 18g, Rhizoma Atractylodis 12g, Mentholum
5.4g, Bulbus Allii 20g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis,
Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri, Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing after grinding
Mill, makes 80 mesh powder, toasts 10min, to obtain final product at 170 DEG C.
Embodiment 7
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 10g, Flos Carthami 14g, Rhizoma Zingiberis Recens 10g, tea
Leaf 26g, Pulvis Talci 6g, Herba Taraxaci 14g, Radix Sophorae Flavescentis 14g, Cortex Dictamni 26g, Semen Plantaginis 10g, Cortex Phellodendri 20g, Rhizoma Atractylodis 6g, Mentholum
6.5g, Bulbus Allii 14g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis,
Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri, Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing after grinding
Mill, makes 120 mesh powder, toasts 30min, to obtain final product at 130 DEG C.
Embodiment 8
The crude drug of the Chinese medicine composition of the present embodiment treatment tinea pedis consists of: Alumen 15g, Flos Carthami 10g, Rhizoma Zingiberis Recens 15g, tea
Leaf 20g, Pulvis Talci 10g, Herba Taraxaci 10g, Radix Sophorae Flavescentis 20g, Cortex Dictamni 20g, Semen Plantaginis 15g, Cortex Phellodendri 15g, Rhizoma Atractylodis 10g, Mentholum
5g, Bulbus Allii 20g；
The preparation method of this Chinese medicine composition, comprises the following steps: take the Alumen of selected weight, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis,
Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri, Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 3 times, every time
Adding the water extraction 2 hours of 3 weight times amount, filter, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The Chinese medicine composition of the present embodiment treatment tinea pedis adds customary adjuvant, according to common process, makes capsule.
Experimental example 1The research of the therapeutic effect to tinea pedis of Chinese medicine composition of the present invention
1, experiment material
In this experimental example, each crude drug is commercially available product.
2, experimental technique
2.1 for reagent thing
Experimental group: the Chinese medicine composition of embodiment 1 preparation；Matched group: placebo.
2.2 experiment packets
Select in medical tinea pedis patient 120 example in March, 2014 in February, 2015, patient age 18-68 year, average year
37.3 years old age；All patients all get rid of the serious systemic diseases such as serious hepatorenal disease, malignant tumor.
Above-mentioned patient is randomly divided into experimental group and matched group, wherein experimental group 60 example, matched group 60 example, and two groups of patients are general
Data is not statistically significant (P ＞ 0.05) after statistical analysis, has comparability.
2.3 medication
The solution of the Chinese medicine composition of experimental group embodiment 1 preparation is treated, and each 50mL adds water every time
500mL dilutes foot bath, soaks 0.5 hour every time, every day 2 times (early, evening each 1 time), takes medicine continuously 4 weeks；Matched group placebo
The solution made is treated, each 50mL, and the 500mL that every time adds water dilutes foot bath, each 0.5 hour, 2 (early, evenings of every day
Each 1 time), treatment 4 weeks continuously.
3, experimental data detection and process
After treating 4 weeks continuously, all patients are carried out the observation of tinea pedis clinical symptoms, it is judged that clinical efficacy.
Symptom assessment standard: (1) is effective: experimenter's tinea pedis clinical symptoms is wholly absent；(2) effective: experimenter's tinea pedis is faced
Bed symptom is obviously improved；(3) invalid: compared with before treatment, experimenter's tinea pedis clinical symptoms is unchanged or increases the weight of.Wherein, effective
Rate and effective percentage sum are referred to as total effective rate.
4, experimental result
The specific experiment result of experimental group and matched group is as shown in table 1.
The specific experiment result of 1 liang of table group patient
| Group | Number of cases | Effective number of cases | Effectively number of cases | Invalid number of cases | Total effective rate (%) |
| Experimental group | 60 | 40 | 16 | 4 | 93.3** |
| Matched group | 60 | 5 | 14 | 41 | 31.7 |
Note: compare with matched group,**P ＜ 0.01
As shown in Table 1, the total effective rate of experimental group is 93.3%, hence it is evident that be better than the total effective rate 31.7% of matched group；Two
The difference that group compares has statistical significance (P < 0.01).This shows, the solution of the Chinese medicine composition of embodiment 1 preparation is permissible
Significantly improve the total effective rate for the treatment of tinea pedis.
