CN106138480A - The medicine of a kind of enhancing immunity or health food - Google Patents
The medicine of a kind of enhancing immunity or health food Download PDFInfo
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- CN106138480A CN106138480A CN201510132359.9A CN201510132359A CN106138480A CN 106138480 A CN106138480 A CN 106138480A CN 201510132359 A CN201510132359 A CN 201510132359A CN 106138480 A CN106138480 A CN 106138480A
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- vitis viniferae
- medicine
- enhancing immunity
- viniferae extract
- health food
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Abstract
The present invention relates to medicine or the health food of a kind of enhancing immunity.It is characterized in that containing functional component: resveratrol, procyanidin, vitamin C.Pharmacological research shows that it has good enhancing immunity effect.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of medicine with enhancing immunity effect or health food.
Background technology
Society dog-eat-dog survival pressure sharply increases, and the pressure of work, erratic diet, too fast rhythm of life are all threaten health.Subhealth state is the most just being popular in many people, improves autoimmunity extremely urgent.This just makes us in the face of an important problem: the most safely and effectively enhancing immunity, it is ensured that the health of health.
Summary of the invention
It is an object of the invention to provide medicine or the health food of a kind of safely and effectively enhancing immunity.
The medicine of enhancing immunity of the present invention or health food, mainly contain following raw material: Pericarpium Vitis viniferae extract, Semen Vitis viniferae extract, vitamin C.
The medicine of enhancing immunity of the present invention or health food, mainly contain following functional component: resveratrol, procyanidin, vitamin C.
Wherein, resveratrol is the effective ingredient of Pericarpium Vitis viniferae extract in Angiospermae, Dicotyledoneae, Fructus Vitis viniferae mesh, Vitaceae, Vitis, Fructus Vitis viniferae, has antioxidation, removes free radical, protection cardiovascular, the effect such as anticancer.Resveratrol is a kind of natural antioxidant; blood viscosity can be reduced; the suppression improper cohesion of platelet and vasodilation, keep unblocked blood flowing, to cerebral embolism; the protected effect of myocardial ischemia; prevention myocardial infarction, overweight people can be risen one control and antiobesity action, can the generation of prophylaxis of cancer and development, there is atherosclerosis and coronary heart disease; ischemic heart desease, the preventive and therapeutic effect of hyperlipidemia.The effect of suppression tumor also has estrogen-like effects, can be used for treating the diseases such as breast carcinoma.The cardiac output decline causing burn or hemorrhagic shock has efficient recovery effect.
Procyanidin is Semen Vitis viniferae extract, the effective ingredient of Pericarpium Vitis viniferae extract in Angiospermae, Dicotyledoneae, Fructus Vitis viniferae mesh, Vitaceae, Vitis, Fructus Vitis viniferae, it it is the most potent free radical scavenger found so far, procyanidin (Semen Vitis viniferae extract) is a kind of new and effective antioxidant, has the strongest activity in vivo.It is demonstrated experimentally that the free radical resisting oxidability of OPC is 50 times of vitamin E, ascorbic 20 times, and absorb the most completely, and it being administered orally and i.e. can reach the highest haemoconcentration in 20 minutes, metabolic half life is for 7 hours.
Vitamin C is antibody and collagen formation, tissue repairing (includes some redox), phenylalanine, tyrosine, the metabolism of folic acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, maintain immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote that the institutes such as nonheme iron absorption are required.
The present invention selects resveratrol oxidation and removing free radicals, procyanidin antioxidation, and vitamin C maintains immunologic function.All medicines share, multinomial compatibility common enhancing human body immunity power.Fundamentally increase immunity, strengthening body resistance.
This medicine or the optimised process of health food:
Weigh the raw material of following weight proportion: Pericarpium Vitis viniferae extract 3.52 parts, Semen Vitis viniferae extract 5 parts, Catergen .5 part, add magnesium stearate 0.25 weight portion, starch 5 weight portion, microcrystalline Cellulose 1.55 weight portion, mixing, capsule fill, make capsule.
This medicine or health food have good enhancing immunity effect.
Relevant pharmacological experimental data
1, laboratory animal
Experiment cleaning grade female ICR white mice, body weight (20 ± 2) g.Detection environmental condition, temperature range 20 ~ 25 DEG C, relative humidity 40% ~ 70%.In Animal House environment, 3d is adapted to before mouse experiment.
2, test method
2.1, experiment packet and cycle each pilot project all set up experimental group and the negative control group of various dose, often group 10, wherein experimental group dosage is respectively by human body recommended dose 1.6g/d(60kg*d) 5 times, 10 times, 30 times of designs low dose group (0.13g/kg), middle dosage group (0.27g/kg), high dose group (0.80g/kg) all experimental grouies per os (gavage) give the sample of various dose, gavage volume is 0.1ml/10g body weight, once/d, counts 30d；Negative group gives the normal saline with same volume.