5, experiment conclusion
Chinese medicine composition of the present invention has significant therapeutic effect to tinea pedis, can be as the medicine of potential treatment tinea pedis
Thing.
Obviously, above-described embodiment is only for clearly demonstrating example, and not restriction to embodiment.Right
For those of ordinary skill in the field, can also make on the basis of the above description other multi-form change or
Variation.Here without also cannot all of embodiment be given exhaustive.And the obvious change thus extended out or
Change among still in the protection domain of the invention.
Claims (10)
1. a Chinese medicine composition, it is characterised in that its crude drug includes:
Alumen 5～25 weight portion, Flos Carthami 2～18 weight portion, Rhizoma Zingiberis Recens 5～25 weight portion, Folium Camelliae sinensis 8～32 weight portion, Pulvis Talci 2～
18 weight portions, Herba Taraxaci 2～18 weight portion, Radix Sophorae Flavescentis 8～32 weight portion, Cortex Dictamni 8～32 weight portion, Semen Plantaginis 5～25 weight
Part, Cortex Phellodendri 5～25 weight portion, Rhizoma Atractylodis 2～18 weight portion, Mentholum 2～8 weight portion, Bulbus Allii 8～32 weight portion.
Chinese medicine composition the most according to claim 1, it is characterised in that its crude drug includes:
Alumen 10～20 weight portion, Flos Carthami 6～14 weight portion, Rhizoma Zingiberis Recens 10～20 weight portion, Folium Camelliae sinensis 14～26 weight portion, Pulvis Talci
6～14 weight portions, Herba Taraxaci 6～14 weight portion, Radix Sophorae Flavescentis 14～26 weight portion, Cortex Dictamni 14～26 weight portion, Semen Plantaginis 10～
20 weight portions, Cortex Phellodendri 10～20 weight portion, Rhizoma Atractylodis 6～14 weight portion, Mentholum 3.5～6.5 weight portion, Bulbus Allii 14～26 weight
Part.
Chinese medicine composition the most according to claim 2, it is characterised in that its crude drug includes:
Alumen 15 weight portion, Flos Carthami 10 weight portion, Rhizoma Zingiberis Recens 15 weight portion, Folium Camelliae sinensis 20 weight portion, Pulvis Talci 10 weight portion, Herba Taraxaci
10 weight portions, Radix Sophorae Flavescentis 20 weight portion, Cortex Dictamni 20 weight portion, Semen Plantaginis 15 weight portion, Cortex Phellodendri 15 weight portion, Rhizoma Atractylodis 10 weight
Part, Mentholum 5 weight portion, Bulbus Allii 20 weight portion；Or
Alumen 10 weight portion, Flos Carthami 14 weight portion, Rhizoma Zingiberis Recens 10 weight portion, Folium Camelliae sinensis 26 weight portion, Pulvis Talci 6 weight portion, Herba Taraxaci
14 weight portions, Radix Sophorae Flavescentis 14 weight portion, Cortex Dictamni 26 weight portion, Semen Plantaginis 10 weight portion, Cortex Phellodendri 20 weight portion, Rhizoma Atractylodis 6 weight portion,
Mentholum 6.5 weight portion, Bulbus Allii 14 weight portion；Or
Alumen 20 weight portion, Flos Carthami 6 weight portion, Rhizoma Zingiberis Recens 20 weight portion, Folium Camelliae sinensis 14 weight portion, Pulvis Talci 14 weight portion, Herba Taraxaci 6
Weight portion, Radix Sophorae Flavescentis 26 weight portion, Cortex Dictamni 14 weight portion, Semen Plantaginis 20 weight portion, Cortex Phellodendri 10 weight portion, Rhizoma Atractylodis 14 weight portion,
Mentholum 3.5 weight portion, Bulbus Allii 26 weight portion；Or
Alumen 13 weight portion, Flos Carthami 9 weight portion, Rhizoma Zingiberis Recens 17 weight portion, Folium Camelliae sinensis 21 weight portion, Pulvis Talci 10 weight portion, Herba Taraxaci 8
Weight portion, Radix Sophorae Flavescentis 19 weight portion, Cortex Dictamni 23 weight portion, Semen Plantaginis 13 weight portion, Cortex Phellodendri 18 weight portion, Rhizoma Atractylodis 12 weight portion,
Mentholum 5.4 weight portion, Bulbus Allii 20 weight portion.
4. according to the Chinese medicine composition described in any one of claim 1-3, it is characterised in that its crude drug also includes: vinegar 65
～135 parts by volume, Spirit 65～135 parts by volume, Sal 14～26 weight portion,
Described weight portion is g/mL with the relation of parts by volume.
5. the preparation method of the Chinese medicine composition described in an any one of claim 1-3, it is characterised in that include following step
Rapid:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing, make 50～150 mesh powder, be baked at 100～200 DEG C after grinding
Few 5min, to obtain final product；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction at least 1 time, the water extraction at least 0.5 every time adding at least 1 weight times amount is little
Time, filtering, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.05-1.30, to obtain final product.
The preparation method of Chinese medicine composition the most according to claim 5, it is characterised in that comprise the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing, make 80～120 mesh powder after grinding, toasts 10 at 130～170 DEG C
～30min, to obtain final product；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 1～5 times, each water extraction 1 adding 1～5 weight times amount～3 hours, mistake
Filter, merging filtrate, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
The preparation method of Chinese medicine composition the most according to claim 6, it is characterised in that comprise the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, grind after mixing or mixing, make 100 mesh powder after grinding, toasts 20min, to obtain final product at 150 DEG C；
Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, heating and refluxing extraction 3 times, the water extraction of addition 3 weight times amount 2 hours, filter every time, merge filter
Liquid, being concentrated into 50 DEG C of relative densities is 1.10-1.25, to obtain final product.
8. the preparation method of the Chinese medicine composition described in a claim 4, it is characterised in that comprise the following steps:
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into the vinegar of selected parts by volume, the Spirit of selected parts by volume and selected weight portion
Sal, airtight immersion 7～10 days under room temperature, filter, to obtain final product；Or
Take the Alumen of selected weight portion, Flos Carthami, Rhizoma Zingiberis Recens, Folium Camelliae sinensis, Pulvis Talci, Herba Taraxaci, Radix Sophorae Flavescentis, Cortex Dictamni, Semen Plantaginis, Cortex Phellodendri,
Rhizoma Atractylodis, Mentholum and Bulbus Allii, be then sequentially added into the vinegar of selected parts by volume, the Spirit of selected parts by volume and selected weight portion
Sal, airtight dipping 1～3 times at 40～50 DEG C, every time dipping 1～5 day, cooling, filter, merge impregnation liquid, to obtain final product.
9. include the preparation of the Chinese medicine composition described in any one of claim 1-4 or include any one of claim 5-8 institute
The preparation of the Chinese medicine composition that the preparation method stated prepares, it is characterised in that
Described Chinese medicine composition adds customary adjuvant, according to common process, makes the most acceptable tablet, capsule, dissipates
Agent, mixture, pill, granule, solution, syrup, soft extract or patch.
10. prepared by the Chinese medicine composition described in any one of claim 1-4, the preparation method described in any one of claim 5-8
The preparation of the Chinese medicine composition described in the Chinese medicine composition obtained or claim 9 answering in the medicine of preparation treatment tinea pedis
With.
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|---|---|---|---|---|
| CN102988934A (en) * | 2012-10-30 | 2013-03-27 | 严中明 | Prescription of traditional Chinese medicine for treating beriberi and use method thereof |
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|---|---|---|---|---|
| CN102988934A (en) * | 2012-10-30 | 2013-03-27 | 严中明 | Prescription of traditional Chinese medicine for treating beriberi and use method thereof |
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