2.2, experimental technique and interpretation of result
2.2.1, splenocyte Cell transformation test: experiment the 30th day, every mice is aseptic took spleen, is placed in and fills in appropriate aseptic Hanks liquid plate, is ground by spleen gently with tweezers, make single cell suspension.Filter through 200 eye mesh screens, or with 4 layers of gauze, spleen is ground, wash 2 times with Hanks liquid, be centrifuged 10min(1000r/min every time).Then, by cell suspension in 1ml complete culture solution, with platform phenol indigo plant dyeing counting viable count (should be more than 95%), adjusting cell concentration is 3 × 106/ml.Cell suspension point holes being added in 24 well culture plates, every hole 1ml, a hole adds 75 μ l ConA liquid (being equivalent to 7.5 μ g/ml), and 5% CO2, as comparison, is put in another hole, cultivates 72h in 37 DEG C of CO2 incubators.Cultivation terminates front 4h, and every hole sucks supernatant 0.7ml gently, adds the 0.7ml RPMI1640 culture fluid without calf serum, is simultaneously introduced MTT(5mg/ml) 50 μ l/ holes, continue to cultivate 4h.After cultivation terminates, every hole adds 1ml acid isopropyl alcohol, piping and druming mixing, makes purple crystal be completely dissolved.Then solution is moved in cuvette, measure optical density value OD value with 721 spectrophotometers at wavelength 570nm.Finally deduct the optical density value in ConA hole by the optical density value adding ConA hole and represent the multiplication capacity of lymphocyte.
2.2.2, mice serum hemolysin test: at experiment the 25th day, every Mus abdomen injection 0.2ml2%(V/V) hematocrit sheep red blood cell (SRBC) (SRBC) suspension, carry out immunity.After 5d, take blood and be centrifuged, collect serum, with normal saline by serum doubling dilution, 37 DEG C of incubation 3h, observe hemagglutination degree, calculating antibody product.
2.2.3 30min before, macrophage phagocytic chicken red blood cell experimental animal is put to death, every Mus abdomen injection 1.0ml20%(V/V) chicken erythrocyte suspension, place after death reinjects 2ml normal saline, take abdominal cavity drop sheet, 37 DEG C of incubation 30min, fix, dyeing, microscopy, counts 100 macrophages, calculates phagocytic rate and phagocytic index.
2.2.4, internal organs/body weight ratio put to death animal, take its thymus and spleen, weigh, calculate thymus/body weight and spleen/body weight ratio.
2.2.5, the multiple samples of experimental data statistics compare employing variance analysis process data；Multisample compares employing q inspection two-by-two.P ＜ 0.05 has statistical significance for difference.
3, result
3.1, the impact of the mice spleen lymphocytes proliferation ability that ConA is induced by the lymphopoiesis ability present invention, is shown in Table 1.Experimental group compares with negative control group, and three dosage groups all can significantly improve the multiplication capacity of splenocyte.
The impact (g/kg) of the mice spleen lymphocytes proliferation ability that ConA is induced by table 1 present invention
Compared with negative control group, P < 0.05
The 3.2 serum hemolysin present invention impact on mice serum hemolysin, is shown in Table 2.Experimental group compares with negative control group, and three dosage groups all can significantly improve mice serum hemolytic antibody product level.
Table 2 present invention impact (g/kg) on the impact of mice serum hemolysin
Compared with negative control group, P < 0.05
3.3, the peritoneal macrophage phagocytosis chicken red blood cell present invention impact on Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell, is shown in Table 3.Experimental group compares with negative control group, and three dosage groups all can improve the phagocytic rate of spleen Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell.
Table 3 present invention impact [g/kg(%)] on Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell
Compared with negative control group, P < 0.05
3.4, internal organs/proportion ratio present invention impact on mice organs/body weight ratio, is shown in Table 4.Three dosage group mouse thymus/body weight ratios and spleen/body weight ratio and negative control group compare, and there was no significant difference (P ＞ 0.05)
Table 4 present invention impact (g/kg, mg/g) on mice organs/proportion ratio
Compared with negative control group, P ＞ 0.05
1, discuss
According to enhancing immunity experimental result decision rule in " function of health food assessment process and the method for inspection ": " enhancing immunity function judges: in cellular immune function, humoral immune function, mononuclear phagocyte function, any two aspect results positives of four aspects of NK cytoactive, can determine that this given the test agent has enhancing immunity function." the study show that: the present invention is on mouse thymus/body weight ratio and spleen/body weight ratio without impact, and the present invention can improve the multiplication capacity of the mouse spleen lymphocyte of ConA induction, can improve mice serum hemolytic antibody product level；The phagocytic rate of Turnover of Mouse Peritoneal Macrophages phagocytosis chicken red blood cell can be improved, illustrate that the present invention has the effect of enhancing immunity.
Detailed description of the invention
Embodiment
1
:
Weigh Pericarpium Vitis viniferae extract 35.7 parts, Semen Vitis viniferae extract 5 parts, vitamin C 2.5 parts add magnesium stearate 0.25 weight portion, starch 5 weight portion, microcrystalline Cellulose 1.55 weight portion, mixing, and capsule fill is packaged into bottle.
Embodiment
2
:
Weigh Pericarpium Vitis viniferae extract 36 parts, Semen Vitis viniferae extract 4 parts, vitamin C 3 parts add magnesium stearate 0.2 weight portion, starch 6 weight portion, microcrystalline Cellulose 1.5 weight portion, mixing, and capsule fill is packaged into bottle.
Embodiment
3
:
Weigh Pericarpium Vitis viniferae extract 36 parts, Semen Vitis viniferae extract 4 parts, vitamin C 3 parts add magnesium stearate 0.25 weight portion, starch 6 weight portion, microcrystalline Cellulose 1.5 weight portion, and mixing is pelletized, and 75 DEG C are dried, and granulate is packaged into bag.
Embodiment
4
:
Weigh Pericarpium Vitis viniferae extract 10 parts, Semen Vitis viniferae extract 1 part, vitamin C 1 part add magnesium stearate 0.25 weight portion, starch 7 weight portion, microcrystalline Cellulose 1.0 weight portion, and mixing is pelletized, and 75 DEG C are dried, and granulate is packaged into bag.
Embodiment
5
:
Weigh Pericarpium Vitis viniferae extract 36 parts, Semen Vitis viniferae extract 4 parts, vitamin C 3 parts add magnesium stearate 0.25 weight portion, starch 4 weight portion, microcrystalline Cellulose 2 weight portion, mixing, and tabletting is aluminum-plastic packaged, is packaged into box.
Embodiment
6
:
Weigh Pericarpium Vitis viniferae extract 34 parts, Semen Vitis viniferae extract 4 parts, vitamin C 3 parts add magnesium stearate 0.25 weight portion, starch 5 weight portion, microcrystalline Cellulose 1 weight portion, and mixing is pelletized, and 75 DEG C are dried, granulate, and capsule fill is aluminum-plastic packaged, is packaged into box.
Claims (6)
1. a medicine with enhancing immunity function or health food, it is characterised in that containing active ingredient: resveratrol, procyanidin, vitamin C.
The medicine with enhancing immunity function the most according to claim 1 or health food, it is characterised in that optimal active ingredient contained by it: Semen Vitis viniferae extract, Pericarpium Vitis viniferae extract, vitamin C.
The medicine with enhancing immunity function the most according to claim 1 or health food, it is characterised in that its weight proportion containing each composition is: resveratrol 1 ~ 40 part, procyanidin 5 ~ 40 parts, vitamin C 1 ~ 10 part.
The medicine with enhancing immunity function the most according to claim 3 or health food, it is characterised in that its weight proportion containing each composition is: Pericarpium Vitis viniferae extract 1 ~ 40 part, Semen Vitis viniferae extract 5 ~ 40 parts, vitamin C 1 ~ 10 part.
The medicine with enhancing immunity function the most according to claim 4 or health food, it is characterised in that its optimum weight proportioning containing each composition is: Pericarpium Vitis viniferae extract 35.7 parts, Semen Vitis viniferae extract 5 parts, Catergen .5 part.
The medicine with enhancing immunity function the most according to claim 5 or health food, it is characterized in that its preparation technology is: weigh the Pericarpium Vitis viniferae extract of above-mentioned weight proportion, Semen Vitis viniferae extract, vitamin C add magnesium stearate 0.25 weight portion, starch 5 weight portion, microcrystalline Cellulose 1.55 weight portion, mixing, capsule fill, makes capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510132359.9A CN106138480A (en) | 2015-03-25 | 2015-03-25 | The medicine of a kind of enhancing immunity or health food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510132359.9A CN106138480A (en) | 2015-03-25 | 2015-03-25 | The medicine of a kind of enhancing immunity or health food |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106138480A true CN106138480A (en) | 2016-11-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510132359.9A Pending CN106138480A (en) | 2015-03-25 | 2015-03-25 | The medicine of a kind of enhancing immunity or health food |
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| Country | Link |
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| CN (1) | CN106138480A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103704720A (en) * | 2013-12-20 | 2014-04-09 | 林元藻 | Anti-aging healthcare food for middle aged and elderly people |
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2015
- 2015-03-25 CN CN201510132359.9A patent/CN106138480A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103704720A (en) * | 2013-12-20 | 2014-04-09 | 林元藻 | Anti-aging healthcare food for middle aged and elderly people |
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Application publication date: 20161123 |